LOCUS       NM_023637               1910 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus seryl-aminoacyl-tRNA synthetase 2 (Sars2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_023637 XM_993801 XM_993815
VERSION     NM_023637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Zanotto,E., Shah,Z.H. and Jacobs,H.T.
  TITLE     The bidirectional promoter of two genes for the mitochondrial
            translational apparatus in mouse is regulated by an array of CCAAT
            boxes interacting with the transcription factor NF-Y
  JOURNAL   Nucleic Acids Res 35 (2), 664-677 (2007)
   PUBMED   17179180
  REMARK    GeneRIF: Identification of an array of 4 CCAAT box elements
            required for efficient transcription of the Sars2 gene.
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Gibbons,W.J. Jr., Yan,Q., Li,R., Li,X. and Guan,M.X.
  TITLE     Genomic organization, expression, and subcellular localization of
            mouse mitochondrial seryl-tRNA synthetase
  JOURNAL   Biochem Biophys Res Commun 317 (3), 774-778 (2004)
   PUBMED   15081407
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Yokogawa,T., Shimada,N., Takeuchi,N., Benkowski,L., Suzuki,T.,
            Omori,A., Ueda,T., Nishikawa,K., Spremulli,L.L. and Watanabe,K.
  TITLE     Characterization and tRNA recognition of mammalian mitochondrial
            seryl-tRNA synthetase
  JOURNAL   J Biol Chem 275 (26), 19913-19920 (2000)
   PUBMED   10764807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX122368.1, AK010491.1 and BY649585.1.
            
            On Mar 18, 2011 this sequence version replaced NM_023637.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140760.1, BC079664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CX122368.1         1-22
            23-1880             AK010491.1         1-1858
            1881-1910           BY649585.1         374-403
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.91 cM"
     gene            1..1910
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /note="seryl-aminoacyl-tRNA synthetase 2"
                     /db_xref="GeneID:71984"
                     /db_xref="MGI:MGI:1919234"
     exon            1..315
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1605
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /EC_number="6.1.1.11"
                     /note="seryl-tRNA synthetase, mitochondrial;
                     seryl-tRNA(Ser/Sec) synthetase; serine--tRNA ligase,
                     mitochondrial"
                     /codon_start=1
                     /product="serine--tRNA ligase, mitochondrial precursor"
                     /protein_id="NP_076126.2"
                     /db_xref="CCDS:CCDS21053.1"
                     /db_xref="GeneID:71984"
                     /db_xref="MGI:MGI:1919234"
                     /translation="MAASMARLWWPFLARQGLRSRGRCVCSQNPRRSFATEKRVRNLL
                     YEHAREGYSELPYLDMESVCACPEKAARSLELRKGELRPADLPAIISTWQELRQLREQ
                     IRSLEAEKEAVAEAVRALLANQDSDQVQKDPQYQGLRARGREIRKQLTPLYPQETQLE
                     EQLYQQALRLPNQTHPDTPVGDESQARVVRVVGEKPAFSFQPRGHLEIGEKLDIIRQK
                     RLSHVSGHRSYYLRGAGALLQHGLVNFTLSKLVSRGFTPMTVPDLLRGAVFEGCGMTP
                     NANPSQIYNIDPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPVRMVCASTCYRAETD
                     TGKEPWGLYRVHHFTKVEMFGVTGPGLEQSSQLLDEFLSLQVEILTELGLHFRVLDMP
                     TQELGLPAYRKFDIEAWMPGRGRYGEVTSASNCTDFQSRRLYIMFETETGELQFAHTV
                     NATACAVPRVLIALLESNQQKDGSVLVPAALQPYLGTDRITAPTHVPLQYIGPNQPQK
                     PRLPGQSATR"
     exon            316..411
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            412..441
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            442..582
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            583..637
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            638..701
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            702..807
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            808..855
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            856..964
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1010
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1098
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1208
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1302
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1395
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1461
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1910
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /note="hexamer: AATAAA"
     polyA_site      1886
                     /gene="Sars2"
                     /gene_synonym="2410015F05Rik; D7Ertd353e; SerRS; SerRSmt"
                     /note="major polyA site"
ORIGIN      
        1 gtctgattgg ctcgtccatg atgagtgact tcttgtttcc actccaagat ggctgcgtcc
       61 atggcgcggc tttggtggcc tttcctggct cgccaggggc tccggtcccg aggacgctgc
      121 gtgtgcagcc agaacccaag gaggagtttc gctacggaga aacgagtccg gaacctcctg
      181 tacgaacacg cacgagaggg ctacagcgag cttccctact tggacatgga gtcggtgtgc
      241 gcatgcccag aaaaagccgc gcgctccctg gagctccgca agggggagct gcggccggcc
      301 gacctgcctg cgattatctc cacgtggcag gagttgaggc agcttcgaga gcagatccgg
      361 agcctggagg cagagaagga ggctgtggca gaggcagtgc gggccctgct ggcaaaccaa
      421 gacagtgacc aagtgcagaa ggacccccaa tatcagggcc tgcgggcccg aggccgggag
      481 atccggaagc agctcacacc cttgtacccc caagagaccc agctagagga gcagctgtac
      541 cagcaggcac tgaggctgcc caaccagacc cacccagaca cgcctgtggg ggacgagagc
      601 caggctagag tggtccgtgt ggtgggtgaa aagccggctt tctccttcca accccgaggc
      661 cacctggaaa ttggcgagaa actggacatc atccggcaga agcgcctgtc tcacgtgtct
      721 ggccaccggt cctattacct gcgtggggca ggagccctct tacagcacgg cctggtcaac
      781 ttcaccctca gcaagcttgt cagcaggggc ttcaccccca tgacggtccc agaccttctg
      841 agaggagctg tgtttgaagg ctgtggaatg acaccaaatg ccaacccatc ccagatttac
      901 aatattgacc cctctcgctt cgaagacctt aacctggccg ggacggcaga ggtggggctg
      961 gcaggatact tcatggacca ctctgtagct ttcagggacc ttccagtcag gatggtctgt
     1021 gccagcacct gctaccgggc agagacagac actgggaagg agccttgggg actgtaccga
     1081 gtccatcact tcactaaggt ggagatgttt ggggtgacag gccctgggct ggagcagagc
     1141 tcgcagctgt tggatgagtt cctgtctctg caggtggaga tcttgacgga gctgggcttg
     1201 cacttccggg tactggacat gcccacccag gaactgggcc ttcctgctta tcgcaagttc
     1261 gacattgagg cctggatgcc tggccgaggc cgctatggag aggtcaccag tgcctccaac
     1321 tgcacagact tccagagccg ccgcctgtac atcatgtttg agacagagac cggggagctg
     1381 cagttcgcac acacggtgaa tgccaccgct tgtgctgttc cccgagtcct cattgccctc
     1441 ctggaaagca atcagcaaaa ggatggttca gtcctcgtgc ccgccgctct ccagccctac
     1501 ctaggcacgg accggatcac agcccctacc catgtgcctc tccagtacat cggccccaat
     1561 cagcctcaga agcccaggct ccccggccag tctgccacca gatgacagct gtctgctcca
     1621 gaggctggcg ttctagagac ccctgatact tagagacttt cccctgtagc tggtcctgat
     1681 gtctctgtag gtgtcacctc ccctcctgga ctcctgagtc tactgtccct tccctgccag
     1741 tgaattattg tcagtgatcc ctctaccatt gaggctgtca gccagaggca cggctcagcc
     1801 tgtgggccgg aagaaggccg tcccagcttc ttcttcccac ctcagtgcgg agcagaatgg
     1861 ccacaataaa tggtcgtgag aacagagtct tctggatcca tgagcacagg
//
