LOCUS       NM_172795               5044 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus sterile alpha and HEAT/Armadillo motif containing 1
            (Sarm1), transcript variant 2, mRNA.
ACCESSION   NM_172795
VERSION     NM_172795.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5044)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5044)
  AUTHORS   Fan,H., Song,C. and Zhang,J.
  TITLE     Sarm1 Controls the MYD88-Mediated Inflammatory Responses in
            Inflammatory Bowel Disease via the Regulation of TRAF3 Recruitment
  JOURNAL   Immunol Invest 53 (5), 800-812 (2024)
   PUBMED   38651786
  REMARK    GeneRIF: Sarm1 Controls the MYD88-Mediated Inflammatory Responses
            in Inflammatory Bowel Disease via the Regulation of TRAF3
            Recruitment.
REFERENCE   3  (bases 1 to 5044)
  AUTHORS   Hinz,F.I., Villegas,C.L.M., Roberts,J.T., Yao,H., Gaddam,S.,
            Delwig,A., Green,S.A., Fredrickson,C., Adrian,M., Asuncion,R.R.,
            Cheung,T.K., Hayne,M., Hackos,D.H., Rose,C.M., Richmond,D. and
            Hoogenraad,C.C.
  TITLE     Context-Specific Stress Causes Compartmentalized SARM1 Activation
            and Local Degeneration in Cortical Neurons
  JOURNAL   J Neurosci 44 (24), e2424232024 (2024)
   PUBMED   38692735
  REMARK    GeneRIF: Context-Specific Stress Causes Compartmentalized SARM1
            Activation and Local Degeneration in Cortical Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5044)
  AUTHORS   Belghazi,M., Iborra,C., Toutendji,O., Lasserre,M., Debanne,D.,
            Goaillard,J.M. and Marqueze-Pouey,B.
  TITLE     High-Resolution Proteomics Unravel a Native Functional Complex of
            Cav1.3, SK3, and Hyperpolarization-Activated Cyclic
            Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons
  JOURNAL   Cells 13 (11), 944 (2024)
   PUBMED   38891076
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5044)
  AUTHORS   Huang,Y., Wu,L., Zhao,Y., Guo,J., Li,R., Ma,S. and Ying,Z.
  TITLE     Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB
            pathway in injured peripheral nerves
  JOURNAL   Cell Rep 43 (2), 113753 (2024)
   PUBMED   38341853
REFERENCE   6  (bases 1 to 5044)
  AUTHORS   Pudla,M., Limposuwan,K. and Utaisincharoen,P.
  TITLE     Burkholderia pseudomallei-induced expression of a negative
            regulator, sterile-alpha and Armadillo motif-containing protein, in
            mouse macrophages: a possible mechanism for suppression of the
            MyD88-independent pathway
  JOURNAL   Infect Immun 79 (7), 2921-2927 (2011)
   PUBMED   21555400
  REMARK    GeneRIF: Burkholderia pseudomallei modulates macrophage defense
            mechanisms by upregulating SARM, thus leading to the suppression of
            IFN-beta and iNOS needed for bacterial elimination
REFERENCE   7  (bases 1 to 5044)
  AUTHORS   Szretter,K.J., Samuel,M.A., Gilfillan,S., Fuchs,A., Colonna,M. and
            Diamond,M.S.
  TITLE     The immune adaptor molecule SARM modulates tumor necrosis factor
            alpha production and microglia activation in the brainstem and
            restricts West Nile Virus pathogenesis
  JOURNAL   J Virol 83 (18), 9329-9338 (2009)
   PUBMED   19587044
  REMARK    GeneRIF: SARM functions to restrict viral infection and neuronal
            injury in a brain region-specific manner, possibly by modulating
            the activation of resident CNS inflammatory cells.
REFERENCE   8  (bases 1 to 5044)
  AUTHORS   Molday,L.L., Wu,W.W. and Molday,R.S.
  TITLE     Retinoschisin (RS1), the protein encoded by the X-linked
            retinoschisis gene, is anchored to the surface of retinal
            photoreceptor and bipolar cells through its interactions with a
            Na/K ATPase-SARM1 complex
  JOURNAL   J Biol Chem 282 (45), 32792-32801 (2007)
   PUBMED   17804407
REFERENCE   9  (bases 1 to 5044)
  AUTHORS   Kim,Y., Zhou,P., Qian,L., Chuang,J.Z., Lee,J., Li,C., Iadecola,C.,
            Nathan,C. and Ding,A.
  TITLE     MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and
            regulates neuronal survival
  JOURNAL   J Exp Med 204 (9), 2063-2074 (2007)
   PUBMED   17724133
REFERENCE   10 (bases 1 to 5044)
  AUTHORS   Mink,M., Fogelgren,B., Olszewski,K., Maroy,P. and Csiszar,K.
  TITLE     A novel human gene (SARM) at chromosome 17q11 encodes a protein
            with a SAM motif and structural similarity to
            Armadillo/beta-catenin that is conserved in mouse, Drosophila, and
            Caenorhabditis elegans
  JOURNAL   Genomics 74 (2), 234-244 (2001)
   PUBMED   11386760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC080850.1 and AL591177.14.
            
            On Dec 15, 2009 this sequence version replaced NM_172795.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080850.1, SRR1660821.84092.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3705              BC080850.1         1-3705
            3706-5044           AL591177.14        11463-12801         c
FEATURES             Location/Qualifiers
     source          1..5044
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..5044
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /note="sterile alpha and HEAT/Armadillo motif containing
                     1"
                     /db_xref="GeneID:237868"
                     /db_xref="MGI:MGI:2136419"
     exon            1..766
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2471
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /EC_number="3.2.2.6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sterile alpha and TIR motif-containing protein 1; sterile
                     alpha and TIR motif containing 1; Tir-1 homolog; NADase
                     SARM1; NADP(+) hydrolase SARM1; NAD(+) hydrolase SARM1"
                     /codon_start=1
                     /product="NAD(+) hydrolase SARM1 isoform 2"
                     /protein_id="NP_766383.2"
                     /db_xref="CCDS:CCDS25105.1"
                     /db_xref="GeneID:237868"
                     /db_xref="MGI:MGI:2136419"
                     /translation="MVLTLLFSAYKLCRFFTMSGPRPGADRLTVPGPDRSGGASPWWA
                     AGGRGSREVSPGVGTEVQGALERSLPELQQALSELKQASAARAVGAGLAEVFQLVEEA
                     WLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRV
                     ARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRT
                     DPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAV
                     LATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLL
                     DSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSALAKR
                     ALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFREQQVDGDLLLRLTDEE
                     LQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSC
                     GLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKLSGDTPDVFI
                     SYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVIAARNFVLVLSAG
                     ALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQALPEDMQAVLTFNGIK
                     WSHEYQEATIEKIIRFLQGRPSQDSSAGSDTSLEGATPMGLP"
     exon            767..1385
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1598
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1690
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1926
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2029
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2219
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2341
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..5044
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4059..4064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /note="hexamer: AATACA"
     polyA_site      4083
                     /gene="Sarm1"
                     /gene_synonym="A830091I15Rik; MyD885; Sarm"
                     /note="major polyA site"
ORIGIN      
        1 ctgttgagca tcttagctcc gctgtgctta gattggagca gcgctttgtt ccgggcaccg
       61 gcgtctctac cctcccgcgt ctggtccatg cttctctctc ccttcatgcc cttcctaagt
      121 cgctgagtcc cggagctgcc ctcctccttc tgcttctaca cttgtagccc agcaccttta
      181 ccggatcctg tttgcttttt tttttttttt tttttttctt tctcctccca aggccggggt
      241 ctctctgcca ggccccgccc ctctaggcct ggcatgtccc ctgctgccca gcgcccatgg
      301 tcctgacgct gctcttctcc gcctacaaac tgtgccgctt cttcaccatg tcaggcccac
      361 ggccgggcgc cgatcggctg acagtgcccg gaccggatcg gagtggtggc gccagcccat
      421 ggtgggctgc gggcggtcgc gggtctcgcg aagtgtcgcc cggagtgggc actgaggtgc
      481 aaggcgccct ggagcgttcg ctgcctgagc tgcagcaggc gctgtccgag ctgaaacagg
      541 caagcgcggc gcgggctgtg ggcgcgggtc tcgccgaggt cttccagctg gtagaggaag
      601 cctggctgct gccggccgtg ggccgcgagg tggcccaagg tctatgcgat gctatacgtc
      661 tggacggtgg cctcgacttg ctgttgcggc tgcttcaggc accggagcta gagacccgtg
      721 tgcaggccgc gcgcttgctg gagcagatcc tggtggctga gaaccgggac cgcgtggcgc
      781 gcatcggtct aggcgtgatc ttgaacctgg cgaaggagcg cgagcctgtg gaactggcac
      841 gaagcgtggc gggcatcttg gagcacatgt tcaagcactc ggaggagacg tgccagcggc
      901 tggtggcggc cggaggcctc gacgcggtgc tgtactggtg ccgccgcaca gacccggcgc
      961 tgctgcgcca ctgcgctctt gcgctggcga actgcgcgct gcacgggggc cagacggtgc
     1021 agcggtgcat ggtggagaag cgcgccgccg agtggctctt cccgctcgct ttctccaagg
     1081 aggacgagct gctgcggctg cacgcctgcc tggcggtggc ggtgttggct accaacaagg
     1141 aggtggaacg cgaggtcgag cattctggca cattggcgct tgtcgagccg ctcgtggcat
     1201 cgctggaccc cggccgcttc gcccgctgcc tggtggatgc cagtgacaca agccagggtc
     1261 gtggaccaga cgacctgcag agcctggtgc tgttgctcga ttcgtcgcgt ttggaggctc
     1321 agtgcatagg agcattctac ctgtgcgcag aggctgccat caagagccta cagggaaaga
     1381 ccaaggtgtt cagcgacatc ggcgctatcc agagcctgaa acgcctggtt tcttactcta
     1441 cgaatggcac cacgtcggcg ctggccaagc gcgcgctgcg cctattgggc gaggaggtgc
     1501 caaggcgcat cctgccctgc gtggccagct ggaaggaagc tgaggtccag acctggctac
     1561 agcagatcgg cttctcccag tactgcgaga actttcggga gcagcaggta gatggtgacc
     1621 tgcttctaag actcacagat gaagaactcc agacagacct aggcatgaaa tcaagcatca
     1681 cccgcaagag gttctttagg gagctcacag agctcaagac cttcgccagc tacgctactt
     1741 gcgaccgcag caacctagcg gactggctgg gcagcctgga tcctcgcttc cgccagtaca
     1801 cctatggcct ggtcagctgc ggtctggacc gctccctgct gcaccgcgtg tcagagcagc
     1861 agctcctgga ggactgtggc atccgcctgg gagtgcaccg cacgcgcatc ctctctgcag
     1921 ccagagaaat gctacattcc ccgctgccct gtactggagg caagctcagt ggggacaccc
     1981 cagatgtctt tatcagttac cggaggaact cagggtccca gctggccagc ctcctgaagg
     2041 tgcacctgca gcttcacggc ttcagcgtct tcatcgacgt ggagaagctg gaagccggca
     2101 aattcgagga caagcttatc caaagcgtca tagcggctcg caattttgtc ctggtgctgt
     2161 ctgctggggc gctggataag tgcatgcagg accatgactg caaggactgg gtgcacaagg
     2221 agattgtgac tgctttaagc tgtggcaaga acattgtgcc catcattgat ggctttgagt
     2281 ggcctgagcc tcaggcgctg cctgaggata tgcaggctgt actcaccttc aacggcatca
     2341 aatggtccca tgagtaccag gaggccacca tcgagaagat catccgcttc ctacagggcc
     2401 gcccctctca ggactcctct gccggatcgg ataccagttt ggagggagct acgccaatgg
     2461 gtctgcctta acctgtcccc agttcccgtg ccctactgtg actcctgatt tagttccctg
     2521 cccttaaagg aatagctcct ctagatgcca ccctgactga ggcaaaccag actgttctca
     2581 ggcaatggct ttcccggctg ccactctgtg gcccacttct aatccagaga tgccaggcac
     2641 aggttagatg agaggacact cctgtgtcag gccctgccat caggacccag ctcccatgca
     2701 gaaccatgtc cctgcttagt tctggacatc caagacaggg gaagaacatt tccccatctc
     2761 ctgacctgag agcagccagc ttgagtaagg tgaggttgcc agcctcccat aagggtcaat
     2821 acaacgcctg gatccccaaa cctgtgctca ggaggaagct ggggctgaga atcccccaag
     2881 gctatctact cacattgtgc ctggacccgg gctcacctgg cttcctcctg cctcatggcc
     2941 ttgctctgta actacctggt accccttcta gacttccttt aggcagcctc ctttggcata
     3001 ttgggagtca gggtgtggct gaactggacc tctgcctggc cttgttgctc ctcctggtgc
     3061 aagaaggggt gctttgctta tgcaaggaga ccataagagc tcactctagc ccaaaccttt
     3121 gtgcgtgcct aaggctctta cctagcctgc tccatctgac ttccccagct cctcacccac
     3181 acagagcttg tcacccacct gctcagggaa gccccaacac caccagtagc ccgagcagaa
     3241 cctgcaccat gggaaaaagg caagccatcc acaggcaagg gctaattcct ggggcagttt
     3301 ctcccaccga agtgtgtcaa atccattggg aatctcatca aaattcagag caggccacct
     3361 gggaagcacc tgggcctctg catttttcag attcccagga gagctgatga aagagagccc
     3421 tcactaatcc agccattcca aacaccccca ccctggtccc tgatcatcac aacagccttt
     3481 tcctctctcc agttttacag agctgagtgg ctgagtgatg ggatcaggtc cccaagttat
     3541 tggtggcagc ctcaggatct tgccttagtc ctggtaccca gatctgttct cctgagactc
     3601 atccaagagg ctgtggccca tgcttggtag ctgcctctcc ctggccacaa agaactgagc
     3661 agtgcagggt gggtcttgac taaaaggtgg agctaagggc atatagaatg tcccatgtcc
     3721 ctccctccac tggacaagaa aggcaagaaa gctggctctt gccattaccc aggctcaagc
     3781 tcagagagct ggcaccaccc tgctgtcgtc ttctggaggc catggggtca cacctctcct
     3841 gaggctagcc aggttacttg cccacggccc acattatcag agagccaaag ggctttctct
     3901 ccaggcctgg ggacactttc ctcctaccgt ccatcttcca tgggtcatgg ctggcctctg
     3961 gctgtgacta tttgcagttt tgtcaccagg aacaaccccc gcatcctatt ctgaggtgag
     4021 gcagatggaa tggtatcctt gatgacaaat tcaatgacaa tacagtgtat gagttcaccc
     4081 taaggaaatg tctgtcttca gtcccatact ctccagtggt ccctgtgggc agtacttaag
     4141 aaatttctgg ttttccttgt ttggggcaca agtcactact acctccactg tctggccttc
     4201 tgttgatctg tcccctactg tcttcttggg gaaccagagc acagccttat gtcccagcca
     4261 ggatagcaaa agtgtcaagc ctcctctagc tagacagtac actgtgtggt gacagagggc
     4321 ctcaacttct gctaagcatg gctgaccaca ctgatcttga gacaggctct tcagtagccc
     4381 ttcaagcagc ccacactcgc atggtctgtg ggttcagggt ttcttcctag ctgagctata
     4441 gctgctgccc ccagattggg gcctagtcag ggagatccct actcttcaac acccaccgtc
     4501 tctagggagc tacgaactgc ttaggaacat taagaggcta aagatccagc cagtttgttc
     4561 atccttcact gagcatctca tcctgggatg tatggagctg gagggatctc agagcatcca
     4621 acagctgtgc ttcctaacgc atccagttag gtccttgcag acagatgtgg gggagtgctg
     4681 atccagtttt ctctagattt gctcaaggtc acatgctgcc agagtgaagc ctttccctcc
     4741 tcacagcctc agggcagtgg ggttagtgga aagcctcttc ttgcttagac ttttctattt
     4801 ccagagggac agtgaagcag aagtgtggaa gccagatggg ccctggtgca gttcagtggg
     4861 ccttagtttt ccctgggatg tatctctttc acctgcatgg tttccagctg ggaaactagc
     4921 ttgcagtttg ggcaggaaga gatagcttca tcaaagacag tggcttccca ttagataaga
     4981 ttctaccttt cagttttgag cccaggtctt tccaacacgc cacacataca cacacacaca
     5041 caca
//
