LOCUS       NM_025535               1253 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus secretion associated Ras related GTPase 1B (Sar1b),
            mRNA.
ACCESSION   NM_025535
VERSION     NM_025535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Tang,V.T., Xiang,J., Chen,Z., McCormick,J., Abbineni,P.S.,
            Chen,X.W., Hoenerhoff,M., Emmer,B.T., Khoriaty,R., Lin,J.D. and
            Ginsburg,D.
  TITLE     Functional overlap between the mammalian Sar1a and Sar1b paralogs
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2322164121 (2024)
   PUBMED   38687799
  REMARK    GeneRIF: Functional overlap between the mammalian Sar1a and Sar1b
            paralogs in vivo.
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Wang,X., Huang,R., Wang,Y., Zhou,W., Hu,Y., Yao,Y., Cheng,K.,
            Li,X., Xu,B., Zhang,J., Xu,Y., Zeng,F., Zhu,Y. and Chen,X.W.
  TITLE     Manganese regulation of COPII condensation controls circulating
            lipid homeostasis
  JOURNAL   Nat Cell Biol 25 (11), 1650-1663 (2023)
   PUBMED   37884645
REFERENCE   4  (bases 1 to 1253)
  AUTHORS   Auclair,N., Sane,A.T., Ahmarani,L., Ould-Chikh,N.E., Patey,N.,
            Beaulieu,J.F., Delvin,E., Spahis,S. and Levy,E.
  TITLE     High-fat diet reveals the impact of Sar1b defects on lipid and
            lipoprotein profile and cholesterol metabolism
  JOURNAL   J Lipid Res 64 (9), 100423 (2023)
   PUBMED   37558128
  REMARK    GeneRIF: High-fat diet reveals the impact of Sar1b defects on lipid
            and lipoprotein profile and cholesterol metabolism.
REFERENCE   5  (bases 1 to 1253)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1253)
  AUTHORS   Marcil,V., Seidman,E., Sinnett,D., Sanchez,R., Spahis,S., Sane,A.
            and Levy,E.
  TITLE     Tissue distribution and regulation of the small Sar1b GTPase in
            mice
  JOURNAL   Cell Physiol Biochem 33 (6), 1815-1826 (2014)
   PUBMED   24969168
  REMARK    GeneRIF: Data suggest the importance of small Sar1b GTPase (Sar1b)
            in organs involved in lipid transport and/or calcium trafficking
            such as the liver, intestine, skeletal muscle and heart.
REFERENCE   7  (bases 1 to 1253)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 1253)
  AUTHORS   Weissman,J.T., Plutner,H. and Balch,W.E.
  TITLE     The mammalian guanine nucleotide exchange factor mSec12 is
            essential for activation of the Sar1 GTPase directing endoplasmic
            reticulum export
  JOURNAL   Traffic 2 (7), 465-475 (2001)
   PUBMED   11422940
REFERENCE   9  (bases 1 to 1253)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1253)
  AUTHORS   Shen,K.A., Hammond,C.M. and Moore,H.P.
  TITLE     Molecular analysis of SAR1-related cDNAs from a mouse pituitary
            cell line
  JOURNAL   FEBS Lett 335 (3), 380-385 (1993)
   PUBMED   8262187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY068863.1, BC082550.1 and BB749343.1.
            
            On Aug 15, 2009 this sequence version replaced NM_025535.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002327.1, AK155429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BY068863.1         1-31
            32-1226             BC082550.1         1-1195
            1227-1253           BB749343.1         410-436
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.41 cM"
     gene            1..1253
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /note="secretion associated Ras related GTPase 1B"
                     /db_xref="GeneID:66397"
                     /db_xref="MGI:MGI:1913647"
     exon            1..129
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     exon            130..204
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..743
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein SAR1b; SAR1b gene homolog; SAR1
                     gene homolog B; SAR1a gene homolog 2"
                     /codon_start=1
                     /product="small COPII coat GTPase SAR1B"
                     /protein_id="NP_079811.1"
                     /db_xref="CCDS:CCDS24661.1"
                     /db_xref="GeneID:66397"
                     /db_xref="MGI:MGI:1913647"
                     /translation="MSFIFDWIYSGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHM
                     LKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDC
                     ADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGK
                     GSVSLKELNARPLEVFMCSVLKRQGYGEGFRWMAQYID"
     exon            205..324
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     exon            325..390
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     exon            391..494
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     exon            495..626
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     exon            627..1253
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /note="hexamer: AATAAA"
     polyA_site      1226
                     /gene="Sar1b"
                     /gene_synonym="2310075M17Rik; 2900019I22Rik; CMRD; Sara1b;
                     Sara2; Sarb"
                     /note="major polyA site"
ORIGIN      
        1 tagcgaggca cccgccgacc cggaaggagc tgagaagagc tggggccctg gcagccatag
       61 cgctttgcac agccggcttg gagcgtgtag gacgggcacg gagcagggtt gcgttctctg
      121 aagtcgcaga cctgtaagat ctggatatgt ccttcatatt tgactggatt tacagtggtt
      181 tcagcagtgt gctgcagttt ctaggattgt ataaaaagtc tggtaaactg gtattccttg
      241 gattggataa tgccgggaaa acaactttgc tacacatgct gaaagatgac aggctcgggc
      301 agcacgtccc aacgctacat cccacttcag aagagcttac tattgctggc atgacgttta
      361 caacttttga tctgggtggg cacgtgcaag cccgaagagt atggaaaaac taccttcctg
      421 ctatcaatgg cattgtattt cttgtggatt gtgcagacca tgaaaggctg ttagaatcaa
      481 aagaagaact tgattcacta atgacagatg aaaccattgc caacgtgcct attctaattc
      541 ttggaaataa gatcgacaga cctgaagcca tcagtgaaga gaggttacga gagatgtttg
      601 gtttatatgg tcagacaaca ggaaagggta gtgtgtcact gaaggagctg aacgcccggc
      661 ctctggaagt gttcatgtgc agtgtgctaa aaaggcaggg ctatggagaa ggcttccgct
      721 ggatggcgca gtacatcgat tagcagcggc cggcccacac acttccagcc ctcagagatc
      781 catcccccaa catgcataac ttgaattcaa tagacttttg ttggtttcag aataggtgtt
      841 tttagattat taatatatct acctgagtgg gaattgcaaa ctgattcaag tttgaatatc
      901 acaatgttag ctttctaatt ccacacagat agtttttaca gtttctaacc ccacatcaat
      961 ccatcaccgt ttataaagat cagcttccca tcagtacatt tgaagcactt tttaacgatg
     1021 tgaaactaca aatataaacc atatttaaaa gctcatcatg tgaaactttt atgtactttt
     1081 tggaaatagt ttttcaattt tagattgtct gcctatcttg tgtacagtta aaatccgctt
     1141 atcagtgatt gcatgatgcc ttacggtttc caagactact ttttcttatg caaacgtcat
     1201 gcaataaaac aaactccaac atttgactca gtgttgggca gctgtttcct ttg
//
