LOCUS       NM_001406330            2877 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus secretion associated Ras related GTPase 1A (Sar1a),
            transcript variant 5, mRNA.
ACCESSION   NM_001406330 XM_030244965
VERSION     NM_001406330.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Tang,V.T., Xiang,J., Chen,Z., McCormick,J., Abbineni,P.S.,
            Chen,X.W., Hoenerhoff,M., Emmer,B.T., Khoriaty,R., Lin,J.D. and
            Ginsburg,D.
  TITLE     Functional overlap between the mammalian Sar1a and Sar1b paralogs
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2322164121 (2024)
   PUBMED   38687799
  REMARK    GeneRIF: Functional overlap between the mammalian Sar1a and Sar1b
            paralogs in vivo.
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Mestres,I., Einsiedel,M., Moller,J. and Cardoso de Toledo,B.
  TITLE     Smad anchor for receptor activation nuclear localization during
            development identifies Layers V and VI of the neocortex
  JOURNAL   J Comp Neurol 528 (13), 2161-2173 (2020)
   PUBMED   32037591
  REMARK    GeneRIF: Smad anchor for receptor activation nuclear localization
            during development identifies Layers V and VI of the neocortex.
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Chang,H.M., Lin,Y.Y., Tsai,P.C., Liang,C.T. and Yan,Y.T.
  TITLE     The FYVE domain of Smad Anchor for Receptor Activation (SARA) is
            required to prevent skin carcinogenesis, but not in mouse
            development
  JOURNAL   PLoS One 9 (8), e105299 (2014)
   PUBMED   25170969
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Bhalla-Gehi,R., Penuela,S., Churko,J.M., Shao,Q. and Laird,D.W.
  TITLE     Pannexin1 and pannexin3 delivery, cell surface dynamics, and
            cytoskeletal interactions
  JOURNAL   J Biol Chem 285 (12), 9147-9160 (2010)
   PUBMED   20086016
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Nori,A., Bortoloso,E., Frasson,F., Valle,G. and Volpe,P.
  TITLE     Vesicle budding from endoplasmic reticulum is involved in
            calsequestrin routing to sarcoplasmic reticulum of skeletal muscles
  JOURNAL   Biochem J 379 (Pt 2), 505-512 (2004)
   PUBMED   14728599
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Shen,K.A., Hammond,C.M. and Moore,H.P.
  TITLE     Molecular analysis of SAR1-related cDNAs from a mouse pituitary
            cell line
  JOURNAL   FEBS Lett 335 (3), 380-385 (1993)
   PUBMED   8262187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124421.4.
            
            On May 13, 2022 this sequence version replaced XM_030244965.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3400131.1,
                                           SRR17784651.645716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC124421.4         17173-17269         c
            98-368              AC124421.4         13255-13525         c
            369-442             AC124421.4         12633-12706         c
            443-562             AC124421.4         12401-12520         c
            563-628             AC124421.4         11967-12032         c
            629-732             AC124421.4         11108-11211         c
            733-864             AC124421.4         7681-7812           c
            865-2877            AC124421.4         4289-6301           c
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.26 cM"
     gene            1..2877
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /note="secretion associated Ras related GTPase 1A"
                     /db_xref="GeneID:20224"
                     /db_xref="MGI:MGI:98230"
     exon            1..97
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..368
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..442
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..981
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 5;
                     GTP-binding protein SAR1a; SAR1a gene homolog 1; SAR1 gene
                     homolog A; small COPII coat GTPase SAR1A"
                     /codon_start=1
                     /product="small COPII coat GTPase SAR1A isoform 1"
                     /protein_id="NP_001393259.1"
                     /db_xref="GeneID:20224"
                     /db_xref="MGI:MGI:98230"
                     /translation="MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHM
                     LKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDC
                     ADHSRLMESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGK
                     GNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID"
     exon            443..562
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..628
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..732
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..864
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..2877
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      997..1002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /note="hexamer: AATAAA"
     polyA_site      1027
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /note="major polyA site"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /note="hexamer: AATAAA"
     polyA_site      2877
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /note="major polyA site"
ORIGIN      
        1 acatccggcg cgtagctggc ggacccgggg actgctggtc tgtgtgctct gagggagggt
       61 cgcgccgcca gccaccgccg gaggagcccc tcgggccaat cccagtggcc taggactcat
      121 tgtgtggacc aaggctgggc acagattttc ctgtctctgt ctcccaagtt ctgggatttc
      181 gtggacatgt caccacacac agctcccatc atggttcata ccaggtgcat gtttggcttc
      241 ttgattcagc tttttacttt ttcaagacag atgttctcta tgtagccctg gctgtcctgg
      301 aacactcttc tgtagatcag gctggtctca aacgaagaga ttctgtctcc caagtgctgg
      361 gattaaaggt tgtaagcatc aataatgtct ttcatctttg agtggatcta caatggcttc
      421 agcagtgtgc tccagttcct aggactctac aagaaatctg gaaaacttgt attcttagga
      481 ttggacaatg cgggcaaaac cactcttctt cacatgctga aagatgacag actaggccag
      541 cacgtaccaa cactccatcc cacttcagaa gaactgacaa ttgctggaat gactttcacc
      601 acttttgatc tcggtgggca tgagcaagca cgtcgcgttt ggaaaaatta tctcccagcg
      661 attaatggca tagtttttct ggtggactgt gcggatcatt ctcgtctcat ggaatccaaa
      721 gttgagctta atgctttaat gactgatgaa acaatatcca acgtgccaat tcttatcttg
      781 ggaaacaaaa ttgacaggac agatgcaatc agtgaagaaa aactccgtga aatatttggg
      841 ctgtacgggc agaccacagg aaaggggaat gtgactctga aggagctgaa cgcccgcccc
      901 atggaagtat tcatgtgcag tgtgctcaag aggcaaggct acggcgaggg tttccgctgg
      961 ctttcccagt atattgactg atgtttggac agtgaaaata aagagtttta cttctggact
     1021 gatcctattc acagcttcct catggacttt tctaatagaa caaggaaagc tctccaacca
     1081 tgtatggcat tgagaagcca cacgtctgtc tacgctcatt gcccagtggt gacatgtgct
     1141 cttctccaca ctgcctgctg ttgctgccgg gcagtgtgtg gggactgggg ctggcagcat
     1201 ttgccaggga aagctgggtg ccatcatggg acacccgaga agaaaaacat gtctcaccac
     1261 tggttgattt caaaagaaag tgattctatt ttttaaagaa agtgttgtta atgtaattgg
     1321 tatcccttct ctaacttttt cagttcacaa tttacttggt ccagattttc tattcttttt
     1381 ttttaactag taaatgaaat ttacatactt cataaaatta tgaacagata gcgcattggg
     1441 ctctgctgtg tgactgcctg ttgagggtgg tacccgagac aagagcctgg agaggacaga
     1501 gcctcggcct tccccagggt ggtctccacc atggtaaggg gagtcctcat ctggagtggg
     1561 tgaagtatca tggtcacgtt gtcaacttta tttgcagtta ccagtttcag caggctttgc
     1621 ttttatactg ttgtgaaatt tcatctctct gtgtagcacc ttcctttttt ccattgtaga
     1681 tataaaaagt gacttttgcc tcatgaaaga gttacagaca tctgtcatgt agaccccatg
     1741 ctgtgggtgt gactgatgct tttgaacata gtctagaggg acggttctga accggagggt
     1801 gcagctcaaa atcatcagct taaggctctg aattctgtgc gattctcatc tggcagcaac
     1861 aagagaaccc aggaaaaacc ctcaggggac tctgtgtttt ctccttcaga aataacagaa
     1921 aacccagatg gccttctggc agcagcgagt gctaacatga aagcagcagc ggccctgtga
     1981 ggatcatgaa caggcttttt atatatatac agatagcatt tggttttctt gctgccgtgt
     2041 gtgatgttaa ctttatattt tacccttgag tgcatgagag gagatggtct gcagatggga
     2101 gggtatcttg attctgattt cctttaatgc aaggtgagag taggttctta agtggagatt
     2161 ctgctgttgc tgctgctgta ttctgacagg ctcgtgtcca gcaagagggt agggaagcta
     2221 gaagcacact cctggagagt gacttaccac attttagttt tgagcactga gcctatggga
     2281 cagtgttttg ttacactgcc gggtttccaa tgcagaggct tggtgaggtg tctgtctgca
     2341 aactgcatgc actgcgttca cccacgtaca gctgggatga gaactgtcag tgtggaaggg
     2401 cctactgtta aagccctgag tgagctaggt aggtgactgt tgtgcccttc attgcctttg
     2461 gctaaagact gtccacatgt ctgtccaggc acatgacagg tgtgagggcc tcagcgttgg
     2521 gttcttcatc tgtctttctc gtttgtccct aattgctcgg tagcaaccta gaagactgga
     2581 ctctgcccag ggtggctctt tgtgaaagtg gtttattctg gccaccggag aaagatggct
     2641 gaacagtggc accagtctgc ttcatgctgc acagaacacc gtcttaagta aggtggccaa
     2701 aagaggttgc tgcagcaagt gcaactctgc cagggccatg gccaggggct ccaatgaact
     2761 gagactcttc attctgttta tcagagtgca catgtgtcct gtttcagcaa aagtaaaact
     2821 gtcatttaca aaaggtcagt ctgtatccta agcattttaa taaaaagcta aaatgaa
//
