LOCUS       NP_001393259             198 aa            linear   ROD 13-DEC-2024
DEFINITION  small COPII coat GTPase SAR1A isoform 1 [Mus musculus].
ACCESSION   NP_001393259 XP_030100825
VERSION     NP_001393259.1
DBSOURCE    REFSEQ: accession NM_001406330.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 198)
  AUTHORS   Tang,V.T., Xiang,J., Chen,Z., McCormick,J., Abbineni,P.S.,
            Chen,X.W., Hoenerhoff,M., Emmer,B.T., Khoriaty,R., Lin,J.D. and
            Ginsburg,D.
  TITLE     Functional overlap between the mammalian Sar1a and Sar1b paralogs
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2322164121 (2024)
   PUBMED   38687799
  REMARK    GeneRIF: Functional overlap between the mammalian Sar1a and Sar1b
            paralogs in vivo.
REFERENCE   2  (residues 1 to 198)
  AUTHORS   Mestres,I., Einsiedel,M., Moller,J. and Cardoso de Toledo,B.
  TITLE     Smad anchor for receptor activation nuclear localization during
            development identifies Layers V and VI of the neocortex
  JOURNAL   J Comp Neurol 528 (13), 2161-2173 (2020)
   PUBMED   32037591
  REMARK    GeneRIF: Smad anchor for receptor activation nuclear localization
            during development identifies Layers V and VI of the neocortex.
REFERENCE   3  (residues 1 to 198)
  AUTHORS   Chang,H.M., Lin,Y.Y., Tsai,P.C., Liang,C.T. and Yan,Y.T.
  TITLE     The FYVE domain of Smad Anchor for Receptor Activation (SARA) is
            required to prevent skin carcinogenesis, but not in mouse
            development
  JOURNAL   PLoS One 9 (8), e105299 (2014)
   PUBMED   25170969
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 198)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 198)
  AUTHORS   Bhalla-Gehi,R., Penuela,S., Churko,J.M., Shao,Q. and Laird,D.W.
  TITLE     Pannexin1 and pannexin3 delivery, cell surface dynamics, and
            cytoskeletal interactions
  JOURNAL   J Biol Chem 285 (12), 9147-9160 (2010)
   PUBMED   20086016
REFERENCE   6  (residues 1 to 198)
  AUTHORS   Nori,A., Bortoloso,E., Frasson,F., Valle,G. and Volpe,P.
  TITLE     Vesicle budding from endoplasmic reticulum is involved in
            calsequestrin routing to sarcoplasmic reticulum of skeletal muscles
  JOURNAL   Biochem J 379 (Pt 2), 505-512 (2004)
   PUBMED   14728599
REFERENCE   7  (residues 1 to 198)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (residues 1 to 198)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (residues 1 to 198)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 198)
  AUTHORS   Shen,K.A., Hammond,C.M. and Moore,H.P.
  TITLE     Molecular analysis of SAR1-related cDNAs from a mouse pituitary
            cell line
  JOURNAL   FEBS Lett 335 (3), 380-385 (1993)
   PUBMED   8262187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124421.4.
            
            On May 13, 2022 this sequence version replaced XP_030100825.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3400131.1,
                                           SRR17784651.645716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.26 cM"
     Protein         1..198
                     /product="small COPII coat GTPase SAR1A isoform 1"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein SAR1a; SAR1a gene homolog 1;
                     SAR1 gene homolog A; small COPII coat GTPase SAR1A"
                     /calculated_mol_wt=22268
     Region          3..197
                     /region_name="Sar1"
                     /note="Sar1 is an essential component of COPII vesicle
                     coats; cd00879"
                     /db_xref="CDD:206645"
     Region          3..5
                     /region_name="STAR, SAR1-N-terminal activation
                     recruitment. Required for the activation by PREB and
                     subsequent recruitment to ER membrane.
                     /evidence=ECO:0000250|UniProtKB:Q9QVY3"
                     /note="propagated from UniProtKB/Swiss-Prot (P36536.1)"
     Site            3..5
                     /site_type="active"
                     /note="STAR motif [active]"
                     /db_xref="CDD:206645"
     Region          15..19
                     /region_name="Mediates recruitment to ER membranes.
                     /evidence=ECO:0000250|UniProtKB:Q9QVY3"
                     /note="propagated from UniProtKB/Swiss-Prot (P36536.1)"
     Site            32..39
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206645"
     Site            order(34..40,56,78,134..135,137,179..181)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206645"
     Site            order(34..35,39,43,50..62,84,89)
                     /site_type="other"
                     /note="GAP interaction site [polypeptide binding]"
                     /db_xref="CDD:206645"
     Site            44..59
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206645"
     Site            order(56..60,65,75,79,85,87..89)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206645"
     Site            56
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206645"
     Site            order(57..64,74,85,88..89)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206645"
     Site            60..74
                     /site_type="active"
                     /note="interswitch region [active]"
                     /db_xref="CDD:206645"
     Site            75..92
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206645"
     Site            75..78
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206645"
     Site            134..137
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206645"
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P36536.1)"
     Site            179..181
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206645"
     CDS             1..198
                     /gene="Sar1a"
                     /gene_synonym="1600019H17Rik; Sara; Sara1"
                     /coded_by="NM_001406330.1:385..981"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="GeneID:20224"
                     /db_xref="MGI:MGI:98230"
ORIGIN      
        1 msfifewiyn gfssvlqflg lykksgklvf lgldnagktt llhmlkddrl gqhvptlhpt
       61 seeltiagmt fttfdlgghe qarrvwknyl paingivflv dcadhsrlme skvelnalmt
      121 detisnvpil ilgnkidrtd aiseeklrei fglygqttgk gnvtlkelna rpmevfmcsv
      181 lkrqgygegf rwlsqyid
//
