LOCUS       NM_001081085            3407 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus suppressor APC domain containing 2 (Sapcd2),
            transcript variant 1, mRNA.
ACCESSION   NM_001081085 XM_130053
VERSION     NM_001081085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Chiu,C.W.N., Monat,C., Robitaille,M., Lacomme,M., Daulat,A.M.,
            Macleod,G., McNeill,H., Cayouette,M. and Angers,S.
  TITLE     SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by
            Negatively Regulating the Galphai-LGN-NuMA Ternary Complex
  JOURNAL   Dev Cell 36 (1), 50-62 (2016)
   PUBMED   26766442
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Chan,T., Kondow,A., Hosoya,A., Hitachi,K., Yukita,A.,
            Okabayashi,K., Nakamura,H., Ozawa,H., Kiyonari,H., Michiue,T.,
            Ito,Y. and Asashima,M.
  TITLE     Ripply2 is essential for precise somite formation during mouse
            early development
  JOURNAL   FEBS Lett 581 (14), 2691-2696 (2007)
   PUBMED   17531978
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Murata,T., Furushima,K., Hirano,M., Kiyonari,H., Nakamura,M.,
            Suda,Y. and Aizawa,S.
  TITLE     ang is a novel gene expressed in early neuroectoderm, but its null
            mutant exhibits no obvious phenotype
  JOURNAL   Gene Expr Patterns 5 (2), 171-178 (2004)
   PUBMED   15567712
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732557.4, AK166625.1, AK163973.1 and CK331200.1.
            
            On Mar 12, 2014 this sequence version replaced NM_001081085.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166625.1, AK154143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AL732557.4         44808-45132
            326-1596            AK166625.1         1-1271
            1597-2676           AK163973.1         816-1895
            2677-3405           AK166625.1         2352-3080
            3406-3407           CK331200.1         1-2                 c
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.2 cM"
     gene            1..3407
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="suppressor APC domain containing 2"
                     /db_xref="GeneID:72080"
                     /db_xref="MGI:MGI:1919330"
     exon            1..964
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1674
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="isoform a is encoded by transcript variant 1;
                     protein C9orf140 homolog; protein Ang; suppressor APC
                     domain-containing protein 2"
                     /codon_start=1
                     /product="suppressor APC domain-containing protein 2
                     isoform a"
                     /protein_id="NP_001074554.1"
                     /db_xref="CCDS:CCDS38073.1"
                     /db_xref="GeneID:72080"
                     /db_xref="MGI:MGI:1919330"
                     /translation="MAVAAMAERGRLSHAAPAPSTEGLPRAFLQSLRTLFDILDDRQR
                     GYVHLREIESRWQGADARELPCGVLEGLRQVAPANGYLTFERFVAGLRTSLLKADGGQ
                     RDQARVAARPGDQSSLQQRLMFAPADEPRTVLERKPLPLSACPASGGPSGTSRNPELL
                     CVPVEAASCPTETERPLSKALEQIPSADLGSSQCDTLQRQPGLLLHPGGRGGSTGAPS
                     TSAEEGAAACKTLGKGTGEARQAPRARGERRRHTITNGVDCSLLKQMKELDQEQEVLL
                     QGLEMMARGRDWYQQQLQRVQERQRRLSQSRAAADFGAEGSPRPLGRLLPKVQEVARC
                     LGELLTAACSGRALPSSSLGPLGPPSPSTPVWQQQTILMLKEQNRLLTQEVTDKSERI
                     TQLEQEKSALIKQLFEARALSQQDSGPLDSTFI"
     exon            965..1066
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1179
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1326
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1434
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1545
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..3407
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1978..1983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="hexamer: AGTAAA"
     polyA_site      1997
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="major polyA site"
     regulatory      2658..2663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="hexamer: ATTAAA"
     polyA_site      2679
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
                     /note="major polyA site"
     polyA_site      2709
                     /gene="Sapcd2"
                     /gene_synonym="2010317E24Rik; 6030458L21Rik; ang"
ORIGIN      
        1 tgcctgggaa ggcggagcgc acatgaacca gagaaaaggc tctaccgagg caggagggat
       61 ggtggacgtg gagacagggg gatcgtgggc agcagcggta agaactctgg ctggttctac
      121 ccgtttctcg ttaagtctcc caagggccgg atggtgtggg cgcccgcccc tagtgcagga
      181 gaaatcaaac tgggactggt ggctgcggag ccaatcccgg aacagatggg ccagtttcga
      241 ccaatagccg ctgagaatat taatgaaagc tgacgcggcg gcgaccagct cttcattcaa
      301 aaacagcagc tattgtcgcc gtggggagcg cgcgccgcct tgcaggttct gccatctggt
      361 cttgcgggga ccgacgcggg tggaagctgg gcgcccatgg ccgtggcagc gatggccgag
      421 cgtggccgcc tatcgcacgc tgcgcccgct cctagtacag aggggctacc gcgagccttt
      481 ctccagagcc tgcgcaccct cttcgacatc ctggacgacc ggcaacgcgg ctacgtgcac
      541 ctgcgggaga tcgagtcccg ctggcaaggt gcagacgcac gcgagctgcc gtgcggcgtg
      601 ctcgagggcc tgcgccaggt ggccccggcc aatggctacc tgaccttcga gcgtttcgta
      661 gcgggcttgc gcacctcgct gctgaaagcc gacggcggcc agcgggatca ggcacgcgtc
      721 gcggcccggc ctggggacca gtcgtccctg cagcagcgcc tgatgttcgc accggccgat
      781 gagccgcgga ctgtcctgga gagaaagcct ctgcctctga gtgcgtgccc tgcttctggt
      841 ggccccagtg gcacctcccg gaaccctgag ctgttatgtg tcccggtgga ggcggcgtcc
      901 tgccccacag agaccgagcg gcccctgagc aaggcgctgg agcaaatccc cagcgcggat
      961 ttgggctctt ctcagtgtga caccctgcag agacaacccg gcctgcttct ccacccagga
     1021 ggcagaggag gcagcacagg agcacctagc acaagtgctg aagaaggtgc agcagcctgt
     1081 aagaccctgg gcaagggcac aggtgaagcc cggcaggctc cacgggcccg aggcgagcgt
     1141 cgaaggcata ccatcaccaa tggtgtggac tgcagcctgt tgaagcagat gaaggagtta
     1201 gaccaggaac aggaggtgct tctgcagggc ctggagatga tggcacgggg ccgagactgg
     1261 taccagcagc agctgcagcg tgtgcaggaa cgtcagcgcc gcctgagcca gagcagagct
     1321 gctgcagact ttggggctga aggaagcccc cgccctctgg ggaggttgct gcccaaagta
     1381 caggaggtgg cccggtgcct gggggagctg ttgactgcag cctgctctgg cagagctctg
     1441 ccttcgtcct ctttagggcc cctgggccct ccctcaccct caactccagt ctggcagcaa
     1501 cagaccatcc tcatgctgaa agaacagaac cggcttctca ctcaggaggt gactgataag
     1561 agtgagcgca tcacgcagct ggagcaggag aagtctgcac tcatcaagca gctgtttgag
     1621 gcccgagcgc tcagccagca ggattcggga cctctggact ccactttcat ctagttggtt
     1681 gtacctctct aggacaagtg cacacagact tagcttcagc tccatgacac tgccgggagc
     1741 ctgtcttctg actgaagacc accagggctt agacctcaga gccctcaagg aggcagctgc
     1801 ctccagactt gggtgctgct agaaatgtac tctgccggaa gctgccactt gccactgtca
     1861 gtgggtggcg gaggatcatc ctcacgttta cctgatttca ggcagcccct acagagaagg
     1921 gggcatgttt acgtctgtcc tgatccacct ggcagggttt cctgggatca ctggcttagt
     1981 aaaaagtact ggtcacactg ggctgtattt ctcataatgc ccagcagggg ctgctagttg
     2041 agcttagttc ctctgccctg tcttaccttg gtattactga gtgagtgagc agatagattt
     2101 ttgagctgag ggtgggctag gaggcccagg aactaggagg ttagaggttc cttctgtcca
     2161 ccagaggcac tatggaaagg tggttgtggc tcagatagga gcagaaggga gacatggaat
     2221 gggaggagga tggggctatc taatagaggg ctctgtgcct gttggaagag ccacaaagtc
     2281 aggggttgtg tgtaacaggc tgagaaggaa aatctggctg cagctggacc aggctagtgt
     2341 ggttcctaga aggaagccaa taacttggct tacccacctt accaaaacta actgtcttta
     2401 aactgttaac taactgggga aagatggcat caagttagct caggttgtgg ccatccccct
     2461 aaggaggtcc tatcccccca aatagataag tttgggcctc ccagccaagt catgcagtgc
     2521 actgtgggca gaatacatca tttattatta tttattttaa agacagggtt tctctgtgta
     2581 gccctgactg tcctggcact ctctatgtag agcaggctgg tctcaaactc tcagagatct
     2641 gcctctctgg tactgggatt aaaggtgtgt gccaccacac ccagcacgtc tgcatctttt
     2701 aatgccctac ttggctcggc agtgtcatcg ttgacttatc cataggaaag caacccaggc
     2761 gtgtgggaag aaactgagcc tgtggatgtg actctctccc tgcttatgcc tcccattggc
     2821 agcttgggtg ggcacagatt ggatgaggag aacctattta gcctgttctg gtggagcact
     2881 gagtcgtcac aggtgagttc tgtggcctga agactccagt gtggaatacg aacccattgt
     2941 gtttggccag caaagcgacc tgatcaagta caagttagtc cagcacccaa accatctttt
     3001 tcaggaactg gagtggtttc tgggcatgga agaaagctag ttctaaaagg tggttgtatt
     3061 ctgcaagatt agtttaccca ggtggacttg ccatctagag acaggtttcc atagcaacag
     3121 gttgggtctg cccctccatc cccatagcct cctttgtgtt ccttgtttta cctctgtacc
     3181 cttccattcc atggcttgcc actcctgtcc ctcaggtcct agagacactt gactagactc
     3241 cagactgggg ctgactctgc ctatcccata gagataggtc tcagcaaggt ctaggccttg
     3301 ccaggctctt cagatggcca ggccacctca gattcacagc ttcacgttct gttcttggct
     3361 ttgcccaaga tagctattct atctacaaaa tagaatcctt tctctgc
//
