LOCUS       NM_021788               1159 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus sin3 associated polypeptide (Sap30), mRNA.
ACCESSION   NM_021788
VERSION     NM_021788.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Ferguson,C.A., Firulli,B.A., Zoia,M., Osterwalder,M. and
            Firulli,A.B.
  TITLE     Identification and characterization of Hand2 upstream genomic
            enhancers active in developing stomach and limbs
  JOURNAL   Dev Dyn 253 (2), 215-232 (2024)
   PUBMED   37551791
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Streubel,G., Fitzpatrick,D.J., Oliviero,G., Scelfo,A., Moran,B.,
            Das,S., Munawar,N., Watson,A., Wynne,K., Negri,G.L., Dillon,E.T.,
            Jammula,S., Hokamp,K., O'Connor,D.P., Pasini,D., Cagney,G. and
            Bracken,A.P.
  TITLE     Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells
            required for self-renewal
  JOURNAL   EMBO J 36 (15), 2216-2232 (2017)
   PUBMED   28554894
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Thut,C.J., Rountree,R.B., Hwa,M. and Kingsley,D.M.
  TITLE     A large-scale in situ screen provides molecular evidence for the
            induction of eye anterior segment structures by the developing lens
  JOURNAL   Dev Biol 231 (1), 63-76 (2001)
   PUBMED   11180952
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Spronk,C.A., Tessari,M., Kaan,A.M., Jansen,J.F., Vermeulen,M.,
            Stunnenberg,H.G. and Vuister,G.W.
  TITLE     The Mad1-Sin3B interaction involves a novel helical fold
  JOURNAL   Nat Struct Biol 7 (12), 1100-1104 (2000)
   PUBMED   11101889
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Dron,M., Tartare,X., Guillo,F., Haik,S., Barbin,G., Maury,C.,
            Tovey,M. and Dandoy-Dron,F.
  TITLE     Mouse scrapie responsive gene 1 (Scrg1): genomic organization,
            physical linkage to sap30, genetic mapping on chromosome 8, and
            expression in neuronal primary cell cultures
  JOURNAL   Genomics 70 (1), 140-149 (2000)
   PUBMED   11087671
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130841.4.
            
            On Jan 5, 2022 this sequence version replaced NM_021788.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE634926.1, CK128837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-589               AC130841.4         83346-83934
            590-715             AC130841.4         85551-85676
            716-814             AC130841.4         86046-86144
            815-1159            AC130841.4         88136-88480
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.85 cM"
     gene            1..1159
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /note="sin3 associated polypeptide"
                     /db_xref="GeneID:60406"
                     /db_xref="MGI:MGI:1929129"
     exon            1..589
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..937
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /note="Sin3-associated protein; sin3-associated
                     polypeptide, 30 kDa; sin3 corepressor complex subunit
                     SAP30; sin3-associated polypeptide p30; 30 kDa
                     Sin3-associated polypeptide; sin3 associated polypeptide,
                     30kD"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP30"
                     /protein_id="NP_068560.1"
                     /db_xref="CCDS:CCDS22316.1"
                     /db_xref="GeneID:60406"
                     /db_xref="MGI:MGI:1929129"
                     /translation="MNGFTPEEMSRGGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEV
                     PGAGAVSASGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIEL
                     DKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRR
                     YKRHFKLPTRPGLNKAQLVEIVGCHFKSIPVNEKDTLTCFIYSVRNDKNKSDLKADSG
                     VH"
     exon            590..715
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            716..814
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1159
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /note="hexamer: AATAAA"
     polyA_site      1159
                     /gene="Sap30"
                     /gene_synonym="30kDa"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggagg cggaggagct gcggtccaac tgctgaagtc tccatgtgac agtgagtggg
       61 gtctcctttc taggcgccac ttcactcctg atcacagtca caggacctgg tagctattcc
      121 agcaccgaca gaccggccgg ccctggactc tgggcgtcgg accgtgccgc caccagactt
      181 ggggtgcgga gtgaacggcc gcccagggga aggaggcgga gcggcgcggc gagcggggct
      241 ctgtagcggc gccggcgccc ccgaactggc agacatgaac ggcttcactc cggaggagat
      301 gagccgaggc ggggacgcgg ccgccgccgt ggccgcggtg gtcgctgctg cggctgccgc
      361 cgcctcggcg gggaatggga acgcagccgg cggtggggca gaggtacccg gtgccggtgc
      421 agtgtcagct tctgggccac ctggagcggc cggtcccggc cctgggcaac tctgttgttt
      481 gcgggaggac ggtgagcggt gcgggcgcgc ggcaggcaac gccagcttca gcaaaaggat
      541 ccagaagagc atctctcaga agaaggtgaa gatcgagctg gataagagtg caaggcatct
      601 ttacatttgt gactatcata agaacttaat tcagagcgtt cggaacagaa ggaagaggaa
      661 aggaagcgat gatgatgggg gagactcgcc tgttcaggac atcgacactc cagaggttga
      721 tttgtaccaa ttacaagtaa atacacttag aagatacaaa agacacttca agcttccaac
      781 cagaccaggt ctaaataaag cacaacttgt tgagatagtt ggttgccact ttaagtctat
      841 tccagtgaac gaaaaagaca ccttaacatg tttcatctac tcagtgagga acgacaagaa
      901 caaatcggat ctcaaggccg acagtggtgt tcactaggag agatgctgtt cacactagcc
      961 catagatgtc tgcctggaaa gaatgtttac tggttttcag atgtagaaat gttcttgtgt
     1021 attttttcta ccgaggattt actttgactt tttttttttt tttaatgttg ttgtcatttt
     1081 tgattctaat aattagttgg aaactcataa actgagcttc ctagattaca catattttaa
     1141 ataaaggtta ttactatta
//
