LOCUS       NM_001357555            4353 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus Sin3A associated protein (Sap130), transcript variant
            3, mRNA.
ACCESSION   NM_001357555 XM_006525950
VERSION     NM_001357555.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4353)
  AUTHORS   Wilson RL, Troja W, Courtney J, Williams A and Jones HN.
  TITLE     Placental and fetal characteristics of the Ohia mouse line
            recapitulate outcomes in human hypoplastic left heart syndrome
  JOURNAL   Placenta 117, 131-138 (2022)
   PUBMED   34890862
REFERENCE   2  (bases 1 to 4353)
  AUTHORS   Lv LL, Wang C, Li ZL, Cao JY, Zhong X, Feng Y, Chen J, Tang TT, Ni
            HF, Wu QL, Wang B, Lan HY and Liu BC.
  TITLE     SAP130 released by damaged tubule drives necroinflammation via
            miRNA-219c/Mincle signaling in acute kidney injury
  JOURNAL   Cell Death Dis 12 (10), 866 (2021)
   PUBMED   34556635
  REMARK    GeneRIF: SAP130 released by damaged tubule drives necroinflammation
            via miRNA-219c/Mincle signaling in acute kidney injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4353)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4353)
  AUTHORS   Yagi H, Liu X, Gabriel GC, Wu Y, Peterson K, Murray SA, Aronow BJ,
            Martin LJ, Benson DW and Lo CW.
  TITLE     The Genetic Landscape of Hypoplastic Left Heart Syndrome
  JOURNAL   Pediatr Cardiol 39 (6), 1069-1081 (2018)
   PUBMED   29569026
REFERENCE   5  (bases 1 to 4353)
  AUTHORS   Kim JW, Roh YS, Jeong H, Yi HK, Lee MH, Lim CW and Kim B.
  TITLE     Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced
            Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1beta in
            Mice
  JOURNAL   Am J Pathol 188 (4), 967-980 (2018)
   PUBMED   29355515
  REMARK    GeneRIF: interaction between Mincle and SAP130 may promote the
            progression of alcoholic liver disease by IL-1beta production in
            Kupffer cells and consequently increase inflammatory immune cell
            infiltration.
REFERENCE   6  (bases 1 to 4353)
  AUTHORS   Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA,
            Rappsilber J and Helin K.
  TITLE     TET1 and hydroxymethylcytosine in transcription and DNA methylation
            fidelity
  JOURNAL   Nature 473 (7347), 343-348 (2011)
   PUBMED   21490601
REFERENCE   7  (bases 1 to 4353)
  AUTHORS   Kim S, Zhang S, Choi KH, Reister R, Do C, Baykiz AF and Gershenfeld
            HK.
  TITLE     An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger
            41, is a candidate gene for anxiety-like behavior and
            beta-carboline-induced seizures
  JOURNAL   Biol Psychiatry 65 (5), 425-431 (2009)
   PUBMED   18986647
REFERENCE   8  (bases 1 to 4353)
  AUTHORS   Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K and Saito T.
  TITLE     Mincle is an ITAM-coupled activating receptor that senses damaged
            cells
  JOURNAL   Nat Immunol 9 (10), 1179-1188 (2008)
   PUBMED   18776906
REFERENCE   9  (bases 1 to 4353)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4353)
  AUTHORS   Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M
            and Reinberg D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156981.13, AC161511.3 and BQ032928.1.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_001357555.2.
            
            On Nov 4, 2017 this sequence version replaced XM_006525950.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.50601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AC156981.13        176886-177311
            427-544             AC156981.13        177740-177857
            545-780             AC156981.13        188799-189034
            781-939             AC156981.13        189892-190050
            940-1051            AC156981.13        191303-191414
            1052-1176           AC156981.13        192249-192373
            1177-1301           AC156981.13        195260-195384
            1302-1449           AC156981.13        208099-208246
            1450-1540           AC156981.13        208394-208484
            1541-1645           AC156981.13        208663-208767
            1646-1787           AC161511.3         153512-153653       c
            1788-1909           AC161511.3         150531-150652       c
            1910-2212           AC161511.3         147337-147639       c
            2213-2387           AC161511.3         145824-145998       c
            2388-2492           AC161511.3         138506-138610       c
            2493-2851           AC161511.3         129128-129486       c
            2852-3100           AC161511.3         116562-116810       c
            3101-3226           AC161511.3         116274-116399       c
            3227-3330           AC161511.3         112564-112667       c
            3331-3444           AC161511.3         107238-107351       c
            3445-4320           AC161511.3         104961-105836       c
            4321-4353           BQ032928.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..4353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.81 cM"
     gene            1..4353
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /note="Sin3A associated protein"
                     /db_xref="GeneID:269003"
                     /db_xref="MGI:MGI:1919782"
     exon            1..426
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..3603
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /EC_number="3.2.1.3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     histone deacetylase complex subunit SAP130;
                     sin3-associated polypeptide p130; 130 kDa Sin3-associated
                     polypeptide; Sin3A associated protein, 130kDa"
                     /codon_start=1
                     /product="histone deacetylase complex subunit SAP130
                     isoform 3"
                     /protein_id="NP_001344484.1"
                     /db_xref="GeneID:269003"
                     /db_xref="MGI:MGI:1919782"
                     /translation="MEAFTEKRLRIPQASGLNVEMSSQQFPRLGTPSPGLSQPPSQIA
                     SSGSAGLINQVATVNDEAGRDADVGTREHVGPSSSLPPREEKQEPVVVRPYPQVQMLP
                     AHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTMSLPP
                     KVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLH
                     IGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHLIHQPIQSRPPVTTS
                     STIPPAVVATVSATRAQSPVITTTAAHAADSTLSRPTLSIQHPPSAAISIQRPAQSRD
                     VTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTLPSTTTAGSV
                     SHTQAPTSTIVTMTMPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPPERSSL
                     IPISGHRASPNPVAMETRNDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTI
                     RQYPVSAQAPNSTITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQ
                     PAPIGTSGIQPAPIGTPGIHSAAPINTQGLQPAAMANQQPQPEGKTSVVLADGATIVA
                     NPISNPFSAAPAATTVVQTHSQSASTNTPAQGSSPRPSILRKKPATDGMAVRKTLLPP
                     QPPDVATPRVESSMRSASGSPRPAGAKPKSEVHVSIATPVTVSLETISNQNAEQPTVA
                     VPPTAQQPPPTIPSMIAAASPPSQPAIALSTIPGAVPVTPPITTIAATPTLSAPVGGT
                     PSTVLGPPVPEIKVKEEAEPVDITRPVSTVPPLATNTVSPSLALLASNLSMPPSDLPP
                     GASPRKKPRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRKSPPKEYIDEEGV
                     RYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQ
                     GWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRC
                     KLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV"
     exon            427..544
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            545..780
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            781..939
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1051
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1176
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1301
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1449
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1540
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1645
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1787
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1909
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2212
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2387
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2492
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2851
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3100
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3226
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3330
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3444
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..4336
                     /gene="Sap130"
                     /gene_synonym="2610304F09Rik; 6720406D06"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagggtgagt gtggctggcg ggcgggctga actgaggcgg gccggggacg cgttccgaat
       61 tgcgttccct ccgtgcctgc agagcccctc gagcccttcg tggcggctgc atataaaagg
      121 gcacactgct tatcttgccg agaggactcc gtaggacgtt ttctccggga gacagagctt
      181 cgacacccgg ggtgtctgga aacgtgtgtc ctgggatctc ggaggggaaa tggggataac
      241 tggggtagac cggagataag cgaagcctga gggggaagac aattttagag accgtggttc
      301 tcgaatccta cccgtgtctc gggttggggg gtggggggat tatccgtgat gaggaagaaa
      361 ggaaatcctt aaatggaggc ctttacggaa aagcgtttga ggattccaca agcatcgggt
      421 cttaatgtgg aaatgagttc ccagcagttt cctcggttag gaaccccttc ccctgggctt
      481 agccagccac cttcacagat tgcaagcagt ggttccgcag gactgataaa ccaagttgcc
      541 acagttaatg atgaggctgg ccgagatgct gatgttggta ccagggagca cgtgggccct
      601 agcagctccc tgccgccccg ggaagagaag caggagccag ttgtggtaag gccctatcca
      661 caggtacaga tgctgcctgc acaccatgct gtcgcctcag ccacccctgt cgcagtgaca
      721 gccccgccag cacacctgac accagcagta ccactctctt tttcggaagg acttatgaag
      781 ccgcccccga agcctaccat gcctagccgt cccattgcgc ctgctccccc ttctaccatg
      841 tcacttcccc cgaaagttcc cgggcaggtt actgttacca tggagagcag catccctcaa
      901 gcttcagcca ttcccgtggc aacaatcagt ggacaacagg ggcatcccag taacctgcat
      961 cacattatga ccacaaatgt gcagatgtcc ataatccgca gcaacgctcc cgggccccca
     1021 cttcacattg gagcttccca cttacctcga ggtgcagctg ctgccgctgt gatgtccagc
     1081 tctaaagtaa ctacagtcct gaggccaact tcacagctgc caaatgctgc tacggcgcag
     1141 ccagcagtac agcacctcat tcaccagcca atccagtctc ggccacctgt gaccacctcc
     1201 agtacaatcc ctcctgctgt agtagcaaca gtctcagcca ccagagcgca gtctcctgtc
     1261 atcactacga cagcggccca cgcggctgac tcgacgctca gtcggcccac tttatctatc
     1321 cagcatccac catctgcagc cattagtatc cagcgtcctg cacagtctcg agatgtgaca
     1381 acaagaatca cactaccttc tcatcctgcg ttagggactc cgaaacagca gctccataca
     1441 atggctcaga aaaccatctt tagtactggc acaccagtgg ctgcagctac agtagcacct
     1501 attctggcaa ccaacacgct tccttcaaca accacagctg gatctgtgtc gcacacacaa
     1561 gctcccacaa gtacaattgt taccatgaca atgccctccc attcatccca tgctactgct
     1621 gtgaccactt caaatatccc agttgctaag gtggtgcccc agcagatcac acacacttcc
     1681 cctcggatcc agcctgatta ccctccagag aggagtagcc tgattcccat ttccggccat
     1741 cgggcctctc caaatccagt ggccatggaa acccgaaatg acaacagacc ttccgttcct
     1801 gttcagttcc agtacttctt gccaacttac ccaccctctg cctacccgct ggctgcacac
     1861 acctacaccc ccatcaccag ctctgtgtcc actatccggc agtacccagt ttctgctcaa
     1921 gccccaaact ccaccatcac agctcaaact ggtgttggtg tagcatctac agtccacctg
     1981 aaccccatgc agctgatgac agtggatgcc tcacatgccc gacatatcca ggggatccag
     2041 ccagcaccca tcagtacaca gggaatccag ccagccccca ttgggacatc agggatccag
     2101 ccagcaccaa ttggcacccc aggaatccat tcagcagccc caatcaacac tcaggggctt
     2161 cagccagcag caatggctaa tcagcagcca cagcctgagg ggaaaacctc agtggtgttg
     2221 gcagatggag ctacaattgt agccaaccct attagcaacc cattcagtgc tgctccagcg
     2281 gcaaccacag tggtccagac acacagtcag agtgctagca ccaacacacc agcccagggc
     2341 tcttctcccc ggcccagcat actgcggaag aaacctgcca cagatgggat ggcagtccgg
     2401 aaaactctcc tccctcctca gcctcctgac gtggctactc ctcgagtaga aagctctatg
     2461 cggagtgctt ctgggtcacc tagacctgca ggtgccaaac ctaaatccga agtgcatgtg
     2521 tctatagcca ctccagttac agtgtccttg gagaccatat ccaatcaaaa tgccgaacag
     2581 cctaccgttg ctgtccctcc gactgcccag cagcctccac cgaccattcc cagcatgatt
     2641 gcggcagcca gtcctccatc ccaaccagcc attgcccttt ccaccattcc cggagccgtg
     2701 cctgtcactc cacccatcac caccattgct gccacaccaa cgctgtcagc cccagtgggc
     2761 ggcactcctt ccacggtcct ggggcctcct gttcctgaga tcaaagtgaa ggaagaagcg
     2821 gagccagtgg acatcaccag gcctgtctcc acagtccctc ctctggccac caacacggtg
     2881 tctccatctc ttgctttgct ggcaagcaac ctgtccatgc ctccaagtga cctcccacct
     2941 ggtgcctccc caaggaaaaa gcctcgaaag cagcagcacg tgatctcgac agaggagggg
     3001 gatatgatgg agacaaacag cactgacgat gagaagtccg ctgccaagag tctcctggta
     3061 aaggctgaga agcgcaagtc tcctcccaaa gagtacattg atgaggaagg tgtgaggtat
     3121 gtcccagtgc gacccagacc tcccattact ttgctacgtc actatcggaa cccctggaaa
     3181 gctgcttatc accactttca gaggtacagt gacgtccggg tcaaagagga gaagaaagct
     3241 atgctacagg aaatagctaa tcagaaagga gtgtcctgcc gtgcccaggg ctggaaagtt
     3301 cacctctgtg ctgcccagtt actacagctg acaaatctag aacacgacgt ttatgaaaga
     3361 ctcaccaacc tacaggaagg gattatccca aagaaaaagg cagcgactga tgacgatcta
     3421 catcgaataa atgagctgat acagggaaac atgcagcggt gtaaactagt gatggaccaa
     3481 atcagtgagg ccagagactc tatgcttaag gttctggatc acaaggaccg ggtgctgaag
     3541 ctgctcaaca agaacgggac ggtcaagaag gtgtcaaagt tgaagcggaa ggagaaggtg
     3601 taggccggaa gaatcaggac tcggaaacag aatttatgaa gaatgatgct gcgggggtcg
     3661 ggggggaggg ggagagggct ttgctacttt gacaatggag cattgaatta caggacactt
     3721 ttcttcattc acttgaggaa gcagatctgg tggcacagaa ggatcagaac tggactgacg
     3781 tgccgagtcc tccttcctcc agacgcacac ctattgcacc tcagttttca gggactccag
     3841 acacttggtg acacagatgg ccggctgagg tttcagcctt tcagcccata gactgtattt
     3901 atctggtgga ttcctgtagg gcctgagctg agcctggact gaaagtatcc acttggacaa
     3961 tctatcctct ctagactaaa cataaaacct cttcttaccc cagtcacttc tcctgtttga
     4021 ctgtccagtg cccaagttgg ccttctacag tggtgccaca gcacccagag aactgccaca
     4081 tctcacgcaa aaggatccag cgatcagttc ttgtcatttt caaaagaacc atttccaagt
     4141 gacactgtta cactgtctgc cctgcctgtg tcagagctgg attcttgtgg aggttgagag
     4201 cagacaacac taactgctct gggatcctgt tctagaggac atttcagtta tctgtccttc
     4261 cctaccgtgt gatgctgtta gtcatatgta ccacgcatct ccaaacatca ataaaggact
     4321 agaagaggtt tttgtaaaaa aaaaaaaaaa aaa
//
