LOCUS       NM_023380               1845 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus SAM domain, SH3 domain and nuclear localization
            signals, 1 (Samsn1), mRNA.
ACCESSION   NM_023380 XM_358875
VERSION     NM_023380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Riel,J.M., Yamauchi,Y., Ruthig,V.A., Malinta,Q.U., Blanco,M.,
            Moretti,C., Cocquet,J. and Ward,M.A.
  TITLE     Rescue of Sly Expression Is Not Sufficient to Rescue Spermiogenic
            Phenotype of Mice with Deletions of Y Chromosome Long Arm
  JOURNAL   Genes (Basel) 10 (2), 133 (2019)
   PUBMED   30759861
  REMARK    GeneRIF: We also carried out transgene rescue by adding Sly1/2
            transgenes to mice with NPYq deletions. We demonstrated that SLY1/2
            expression in mutant mice decreased proportionally to deletion
            size, with ~12% of SLY1/2 retained in shSLY sh367 testes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Amend,S.R., Wilson,W.C., Chu,L., Lu,L., Liu,P., Serie,D., Su,X.,
            Xu,Y., Wang,D., Gramolini,A., Wen,X.Y., O'Neal,J., Hurchla,M.,
            Vachon,C.M., Colditz,G., Vij,R., Weilbaecher,K.N. and Tomasson,M.H.
  TITLE     Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse
            Strain Suggests the Origin of Disease Involves Multiple Cell Types
  JOURNAL   PLoS One 10 (5), e0127828 (2015)
   PUBMED   26020268
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Schmitt,F., Schall,D., Bucher,K., Schindler,T.I., Hector,A.,
            Biedermann,T., Zemlin,M., Hartl,D. and Beer-Hammer,S.
  TITLE     SLy2 controls the antibody response to pneumococcal vaccine through
            an IL-5Ralpha-dependent mechanism in B-1 cells
  JOURNAL   Eur J Immunol 45 (1), 60-70 (2015)
   PUBMED   25330943
  REMARK    GeneRIF: SLy2 controls the antibody response to pneumococcal
            vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Noll,J.E., Hewett,D.R., Williams,S.A., Vandyke,K., Kok,C., To,L.B.
            and Zannettino,A.C.
  TITLE     SAMSN1 is a tumor suppressor gene in multiple myeloma
  JOURNAL   Neoplasia 16 (7), 572-585 (2014)
   PUBMED   25117979
  REMARK    GeneRIF: This is the first study to identify deletion of a key gene
            in the C57BL/KaLwRij mice that also displays reduced gene
            expression in patients with MM and is therefore likely to play an
            integral role in MM disease development.
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   von Holleben,M., Gohla,A., Janssen,K.P., Iritani,B.M. and
            Beer-Hammer,S.
  TITLE     Immunoinhibitory adapter protein Src homology domain 3 lymphocyte
            protein 2 (SLy2) regulates actin dynamics and B cell spreading
  JOURNAL   J Biol Chem 286 (15), 13489-13501 (2011)
   PUBMED   21296879
  REMARK    GeneRIF: the immunoinhibitory roles of SLy2 in vivo and suggest
            that the physiological up-regulation of SLy2 observed upon B cell
            activation functions to counteract excessive B cell spreading.
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Wang,D., Stewart,A.K., Zhuang,L., Zhu,Y., Wang,Y., Shi,C.,
            Keating,A., Slutsky,A., Zhang,H. and Wen,X.Y.
  TITLE     Enhanced adaptive immunity in mice lacking the immunoinhibitory
            adaptor Hacs1
  JOURNAL   FASEB J 24 (3), 947-956 (2010)
   PUBMED   19923443
  REMARK    GeneRIF: This study suggests that Hacs1 is an immunoinhibitory
            adaptor that might be a useful target for immune suppression
            therapy.
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Zhu,Y.X., Benn,S., Li,Z.H., Wei,E., Masih-Khan,E., Trieu,Y.,
            Bali,M., McGlade,C.J., Claudio,J.O. and Stewart,A.K.
  TITLE     The SH3-SAM adaptor HACS1 is up-regulated in B cell activation
            signaling cascades
  JOURNAL   J Exp Med 200 (6), 737-747 (2004)
   PUBMED   15381729
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Claudio,J.O., Zhu,Y.X., Benn,S.J., Shukla,A.H., McGlade,C.J.,
            Falcioni,N. and Stewart,A.K.
  TITLE     HACS1 encodes a novel SH3-SAM adaptor protein differentially
            expressed in normal and malignant hematopoietic cells
  JOURNAL   Oncogene 20 (38), 5373-5377 (2001)
   PUBMED   11536050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ333189.1.
            
            On Jan 24, 2006 this sequence version replaced NM_023380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ333189.1, BC064778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 43.36 cM"
     gene            1..1845
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /note="SAM domain, SH3 domain and nuclear localization
                     signals, 1"
                     /db_xref="GeneID:67742"
                     /db_xref="MGI:MGI:1914992"
     exon            1..137
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1199
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /note="SAM domain, SH3 domain and nuclear localization
                     signals protein 1; SH3-lymphocyte protein 2; SH3 protein
                     expressed in lymphocytes 2; SAM domain, SH3 domain and
                     nuclear localisation signals, 1"
                     /codon_start=1
                     /product="SAM domain-containing protein SAMSN-1"
                     /protein_id="NP_075869.2"
                     /db_xref="CCDS:CCDS37378.1"
                     /db_xref="GeneID:67742"
                     /db_xref="MGI:MGI:1914992"
                     /translation="MLKRKPSNASDKEKHQKPKRSSSFGNFDRFRNNSVSKSDDSIEV
                     HDRELTNGSEEQSKTSSSGGSLGKKVRAISWTMKKKVGKKYIKALSEEKEEESGEEAL
                     PYRNSDPMIGTHTEKISLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDSPY
                     SGPFCGRAKVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIY
                     VDVILEEEAAPKKIKVPRSRRRENHQTIQEFLERIHLQEYTSTLLLNGYETLDDLKDI
                     KESHLIELNIADPEDRARLLSAAESLLDEETTVEHEKESVPLSSNPDILSASQLEDCP
                     RDSGCYISSENSDNGKEDLESENLSDMVQKIAITESSD"
     exon            138..209
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..359
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..489
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..641
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..848
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..999
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1845
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="Samsn1"
                     /gene_synonym="4930571B16Rik; 930571B16Rik; Hacs1; SLy2"
                     /note="major polyA site"
ORIGIN      
        1 cacggagagc acccgtgcct gctctcagtt gtctctgtaa cagcagcaac tgtgctcact
       61 agaggtggcc agaattcaaa atgctaaaga ggaagccatc caatgcctca gacaaggaga
      121 aacaccaaaa accgaagcgc agcagcagtt ttgggaattt tgaccgtttt cggaataatt
      181 ccgtatcaaa atctgatgac tcaattgagg tccatgacag ggaactgaca aatggaagtg
      241 aagaacaaag caagacttca agcagtggag gaagtctagg taaaaaagtg agggctattt
      301 catggacaat gaagaaaaaa gtaggaaaaa aatacatcaa agctctttct gaggaaaaag
      361 aggaagaaag tggagaggaa gccctcccat atcggaacag tgatcccatg attggaacac
      421 atacagagaa gatctcactc aaagccagcg actctatgga cagtctttac agtgggcaga
      481 gttcatcaag tggaataaca agctgttcag atggaacaag taatcgggac agcttccgac
      541 tggatgatga cagcccctac tcagggccat tctgtggccg ggccaaagtg cacacagact
      601 tcacgccaag tccctatgac accgactccc ttaaaatcaa gaaaggagac atcatagaca
      661 ttatctgcaa aacaccaatg ggaatgtgga cagggatgct gaacaataaa gtgggaaact
      721 tcaaatttat ttatgtggat gttatcttag aagaggaagc agctcctaag aagataaagg
      781 tccccagaag caggagaaga gagaaccacc agactatcca ggagttctta gagaggattc
      841 accttcagga atacacttca acacttctgc ttaatggcta tgagaccctg gatgacttga
      901 aggatatcaa agaaagtcat ctcattgaat taaacattgc agatccagaa gacagggcga
      961 ggctgctgtc tgctgccgag agtctcctgg atgaagaaac cactgtagaa catgaaaagg
     1021 aatccgtgcc tctatcctca aacccagaca tcttgagtgc atcacagcta gaggactgcc
     1081 cgagggactc tggctgttat atctcatcgg aaaactcaga taatggcaag gaagatctgg
     1141 agtcagaaaa tctgtctgac atggtgcaga agattgccat cacagaatcc agtgactgaa
     1201 cacacactct catgtccaca cccgcagccg aattccattt gaacttcttg tatgctacag
     1261 gatcaaatgg aaggtttcca aatgtacccc aaagtgctaa gtgtttcagt ctgtacaatt
     1321 gttcatgtaa atttatattt ctcacttacc aatgagtgtg aataaaatgt atatttatta
     1381 agtactatgt gttaaagttt acctgcctgt attagaaaaa aaagacatga tgcaagccca
     1441 tgtgtggtat gtactgtatt cgtctctatt tcataagtgt aaaaaatata gacatggaga
     1501 ccacgtacta atatatatta ttgaattttt tttatagaag aagtttcagt ttaactaatt
     1561 tctataggta gaatatatac tcatttttga agtactggga agttggggac tgagattaga
     1621 gacttgtttt caaagatgga gttttagtaa caattttctg tttgtttctt cactctgtta
     1681 tctgatatgc agagagagtt aacaatatat tgtctgtttt ggctaagtaa acatagttgt
     1741 agagatgtct agtaaacaag gatgttttgt ctttatatgt aaatattttt taattttcta
     1801 tatcctaata ataacaaaat aaactatgta catattatat ctgct
//
