LOCUS       NM_018851               3756 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus SAM domain and HD domain, 1 (Samhd1), transcript
            variant 1, mRNA.
ACCESSION   NM_018851 XM_977847
VERSION     NM_018851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3756)
  AUTHORS   Tada,T., Minnee,J. and Landau,N.R.
  TITLE     Vectored immunoprophylaxis and treatment of SARS-CoV-2 infection in
            a preclinical model
  JOURNAL   Proc Natl Acad Sci U S A 120 (23), e2303509120 (2023)
   PUBMED   37252952
REFERENCE   2  (bases 1 to 3756)
  AUTHORS   Xu,B., Sui,Q., Hu,H., Hu,X., Zhou,X., Qian,C. and Li,N.
  TITLE     SAMHD1 Attenuates Acute Inflammation by Maintaining Mitochondrial
            Function in Macrophages via Interaction with VDAC1
  JOURNAL   Int J Mol Sci 24 (9), 7888 (2023)
   PUBMED   37175593
  REMARK    GeneRIF: SAMHD1 Attenuates Acute Inflammation by Maintaining
            Mitochondrial Function in Macrophages via Interaction with VDAC1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3756)
  AUTHORS   Tada,T., Peng,J.Y., Dcosta,B.M. and Landau,N.R.
  TITLE     Single-epitope T cell-based vaccine protects against SARS-CoV-2
            infection in a preclinical animal model
  JOURNAL   JCI Insight 8 (7), e167306 (2023)
   PUBMED   37036004
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3756)
  AUTHORS   Schumann,T., Ramon,S.C., Schubert,N., Mayo,M.A., Hega,M.,
            Maser,K.I., Ada,S.R., Sydow,L., Hajikazemi,M., Badstubner,M.,
            Muller,P., Ge,Y., Shakeri,F., Buness,A., Rupf,B., Lienenklaus,S.,
            Utess,B., Muhandes,L., Haase,M., Rupp,L., Schmitz,M., Gramberg,T.,
            Manel,N., Hartmann,G., Zillinger,T., Kato,H., Bauer,S.,
            Gerbaulet,A., Paeschke,K., Roers,A. and Behrendt,R.
  TITLE     Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent
            manner
  JOURNAL   J Exp Med 220 (1) (2023)
   PUBMED   36346347
  REMARK    GeneRIF: Deficiency for SAMHD1 activates MDA5 in a
            cGAS/STING-dependent manner.
REFERENCE   5  (bases 1 to 3756)
  AUTHORS   Barrett,B., Nguyen,D.H., Xu,J., Guo,K., Shetty,S., Jones,S.T.,
            Mickens,K.L., Shepard,C., Roers,A., Behrendt,R., Wu,L., Kim,B. and
            Santiago,M.L.
  TITLE     SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice
            Exposed to Lipopolysaccharide
  JOURNAL   J Immunol 208 (2), 444-453 (2022)
   PUBMED   34893529
  REMARK    GeneRIF: SAMHD1 Promotes the Antiretroviral Adaptive Immune
            Response in Mice Exposed to Lipopolysaccharide.
REFERENCE   6  (bases 1 to 3756)
  AUTHORS   Powell,R.D., Holland,P.J., Hollis,T. and Perrino,F.W.
  TITLE     Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1
            is a dGTP-regulated deoxynucleotide triphosphohydrolase
  JOURNAL   J Biol Chem 286 (51), 43596-43600 (2011)
   PUBMED   22069334
  REMARK    GeneRIF: Vpx targets SAMHD1 for degradation in a viral strategy to
            control cellular deoxynucleotide levels for efficient replication
REFERENCE   7  (bases 1 to 3756)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 3756)
  AUTHORS   Jerez-Timaure,N.C., Eisen,E.J. and Pomp,D.
  TITLE     Fine mapping of a QTL region with large effects on growth and
            fatness on mouse chromosome 2
  JOURNAL   Physiol Genomics 21 (3), 411-422 (2005)
   PUBMED   15769905
REFERENCE   9  (bases 1 to 3756)
  AUTHORS   Li,N., Zhang,W. and Cao,X.
  TITLE     Identification of human homologue of mouse IFN-gamma induced
            protein from human dendritic cells
  JOURNAL   Immunol Lett 74 (3), 221-224 (2000)
   PUBMED   11064105
REFERENCE   10 (bases 1 to 3756)
  AUTHORS   Lafuse,W.P., Brown,D., Castle,L. and Zwilling,B.S.
  TITLE     Cloning and characterization of a novel cDNA that is
            IFN-gamma-induced in mouse peritoneal macrophages and encodes a
            putative GTP-binding protein
  JOURNAL   J Leukoc Biol 57 (3), 477-483 (1995)
   PUBMED   7884320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067198.1 and DV645873.1.
            
            On May 15, 2019 this sequence version replaced NM_018851.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067198.1, AK151335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2266              BC067198.1         50-2315
            2267-2271           DV645873.1         104-108
            2272-3756           BC067198.1         2321-3805
FEATURES             Location/Qualifiers
     source          1..3756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.0 cM"
     gene            1..3756
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /note="SAM domain and HD domain, 1"
                     /db_xref="GeneID:56045"
                     /db_xref="MGI:MGI:1927468"
     exon            1..218
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..285
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..358
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..519
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..635
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..706
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..862
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..963
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1105
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1197
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1313
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1450
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1543
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1648
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1786
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..3756
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /note="hexamer: AGTAAA"
     polyA_site      1891
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /note="major polyA site"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /note="hexamer: ATTAAA"
     polyA_site      3756
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /note="major polyA site"
ORIGIN      
        1 ggtagccatg cagagcgcac ccttggagca gccagctaag cgaccccgct gcgatggcag
       61 cccaaggacg ccaccgagca ctcctcctgc aacagctaat ctgtctgcag acgacgactt
      121 ccaaaacacc gacctccgaa cctgggaacc ggaggacgtg tgctccttct tagagaatcg
      181 tggtttccga gagaagaaag tgctggacat cttcagagac aataaaatcg ccggctcgtt
      241 tctgcccttt ttggatgagg atcgtctgga agatctggga gtaagttcct tggaggagag
      301 gaagaagatg atagaatgta tccagcagct gagtcagtct cggattgatc taatgaaggt
      361 atttaatgat cccattcatg gccacattga gttccaccct ctccttatca gaatcatcga
      421 cacacctcag ttccagcgac ttcgctatat caagcagctg gggggcggct actatgtttt
      481 ccctggagcg tcccacaatc gcttcgaaca cagtctcgga gtggggtacc tagcaggctg
      541 cctggtgcga gcacttgccg aaaaacagcc agagctacag atcagtgagc gagatatact
      601 ctgtgttcag attgcggggc tctgccacga cctaggtcat gggccatttt ctcatatgtt
      661 tgatggaagg tttatcccac gggctcgccc agagaaaaag tggaagcacg aacagggctc
      721 cattgagatg tttgagcatc tggtcaattc taatgaactc aaacttgtca tgaagaacta
      781 tggtctcgtc cctgaagaag acattacctt tatcaaggaa caaattatgg gaccacctat
      841 aacaccagtc aaagattcct tgtggccgta taaaggccgc cctgccacga agagcttcct
      901 ttacgagata gtgtctaaca agaggaatgg catcgacgta gacaaatggg attattttgc
      961 cagagactgt caccatcttg gaatccaaaa taattttgat tacaagcgct tcattaagtt
     1021 tgcccgtatc tgtgaagtgg agtacaaggt caaggaggac aagacctaca tccgtaaggt
     1081 gaagcacatt tgttcgagag aaaaggaggt tggaaatctg tatgacatgt tccacactcg
     1141 caactgctta caccgaagag cttaccaaca caagatcagc aacctcatcg acataatgat
     1201 tacagatgcc ttcctcaaag cagaccccta cgtggagatt acagggactg ccgggaagaa
     1261 gttccgcatt tccacagcca ttgatgacat ggaagccttc actaagttga cggataacat
     1321 ttttctggag gttttacact ctactgatcc acagttgtct gaggcccaaa gtattttaag
     1381 gaacattgaa tgccgcaatc tatacaagta tttgggtgag acccagccaa agcgtgagaa
     1441 gattaggaag gaagaatatg aacggcttcc ccaagaagtt gctaaagcca aacctgaaaa
     1501 agccccggat gttgaactga aggccgaaga tttcatagtt gatgttatca atgtggatta
     1561 tgggatggaa gacaagaatc caatcgatcg tgttcacttc tattgtaaga gcaacagcaa
     1621 gcaagcggtc aggatcaata aagagcaggt gtcacaactg ctgccagaga aatttgcaga
     1681 gcagctcatt cgggtgtact gtaagaagaa agacgggaag agcctggacg ccgccgggaa
     1741 gcactttgtt cagtggtgtg cgctcaggga cttcaccaag ccacaggatg gtgacattat
     1801 agctccactc ataacacctc tgaaatggaa taataagact tcatcttgcc tccaagaagt
     1861 atccaaagta aaaacatgtc taaaatttta agtgaatatc tgcggttagt tcttttcaaa
     1921 aacctctttc cctcttcaca attaagttag gaaatataat ccgggcccac caatgacctt
     1981 tatttagtat ctggaatgta ttctcgtgct ggggtggggg ggtctcgttt tcattcaaaa
     2041 tgaaaaatgg taacattaac aaatttttcc tatctagcct gtggtggttt gactaagaat
     2101 ggtcccataa ggtcatataa ttcaatgcct ggtcaccagg gagtggaact gtttgaaagg
     2161 attacaagga tcgagacagt gtggccttgc tataggaagt gtgtcacaga agatgtgcat
     2221 gctcttgtac tctctctctc tctctctctc tctctctctc tctctccctc cctccctccc
     2281 tccctccctc cctccctccc tcctgtccat cagctaccac acagcgcctg ttcctcgcca
     2341 tgatggtgga ttaaccctct gaagctgtaa gcacaccccc agttaaccgc tttcctttat
     2401 aagagttgcc ttggccgtgg tgtctcttga ctgagacaga tgctgtaaga agcattatct
     2461 ggtgtatttt tagcactgac tgaaaccttt ctcctttagc aacctatttc ccaggataac
     2521 tctcccatct atcctgaact cttgggacaa aggattgcct tttgttttta aatcaggaat
     2581 tgagacaagg gtacaaacta gaatggaaat tgtgatgcgc cgtgtagtta aaaaaaaaac
     2641 caaaatccca gcccactgaa gaggtgcccg gcaccctgct ccccccacaa caccccacca
     2701 cttccatccc tgttaagtgc caggcatggg gggcatcggg agcagttctt tcctcagagg
     2761 agctgaggtg tgtcaggcgg gtactctacc gatgacctca gctccatctc tgtcttcctg
     2821 gtacaactcc ccctgtcccc tgctttagga gaggctaggt tcagaggaca cctcatacca
     2881 ggctactcct gagtctgtcg tgactccaga caaaatcaga gttttaaagc acctgcaacc
     2941 cctccagccc caggggactc actgctgcca gcctggggac aggtcttcgc ccatctcttc
     3001 tgagctgaac tggtcagctg accaccgacc ccaccctctg gctgctctct ccggcaccac
     3061 tgttgctgca gtgtgtttac gggttttaga acattctgga ctgcctttgt gagcttagca
     3121 gactgcgcag tgagtctcag gttctctttg tagcttgctg ttcctaccag tgccgagccg
     3181 ctgtggttct ccctgctgcc cccctcaccc ccactttgca cagctttacc aggaattgag
     3241 tccaattgga gccaacagtg gtcaacagaa atgctagaga tgcaggcagt ggggacagag
     3301 gcaggagctg gaggcgacat cttagtgatg atgctctccc gggcgagcag ccttgtgctg
     3361 cctctctcct ccgggtagcc acgttctgtc ttgtccactc atgggtgaag agtatttggt
     3421 gtgtctgcca ctatggggtc ataaatgcac acgggaggtg ctagctcccc cactagccac
     3481 ggtgcctctg tagatccacg agacagctag gggtccccct cccctttgtg tgcccagact
     3541 caaggttaag aagtggaaag ttttctgcga atatttttgt atttttgcca gtctatattt
     3601 tttaaatcat tatggtttat tgtggagttt tgtagtccta attttgtacc atggtatgtg
     3661 ggaaacaaat ctgacccatt ttctgccttt gatgctgttt tccttgtgag tacctgtgtc
     3721 gtttacgaga ctgcattaaa aatggagatt ttaaca
//
