LOCUS       NP_061339                627 aa            linear   ROD 01-JUN-2024
DEFINITION  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform 1
            [Mus musculus].
ACCESSION   NP_061339 XP_982941
VERSION     NP_061339.4
DBSOURCE    REFSEQ: accession NM_018851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 627)
  AUTHORS   Tada,T., Minnee,J. and Landau,N.R.
  TITLE     Vectored immunoprophylaxis and treatment of SARS-CoV-2 infection in
            a preclinical model
  JOURNAL   Proc Natl Acad Sci U S A 120 (23), e2303509120 (2023)
   PUBMED   37252952
REFERENCE   2  (residues 1 to 627)
  AUTHORS   Xu,B., Sui,Q., Hu,H., Hu,X., Zhou,X., Qian,C. and Li,N.
  TITLE     SAMHD1 Attenuates Acute Inflammation by Maintaining Mitochondrial
            Function in Macrophages via Interaction with VDAC1
  JOURNAL   Int J Mol Sci 24 (9), 7888 (2023)
   PUBMED   37175593
  REMARK    GeneRIF: SAMHD1 Attenuates Acute Inflammation by Maintaining
            Mitochondrial Function in Macrophages via Interaction with VDAC1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 627)
  AUTHORS   Tada,T., Peng,J.Y., Dcosta,B.M. and Landau,N.R.
  TITLE     Single-epitope T cell-based vaccine protects against SARS-CoV-2
            infection in a preclinical animal model
  JOURNAL   JCI Insight 8 (7), e167306 (2023)
   PUBMED   37036004
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 627)
  AUTHORS   Schumann,T., Ramon,S.C., Schubert,N., Mayo,M.A., Hega,M.,
            Maser,K.I., Ada,S.R., Sydow,L., Hajikazemi,M., Badstubner,M.,
            Muller,P., Ge,Y., Shakeri,F., Buness,A., Rupf,B., Lienenklaus,S.,
            Utess,B., Muhandes,L., Haase,M., Rupp,L., Schmitz,M., Gramberg,T.,
            Manel,N., Hartmann,G., Zillinger,T., Kato,H., Bauer,S.,
            Gerbaulet,A., Paeschke,K., Roers,A. and Behrendt,R.
  TITLE     Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent
            manner
  JOURNAL   J Exp Med 220 (1) (2023)
   PUBMED   36346347
  REMARK    GeneRIF: Deficiency for SAMHD1 activates MDA5 in a
            cGAS/STING-dependent manner.
REFERENCE   5  (residues 1 to 627)
  AUTHORS   Barrett,B., Nguyen,D.H., Xu,J., Guo,K., Shetty,S., Jones,S.T.,
            Mickens,K.L., Shepard,C., Roers,A., Behrendt,R., Wu,L., Kim,B. and
            Santiago,M.L.
  TITLE     SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice
            Exposed to Lipopolysaccharide
  JOURNAL   J Immunol 208 (2), 444-453 (2022)
   PUBMED   34893529
  REMARK    GeneRIF: SAMHD1 Promotes the Antiretroviral Adaptive Immune
            Response in Mice Exposed to Lipopolysaccharide.
REFERENCE   6  (residues 1 to 627)
  AUTHORS   Powell,R.D., Holland,P.J., Hollis,T. and Perrino,F.W.
  TITLE     Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1
            is a dGTP-regulated deoxynucleotide triphosphohydrolase
  JOURNAL   J Biol Chem 286 (51), 43596-43600 (2011)
   PUBMED   22069334
  REMARK    GeneRIF: Vpx targets SAMHD1 for degradation in a viral strategy to
            control cellular deoxynucleotide levels for efficient replication
REFERENCE   7  (residues 1 to 627)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (residues 1 to 627)
  AUTHORS   Jerez-Timaure,N.C., Eisen,E.J. and Pomp,D.
  TITLE     Fine mapping of a QTL region with large effects on growth and
            fatness on mouse chromosome 2
  JOURNAL   Physiol Genomics 21 (3), 411-422 (2005)
   PUBMED   15769905
REFERENCE   9  (residues 1 to 627)
  AUTHORS   Li,N., Zhang,W. and Cao,X.
  TITLE     Identification of human homologue of mouse IFN-gamma induced
            protein from human dendritic cells
  JOURNAL   Immunol Lett 74 (3), 221-224 (2000)
   PUBMED   11064105
REFERENCE   10 (residues 1 to 627)
  AUTHORS   Lafuse,W.P., Brown,D., Castle,L. and Zwilling,B.S.
  TITLE     Cloning and characterization of a novel cDNA that is
            IFN-gamma-induced in mouse peritoneal macrophages and encodes a
            putative GTP-binding protein
  JOURNAL   J Leukoc Biol 57 (3), 477-483 (1995)
   PUBMED   7884320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067198.1 and DV645873.1.
            
            On May 15, 2019 this sequence version replaced NP_061339.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067198.1, AK151335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.0 cM"
     Protein         1..627
                     /product="deoxynucleoside triphosphate triphosphohydrolase
                     SAMHD1 isoform 1"
                     /note="IFN-gamma induced; SAM domain and HD
                     domain-containing protein 1; interferon-gamma-inducible
                     protein Mg11; dNTPase; deoxynucleoside triphosphate
                     triphosphohydrolase SAMHD1"
                     /calculated_mol_wt=72520
     Region          42..111
                     /region_name="SAM_HD"
                     /note="SAM domain of HD-phosphohydrolase; cd09508"
                     /db_xref="CDD:188907"
     Region          116..469
                     /region_name="YdhJ"
                     /note="HD superfamily phosphohydrolase [General function
                     prediction only]; COG1078"
                     /db_xref="CDD:440696"
     CDS             1..627
                     /gene="Samhd1"
                     /gene_synonym="E330031J07Rik; Mg11; mSAMHD1"
                     /coded_by="NM_018851.4:8..1891"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16973.2"
                     /db_xref="GeneID:56045"
                     /db_xref="MGI:MGI:1927468"
ORIGIN      
        1 mqsapleqpa krprcdgspr tppstppata nlsadddfqn tdlrtweped vcsflenrgf
       61 rekkvldifr dnkiagsflp fldedrledl gvssleerkk mieciqqlsq sridlmkvfn
      121 dpihghiefh plliriidtp qfqrlryikq lgggyyvfpg ashnrfehsl gvgylagclv
      181 ralaekqpel qiserdilcv qiaglchdlg hgpfshmfdg rfiprarpek kwkheqgsie
      241 mfehlvnsne lklvmknygl vpeeditfik eqimgppitp vkdslwpykg rpatksflye
      301 ivsnkrngid vdkwdyfard chhlgiqnnf dykrfikfar iceveykvke dktyirkvkh
      361 icsrekevgn lydmfhtrnc lhrrayqhki snlidimitd aflkadpyve itgtagkkfr
      421 istaiddmea ftkltdnifl evlhstdpql seaqsilrni ecrnlykylg etqpkrekir
      481 keeyerlpqe vakakpekap dvelkaedfi vdvinvdygm edknpidrvh fycksnskqa
      541 vrinkeqvsq llpekfaeql irvyckkkdg ksldaagkhf vqwcalrdft kpqdgdiiap
      601 litplkwnnk tssclqevsk vktclkf
//
