LOCUS       NM_010156               5344 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus sterile alpha motif domain containing 9-like (Samd9l),
            mRNA.
ACCESSION   NM_010156 XM_620286 XM_908922
VERSION     NM_010156.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5344)
  AUTHORS   Jung,M.
  TITLE     Inflammation fuels bone marrow exhaustion caused by Samd9l mutation
  JOURNAL   J Clin Invest 132 (21), e164136 (2022)
   PUBMED   36317635
  REMARK    GeneRIF: Inflammation fuels bone marrow exhaustion caused by Samd9l
            mutation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5344)
  AUTHORS   Abdelhamed S, Thomas ME 3rd, Westover T, Umeda M, Xiong E, Rolle C,
            Walsh MP, Wu H, Schwartz JR, Valentine V, Valentine M, Pounds S, Ma
            J, Janke LJ and Klco JM.
  TITLE     Mutant Samd9l expression impairs hematopoiesis and induces bone
            marrow failure in mice
  JOURNAL   J Clin Invest 132 (21), e158869 (2022)
   PUBMED   36074606
  REMARK    GeneRIF: Mutant Samd9l expression impairs hematopoiesis and induces
            bone marrow failure in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5344)
  AUTHORS   Nagamachi A, Kanai A, Nakamura M, Okuda H, Yokoyama A, Shinriki S,
            Matsui H and Inaba T.
  TITLE     Multiorgan failure with abnormal receptor metabolism in mice
            mimicking Samd9/9L syndromes
  JOURNAL   J Clin Invest 131 (4) (2021)
   PUBMED   33373325
  REMARK    GeneRIF: Multiorgan failure with abnormal receptor metabolism in
            mice mimicking Samd9/9L syndromes.
REFERENCE   4  (bases 1 to 5344)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 5344)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5344)
  AUTHORS   Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K,
            Suda T, Nakamura T, Wolff L, Honda H and Inaba T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
  REMARK    GeneRIF: Haploinsufficiency of SAMD9L, an endosome fusion
            facilitator, causes myeloid malignancies in mice mimicking human
            diseases with monosomy 7.
REFERENCE   7  (bases 1 to 5344)
  AUTHORS   Li,Q., Guo,H., Matsui,H., Honda,H., Inaba,T., Sundberg,J.P.,
            Sprecher,E. and Uitto,J.
  TITLE     Mouse Samd9l is not a functional paralogue of the human SAMD9, the
            gene mutated in normophosphataemic familial tumoral calcinosis
  JOURNAL   Exp Dermatol 21 (7), 554-556 (2012)
   PUBMED   22716256
  REMARK    GeneRIF: Mouse Samd9l is not a functional paralogue of the human
            SAMD9.
REFERENCE   8  (bases 1 to 5344)
  AUTHORS   Jiang Q, Quaynor B, Sun A, Li Q, Matsui H, Honda H, Inaba T,
            Sprecher E and Uitto J.
  TITLE     The Samd9L gene: transcriptional regulation and tissue-specific
            expression in mouse development
  JOURNAL   J Invest Dermatol 131 (7), 1428-1434 (2011)
   PUBMED   21412262
  REMARK    GeneRIF: mouse Samd9L revealed near-ubiquitous expression, with the
            highest level in the kidney, a major organ regulating
            calcium-phosphate homeostasis and the site of calcitonin hormonal
            action.
REFERENCE   9  (bases 1 to 5344)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 5344)
  AUTHORS   Thomas JW, Lee-Lin SQ and Green ED.
  TITLE     Human-mouse comparative mapping of the genomic region containing
            CDK6: localization of an evolutionary breakpoint
  JOURNAL   Mamm Genome 10 (7), 764-767 (1999)
   PUBMED   10384057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052535.1, BC079894.1 and AK035419.1.
            
            [WARNING] On Apr 21, 2023 this sequence was replaced by
            NM_010156.4.
            
            On or before Apr 19, 2009 this sequence version replaced
            XM_908922.2, XM_620286.3, NM_010156.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079894.1, AK173329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AK052535.1         2-80
            80-2363             BC079894.1         1-2284
            2364-2371           AK035419.1         235-242
            2372-5344           BC079894.1         2293-5265
FEATURES             Location/Qualifiers
     source          1..5344
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.76 cM"
     gene            1..5344
                     /gene="Samd9l"
                     /gene_synonym="ESTM25; mKIAA2005"
                     /note="sterile alpha motif domain containing 9-like"
                     /db_xref="GeneID:209086"
                     /db_xref="MGI:MGI:1343184"
     exon            1..304
                     /gene="Samd9l"
                     /gene_synonym="ESTM25; mKIAA2005"
                     /inference="alignment:Splign:2.1.0"
     exon            305..5329
                     /gene="Samd9l"
                     /gene_synonym="ESTM25; mKIAA2005"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..5066
                     /gene="Samd9l"
                     /gene_synonym="ESTM25; mKIAA2005"
                     /note="SAM domain-containing protein 9-like; v-myc
                     myelocytomatosis viral related oncogene, neuroblastoma
                     derived"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein
                     9-like"
                     /protein_id="NP_034286.2"
                     /db_xref="CCDS:CCDS51712.1"
                     /db_xref="GeneID:209086"
                     /db_xref="MGI:MGI:1343184"
                     /translation="MSGQVTQPKLIKDWTKEHVRKWVTEDLNIVEKYAQILFKEEVTG
                     MVLQELTEEDLREMGLPRGPALLIKRMYNKLISSPESHNQDSRELNDKKLSTKEQQTK
                     TKNEEENSVSSNSDHGLRETGQNEEQEPSLTKENMLGDVVTKDMEDNKPKPEQMSCTP
                     YPFDSFCDVKQYIEHSILRVAETGPLNLIDPIHEFKAFTNTKKATEEDIKMKFSNETF
                     RFAAACMNSRTNGTIHFGVKDKPHGEIVGVQVTSKDIFVNHFNTMITKYFEDSEISEA
                     RACIREPRFVEVLLQNNTQSNRFVIEVDVIPRHSICQEKYFYIMMQSSTGKTWKQSKD
                     TSLFVREGASSKNILGNPNQRDREFKKFLEDLKMWTASRKAAEEELRMVTKKESEGLK
                     LSKLLTRHQGSLDESYYDWYILVTNTCAPTQLEHLEFIKEMKLFAVLDFDPYSHIKGV
                     VKAYRESRIANLHLPSHYEEKTTIAEKISTLKLYEQPSWIFCNGRVDLSCQPLEPHLW
                     QRDRASGVRRLISFLTDENIIVKGKVLVVFLLLSPIENQKDPLIETFCAFYQVFNGMD
                     NMLCICVNSAIYQQWSDLLQVRLEIKDDLAKHSISTLNIELVNNTILKLKSVIQSSRR
                     FLPSCGSSSVILEKMDEDIMSALEILCENECKDTDIEKDESQFLEFKKSREEHFYRGG
                     RVSWWNFYFSSENYSSAFVKRDSFEELTTLIQQCADSPKPVFVKVINLYHHPGCGGTT
                     LAMHVLWDLKQKFRCAVLKNKATDFVEIGEQVSKLMSYKATSHEDFIPVLLLVDDFEE
                     QENAYILQNAINAFIAEKGLRYEKTLVIILNCMRSQNPDESAKLANSISLKYQLSPKE
                     QRAFEAKLQEIEKEHKNCENFYSFMILKGNFDTTYIKNVVKNTLKDLDAKSRRAQLIS
                     YLALLNSYVTDSTISVSQCEIFLGITYTKKYGKPETVEKNMGTYSTLLIRTEVSDYGR
                     YTGIRIIHPLIATHCLKELEMSYRMDKCQIALNMLEENVLYDSGLGRDKFKYDVQTLL
                     LTRQRKEHGAETDTLFSPLIEELQNEETEKVLIAGSDRFPQNAFICQALARHFYIKEK
                     NFSTALVWANLAKRKAPKNSYISDTLGQVYKSELKQWLGKNKTCGNISVDDLAYFLEV
                     AEKASKAFKESQNQSDSKDYGTEAWSPQNSQRRYDTFNTAGFFGEIEVGLDTIQLLQL
                     TPLFHKENEISKESMAEFLSGKGTILSDPKGEYCVVLSKFTSLLQNLHSDLERCFHFF
                     GDYMGFLKPRNTPKELTELLLSKKVSRCFKKYVELFCHLDTNLVQGKEDLLLQKENCR
                     KRIQAWRADTFSGLLEYLNPNHKEANNIENIVGNYTFLLQDILNKQLSKVLTKDIQNF
                     ILANIILSCLKPSSKYILPFSTLKKKLREVLQIVGLTHSYPDPYFLACLLFWPENKEL
                     DEDSTLIEKYVSSLNRSFRRQYKHMCRSRQPSTLFYLGQKKGLNSLVHKAEIERYFSE
                     VQDSNSFWHSGVVWEKREVKDLLRLLDGQAEGKLISLEYGTEAKIKIPVTSVYSAPLR
                     SGRNIERVSFYLGFSIEGPLAYGIKVI"
ORIGIN      
        1 atttcaggaa gtctctttct gtatcagaat cgaaactgga aactgaagca gaggtggttt
       61 tttacttcct tacactcttg ccagcattag ccacaccctg gtgtctctca gccagtttaa
      121 gctggtgtta aggtagacaa gcagactggt taagaccacc aagactaaat gaagttgttt
      181 gtcacggaca tcttgggagg aagagaatac agataccaga cattttcttt actaaaatgg
      241 acaggttttg ttttcttttt tccttttaaa cgatttttta tgtagaagaa atttgaaaat
      301 ttggggaata aatttgaagc ttgaacatga gtggacaagt aactcaacca aaattgatca
      361 aagactggac caaagaacat gtaagaaaat gggttactga agatcttaac attgttgaga
      421 aatatgctca aatcttgttc aaagaagagg taacagggat ggtcctgcag gaattaactg
      481 aagaggatct tagagaaatg ggcttgccac ggggtccagc acttctgata aaacgcatgt
      541 ataacaaact aattagttcc cctgaaagtc acaatcaaga ttccagagaa ttaaatgata
      601 aaaaactctc aacaaaagaa cagcaaacaa agaccaaaaa tgaggaagaa aactcagttt
      661 catccaacag tgatcatggt ctcagggaga cagggcagaa tgaagaacaa gaaccaagtc
      721 ttacgaaaga aaacatgtta ggtgatgtgg tgactaaaga catggaagat aataagccca
      781 aaccagaaca gatgtcttgc acgccatacc cttttgattc tttttgtgat gtcaaacaat
      841 acatagaaca ttctattcta cgtgttgctg agacagggcc actcaatctc attgacccaa
      901 tacatgaatt caaagccttt acaaacacaa agaaagccac agaagaggac ataaaaatga
      961 aatttagcaa tgagactttc cgatttgcag cagcttgtat gaattcacgt accaatggca
     1021 ctattcattt tggagtaaaa gacaaaccac acggggaaat tgttggtgtg caagtcacca
     1081 gtaaagatat ctttgttaac catttcaaca caatgatcac gaagtatttt gaagacagtg
     1141 aaatcagtga agccagggct tgtatccggg aaccacggtt cgtggaagtc cttttgcaga
     1201 ataatacaca atctaataga tttgtcattg aggtagatgt tattcccaga cattctatat
     1261 gtcaagaaaa gtatttctac attatgatgc aaagtagcac aggcaaaaca tggaaacaaa
     1321 gcaaagatac ttcattgttt gtaagagaag gagctagctc taagaatatc ctgggcaatc
     1381 ccaaccaacg ggatagagag ttcaagaaat ttctagagga tttaaagatg tggacagcgt
     1441 ctagaaaagc ggccgaagaa gaacttagaa tggtaactaa gaaagagagt gaaggactaa
     1501 aactgtctaa acttttgacc agacaccaag gctcacttga tgaatcttac tatgattggt
     1561 acattcttgt aacaaatacc tgtgcaccaa ctcaattaga gcacttagag ttcataaagg
     1621 aaatgaaatt gtttgctgtg ctagattttg atccttattc tcacatcaag ggagtggtca
     1681 aagcttacag agaaagcaga atagcaaacc ttcacctgcc cagtcactat gaggaaaaaa
     1741 ctaccatagc agagaaaatt tctactctga aactttatga gcaacctagc tggatcttct
     1801 gcaatggcag agtagacttg tcatgtcaac ctctagagcc acatttatgg cagagagata
     1861 gagcttctgg ggttagaaga cttatttcat tcctcacaga cgaaaatatc atagtaaaag
     1921 ggaaggtttt ggtggtgttc ctcttacttt ctcccataga aaaccaaaaa gatccactca
     1981 ttgagacttt ttgtgctttc tatcaagttt tcaatggaat ggacaatatg ttgtgtatct
     2041 gtgtcaactc agctatctac caacaatgga gtgatctact acaagtaaga ctggaaatca
     2101 aagatgatct ggcaaaacat agcatttcca ctttaaacat agaactagtc aacaatacca
     2161 tcctcaaact gaaatcagtg attcaatctt caaggagatt tttgccctcc tgtggctcct
     2221 cctctgttat tctggagaaa atggatgaag atatcatgag tgcattggaa atcctctgtg
     2281 aaaatgagtg taaagacaca gacatagaga aagatgaatc tcaattccta gaatttaaga
     2341 aatcaagaga agaacacttt tatcgaggag gcagagtatc ctggtggaat ttctattttt
     2401 cttctgaaaa ctattcttca gcttttgtaa aaagggatag ttttgaagag ctaacaacat
     2461 taatacaaca gtgtgcagac tctcctaaac cagtgtttgt caaagtcatc aacctgtacc
     2521 atcacccagg ctgtggaggt actacgttgg cgatgcatgt tctctgggac ttaaagcaga
     2581 agtttcggtg tgctgtcttg aaaaacaaag caactgattt tgtagagatt ggagaacaag
     2641 taagcaagct aatgagctac aaggctacca gccacgagga cttcattccc gttcttctcc
     2701 ttgtggatga tttcgaagaa caagagaacg cctatattct gcagaatgcc atcaatgcct
     2761 ttatagcaga aaagggtctg agatatgaaa aaacattagt cataatcctg aactgcatga
     2821 gatctcagaa tccagatgaa agtgcaaagt tagcaaatag catttcacta aaataccaac
     2881 tttctccaaa agaacaaaga gcctttgagg ccaaactaca ggaaattgaa aaggagcata
     2941 agaactgtga aaacttttat tcgttcatga tcttgaaagg caactttgat acaacttaca
     3001 taaagaatgt agtgaagaat actctgaagg acctggatgc taaaagcagg agggcccagc
     3061 tcatttctta cctggcatta ctcaactctt atgttacaga ttctaccatt tcagtatcac
     3121 agtgtgaaat atttttggga atcacttaca ccaagaaata tgggaaacct gaaactgtag
     3181 aaaagaacat gggaacctat tccacacttc taataagaac tgaagtttca gattatggga
     3241 ggtacactgg tatacgtatc attcaccctc taattgccac ccactgttta aaagaactgg
     3301 aaatgagcta cagaatggat aagtgtcaga ttgcactaaa tatgctagaa gagaatgtat
     3361 tgtatgattc tggtctagga agggacaaat ttaaatatga tgtgcaaact ctattgctta
     3421 caagacaacg caaggaacat ggagctgaaa cagacactct cttttcccca ttgattgaag
     3481 aattgcagaa tgaggaaact gaaaaggtct tgatcgcagg aagtgatcga ttcccacaaa
     3541 atgcattcat ttgtcaagct ttagcaagac acttctatat taaagagaag aactttagca
     3601 ctgctttagt ctgggcaaat ctggccaaaa ggaaagcacc taagaattct tatatttcag
     3661 atacacttgg tcaagtttac aaaagtgagc tcaaacagtg gttgggtaaa aataagacat
     3721 gtggaaatat tagtgtggat gatctggcct atttcctaga agttgctgaa aaggcttcaa
     3781 aagccttcaa agagtctcag aatcaatctg atagtaagga ctatggaact gaggcatggt
     3841 caccacagaa ttcccaaaga agatatgaca ctttcaacac agccggcttc ttcggagaaa
     3901 tagaagtagg tcttgacact atccagcttc ttcagctcac accccttttc cataaagaaa
     3961 atgaaatatc aaaagaatct atggcagagt ttttatctgg aaaggggacc atcctttcag
     4021 acccaaaagg tgaatattgt gttgttctca gcaaatttac atcccttcta cagaatttac
     4081 attcagattt ggaaagatgt tttcattttt ttggtgatta tatgggtttt ctgaaaccaa
     4141 ggaatactcc aaaagaattg acagaactct tactaagtaa gaaagtcagc cgctgtttca
     4201 agaaatatgt agaacttttc tgccatttag ataccaactt ggtacagggc aaagaagatc
     4261 tgttacttca aaaggagaac tgtaggaagc gcatacaagc ttggcgagca gatacatttt
     4321 caggactcct tgaatatctt aatccaaatc acaaagaagc taacaacata gaaaatatag
     4381 tgggaaacta taccttccta ttacaggata tcctaaacaa gcaactgtca aaggtgctga
     4441 ccaaggacat acaaaatttc attttggcca acattattct cagttgtcta aagcccagtt
     4501 ccaagtatat cttgccattt agcacactga aaaaaaagct cagagaggtc ctgcagattg
     4561 tggggctaac tcattcatat cctgatcctt atttcttggc ctgcctccta ttctggccag
     4621 aaaacaaaga gctagatgaa gactccacac taatagaaaa gtatgtctca tccttgaatc
     4681 gatccttcag gagacagtac aagcacatgt gtaggtccag gcagccaagc acactcttct
     4741 acctggggca gaagaagggt cttaacagtc ttgttcataa ggctgaaatc gagcgctact
     4801 tcagtgaagt gcaagattca aattccttct ggcacagtgg agtagtgtgg gaaaaaagag
     4861 aggtcaaaga cctcctacgc ctgctggatg gccaggctga aggcaaacta atctcactag
     4921 aatatggaac agaggcaaaa ataaaaatac cagtgacttc tgtgtattca gctccactca
     4981 gaagtggaag gaacatagag agagtgtcct tctacctagg attttccatt gagggtcctc
     5041 tggcatatgg cataaaagtg atctaaggag gtatattcgt tcaacaatgt taatttgcat
     5101 ctatcattgt acttactctt tctagcccat agagtgcatt tttggcttaa ttataatcac
     5161 atagtttgct tctttttctc tgtatcagtt atgggaaact ttgtaggaca agaaatatgt
     5221 ccataccaca gagcttggcc cacagtagca tcagctattc catatcctca atttgcattc
     5281 ccaaacagac atatttggct catcaataaa acatctgttg taaattaaaa aaaaaaaaaa
     5341 aaaa
//
