LOCUS       NM_175021               4391 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus sterile alpha motif domain containing 4B (Samd4b),
            mRNA.
ACCESSION   NM_175021 XM_993353 XM_993381 XM_993404
VERSION     NM_175021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4391)
  AUTHORS   Bernhardt,L., Dittrich,M., El-Merahbi,R., Saliba,A.E., Muller,T.,
            Sumara,G., Vogel,J., Nichols-Burns,S., Mitchell,M., Haaf,T. and El
            Hajj,N.
  TITLE     A genome-wide transcriptomic analysis of embryos fathered by obese
            males in a murine model of diet-induced obesity
  JOURNAL   Sci Rep 11 (1), 1979 (2021)
   PUBMED   33479343
  REMARK    GeneRIF: A genome-wide transcriptomic analysis of embryos fathered
            by obese males in a murine model of diet-induced obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4391)
  AUTHORS   Amadei,G., Zander,M.A., Yang,G., Dumelie,J.G., Vessey,J.P.,
            Lipshitz,H.D., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     A Smaug2-Based Translational Repression Complex Determines the
            Balance between Precursor Maintenance versus Differentiation during
            Mammalian Neurogenesis
  JOURNAL   J Neurosci 35 (47), 15666-15681 (2015)
   PUBMED   26609159
  REMARK    GeneRIF: Smaug2 (and Nanos1) are critical regulators of neural stem
            cell differentiation and translational repression.
REFERENCE   3  (bases 1 to 4391)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149606.6.
            
            On Jul 25, 2009 this sequence version replaced NM_175021.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.19258.1,
                                           SRR13948564.2913545.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC149606.6         77153-77206
            55-456              AC149606.6         89507-89908
            457-927             AC149606.6         99002-99472
            928-1167            AC149606.6         105169-105408
            1168-1277           AC149606.6         105766-105875
            1278-1364           AC149606.6         106027-106113
            1365-1683           AC149606.6         106657-106975
            1684-1769           AC149606.6         107305-107390
            1770-1888           AC149606.6         107737-107855
            1889-2087           AC149606.6         109282-109480
            2088-2211           AC149606.6         109601-109724
            2212-2295           AC149606.6         111437-111520
            2296-4391           AC149606.6         111727-113822
FEATURES             Location/Qualifiers
     source          1..4391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.73 cM"
     gene            1..4391
                     /gene="Samd4b"
                     /note="sterile alpha motif domain containing 4B"
                     /db_xref="GeneID:233033"
                     /db_xref="MGI:MGI:2448542"
     exon            1..54
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            55..456
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2324
                     /gene="Samd4b"
                     /note="mSmaug2; smaug 2; sterile alpha motif
                     domain-containing protein 4B"
                     /codon_start=1
                     /product="protein Smaug homolog 2"
                     /protein_id="NP_778186.2"
                     /db_xref="CCDS:CCDS21044.1"
                     /db_xref="GeneID:233033"
                     /db_xref="MGI:MGI:2448542"
                     /translation="MMFRDQVGILASWFKGWNECEQTVALLSLLKRVTRTQARFLQLC
                     LEHSLADCNDIHLLESEANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYM
                     RLLQKVLAYSIESNAFIEESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRT
                     RPEPSYHSRQGSDEWGGPAELAPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGS
                     NANTGLPCQIHPSPLKRSMSLIPTSPQAPGEWPSPEELGARAAFTTPDHAPLSPQSSV
                     ASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQ
                     HLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIK
                     AYSVLQATPTAKDEGRGEPLLPGAEPPLTHPGSDKGTEAKDPPAAENYPPPPAPAPSD
                     SSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTET
                     QKKRLLSWKQQVLKLLRTFPRKAALDMQSYRQQKGWAFGSNSLPIAGSVGMGVARRTQ
                     RQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPS
                     QSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGPDLEINPTLESLCLSMTEHALGDGTD
                     KTSTI"
     exon            457..927
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1167
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1277
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1364
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1683
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1769
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1888
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2087
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2211
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2295
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..4391
                     /gene="Samd4b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4367..4372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samd4b"
                     /note="hexamer: AACAAA"
     polyA_site      4391
                     /gene="Samd4b"
                     /note="major polyA site"
ORIGIN      
        1 cggcggctgc ccgaggaggt gcgggtggcg gcggcggcgg cggaggccga ggcggagcct
       61 ggagaggtgt ggctggacca agacctcccc tgatgtaagc aggctccctc ctccccccac
      121 cacccgttgc caccacgcca ggggacatcc tcaagccctg gcccttaggg gagaggtaac
      181 aggagcccag agccgagacc atgtgacggc gctggccctt gccaccgccg tcccccaacc
      241 ctggccccag gcctggcacc atgatgttcc gagaccaagt gggcatcctc gctagctggt
      301 tcaagggctg gaatgagtgt gaacagacag tggccctgct gtcccttctg aagcgggtca
      361 cccgtaccca agcccgcttt ctgcagctct gcctggagca ctcgctggcg gactgcaatg
      421 atatccacct gctggagtca gaggccaaca gtgctgccat cgtcagccag tggcaacagg
      481 agtccaaaga gaaggtggtg tccctcctgc tgtcccatct gcccctgctc cagccaggca
      541 acacggaggc caagtccgag tacatgagac tgctgcagaa agtgctggcc tactccatcg
      601 agagcaatgc cttcattgag gagagccgcc aactcctctc ctatgccctc atccacccag
      661 ccaccacact ggaggaccgc aatgcgctag ccctctggct gagccacctg gaagagcggc
      721 tagctagtgg tttccgcacc cggccagagc cctcctacca ttcacgccag ggctcagatg
      781 aatggggtgg acctgcagag ctggcccctg gagaggcagg gccaggctgg caggacaagc
      841 cacccaggga aaatggacac gtacccttcc acccatccag ctctgtgccg ccggccatca
      901 acagtattgg gagcaatgca aacacaggtc tcccctgcca aatccaccct agcccactga
      961 agcgctccat gtcactcatc cctacgagcc cacaggcccc tggtgagtgg ccgagtccag
     1021 aggagcttgg ggcccgggct gctttcacca cgcccgacca cgcacccctc tcgccacaga
     1081 gcagtgtggc ctcctctggc agtgagcaga cggaggagca gggctccagc cggaacactt
     1141 tccaggagga tggcagcggg atgaaagatg tgccctcatg gctcaagagc ctccgcttgc
     1201 acaagtatgc tgctctgttc tcacagatga gctacgaaga gatgatgacc ctcactgagc
     1261 agcacctaga gtcgcagaat gtcaccaaag gtgcccggca caagatagcc ctgagcatcc
     1321 aaaagctgcg ggagagacag agcgtcctca agtccctaga gaaggatgtg ctggaaggtg
     1381 gcaatctgcg gaatgctctg caggaactgc agcagatcat catcactcct atcaaggcct
     1441 acagtgtcct tcaggccacc cctactgcca aggatgaggg tcggggggag ccgctgctgc
     1501 caggtgctga gcctcccctc acccaccctg gatcagacaa gggcactgag gccaaggacc
     1561 ctccagctgc agagaactat cctcctccac cagctccagc cccctctgat agcagtgagc
     1621 cagccccagc tcccgtcgcc gacggagaca tccccagcca gtttacacgg gtgatgggca
     1681 aagtatgcac ccagctgctg gtgtcccgac cagacgagga gaacatcacc agttacctcc
     1741 agctcatcga aaagtgcctg actcatgagg ctttcacaga gacacagaag aagcggttgc
     1801 tgtcctggaa gcagcaagtg ctgaaactcc tccggacatt ccctcgaaaa gctgcactgg
     1861 acatgcagag ctaccggcag cagaagggct gggcatttgg ctccaactcg ctccccatag
     1921 ctggctctgt ggggatgggt gttgcccggc ggacccagcg gcagttccca atgcctcctc
     1981 gggcattacc acctggcagg atgggcctcc tgagcccttc aggcattggg ggtgtctctc
     2041 ctcgacatgc ccttaccagc cccagtcttg ggggtcaggg ccgacagaac ctgtggtttg
     2101 ccaatcctgg aggcagcaac agcatgccca gccagagccg cagctctgtg cagcgcactc
     2161 actcgctccc agttcactcg tcaccccagg ctattctcat gttccctcca gactgcccgg
     2221 tacctgggcc tgacctggag atcaatccta ccctggagtc tctgtgtctg agcatgacag
     2281 aacacgcctt gggtgatggg acagacaaaa cctccaccat ctgacgggac ccacagccca
     2341 gcgcacccat aggctccctg ggcggcgggc gggggccatc ccccaacagg cttctcctca
     2401 gcagcgagag ggtgggctgg cgcagctata cattctgata tttttctact catcctctta
     2461 acttttgttt aacattggca cacgccttgc tcactcccag gcccattgag ggatctcagc
     2521 tgaggccagg gacagagagg gcagccagag gcaaggactg gccagactgc ctgccttttc
     2581 cctcccaaat cccccactag ccccatccta cccctgcctc cttcagactg ctgacacctg
     2641 tccttcccca agagagcaga cttcctcaga gacaaactga cagtcacctt gcgcaacctg
     2701 cccttcagac acatgacagt gggggaatga gcagtgtgga cagcctgctc caccagtatg
     2761 tcactggaaa agagcccctc tcccttacct cctacctttc atcattccta ccattcctga
     2821 agacaggcac caccttcctc ctttttttct taccctgttt atcagaggtt ctctacaatt
     2881 aatttcttag gcctatttaa gatacatatt tatatagttc ttaacggttt ttctctgatc
     2941 attccctgtc atttttagaa tccctaggcc tctctctgag ccaggacagt ggcagggggg
     3001 gcctgaactt tatgaggaga gggcagagcc ccctcctgca gaccctcttg cccttcccca
     3061 tcccagcccc ggctcccaga tgcagaggtt gaaggtgggc agccccaggc cctcagtgag
     3121 gtcaggaagt ctgttgcctt aatgtccctt tccccccacc aacataaccc ttctctgttc
     3181 cccaggtctg tgcaagactt gagggtagga accagggaat ggggggtgtt gggtttttgt
     3241 tttcttgcct accctctctg tcaaactttc ccacccccat tatgtcatga cctcatgtaa
     3301 gtggaacact atatcataac ccagaggtgc agcccagcct gagtcacata aaccctctac
     3361 tccctgttct tgatgagggc tggtgctggg gcccaggtgg agggagggaa tttgggattc
     3421 aggctgtggg gaagccaggg tcccctattc caaactcctc tttcccctca acctacaccc
     3481 tcattgggac attctcaagc ttttcacacg aaaaggaaaa aaatgttatt tttagataca
     3541 ttttatgaat aacttttgtt atgaatatgg ctggtaacca ttgtgtatgt tattaaagat
     3601 acaaaatgtt gggaaaaaac aaaaccaaaa aaaagaaaaa agaaaaaaaa aggaaaaaag
     3661 aaagccttcc ctgcactatc agcccatccc cccagacctt gcccctacct cctggtctgt
     3721 ggacctcccc tgctttgagc ccagggaggg agaagaagcc agggggtaga gtggccctgg
     3781 ggacctgcct gtggtcccca ccacctctcc cagtgccggg ctgggcgggg tgtcaggtgt
     3841 atttatgtac ctcttgcaca ctcatcaacc tatgcaagtc cccaccccgg ccctccaggt
     3901 ttctgtgcct ttgatcattc cccctcttaa ctcccaggct tctccggccc ctcccactaa
     3961 cagtgggaag tggggtgaaa ggccacctgt ttggaataag cagggtgtcc ctctcatggg
     4021 accctcgccc ccacaagccg gtccagtctt gtcttgttca cttcccatca gggtgactga
     4081 ccctgcctgg cactggaagg tgatgaggga taccctcccc aagagggagg tgagagcttc
     4141 ccacccatct gacagcagag tgcaggacgc aggcggcctc gctctgacag gcaggaccct
     4201 gaccctccca cccccatgcc cctccatggt ttcaccctac cctacccact tctgtcccca
     4261 gccccactgg cagaatcagc tttgagtaac tgtacatttt tctcgctgtt ggaaaagact
     4321 tatttgttga agtttcgatt gttaatggtc tgggcttatt ttggaaaaca aaaaaaacaa
     4381 aaacaaaata a
//
