LOCUS       NP_001108626             514 aa            linear   ROD 01-MAY-2025
DEFINITION  sterile alpha motif domain-containing protein 3 isoform 2 [Mus
            musculus].
ACCESSION   NP_001108626
VERSION     NP_001108626.1
DBSOURCE    REFSEQ: accession NM_001115154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Peters,A.E., Knopper,K., Grafen,A. and Kastenmuller,W.
  TITLE     A multifunctional mouse model to study the role of Samd3
  JOURNAL   Eur J Immunol 52 (2), 328-337 (2022)
   PUBMED   34626120
  REMARK    GeneRIF: A multifunctional mouse model to study the role of Samd3.
REFERENCE   3  (residues 1 to 514)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 514)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 514)
  AUTHORS   Quintana-Urzainqui,I., Kozic,Z., Mitra,S., Tian,T., Manuel,M.,
            Mason,J.O. and Price,D.J.
  TITLE     Tissue-Specific Actions of Pax6 on Proliferation and
            Differentiation Balance in Developing Forebrain Are Foxg1 Dependent
  JOURNAL   iScience 10, 171-191 (2018)
   PUBMED   30529950
REFERENCE   6  (residues 1 to 514)
  AUTHORS   Kashiwagi,I., Morita,R., Schichita,T., Komai,K., Saeki,K.,
            Matsumoto,M., Takeda,K., Nomura,M., Hayashi,A., Kanai,T. and
            Yoshimura,A.
  TITLE     Smad2 and Smad3 Inversely Regulate TGF-beta Autoinduction in
            Clostridium butyricum-Activated Dendritic Cells
  JOURNAL   Immunity 43 (1), 65-79 (2015)
   PUBMED   26141582
REFERENCE   7  (residues 1 to 514)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091763.25.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.797400.1,
                                           SRR7345562.4032860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 13.57 cM"
     Protein         1..514
                     /product="sterile alpha motif domain-containing protein 3
                     isoform 2"
                     /note="sterile alpha motif domain-containing protein 3;
                     SAM domain-containing protein 3"
                     /calculated_mol_wt=59683
     Region          1..66
                     /region_name="SAM_Samd3"
                     /note="SAM domain of Samd3 subfamily; cd09526"
                     /db_xref="CDD:188925"
     Region          67..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C4H2.3)"
     CDS             1..514
                     /gene="Samd3"
                     /gene_synonym="Gm623"
                     /coded_by="NM_001115154.2:90..1634"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48525.1"
                     /db_xref="GeneID:268288"
                     /db_xref="MGI:MGI:2685469"
ORIGIN      
        1 metwsvdqvc kwlveknlge lvprfqeeev sgatllalnd rmvqqlvkki ghqavlmdfi
       61 kkykqgnqel kptggpadts tltpaqaape heqnpsptsh gdqtslypav ldnrlidqrv
      121 lkqrrnvkhv larhkalqwt ksyilpefpy dvkcmlveqk rpdhsmriri ieflqadmtk
      181 ylegslyptt qqyndvvnal lqahpflded gcgfflwkra lkdrfkyirr pieddeqvmr
      241 nkckfghrrg qtrksladiq sneikivqik eesahldsev dehiswfqqe ymkterdwre
      301 vdkrmsqtle irrkmiggqt plkdilkmfp flkcpyqmfr evqiltktdi ykktrhiles
      361 yseniltafs vldnpintal qekmkhytde gvlkymkmta tclllphvfg depslfvvvn
      421 gkvhvstpvl evknpfhing cefslylnke kltkvddcvt alaalvsafr vfgiecprrl
      481 sqtfnfletl ifdmqspqfp slkekeirsq ppit
//
