LOCUS       NM_146025               3334 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus sterile alpha motif domain containing 14 (Samd14),
            transcript variant 2, mRNA.
ACCESSION   NM_146025 NM_178049
VERSION     NM_146025.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Schaefer,M.A., Roy,P., Chava,S., Meyerson,A., Duncan,A.L., Chee,L.
            and Hewitt,K.J.
  TITLE     Physiological and regenerative functions of sterile-alpha motif
            protein-14 in hematopoiesis
  JOURNAL   Exp Hematol 128, 38-47 (2023)
   PUBMED   37722652
  REMARK    GeneRIF: Physiological and regenerative functions of sterile-alpha
            motif protein-14 in hematopoiesis.
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Ray,S., Chee,L., Zhou,Y., Schaefer,M.A., Naldrett,M.J., Alvarez,S.,
            Woods,N.T. and Hewitt,K.J.
  TITLE     Functional requirements for a Samd14-capping protein complex in
            stress erythropoiesis
  JOURNAL   Elife 11, e76497 (2022)
   PUBMED   35713400
  REMARK    GeneRIF: Functional requirements for a Samd14-capping protein
            complex in stress erythropoiesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Ray,S., Chee,L., Matson,D.R., Palermo,N.Y., Bresnick,E.H. and
            Hewitt,K.J.
  TITLE     Sterile alpha-motif domain requirement for cellular signaling and
            survival
  JOURNAL   J Biol Chem 295 (20), 7113-7125 (2020)
   PUBMED   32241909
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Hewitt,K.J., Katsumura,K.R., Matson,D.R., Devadas,P., Tanimura,N.,
            Hebert,A.S., Coon,J.J., Kim,J.S., Dewey,C.N., Keles,S., Hao,S.,
            Paulson,R.F. and Bresnick,E.H.
  TITLE     GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell
            Regeneration and Survival in Severe Anemia
  JOURNAL   Dev Cell 42 (3), 213-225 (2017)
   PUBMED   28787589
  REMARK    GeneRIF: The Samd14 enhancer is essential for erythrocyte
            regeneration in severe anemia.
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049753.1, BC034054.1 and AI854782.1.
            
            On or before Nov 17, 2006 this sequence version replaced
            NM_178049.2, NM_146025.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049753.1, AK047184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AK049753.1         2-481
            481-3315            BC034054.1         5-2839
            3316-3334           AI854782.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..3334
                     /gene="Samd14"
                     /note="sterile alpha motif domain containing 14"
                     /db_xref="GeneID:217125"
                     /db_xref="MGI:MGI:2384945"
     exon            1..698
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            699..753
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     CDS             711..1964
                     /gene="Samd14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sterile alpha motif domain-containing protein 14; SAM
                     domain-containing protein 14"
                     /codon_start=1
                     /product="sterile alpha motif domain-containing protein 14
                     isoform 2"
                     /protein_id="NP_666137.1"
                     /db_xref="CCDS:CCDS25269.1"
                     /db_xref="GeneID:217125"
                     /db_xref="MGI:MGI:2384945"
                     /translation="MASSKLREPVDEVFDLDLAVPETTRLDSSLHKARAQLLAKGRRH
                     RPSRSRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPASGSFCLEP
                     PGLRRSLDEDEPPPSPLARYRPLHNAASHEGLAATSGSPPRSAPSSDSSPSFVRRYPR
                     AEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTSRSRKEKGSNRLSM
                     GSRESVEGSGRTGSSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQES
                     TLSDDSTPPSSSPKIPGGPRQETKCSYPYHTLSQSSDEFLDESLPAVQHWTSQQVGQW
                     LHSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKELAAAAEK
                     ERKAQEKTAKQREKLRRRENDAKKS"
     exon            754..920
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1209
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1297
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1532
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1652
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1808
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..3318
                     /gene="Samd14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Samd14"
                     /note="hexamer: AATAAA"
     polyA_site      3315
                     /gene="Samd14"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgaga ctcccgcggt ccgagaagta gcggcaattg ggatcccggg gccggccgcg
       61 ggcacccgcc gcctcctccc ctcggtccta gctgcttccg ccccgcccgc cctcctcttc
      121 cctccttccc taccgttctt tgtctcccgg gcgctcggcc tccccataag cgtatcgccc
      181 cccccgcccc ccccgtcgcc ttatcccggg cgacccccca cggacctagc cactgcgacg
      241 ctacacaaat cggccggtgg cgcgagggtt cgcgaccccc ggggtttggc gggggcgggg
      301 cgggaggtgg cgttcaggtt ctctctctct ctctctctct ctctctctct ctctctctct
      361 cacacacaca cacacacaca cacacacaca catacacgta cacgcacgca cacacggagc
      421 atcctcccgt caggtttccc cgtccagccc cgcccgcgcc tcctgcttcc cgcagacctt
      481 ctccctgcat ccctacacac ctcgcctctc cattctttcc gggactctcc ccgccgatcc
      541 cccacaacac cctggaatgg agcgactcca gccagcccgg agccccccgc gaccggggtg
      601 aaagtccttc gcccctctcc tgcccggcag tcgccccgaa caccatgggc ctgaggggtt
      661 cccggggcgc cggacgctga aaatgacgga tgctggagct ctcttgagtc atggcttcct
      721 caaagctccg agaacctgtg gatgaagttt ttgacctgga cttggctgta ccagagacca
      781 ccagactgga cagcagctta cacaaagcca gggctcaact gctggccaag ggccggagac
      841 accggccttc ccgttccagg ctacgagaca gtgccagctc tgccgaggac ggtgaaggct
      901 ctgatgggcc cggaggcaag gtgaccgacg gctgcggtag cccgctgcac cggctgcgct
      961 cgcctctaca ttcgggtcca ggctccccag ccagtggatc tttctgcctg gagcccccgg
     1021 gcttgaggcg cagtctggat gaggacgaac cgccgccctc gccactcgct cggtaccggc
     1081 ccctgcacaa cgccgcctcg catgagggcc tggccgccac ctccggctcg ccaccacgct
     1141 ctgcaccctc ctccgacagc tcccccagct tcgtgcgtcg ttaccctcga gcagagccgc
     1201 acagcgaaga tgacagccgg gatgccagcc cccctgagcc tgccagcccc accatcggct
     1261 tggacaagaa gactcgcagg aaattcctgg acctgggggt cactctccgc cgagcatcca
     1321 ccagcaggag caggaaggag aagggtagca accgcctgtc catgggcagc agggagtctg
     1381 tagaaggttc tggaaggaca ggaagctccc cgttcctgcc cttttcctgg ttcacggaca
     1441 gcggcaaggg ctctgcttcc tcggggagta ccacctcccc gacctgttcc cccaaacacg
     1501 agggcttcag ccccaagaag tcagcttccc aggaatctac cctgagcgat gactccacac
     1561 cccccagcag cagccccaag atccccggtg gtcctcgaca ggagaccaag tgttcctatc
     1621 cctaccacac gctgtcccag tcttcggatg agttcctgga tgagtccctc cctgccgtac
     1681 aacactggac cagccagcag gtgggccagt ggctacacag cctcaacctg gagcagtatg
     1741 ctgccgagtt tgctgcccgg caggtggatg ggccgcagct cctgcagctg gacggaagca
     1801 aactgaagag cctggggctc agcaattcgc atgaccgagc actggtgaag cggaagttga
     1861 aggagctggc agcggctgct gagaaggaac ggaaggcgca ggagaagacc gcaaagcagc
     1921 gggagaagct gcggcgccgc gagaacgatg ccaagaagag ctagggatgg ctggcggggc
     1981 tggcaccccg gcgcacttgc agccacctac atgggcctca ccagggaggc agggtccagg
     2041 caccaggctc tcggagcacg cggcccccct ctcaccctgt ttggactgag tcctctggag
     2101 ggagacccca ggggggaggg cccagtaata aacccaattt cgaggacttg tttggcgcag
     2161 acttccaggg ggaagcaggt ggcagatgaa gagggcagag gccaggaatg cagcaaacgc
     2221 ggagcccaga ggagcctggt tcaggtggaa cctccgccct ctgactagag tggtccgagc
     2281 aggaagaaat ctagcaggag aggccctacc atggccagga ttcctaggtt tagagagtag
     2341 cctgggcaac ccgactggag acaggagaca gctgtgtctc ctcacctttt gaaggtggct
     2401 gtgtggtggg agaacagatc tccccagaga ggccagtggg cagtgccagt agcactcagg
     2461 gtggattccc agacacctcc tcagaggaga gagagagcag ggcaggataa gctggcctct
     2521 gtaaggaagg cagaggggga gaagggagct ctcactcact ctctctctct tcccctccct
     2581 cacctgcagg ttccagcaca caggtctgct cctctcccat tgagtccctt tcgcagagct
     2641 aaaatccact tcttcggaga gtacttgagc cttcgagggc aggaaaaatt gagagctgtt
     2701 ggggacacgg gtcactcccc caactagtgt ctagatggtg aagaggcaca ccctaagtgt
     2761 ggcctgcatg ctgccagatt gaaagggtcc atcagcttcc ctggtgccct gggtgtgtca
     2821 aggcctcaga ggcctggggc ggatggacag acactgctgg cttaggtttg ctaggctaca
     2881 gagggggact gggccagccc cgcgtgggac tggcacatgt cctttgtagg gcgtgttcag
     2941 agatagaggg tccaggtgca atgctgaccc agcttcttgg gtgctggtca gttactacta
     3001 ggcccaggtt ttagatgaca aacccccacc cctcccagtt tcctggagag gtgaacagga
     3061 cctgcatgtt aactccctct ctcctgcctg ggaaagtggc tgaaggccag ggccctatgt
     3121 ttgtgctcag tcaccttcac tggaagaggg ggcctcatag ggaaaactaa ggtatcgggg
     3181 cactggcact tcctagactg ggtggggagg gtggaggctc tactgtcccc gaagccgtga
     3241 agagccaagt gtgcccacct gcatgtgaag ggggaagatg gctatcaact tctttcaata
     3301 aatacttacc acacaccaaa aaaaaaaaaa aaaa
//
