LOCUS       NM_175303               5104 bp    mRNA    linear   ROD 25-DEC-2023
DEFINITION  Mus musculus spalt like transcription factor 4 (Sall4), transcript
            variant a, mRNA.
ACCESSION   NM_175303 NM_029395
VERSION     NM_175303.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5104)
  AUTHORS   Katano W, Mori S, Sasaki S, Tajika Y, Tomita K, Takeuchi JK and
            Koshiba-Takeuchi K.
  TITLE     Sall1 and Sall4 cooperatively interact with Myocd and SRF to
            promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38014633
  REMARK    GeneRIF: Sall1 and Sall4 cooperatively interact with Myocd and SRF
            to promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes.
REFERENCE   2  (bases 1 to 5104)
  AUTHORS   Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu
            F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G, Suo
            S and Peng G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5104)
  AUTHORS   Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura
            R, Chai L and Pandolfi PP.
  TITLE     Functional antagonism between Sall4 and Plzf defines germline
            progenitors
  JOURNAL   Cell Stem Cell 10 (3), 284-298 (2012)
   PUBMED   22385656
  REMARK    GeneRIF: Plzf antagonizes Sall4 function by displacing Sall4 from
            cognate chromatin to induce Sall1 expression
REFERENCE   4  (bases 1 to 5104)
  AUTHORS   Warren,M., Wang,W., Spiden,S., Chen-Murchie,D., Tannahill,D.,
            Steel,K.P. and Bradley,A.
  TITLE     A Sall4 mutant mouse model useful for studying the role of Sall4 in
            early embryonic development and organogenesis
  JOURNAL   Genesis 45 (1), 51-58 (2007)
   PUBMED   17216607
REFERENCE   5  (bases 1 to 5104)
  AUTHORS   Elling U, Klasen C, Eisenberger T, Anlag K and Treier M.
  TITLE     Murine inner cell mass-derived lineages depend on Sall4 function
  JOURNAL   Proc Natl Acad Sci U S A 103 (44), 16319-16324 (2006)
   PUBMED   17060609
  REMARK    GeneRIF: Sall4 as an essential transcription factor required for
            the early development of inner cell mass-derived cell lineages
REFERENCE   6  (bases 1 to 5104)
  AUTHORS   Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y,
            Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N and
            Nishinakamura R.
  TITLE     The murine homolog of SALL4, a causative gene in Okihiro syndrome,
            is essential for embryonic stem cell proliferation, and cooperates
            with Sall1 in anorectal, heart, brain and kidney development
  JOURNAL   Development 133 (15), 3005-3013 (2006)
   PUBMED   16790473
  REMARK    GeneRIF: Sall4 and Sall1 form heterodimers, and a truncated Sall1
            caused mislocalization of Sall4 in the heterochromatin; thus, some
            symptoms of Townes-Brocks syndrome caused by SALL1 truncations
            could result from SALL4 inhibition.
REFERENCE   7  (bases 1 to 5104)
  AUTHORS   Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui
            CC, Srivastava D and Bruneau BG.
  TITLE     Cooperative and antagonistic interactions between Sall4 and Tbx5
            pattern the mouse limb and heart
  JOURNAL   Nat Genet 38 (2), 175-183 (2006)
   PUBMED   16380715
  REMARK    GeneRIF: A positive and negative feed-forward circuit between Tbx5
            and Sall4 ensures precise patterning of embryonic limb and heart
            and provides a unifying mechanism for heart/hand syndromes.
REFERENCE   8  (bases 1 to 5104)
  AUTHORS   Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F,
            MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida
            M, Linardopoulos S and Balmain A.
  TITLE     Identification of Stk6/STK15 as a candidate low-penetrance
            tumor-susceptibility gene in mouse and human
  JOURNAL   Nat Genet 34 (4), 403-412 (2003)
   PUBMED   12881723
REFERENCE   9  (bases 1 to 5104)
  AUTHORS   Kohlhase J, Heinrich M, Liebers M, Frohlich Archangelo L, Reardon W
            and Kispert A.
  TITLE     Cloning and expression analysis of SALL4, the murine homologue of
            the gene mutated in Okihiro syndrome
  JOURNAL   Cytogenet Genome Res 98 (4), 274-277 (2002)
   PUBMED   12826753
  REMARK    GeneRIF: cloning and expression analysis; prominent expression in
            the developing midbrain, branchial arches and the limbs suggests an
            important function of SALL4 during development of these structures
REFERENCE   10 (bases 1 to 5104)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB867997.1, AK049188.1,
            CK341198.1, AK017633.1 and BC067396.1.
            
            [WARNING] On Jan 26, 2024 this sequence was replaced by
            NM_175303.5.
            
            On Apr 3, 2015 this sequence version replaced NM_175303.3.
            
            Summary: This gene belongs to the spalt family of zinc finger
            transcription factors. In mouse, functions for this gene have been
            described in many embryonic developmental processes, including
            brain, heart, and limb development. In addition, this gene is an
            important pluripotency factor that is required for stem cell
            maintenance. Homozygous mutant mice display embryonic lethality,
            while conditional knock-out in embryonic germ cells results in
            failure to establish a robust stem cell population. A pseudogene of
            this gene is found on chromosome 2. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145388.1, AK049188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BB867997.1         3-75
            74-3076             AK049188.1         2-3004
            3077-3440           CK341198.1         179-542             c
            3441-5069           AK017633.1         7-1635
            5070-5104           BC067396.1         1438-1472
FEATURES             Location/Qualifiers
     source          1..5104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.99 cM"
     gene            1..5104
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /note="spalt like transcription factor 4"
                     /db_xref="GeneID:99377"
                     /db_xref="MGI:MGI:2139360"
     exon            1..290
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..3376
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /note="isoform a is encoded by transcript variant a;
                     sal-like protein 4; sal-like 4; zinc finger protein SALL4"
                     /codon_start=1
                     /product="sal-like protein 4 isoform a"
                     /protein_id="NP_780512.2"
                     /db_xref="CCDS:CCDS17115.1"
                     /db_xref="GeneID:99377"
                     /db_xref="MGI:MGI:2139360"
                     /translation="MSRRKQAKPQHINWEEGQGEQPQQLPSPDLAEALAAEEPGAPVN
                     SPGNCDEASEDSIPVKRPRREDTHICNKCCAEFFSLSEFMEHKKSCTKTPPVLIMNDS
                     EGPVPSEDFSRAALSHQLGSPSNKDSLQENGSSSGDLKKLGTDSILYLKTEATQPSTP
                     QDISYLPKGKVANTNVTLQALRGTKVAVNQRGAEAPMAPMPAAQGIPWVLEQILCLQQ
                     QQLQQIQLTEQIRVQVNMWAAHALHSGVAGADTLKALSSHVSQQVSVSQQVSAAVALL
                     SQKASNPALSLDALKQAKLPHASVPSAASPLSSGLTSFTLKPDGTRVLPNFVSRLPSA
                     LLPQTPGSVLLQSPFSAVTLDQSKKGKGKPQNLSASASVLDVKAKDEVVLGKHKCRYC
                     PKVFGTDSSLQIHLRSHTGERPYVCPICGHRFTTKGNLKVHLQRHPEVKANPQLLAEF
                     QDKGAVSAASHYALPVPVPADESSLSVDAEPVPVTGTPSLGLPQKLTSGPNSRDLMGG
                     SLPNDMQPGPSPESEAGLPLLGVGMIHNPPKAGGFQGTGAPESGSETLKLQQLVENID
                     KATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHR
                     TNTTVKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPESPCDFTAPEPVAVSE
                     NGSASGVCQDDAAEGMEAEEVCSQDVPSGPSTVSLPVPSAHLASPSLGFSVLASLDTQ
                     GKGALPALALQRQSSRENSSLEGGDTGPANDSSLLVGDQECQSRSPDATETMCYQAVS
                     PANSQAGSVKSRSPEGHKAEGVESCRVDTEGRTSLPPTFIRAQPTFVKVEVPGTFVGP
                     PSMPSGMPPLLASQPQPRRQAKQHCCTRCGKNFSSASALQIHERTHTGEKPFVCNICG
                     RAFTTKGNLKVHYMTHGANNNSARRGRKLAIENPMAALSAEGKRAPEVFSKELLSPAV
                     SVDPASWNQYTSVLNGGLAMKTNEISVIQSGGIPTLPVSLGASSVVSNGTISKLDGSQ
                     TGVSMPMSGNGEKLAVPDGMAKHQFPHFLEENKIAVS"
     exon            291..2657
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2944
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..5073
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5047..5052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
     polyA_site      5073
                     /gene="Sall4"
                     /gene_synonym="5730441M18Rik; C330011P20Rik; Tex20"
ORIGIN      
        1 aggccaatca gctgtcagag ctcatgataa atcgcaatgc attattgata ataataatta
       61 ctgggacatg cgcgtttcgg ccgaaggggg ctaaaatttc ccaactccag gaattggtgg
      121 cggagagggg gcaagtcacc agggctcttc ccggcgcccc aatgcgcgca ccatgtcgag
      181 gcgcaagcag gcgaagcccc agcacatcaa ctgggaggag ggccagggcg agcagcctca
      241 gcagctaccg agccccgacc tcgccgaggc gctggcggcg gaggaacccg gtgctccagt
      301 gaactcccct gggaactgcg atgaagcctc agaggactcc ataccggtga agcggccccg
      361 gcgggaggac actcacatct gcaacaaatg ctgtgccgag ttctttagtc tctctgaatt
      421 catggaacac aagaaaagtt gcactaaaac ccctcctgtc ctcatcatga atgacagcga
      481 ggggccagtg ccttcagagg acttttccag agctgccctg agccaccagc tgggcagccc
      541 aagcaataaa gacagtctcc aggagaacgg cagcagctcg ggggacttga agaagctggg
      601 cacggactcc atcctgtact tgaagacaga ggctacccag ccatccacac cccaggacat
      661 aagctattta cccaaaggca aagtagccaa caccaatgtg actctgcagg cgctccgcgg
      721 caccaaggtg gccgtgaacc aacggggtgc agaggcaccc atggcgccca tgcctgctgc
      781 ccaaggcatc ccttgggtcc tggagcagat cctgtgcctg cagcagcagc aactccagca
      841 aatccagctt acggaacaga ttcgcgtcca ggtgaacatg tgggcagcgc acgcgctcca
      901 ctctggagtg gcgggggccg acacgctgaa ggccttaagc agccatgtgt ctcagcaagt
      961 gtccgtgtcc cagcaggtgt cggctgccgt ggccctgctc agccagaaag cctcaaaccc
     1021 agctctgtcg ctcgatgcct tgaaacaagc caagctacct catgccagcg tcccctccgc
     1081 agccagcccg ttgtcctcgg ggttaacgtc cttcaccttg aagcctgacg ggacacgggt
     1141 tctccccaac ttcgtgtctc gccttcccag tgccctgcta cctcagactc cgggctctgt
     1201 gctcctgcag agtcccttct ccgctgtgac gctcgaccag tccaagaaag gaaaggggaa
     1261 accccagaac ctctccgcct ctgcctcggt gttagatgtc aaggccaagg acgaagtcgt
     1321 cctcggtaag cacaagtgta ggtactgtcc caaggttttc gggacagata gctcccttca
     1381 gattcacctt cgctcccaca ccggagagag accttacgtg tgccctatct gtggtcaccg
     1441 cttcaccacc aagggcaatc tcaaggtcca cttacaacga caccctgagg tgaaggcaaa
     1501 cccccagctg ttggccgaat tccaggacaa aggggcagtg agtgccgctt ctcactatgc
     1561 actccctgtc cccgtccctg ccgatgaatc gagtctctct gtagacgccg agcctgtccc
     1621 ggtcacggga accccttctc tagggctacc tcaaaagctc acgtcagggc ctaattccag
     1681 ggacctcatg ggtggctcct tgcccaatga catgcagcca gggccttctc cagaaagtga
     1741 ggcgggcctt ccactccttg gggtggggat gatacataat cccccaaagg ctgggggctt
     1801 ccagggcact ggggccccag agtcagggtc cgagaccctg aaattgcagc aactagtgga
     1861 gaacatagac aaggccacta ctgaccccaa cgagtgtctc atttgtcatc gggtcctcag
     1921 ctgtcagagt tccctgaaga tgcattaccg tacccacaca ggggagagac cattccagtg
     1981 caagatctgt ggccgggcct tctccaccaa aggcaacctg aagacacacc ttggggttca
     2041 ccgaaccaac acgaccgtaa agacccaaca ttcgtgcccc atctgccaga agaaattcac
     2101 caacgccgtc atgttacagc agcatatccg gatgcacatg ggtggccaga tccccaacac
     2161 ccctctgcca gagagtccct gtgacttcac ggctcccgag cccgtggccg tcagtgagaa
     2221 tggcagtgcc agcggggtct gccaggacga cgcagcagaa gggatggaag ccgaggaggt
     2281 ctgttctcag gatgttccca gtggcccctc aactgtctct ctgccggttc ccagtgccca
     2341 cctggcatcg ccctctctgg gcttctctgt gttggcctcc ctggatacgc aggggaaagg
     2401 ggctcttccg gcgctggccc tgcagaggca gagcagtcga gaaaacagct ccctggaggg
     2461 cggtgacact ggtccagcca atgactcttc cttgctcgtg ggtgaccagg agtgtcagag
     2521 ccgaagccca gatgccacgg agaccatgtg ctaccaggca gtgtcacctg ccaatagcca
     2581 agccggaagt gtcaagtccc ggtctcccga gggtcacaag gccgagggcg tggagagctg
     2641 ccgcgttgac accgaaggtc gtaccagcct ccctccaaca tttatccgag cacagcccac
     2701 ctttgtcaaa gttgaagtgc ctggcacctt tgtgggaccc cccagcatgc cctcgggtat
     2761 gccgcctttg ctagcatcgc agccgcagcc acgccgccag gccaagcagc actgctgcac
     2821 acggtgtgga aagaacttct cgtctgccag tgccctgcag atccacgagc gaacacacac
     2881 gggagagaag cctttcgtgt gtaacatatg cgggcgggcc ttcaccacga aaggcaacct
     2941 gaaggtacac tacatgactc atggggccaa caataactcc gcccgccggg gaaggaagct
     3001 ggccatagag aaccccatgg ccgcgctgag tgctgaggga aagagagcgc ccgaggtgtt
     3061 ttccaaggag ctcctgtccc ccgcggtgag tgtggacccc gcctcctgga accagtacac
     3121 cagcgtcctg aatgggggtc tggccatgaa gaccaacgag atctccgtga tccagagcgg
     3181 aggcatcccc acgctgcctg tgtcgctggg ggccagctct gtggtgagca atggcacgat
     3241 ttccaagctt gacggctctc agaccggtgt gagcatgccc atgagcggga acggagaaaa
     3301 gctcgctgtt cccgacggca tggccaaaca ccagttccct cacttcctgg aggaaaataa
     3361 gattgctgtc agctaaggag gaagaggaga ggagtcttct gcagggagat tctagaatct
     3421 gctttattct ttagtttttt gttttttttt ttttttctta acccacctcc tttttttatt
     3481 ttcttcctct tcctgatatg caagtgatgt ggcttgtgac catagccttg ggcaatccta
     3541 caatcacgag agttgctatg ctgctttcca aaaaaaagat gaaaaatgga ggaaaagtga
     3601 aaaacaacaa aaacaaacca aaaaaaaaaa tgataaaaag ccagactttt tgtttttgtt
     3661 tttaaaccat tttggaaaga agcgggtttt gaaaaatagt tctgttaatt tgggacaaat
     3721 tatattctag aagctttgtg tgacctcatg gctgtttcca aagactgtca tcaacctgtt
     3781 tcgaagtgaa acagttggga ctcattggac cacagtggaa gtgacaactc cttaacccag
     3841 tcctggggtg agggtgtggt gtccttctgt ggtgactaat gcgggtaaat gtagggacct
     3901 ggttttatgc ctcccgaccc tgtcttcatc ctctgttttt ttttttttgt ttttgatttt
     3961 gtttttttta aatgtacttt aagagaaaag gagaagagaa tgccagaaaa ctaagatggt
     4021 tcaattaatc cacttccttc agccttatgc ccttggatag gacatcctcc atacaccggc
     4081 catggtccct cggaaagccc acaatttctc ctgctgcttc cttaaatatt tcagagccct
     4141 tagagtatgc ctccaacccc tgctacccca tctcccacaa accaccttcc caggccccag
     4201 ggtggggaca ggcaccagag tgggcacctc aggagatttt ctgaggttgt cttcagtgcc
     4261 cgctacattg gaaaactgcc tgtttcctag tggcaccagg agggttgcct cgactccacg
     4321 tgcatgctat cctttctgtt tatttcggtt attccaagac ccaaagacct tcacacccac
     4381 ccaccctccg ccgcctgccg tcatgaaggt tatagagttg agaccagcaa gtcttggatg
     4441 tgagggcttt aatttatcta cctcaattat ctttattttt gtagccaaaa gtcttctcta
     4501 ttttgctatt tttgcgacca cccaagtatt gccaggtctt aaacctaaga gttcttatac
     4561 tggtaagaag gccccgaagc tcaagaagtc ttcgtggttg gttctgtggg ttttgttttt
     4621 gtttttaatt acatttttgt tcgtgtaata attctgaaca gctgttgtaa cagtgttcca
     4681 atggtttagt gaggtaggag agatttctcc agtctctggg tagaaaattc tgcctgccgt
     4741 gttgaatgcc cttgccaaat gaagatggag actctcgccc agtgtttcct ctgacttgtt
     4801 gcacctgatt ttaggatcca aaacttgttt tgttgttact tctttctttt tctctttctt
     4861 tttttcgcca agtcgtgcct ttccttctgg gattgtaagt gaaccccgtg atcaagtgtt
     4921 caccggttca cctgtttaca ctgtgaagtg ggtatcttac ggagaacaca ccagccttgg
     4981 ttttctcacg ccccgtgaat gaatgtgtac gccacagttt tacctgctga tactgtaagg
     5041 tctgaaaata aagtgaatgt tttccctcca tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5101 aaaa
//
