LOCUS       NM_009118               1718 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus S-antigen, retina and pineal gland (arrestin) (Sag),
            mRNA.
ACCESSION   NM_009118
VERSION     NM_009118.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Sires,A., Pazo-Gonzalez,M., Lopez-Soriano,J., Mendez,A., de la
            Rosa,E.J., de la Villa,P., Comella,J.X., Hernandez-Sanchez,C. and
            Sole,M.
  TITLE     The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers
            Arrestin-1 Translocation upon Light Reception in the Retina
  JOURNAL   Cells 12 (3), 487 (2023)
   PUBMED   36766830
  REMARK    GeneRIF: The Absence of FAIM Leads to a Delay in Dark Adaptation
            and Hampers Arrestin-1 Translocation upon Light Reception in the
            Retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Tan,M., Chang,Y., Liu,X., Li,H., Tang,Z., Nyati,M.K. and Sun,Y.
  TITLE     The Sag-Shoc2 axis regulates conversion of mPanINs to cystic
            lesions in Kras pancreatic tumor model
  JOURNAL   Cell Rep 41 (12), 111837 (2022)
   PUBMED   36543126
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Hsieh,C.L., Yao,Y., Gurevich,V.V. and Chen,J.
  TITLE     Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo
  JOURNAL   J Neurosci 42 (17), 3537-3545 (2022)
   PUBMED   35332081
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Miller,E.B., Karlen,S.J., Ronning,K.E. and Burns,M.E.
  TITLE     Tracking distinct microglia subpopulations with photoconvertible
            Dendra2 in vivo
  JOURNAL   J Neuroinflammation 18 (1), 235 (2021)
   PUBMED   34654439
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Shinohara,T., Kikuchi,T., Tsuda,M. and Yamaki,K.
  TITLE     A family of retinal S-antigens (arrestins) and their genes:
            comparative analysis of human, mouse, rat, bovine and Drosophila
  JOURNAL   Comp Biochem Physiol B 103 (3), 505-509 (1992)
   PUBMED   1458825
  REMARK    Review article
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Traut,W., Seldin,M.F. and Winking,H.
  TITLE     Genetic mapping and assignment of a long-range repeat cluster to
            band D of chromosome 1 in Mus musculus and M. spretus
  JOURNAL   Cytogenet Cell Genet 60 (2), 128-130 (1992)
   PUBMED   1611911
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Malo,D., Schurr,E., Epstein,D.J., Vekemans,M., Skamene,E. and
            Gros,P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Danciger,M., Kozak,C.A., Abe,T., Shinohara,T. and Farber,D.B.
  TITLE     The gene for retinal rod 33-kDa protein is on mouse chromosome 1,
            near Lamb2
  JOURNAL   Cytogenet Cell Genet 56 (3-4), 202-205 (1991)
   PUBMED   1675982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102630.6 and M24086.1.
            
            On Jul 19, 2005 this sequence version replaced NM_009118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24086.1, AK149299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC102630.6         101280-101493
            215-1718            M24086.1           2-1505
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.44 cM"
     gene            1..1718
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /note="S-antigen, retina and pineal gland (arrestin)"
                     /db_xref="GeneID:20215"
                     /db_xref="MGI:MGI:98227"
     exon            1..333
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            334..438
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1584
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /note="S-AG; 48 kDa protein; rod photoreceptor arrestin;
                     rod arrestin; arrestin 1; visual arrestin 1; retinal
                     S-antigen"
                     /codon_start=1
                     /product="S-arrestin"
                     /protein_id="NP_033144.1"
                     /db_xref="CCDS:CCDS35656.1"
                     /db_xref="GeneID:20215"
                     /db_xref="MGI:MGI:98227"
                     /translation="MAACGKTNKSHVIFKKVSRDKSVTIYLGKRDYVDHVSQVEPVDG
                     VVLVDPELVKGKKVYVTLTCAFRYGQEDIDVMGLTFRRDLYFSRVQVYPPVGAMSVLT
                     QLQESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDVGKSCGVDFEVKAFASDITDP
                     EEDKIPKKSSVRLLIRKVQHAPPEMGPQPSAEASWQFFMSDKPLNLSVSLSKEIYFHG
                     EPIPVTVTVTNNTDKVVKKIKVSVEQIANVVLYSSDYYVKPVASEETQEKVQPNSTLT
                     KTLVLVPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVMGILVSYHIKVKL
                     TVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESVQDENLVFEEFARQNLKDTGENTE
                     GKKDEDAGQDE"
     exon            439..499
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            500..544
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            545..738
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            739..798
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            799..875
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1011
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1096
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1169
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1307
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1385
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1409
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1465
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1475
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1718
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
     polyA_site      1718
                     /gene="Sag"
                     /gene_synonym="A930001K18Rik; Arr1; arrestin; Irbp"
ORIGIN      
        1 gctcgtgcat ctttgggacc ctctgagaag attggagctc ccagctaatg ctagaactgc
       61 tgaagtgggc aatctgccat ctcgataatc caatcagctc cctgctcctc aaatctgatt
      121 tggtttttag acactgagac ctaacagctg ggcacagatc cctacaaatt ccccccccgg
      181 ggcagccagg ggcctcaccc ttgccctgtg gggttatctg ataggattgc accaggtccc
      241 tcagagcgtg ggctggctgc tcactgtcga aaagcacagg taccctctcg tgacttctct
      301 ggccagctca actgggtggt gacaaattac aagccttcca acctctgacg tacatcccaa
      361 gggacagaca gcatggcagc ctgcgggaag accaataaat cccacgtcat cttcaagaag
      421 gtctctcggg acaagtcggt gaccatctac ctggggaaga gagactatgt agaccacgtc
      481 agccaagtag agcctgtaga tggtgttgtg ctggtggacc ctgagcttgt gaaggggaag
      541 aaggtgtatg tcaccctgac ctgcgccttc cgctatggcc aggaggacat tgatgtgatg
      601 ggcctgacct tccgcaggga cctgtatttt tctcgggtcc aggtataccc tcctgttggg
      661 gccatgagtg tcctcaccca actccaagag agcctgctca agaaactggg agacaacacg
      721 tacccctttc tgctcacgtt tcctgactac ctaccctgtt cagtgatgtt gcagccagct
      781 ccccaggatg taggcaagag ctgtggggtt gactttgagg ttaaagcatt tgcctcagac
      841 atcacagatc ctgaggagga caagatcccc aagaagagct ctgtgcggtt actgatccgg
      901 aaagtgcagc atgccccacc tgagatgggt ccccagccca gtgctgaagc ctcctggcag
      961 ttcttcatgt ctgacaagcc cctgaacctc tcagtctccc tcagcaaaga gatatatttc
     1021 catggggagc ccatccccgt gactgtgacc gtgaccaaca acaccgacaa ggttgtgaag
     1081 aagattaaag tatcagtgga acagatagcc aatgtggttc tctactcaag tgactattac
     1141 gtcaagcctg tagcctcgga ggaaacacaa gaaaaagtgc agccaaacag cactttgacc
     1201 aagacactgg tgctggtgcc cctactggct aacaacagag aaagaagagg catcgcgctg
     1261 gatgggaaga tcaagcatga ggacacaaac ctggcctcca gcaccatcat caaggagggc
     1321 atcgaccgga ccgtcatggg gatcctggtg tcataccata tcaaggtgaa gctcacggtg
     1381 tcgggctttc taggagagct cacatccagt gaagtggcta ccgaggtgcc gttccgcctc
     1441 atgcacccgc agcctgagga tccagcaaaa gaaagtgttc aggatgaaaa tttggttttt
     1501 gaagagtttg ctcgccaaaa tctgaaagat actggagaga acacagaagg gaagaaagat
     1561 gaggatgctg gccaggatga gtgaagactt agcctagatg cctagaaact gcttgtagtt
     1621 ccgggtgcct tgagggaagc ccccggtaga ctctcaaagt tatgctagat atcaaagcat
     1681 gagcattcct cccagaaata aagtctctgg gtcctctt
//
