LOCUS       NM_001414449            3147 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus scaffold attachment factor B2 (Safb2), transcript
            variant 3, mRNA.
ACCESSION   NM_001414449 XM_036160554
VERSION     NM_001414449.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3147)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3147)
  AUTHORS   Jiang,S., Katz,T.A., Garee,J.P., DeMayo,F.J., Lee,A.V. and
            Oesterreich,S.
  TITLE     Scaffold attachment factor B2 (SAFB2)-null mice reveal
            non-redundant functions of SAFB2 compared with its paralog, SAFB1
  JOURNAL   Dis Model Mech 8 (9), 1121-1127 (2015)
   PUBMED   26092125
  REMARK    GeneRIF: despite a high degree of sequence similarity, SAFB1(-/-)
            and SAFB2(-/-) mice do not totally phenocopy each other
REFERENCE   3  (bases 1 to 3147)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   4  (bases 1 to 3147)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3147)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   6  (bases 1 to 3147)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 3147)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 3147)
  AUTHORS   Townson,S.M., Dobrzycka,K.M., Lee,A.V., Air,M., Deng,W., Kang,K.,
            Jiang,S., Kioka,N., Michaelis,K. and Oesterreich,S.
  TITLE     SAFB2, a new scaffold attachment factor homolog and estrogen
            receptor corepressor
  JOURNAL   J Biol Chem 278 (22), 20059-20068 (2003)
   PUBMED   12660241
REFERENCE   9  (bases 1 to 3147)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3147)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485788.18.
            
            On Nov 25, 2022 this sequence version replaced XM_036160554.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.201529.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               CT485788.18        78298-78548         c
            252-339             CT485788.18        77008-77095         c
            340-404             CT485788.18        72945-73009         c
            405-608             CT485788.18        72665-72868         c
            609-671             CT485788.18        71867-71929         c
            672-699             CT485788.18        70902-70929         c
            700-1357            CT485788.18        69379-70036         c
            1358-1407           CT485788.18        68927-68976         c
            1408-1508           CT485788.18        68226-68326         c
            1509-1658           CT485788.18        65424-65573         c
            1659-1768           CT485788.18        65234-65343         c
            1769-1896           CT485788.18        62919-63046         c
            1897-1988           CT485788.18        61557-61648         c
            1989-2125           CT485788.18        60903-61039         c
            2126-2416           CT485788.18        60350-60640         c
            2417-2554           CT485788.18        59969-60106         c
            2555-2597           CT485788.18        59243-59285         c
            2598-2728           CT485788.18        58528-58658         c
            2729-2841           CT485788.18        57536-57648         c
            2842-2911           CT485788.18        57386-57455         c
            2912-3147           CT485788.18        54995-55230         c
FEATURES             Location/Qualifiers
     source          1..3147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.39 cM"
     gene            1..3147
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /note="scaffold attachment factor B2"
                     /db_xref="GeneID:224902"
                     /db_xref="MGI:MGI:2146808"
     exon            1..251
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2915
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /note="isoform 3 is encoded by transcript variant 3;
                     SAF-B2"
                     /codon_start=1
                     /product="scaffold attachment factor B2 isoform 3"
                     /protein_id="NP_001401378.1"
                     /db_xref="GeneID:224902"
                     /db_xref="MGI:MGI:2146808"
                     /translation="MAEPGTGSGDPAFGPGASESGTRRLSDLRVIDLRAELKKRNLDT
                     GGNKSVLMERLRKAFKEEGQEPEEVGISWGAVSKRAVKRNTKGSKMEEEGSEDNGLEE
                     DSRYGQDGVVILQSSQDRDTMDTGVPDGMEAEDLSVPCLGKADTVNQILHAFDDSKEY
                     VAAQLGQLPAQLLKHAVDEEVFKNTLEASVSDLKVTLADEEAPMEPENEKILDILGET
                     CKSEPVKEEGSELEQPFAQATSSVGPDRKLAEEEDLFESCGHPEEEEEEEEEDQEEEQ
                     EEEGDLALASSSKSESPSTRCQWSEADAPLAVVKRELADAPGGGGGTRHRRKRKRRRK
                     HQAQAEALGTGGGAGMNCEPVGLEEPVEQSSTAAQLPEATSQELVRAPTAALSPEPQD
                     SKEDVKKFAFDACNDVPAPPKESSASEGADQKMSSVKEEQDIKPVIKDEKGRASCSSG
                     RNLWVSGLSSSTRAADLKSLFSKHGKVIGAKVVTNARSPGARCYGFVTMSTSDEATKC
                     ISHLHRTELHGRMISVEKAKNEPSEKKSSDRRACDQKEKVPGPDRPHPVKIKTEKTVI
                     KKEEKLERKEEKGPEDIKKEKDQDELTPGAAGHSRVTKSGSRGMERTVVMDKSKGEPV
                     ISVKATSRSKDRSSKSQDRKSEGREKRDILSFDKIKEQRERERQRQREREIRETERRR
                     EREQREREQRLDAFQERREKARLQRERMQLQCQRQRLERERLERERLERERMRVERER
                     RKEQQRIMREREELRRQQEQLRAEQERRALRRPYDLDARRDDGYWPEGKRAALEDRYR
                     DFPRPDHRFHDFDHRDRGHYQEHVIDRRDGSRTRVEERDGQYYPDDQHSHGRLLEHHA
                     WDSGDGWHGYSSDKKLNEGQGLPPPPRVSREWAEHSSQLEEQQVPVWHSAVDTNMTGH
                     EHIRWRGAERGLAGGPGHGHVAAGRGGMAG"
     exon            252..339
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            340..404
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            405..608
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            609..671
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            672..699
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1357
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1407
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1508
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1658
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1768
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1896
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1988
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2125
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2416
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2554
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2597
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2728
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2841
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2911
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3147
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /note="hexamer: ATTAAA"
     polyA_site      3147
                     /gene="Safb2"
                     /gene_synonym="mKIAA0138"
                     /note="major polyA site"
ORIGIN      
        1 gtactacctc cgagccgcca cagctggtgc cagcgagtgg agggggttcc ggagcgagtt
       61 gggaagtcgc ggaagcgagg atggcggaac ccgggaccgg gtcgggcgac cccgcctttg
      121 gtccgggcgc ctcggagagt gggacgcggc ggctcagcga cctgcgggtg atcgacctga
      181 gggcggagct gaaaaagcgg aacctggata cgggaggcaa caagagcgtg ctgatggagc
      241 ggctgaggaa ggcatttaag gaggaaggac aagaacctga ggaggttgga atcagctggg
      301 gagctgtgag caagagggct gtaaagagaa acaccaaagg atccaagatg gaggaggagg
      361 gcagcgagga caacggcctg gaggaagatt ccagatatgg gcaggatggg gttgtgattc
      421 ttcagagttc acaagacagg gacaccatgg atacaggtgt gccagatggg atggaggctg
      481 aggacctcag tgtgccctgc ctggggaagg ccgacaccgt caaccagatt cttcatgctt
      541 ttgatgacag taaagagtac gtggccgcgc agctgggaca gcttccagct cagctcctga
      601 agcatgctgt ggatgaggag gtcttcaaga acactctgga agcttccgtg tcagacctta
      661 aagtaactct ggctgatgaa gaagccccca tggaaccaga aaatgagaaa atactcgaca
      721 ttttggggga aacttgtaaa tctgagccag taaaagaaga aggttcggag ctggagcagc
      781 cctttgccca ggccacgagt agcgtggggc cagacaggaa gctggcggag gaagaggacc
      841 tatttgagag ctgcggccac ccggaagagg aagaggaaga ggaggaagaa gatcaggaag
      901 aggagcagga ggaggaggga gatttagctt tggccagcag cagcaagtct gagtctccaa
      961 gcactcggtg tcagtggagc gaggcagatg ccccgttagc agtagtgaaa agggagctgg
     1021 cagatgcgcc gggtggaggt ggaggtactc ggcacaggcg gaagcgcaag cgaaggcgga
     1081 agcatcaggc gcaggcagaa gctctgggca caggtggagg tgccgggatg aactgcgagc
     1141 ctgtagggct agaggagcca gttgaacaga gtagcacggc tgcccagctc ccggaggcca
     1201 ccagccagga gctggtgcga gcgcccacgg cagccctgag ccctgagccc caagatagca
     1261 aagaagacgt gaagaagttt gcttttgacg cttgtaatga cgtccctgcg cctcctaaag
     1321 agtcctcagc cagtgagggc gctgatcaga aaatgagctc tgttaaggaa gaacaagata
     1381 taaagccagt cattaaagat gaaaaaggcc gtgccagctg tagctcagga aggaacctgt
     1441 gggtcagtgg gctgtcctcc agcacccgtg ctgctgacct caagagcctc ttcagcaagc
     1501 atgggaaggt catcggagcc aaggtggtca ccaatgcccg cagtccaggg gctcggtgct
     1561 atggatttgt gacaatgtcc acgtcagatg aggccaccaa atgcattagc cacctgcaca
     1621 gaactgaact acatgggagg atgatctctg tggagaaggc caagaatgaa ccctctgaga
     1681 agaagtcgtc agacaggaga gcatgtgacc aaaaggagaa ggtgccaggg ccggacaggc
     1741 ctcaccctgt gaagatcaag acggagaaaa ctgtgatcaa gaaggaagaa aaactggaaa
     1801 gaaaagagga gaaagggcca gaagacatta aaaaggagaa ggatcaagat gaactcacac
     1861 caggagctgc tggtcattct cgagtcacca aatcaggaag cagaggcatg gagcgtacag
     1921 tcgtgatgga caagtccaag ggcgagcccg tcatcagtgt gaaggccaca agcaggtcaa
     1981 aggacagaag ctccaaaagt caagaccgaa agtcagaggg cagggagaag agagacatac
     2041 tgtcattcga caagatcaag gagcagcggg agagggagcg ccagaggcag agggagcgtg
     2101 aaatccggga gacagagcga agacgggagc gggagcagcg agagcgggag cagcgtctgg
     2161 atgccttcca ggagcgacgg gagaaggctc gcttgcagcg ggaacggatg cagctccagt
     2221 gccagcggca gcggttggag cgggagcggc tggagcggga gaggctggag cgggagcgca
     2281 tgagagtgga gcgtgaaagg cgcaaggaac agcagcgcat tatgcgtgag cgggaggagc
     2341 tgcggcggca gcaagaacag ctgcgtgctg agcaggaacg gcgggcactg cgcagaccct
     2401 acgacctgga tgctaggaga gacgatggct actggccaga agggaagcgt gcagccttag
     2461 aggacagata ccgagacttt ccacggccag atcaccgctt ccatgacttt gatcaccgag
     2521 atcgtggcca ttaccaggag catgtcatag acaggcggga tgggtccaga accagagtgg
     2581 aggagcggga tgggcagtac tacccagatg accagcacag ccatggaagg ctcctagagc
     2641 accatgcttg ggattccgga gacggctggc atggctacag ctctgacaag aagttgaatg
     2701 aaggccaagg gctaccccct ccccccaggg tcagccgaga gtgggcggag cacagctcac
     2761 agttggagga gcagcaggtt cctgtctggc acagtgctgt ggacacaaac atgacgggcc
     2821 atgaacacat acggtggcga ggtgctgagc ggggccttgc aggaggacct gggcatgggc
     2881 atgtggcagc aggccggggt ggcatggctg ggtgatccct gcatctcttc agacatgcta
     2941 ggacccctca tgggacaagc attaaggaac ctgcacctac tgtgcacact gtctgtggtt
     3001 ctttatggaa cttctgtgac ctgtatccac ttgctcctgg tcccagttct ctcaggccta
     3061 tcccttttta gatacctgcc tgtcccctac ccctgaccgt ccttaggtta cttttttctt
     3121 ttcttattaa aacaaagttg ttctttt
//
