LOCUS       NM_019748               2017 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus SUMO1 activating enzyme subunit 1 (Sae1), transcript
            variant 1, mRNA.
ACCESSION   NM_019748
VERSION     NM_019748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Zhao,Y., Zheng,D. and Cvekl,A.
  TITLE     A comprehensive spatial-temporal transcriptomic analysis of
            differentiating nascent mouse lens epithelial and fiber cells
  JOURNAL   Exp Eye Res 175, 56-72 (2018)
   PUBMED   29883638
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Kanemaru,A. and Saitoh,H.
  TITLE     High-yield expression of mouse Aos1-Uba2-fusion SUMO-activating
            enzyme, mAU, in a baculovirus-insect cell system
  JOURNAL   Biosci Biotechnol Biochem 77 (7), 1575-1578 (2013)
   PUBMED   23832333
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Ban,R., Nishida,T. and Urano,T.
  TITLE     Mitotic kinase Aurora-B is regulated by SUMO-2/3
            conjugation/deconjugation during mitosis
  JOURNAL   Genes Cells 16 (6), 652-669 (2011)
   PUBMED   21554500
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Uchimura,Y., Nakao,M. and Saitoh,H.
  TITLE     Generation of SUMO-1 modified proteins in E. coli: towards
            understanding the biochemistry/structural biology of the SUMO-1
            pathway
  JOURNAL   FEBS Lett 564 (1-2), 85-90 (2004)
   PUBMED   15094046
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Su,H.L. and Li,S.S.
  TITLE     Molecular features of human ubiquitin-like SUMO genes and their
            encoded proteins
  JOURNAL   Gene 296 (1-2), 65-73 (2002)
   PUBMED   12383504
REFERENCE   9  (bases 1 to 2017)
  AUTHORS   Azuma,Y., Tan,S.H., Cavenagh,M.M., Ainsztein,A.M., Saitoh,H. and
            Dasso,M.
  TITLE     Expression and regulation of the mammalian SUMO-1 E1 enzyme
  JOURNAL   FASEB J 15 (10), 1825-1827 (2001)
   PUBMED   11481243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB838763.1, AC164880.3 and BC068164.1.
            
            On Oct 24, 2013 this sequence version replaced NM_019748.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068164.1, AK087556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BB838763.1         2-45
            45-45               AC164880.3         121895-121895
            46-111              BB838763.1         47-112
            112-2017            BC068164.1         1-1906
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.88 cM"
     gene            1..2017
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /note="SUMO1 activating enzyme subunit 1"
                     /db_xref="GeneID:56459"
                     /db_xref="MGI:MGI:1929264"
     exon            1..256
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            257..368
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            369..542
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            543..685
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            686..785
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            786..891
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1036
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1106
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1986
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /note="hexamer: AATAAA"
     polyA_site      1986
                     /gene="Sae1"
                     /gene_synonym="2400010M20Rik; 2610044L12Rik; AOS1;
                     D7Ertd177e; HSPC140; Sua1; Uble1a"
                     /note="major polyA site"
ORIGIN      
        1 ttcggtatcc acgtggtctc ccgcaaagca cggaggtggc actgcgcagg cgcggctctc
       61 tgcgcaggcg caagcgcgtc cccggtgcac ggactcgctg ctggcggtta gcgagagcgg
      121 gagcgggtga gctgaaagcc ggcgccatgg tagagaagga ggaggctggc ggcggcggcg
      181 gcggtggcat cagcgaggag gaggcagcgc agtatgaccg acagatccgc ctgtggggac
      241 tggaggccca gaagcggctt cgagcttccc gggtgctgat tgttggcatg aaaggacttg
      301 gagctgaaat tgccaagaat cttatcctgg caggagtcaa agggctcacc atgctggacc
      361 acgaacaggt atctccagaa gaccctggag ctcagttctt gattcagact gggtctgtgg
      421 gccgcaatag ggccgaggcc tctttggaac gagcccagaa tctcaatccc atggtggatg
      481 taaaggtgga cactgaggat gtagagaaga agccagagtc cttcttcacg aagtttgatg
      541 cggtgtgcct gacttgctgc tccagagatg tcatcattaa agtcgaccag atctgtcaca
      601 gaaacagcat taagttcttc acaggagatg tctttgggta ccatgggtac acctttgcga
      661 atcttggaga gcatgaattt gtagaagaga aaaccaaagt tgccaaagta agccaaggag
      721 tggaagatgg acctgaggcc aagagagcaa agcttgattc atcagagaca accatggtca
      781 aaaagaaagt gcttttttgc cctgtaaaag aggcgctaga agtggactgg agtggagaga
      841 aagccaaggc tgccctgaag cgtactgccc ccgactactt tctgctgcaa gtgctgctga
      901 aattccgcac agataaaggg agagatccga cttctgagag ctacaaggag gatgcggagc
      961 tgctgctgca gatacggaat gacgtgtttg actccctggg catcagtcct gacctgcttc
     1021 ccgatgactt tgtcaggtac tgcttctctg agatggcccc agtatgtgct gtggttggag
     1081 ggatcttggc acaggaaatt gtgaaggccc tgtctcaaag ggaccctcct cacaacaact
     1141 tcttcttctt cgacggcatg aaggggagtg gaattgtgga gtgccttggt ccccagtgag
     1201 ctgaggtgtg tacaaggcca ccgagtcacc tgccctctct ccggatcatt tttctagagc
     1261 aagcaggcca gacttcatcc tgcctttgtc ttcgaagcta tcagggaact gcggggtccc
     1321 aaatatgata atcacgtggc acctctggca ttgctccctt gggctgtcac tggggactgg
     1381 cagtgcctag tgagagagag catcatactt catgatgtca gagtgtcttg tcacggtttg
     1441 gacttaactt ccctctatag tcagcagagg ggatccgagg cccagtgctg cctggagaac
     1501 tgagaataga cctctgttgt tgacccttcc tcaggctgga gcctgggtgt tggaagggag
     1561 agactgtcac ccagttgtca tgtcttttgg ttgtgagcct atgcacctta cctttaatgg
     1621 ttgaaccatc ttttcagccc aaacagttta tttctaaaaa gtagatttaa tgctaggggc
     1681 cattatgcag gcttgtaatc ctagatgttg ggatgccggg gcaggattta ctgtaaattt
     1741 cagggccaag ttggtctaca taatgtacca agaacctttc tcaaaatata ataaagggca
     1801 tattccagag ttagggtggg gcactgttac ccagctcctt atactgggca cccgggcccc
     1861 tgacaggagt gggttggggg gcagttggtt tggtcttcct tctaggagta tgagggcagc
     1921 ctgtctagtt tgtagatccc cttggttgct ggataaagga tgataataaa gtgtctttct
     1981 cttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
