LOCUS       NM_015788              15768 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sacsin (Sacs), transcript variant 1, mRNA.
ACCESSION   NM_015788 XM_006519228 XM_484383
VERSION     NM_015788.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15768)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 15768)
  AUTHORS   Marquez,B.T., Leung,T.C.S., Hui,J., Charron,F., McKinney,R.A. and
            Watt,A.J.
  TITLE     A mitochondrial-targeted antioxidant (MitoQ) improves motor
            coordination and reduces Purkinje cell death in a mouse model of
            ARSACS
  JOURNAL   Neurobiol Dis 183, 106157 (2023)
   PUBMED   37209925
REFERENCE   3  (bases 1 to 15768)
  AUTHORS   Romano,L.E.L., Aw,W.Y., Hixson,K.M., Novoselova,T.V., Havener,T.M.,
            Howell,S., Taylor-Blake,B., Hall,C.L., Xing,L., Beri,J.,
            Nethisinghe,S., Perna,L., Hatimy,A., Altadonna,G.C., Graves,L.M.,
            Herring,L.E., Hickey,A.J., Thalassinos,K., Chapple,J.P. and
            Wolter,J.M.
  TITLE     Multi-omic profiling reveals the ataxia protein sacsin is required
            for integrin trafficking and synaptic organization
  JOURNAL   Cell Rep 41 (5), 111580 (2022)
   PUBMED   36323248
REFERENCE   4  (bases 1 to 15768)
  AUTHORS   Lariviere,R., Sgarioto,N., Marquez,B.T., Gaudet,R., Choquet,K.,
            McKinney,R.A., Watt,A.J. and Brais,B.
  TITLE     Sacs R272C missense homozygous mice develop an ataxia phenotype
  JOURNAL   Mol Brain 12 (1), 19 (2019)
   PUBMED   30866998
  REMARK    GeneRIF: Sacs missense mutation largely lead to loss of sacsin
            function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15768)
  AUTHORS   Gentil,B.J., Lai,G.T., Menade,M., Lariviere,R., Minotti,S.,
            Gehring,K., Chapple,J.P., Brais,B. and Durham,H.D.
  TITLE     Sacsin, mutated in the ataxia ARSACS, regulates intermediate
            filament assembly and dynamics
  JOURNAL   FASEB J 33 (2), 2982-2994 (2019)
   PUBMED   30332300
REFERENCE   6  (bases 1 to 15768)
  AUTHORS   Lariviere,R., Gaudet,R., Gentil,B.J., Girard,M., Conte,T.C.,
            Minotti,S., Leclerc-Desaulniers,K., Gehring,K., McKinney,R.A.,
            Shoubridge,E.A., McPherson,P.S., Durham,H.D. and Brais,B.
  TITLE     Sacs knockout mice present pathophysiological defects underlying
            autosomal recessive spastic ataxia of Charlevoix-Saguenay
  JOURNAL   Hum Mol Genet 24 (3), 727-739 (2015)
   PUBMED   25260547
  REMARK    GeneRIF: Results indicate that the Sacs-/- mouse is a well-suited
            rodent model of the human condition and suggest that disruption of
            mitochondria organization and positioning cause autosomal recessive
            spastic ataxia of Charlevoix-Saguenay pathology.
REFERENCE   7  (bases 1 to 15768)
  AUTHORS   Girard,M., Lariviere,R., Parfitt,D.A., Deane,E.C., Gaudet,R.,
            Nossova,N., Blondeau,F., Prenosil,G., Vermeulen,E.G., Duchen,M.R.,
            Richter,A., Shoubridge,E.A., Gehring,K., McKinney,R.A., Brais,B.,
            Chapple,J.P. and McPherson,P.S.
  TITLE     Mitochondrial dysfunction and Purkinje cell loss in autosomal
            recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)
  JOURNAL   Proc Natl Acad Sci U S A 109 (5), 1661-1666 (2012)
   PUBMED   22307627
REFERENCE   8  (bases 1 to 15768)
  AUTHORS   Parfitt,D.A., Michael,G.J., Vermeulen,E.G., Prodromou,N.V.,
            Webb,T.R., Gallo,J.M., Cheetham,M.E., Nicoll,W.S., Blatch,G.L. and
            Chapple,J.P.
  TITLE     The ataxia protein sacsin is a functional co-chaperone that
            protects against polyglutamine-expanded ataxin-1
  JOURNAL   Hum Mol Genet 18 (9), 1556-1565 (2009)
   PUBMED   19208651
REFERENCE   9  (bases 1 to 15768)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
REFERENCE   10 (bases 1 to 15768)
  AUTHORS   Engert,J.C., Berube,P., Mercier,J., Dore,C., Lepage,P., Ge,B.,
            Bouchard,J.P., Mathieu,J., Melancon,S.B., Schalling,M.,
            Lander,E.S., Morgan,K., Hudson,T.J. and Richter,A.
  TITLE     ARSACS, a spastic ataxia common in northeastern Quebec, is caused
            by mutations in a new gene encoding an 11.5-kb ORF
  JOURNAL   Nat Genet 24 (2), 120-125 (2000)
   PUBMED   10655055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124555.4 and AC138718.3.
            
            On or before Apr 17, 2018 this sequence version replaced
            XM_006519228.1, NM_015788.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164132,
                              SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC124555.4         42718-43032         c
            316-795             AC124555.4         33418-33897         c
            796-946             AC124555.4         8041-8191           c
            947-1034            AC124555.4         2180-2267           c
            1035-1120           AC124555.4         459-544             c
            1121-1232           AC138718.3         130447-130558
            1233-1379           AC138718.3         136097-136243
            1380-2874           AC138718.3         137593-139087
            2875-2966           AC138718.3         139883-139974
            2967-15768          AC138718.3         149193-161994
FEATURES             Location/Qualifiers
     source          1..15768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 32.13 cM"
     gene            1..15768
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /note="sacsin"
                     /db_xref="GeneID:50720"
                     /db_xref="MGI:MGI:1354724"
     exon            1..315
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..795
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..14524
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /note="isoform 1 is encoded by transcript variant 1; dnaJ
                     homolog subfamily C member 29"
                     /codon_start=1
                     /product="sacsin isoform 1"
                     /protein_id="NP_056603.2"
                     /db_xref="CCDS:CCDS88683.1"
                     /db_xref="GeneID:50720"
                     /db_xref="MGI:MGI:1354724"
                     /translation="METEETRWVRVTVLRGCVGCRTVAVPATATGRDLKERIFAETSF
                     PVAEQRLWRGDREIPDWIKIGDLTSKTCHLFVNLQSKGLKGGGRFGQTTPPLVDFLKD
                     ILRRYPEGGQILKELIQNAEDAGATEVKFLYDETQYGTETLWSKDMAQYQGSALYVYN
                     NAVFTPEDWHGIQEIARSRKKDDPLKVGRFGIGFNSVYHITDVPCIFSGDQIGMLDPH
                     QTLFGPHESGQCWNLKDDIKEINELPDQFAPFIGVFGSTKETFTNGSFPGTFFRFPLR
                     LQPSQLSSNLYTKQKVLELFDSFRADADTVLLFLKSVQAVSLHVREADGTEKLVFRVT
                     ASENKALKHERPNSIKILGTAISNYCKKIPSNSVTCVTYHINIVLEDESTKDAQKTSW
                     LVCNSVGGRGISSKLDSLADELKFVPIIGLAMPLSGKDEENGAISDFSGKAFCFLPLP
                     PGEESRTGLPVHISGFFGLTDNRRSIKWRELDQWRDPAALWNEYLIVNVVPKTYATLI
                     LDSIKRLETEKSSDFPLSVDTIYKLWPEASKVKAHWHPVLGPLFSELFQHAVIYSIGG
                     EWVKLEQVHFSELDGSLESTRSVLNYLQSSGKQIAKVPGNLAAAVQLSAASATSSASP
                     VRKVTPAWVRQVLRKCAHLGSAEEKLHLLEFVLSDQAYSELLGLELLPLQSGAFVPFS
                     SSVSDQDVVYITSEEFPRSLFPGLEARLILENLKPHLLAALKEAAQTRGRPCTQLQLL
                     NPERFARLIKEVMNTFWPGRELVVQWYPFSEDKRHPSLSWLKMVWKNLYIHFSEDLTL
                     FDEMPLIPRTLLNEDQTCVELIRLRIPSVVILDDETEAQLPEFLADIVQKLGGIVLKR
                     LDTSIQHPLVKKYIHSPLPSAILQIMEKIPLQKLCNQIASLLPTHKDALRKFLASLTD
                     TSEKEKRIIQELTIFKRINHSSDQGISSYTKLKGCKVLDHTAKLPTDLRLSVSVIDSS
                     DEATIRLANMLKIEKLKTTSCLKFVLKDIGNAFYTQEEVTQLMLWILENLSSLKNENS
                     NVLDWLMPLKFIHMSQGHVVAAGDLFDPDIEVLRDLFYNEEEACFPPTIFTSPDILHS
                     LRQIGLKNESSLKEKDVVQVARKIEALQVSSCQNQDVLMKKAKTLLLVLNKNQTLLQS
                     SEGKMALKKIKWVPACKERPPNYPGSLVWKGDLCNLCAPPDMCDAAHAVLVGSSLPLV
                     ESVHVNLEQALSIFTKPTINAVLKHFKTVVDWYTSKTFSDEDYYQFQHILLEIYGFMH
                     DHLSEGKDSFKALKFPWVWTGKNFCPLAQAVIKPTHDLDLQPYLYNVPKTMAKFHQLF
                     KACGSIEELTSDHISMVIQKVYLKSDQELSEEESKQNLHLMLNIMRWLYSNQIPASPN
                     TPVPIYHSRNPSKLVMKPIHECCYCDIKVDDLNDLLEDSVEPIILVHEDIPMKTAEWL
                     KVPCLSTRLINPENMGFEQSGQREPLTVRIKNILEEYPSVSDIFKELLQNADDANATE
                     CSFMIDMRRNMDIRENLLDPGMAACHGPALWSFNNSEFSDSDFLNITRLGESLKRGEV
                     DKVGKFGLGFNSVYHITDIPIIMSREFMIMFDPNINHISKHIKDRSNPGIKINWSKQQ
                     KRLRKFPNQFKPFIDVFGCQLPLAVEAPYSYNGTLFRLSFRTQQEAKVSEVSSTCYNT
                     ADIYSLVDEFSLCGHRLIIFTQSVNSMYLKYLKIEETNPSLAQDTIIIKKKVCPSKAL
                     NAPVLSVLKEAAKLMKTCSSSNKKLPTDVPKSSCILQITVEEFHHVFRRIADLQSPLF
                     RGPDDDPATLFEMAKSGQSKKPSDELPQKTVDCTTWLICTCMDTGEALKFSLNESGRR
                     LGLVPCGAVGVLLHETQEQKWTVKPHIGEVFCYLPLRIKTGLPIHINGCFAVTSNRKE
                     IWKTDTKGRWNTTFMRHVIVKAYLQALSVLRDLAIGGELTDYTYYAVWPDPDLVHDDF
                     SVICKGFYEDIAHGKGKELTRVFSDGSMWVSMKNVRFLDDSILQRKDVGSAAFKIFLK
                     YLKKTGSKNLCAVELPSSVKAGFEEAGCKQILLENTFSEKQFFSEVFFPNIQEIEAEL
                     RDPLMNFVLNEKLDEFSGILRVTPCVPCSLEGHPLVLPSRLIHPEGRVAKLFDTKDGR
                     FPYGSTQDYLNPIILIKLVQLGMAKDDILWDDMLERAESVAEINKSDHAAACLRSSIL
                     LSLIDEKLKIKDPRAKDFAAKYQTIPFLPFLTKPAGFSLEWKGNSFKPETMFAATDIY
                     TAEYQDIVCLLQPILNENSHSFRGCGSVSLAVKEFLGLLKKPTVDLVINQLKQVAKSV
                     DDGITLYQENITNACYKYLHEAVLQNEMAKATIIEKLKPFCFILVENVYVESEKVSFH
                     LNFEAAPYLYQLPNKYKNNFRELFESVGVRQSFTVEDFALVLESIDQERGKKQITEEN
                     FQLCRRIISEGIWSLIREKRQEFCEKNYGKILLPDTNLLLLPAKSLCYNDCPWIKVKD
                     STVKYCHADIPREVAVKLGAIPKRHKALERYASNICFTALGTEFGQKEKLTSRIKSIL
                     NAYPSEKEMLKELLQNADDAKATEICFVFDPRQHPVDRIFDDKWAPLQGPALCVYNNQ
                     PFTEDDVRGIQNLGKGTKEGNPCKTGQYGIGFNSVYHITDCPSFISGNDILCIFDPHA
                     RYAPGATSVSPGRMFRDLDADFRTQFSDVLDLYLGNHFKLDNCTMFRFPLRNAEMAQV
                     SEISSVPSSDRMVQNLLDKLRSDGAELLMFLNHMEKISICEIDKATGGLNVLYSVKGK
                     ITDGDRLKRKQFHASVIDSVTKKRQLKDIPVQQITYTMDTEDSEGNLTTWLICNRSGF
                     SSMEKVSKSVISAHKNQDITLFPRGGVAACITHNYKKPHRAFCFLPLSLETGLPFHVN
                     GHFALDSARRNLWRDDNGVGVRSDWNNSLMTALIAPAYVELLIQLKKRYFPGSDPTLS
                     VLQNTPIHVVKDTLKKFLSFFPVNRLDLQPDLYCLVKALYSCIHEDMKRLLPVVRAPN
                     IDGSDLHSAVIITWINMSTSNKTRPFFDNLLQDELQHLKNADYNITTRKTVAENVYRL
                     KHLLLEIGFNLVYNCDETANLYHCLVDADIPVSYVTPADVRSFLMTFSSPDTNCHIGK
                     LPCRLQQTNLKLFHSLKLLVDYCFKDAEESEFEVEGLPLLITLDSVLQIFDGKRPKFL
                     TTYHELIPSRKDLFMNTLYLKYSSVLLNCKVAKVFDISSFADLLSSVLPREYKTKNCA
                     KWKDNFASESWLKNAWHFISESVSVTDDQEEPKPAFDVIVDILKDWALLPGTKFTVST
                     SQLVVPEGDVLIPLSLMHIAVFPNAQSDKVFHALMKAGCIQLALNKICSKDSALVPLL
                     SCHTANIDSPASILKAVHYMVQTSTFRTEKLMENDFEALLMYFNCNLSHLMSQDDIKI
                     LKSLPCYKSISGRYMSIAKFGTCYVLTKSIPSAEVEKWTQSSSSAFLEEKVHLKELYE
                     VLGCVPVDDLEVYLKHLLPKIENLSYDAKLEHLIYLKNRLASIEEPSEIKEQLFEKLE
                     SLLIIHDANNRLKQAKHFYDRTVRVFEVMLPEKLFIPKEFFKKLEQVIKPKNQAAFMT
                     SWVEFLRNIGLKYALSQQQLLQFAKEISVRANTENWSKETLQSTVDILLHHIFQERMD
                     LLSGNFLKELSLIPFLCPERAPAEYIRFHPQYQEVNGTLPLIKFNGAQVNPKFKQCDV
                     LQLLWTSCPILPEKATPLSIKEQEGSDLAPQEQLEQVLNMLNVNLDPPLDKVINNCRN
                     ICNITTLDEEMVKTRAKVLRSIYEFLSAEKREFRFQLRGVAFVMVEDGWKLLKPEEVV
                     INLEYEADFKPYLYKLPLELGTFHQLFKHLGTEDIISTKQYVEVLSRIFKSSEGKQLD
                     PNEMRTVKRVVSGLFKSLQNDSVKVRSDLENARDLALYLPSQDGKLVKSSILVFDDAP
                     HYKSRIQGNIGVQMLVDLSQCYLGKDHGFHTKLIMLFPQKLRPRLLSSILEEQLDEET
                     PKVCQFGALCSLQGRLQLLLSSEQFITGLIRIMKHENDNAFLANEEKAIRLCKALREG
                     LKVSCFEKLQTTLRVKGFNPIPHSRSETFAFLKRFGNAVILLYIQHSDSKDINFLLAL
                     AMTLKSATDNLISDTSYLIAMLGCNDIYRISEKLDSLGVKYDSSEPSKLELPMPGTPI
                     PAEIHYTLLMDPMNVFYPGEYVGYLVDAEGGDIYGSYQPTYTYAIIVQEVEREDADNT
                     SFLGKIYQIDIGYSEYKIVSSLDLYKFSRPDESSQNRDSAPTTPTSPTEFLTPGLRSI
                     PPLFSGKESHKSPSTKHHSPRKLKVNALPEILKEVTSVVEQAWKLPESERKKIIRRLY
                     LKWHPDKNPENHDIANEVFKHLQNEINRLEKQAFLDQNADRASRRTFSTSASRFQSDK
                     YSFQRFYTSWNQEATSHKSERQQQSKEKCPPSAGQTYSQRFFVPPTFKSVGNPVEARR
                     WLRQARANFSAARNDLHKNANEWVCFKCYLSTKLALIAADYAVRGKSDKDVKPTALAQ
                     KIEEYSQQLEGLTNDVHTLEAYGVDSLKTRYPDLLPFPQIPNDRFTSEVAMRVMECTA
                     CIIIKLENFIQQKV"
     exon            796..946
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1034
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1120
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1232
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1379
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..2874
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2966
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..15768
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15744..15749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      15768
                     /gene="Sacs"
                     /gene_synonym="A230052M14; DNAJC29; E130115J16Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgcactctcc cggccctgcg ctgaatgcag tggcagtaac gctggctggg acttgtttgt
       61 tgttggtaca aaaggcacac aaaggccgga caaccaggtt gatgatggcc accgtgagac
      121 tctgagggtc cctcggactg cggactgcgt ctagtctagg aacagctaca tcgggcgttg
      181 cgacccgctg gagccgggtg gtgcggtcgc tgctacagct gctgctgctc cagctgggcc
      241 gtggaccact gtcctctgca tcttcgcccc caaggaagac agagcagctc tggcgtgtag
      301 tgccacagcg cacggggtcc ttgaggtaaa gccaagatgc cagtggctcc agacctggga
      361 gaagtgttct aaatggcaag catctcataa ctcctgagat gagggtgggc agtgccctac
      421 ccaagcagct ccgcagcatc ttccctctgc agctccaaca gggaccatag aagagccagc
      481 gaggagacat taaggttgcc tctgggaaaa gccgaaaact cccagccagc tgatactagt
      541 ttgctttaaa aaggcaacct tatcagatca gagtagcata cagaacacag gaacaaaaca
      601 caatgttttc tgatgtcaga tgatgacaga tgctggggaa gactggcttt tcaccagcca
      661 gaaagagctt cgcttagagt gcacatcgac aagaaacaca ggaaacacag aggagcctta
      721 agcagaagga agcaggtgcc gtctatggtc ttcaaggaca gctgctccgg tgaccatgga
      781 gaccgaggag acgaggtggg tccgcgtgac cgtgctccgc ggctgcgtgg gctgcaggac
      841 cgtggcggtg ccggcgaccg ctaccgggcg ggacctcaag gagcgcatct tcgctgagac
      901 cagctttccg gtggcggagc agcgactgtg gcgcggagac agggagatac ctgattggat
      961 caagattgga gacctgactt ctaaaacctg tcatcttttt gtaaaccttc aatcaaaagg
     1021 cttaaagggg ggaggtcgat ttggtcaaac aactccacca cttgttgatt ttctcaagga
     1081 tattttaaga agatatccag aaggaggaca gatccttaag gaattaattc agaatgcaga
     1141 agatgctggg gccacagagg ttaaattttt atatgatgaa acacaatatg gaacggagac
     1201 tctttggtcg aaagatatgg cacaatatca gggctcagct ctttatgtgt acaacaatgc
     1261 ggttttcacc ccagaggact ggcatggcat tcaggaaata gcaagaagca ggaaaaaaga
     1321 tgatcccctg aaggttggaa gatttggaat tgggtttaat tctgtctacc atataacaga
     1381 tgttccttgt atctttagtg gtgaccagat aggaatgcta gatcctcatc aaacactgtt
     1441 tggcccccat gaatctggcc aatgttggaa tctcaaagat gacatcaaag aaataaatga
     1501 gcttccggat cagtttgccc ccttcattgg tgtttttgga agcaccaagg aaacctttac
     1561 aaatggcagc ttcccaggga catttttccg tttccctctt cgcttacagc cttcccagct
     1621 tagcagcaat ctctacacta agcagaaggt tctggagttg tttgactctt tccgggcgga
     1681 tgcagacaca gtgctactct tcctgaagag tgtgcaggcg gtgtctttac atgtccgaga
     1741 ggctgatggg acagaaaaac tggtatttag agtgactgct agtgagaata aggccctgaa
     1801 acatgaacgg ccaaattcta tcaagattct gggaacggct ataagtaact attgtaaaaa
     1861 gatcccaagc aacagtgtca cctgtgtaac atatcatata aacatagttc tggaggatga
     1921 gagcacgaaa gatgcccaga agacgtcgtg gttggtatgt aacagtgtgg gcgggcgggg
     1981 cattagtagt aaactggatt ctttggctga tgaactgaaa tttgttccaa tcattggact
     2041 agccatgcct ttatcaggca aggatgaaga aaatggagca atatctgatt tctcaggaaa
     2101 agcattttgt tttcttcctc tgcctcctgg tgaagaaagc agaacaggac ttccagttca
     2161 tatcagtggt ttctttggcc tgactgacaa ccgcaggagc ataaaatgga gagagttgga
     2221 ccaatggaga gaccctgcgg ccttgtggaa tgaatatctt attgtgaatg ttgttcccaa
     2281 aacttatgct actctcatcc tagattcaat aaaacgcctg gagacagaga agagctctga
     2341 tttcccctta tcagttgaca ccatctacaa actttggcct gaggccagca aggtcaaggc
     2401 acactggcat ccagtgttgg gtccactgtt tagtgaactg ttccagcatg ctgtcattta
     2461 ctcaattggt ggcgagtggg tgaagctgga gcaggtgcac ttctcagaac ttgacggaag
     2521 tttagaatcc acgcgatctg tgctcaacta cctccagagc tcagggaagc agattgccaa
     2581 ggtcccaggg aacttggctg ctgctgttca gctcagtgca gcctctgcca cctccagtgc
     2641 gtctcctgtg agaaaggtga cgcctgcgtg ggtgcggcag gtactgagga agtgtgcaca
     2701 cctgggcagt gcggaagaaa agctgcatct tctggaattt gtgctttccg accaagccta
     2761 cagtgagctg ctcgggcttg agctgttgcc tttacagagc ggggcttttg tccccttctc
     2821 ctcgtctgtc tctgatcaag atgttgttta catcacctca gaagaattcc caaggtccct
     2881 tttcccaggt cttgaagcaa gacttatttt ggagaacttg aagcctcacc ttctagctgc
     2941 tttaaaagaa gctgcgcaga cccgaggaag accatgtact cagctgcagc ttctaaatcc
     3001 agagcgattt gcacgtctta ttaaagaagt catgaataca ttctggcctg gtcgagagtt
     3061 ggtggttcag tggtatccat ttagtgaaga caaacgtcac ccatcccttt catggcttaa
     3121 gatggtttgg aagaatctct atatacattt ctcggaagat ttgactttat ttgatgagat
     3181 gccacttatc cctagaactc tactgaatga ggaccagacg tgtgtggaac tcatcagact
     3241 caggatccca tcagtagtca ttttagatga tgaaactgaa gctcagcttc cagaattctt
     3301 agcagatatt gtacaaaaac ttggagggat tgtcctgaaa agactagata cctctattca
     3361 gcatccactt gttaaaaaat acattcattc cccactcccg agtgctattt tgcagataat
     3421 ggagaagata cctctacaga agttgtgtaa tcaaatagca tcattacttc caacccacaa
     3481 agatgctcta aggaagtttt tggccagctt aactgatacc agtgaaaaag agaaaagaat
     3541 aattcaagaa ttgacaatat tcaaaagaat taatcactca tcagatcaag ggatttcctc
     3601 ttacacaaaa ttaaaaggat gtaaagtttt ggatcatacc gccaagcttc caacagatct
     3661 acggctatca gtttcagtaa tagatagtag tgatgaagcc accattcgtt tggcaaacat
     3721 gttgaaaatt gaaaaattga agactacaag ctgtttaaag tttgttttaa aagatattgg
     3781 aaatgcattt tatacacagg aagaggtaac acaacttatg ctttggatcc ttgagaatct
     3841 atcctctctt aaaaatgaga attcaaatgt gcttgattgg ttaatgccac taaaattcat
     3901 tcatatgtcc cagggacatg tggtagcagc tggtgatctc tttgatcctg atatagaagt
     3961 actaagggat ctcttttata atgaagaaga agcttgtttc ccacctacaa tttttacctc
     4021 accagatatc cttcactctt tgagacagat tggcttaaaa aatgaatcca gtctaaaaga
     4081 aaaagatgtt gtacaagtgg caagaaaaat tgaagcttta caggtcagtt cctgtcagaa
     4141 tcaggatgtt ctcatgaaga aagccaaaac actcttactg gtcttgaata aaaaccagac
     4201 actcttgcag tcttctgaag ggaagatggc attgaagaaa atcaaatggg ttccagcctg
     4261 caaggaaaga cctccaaatt atcccggttc cttagtctgg aaaggggatc tctgtaatct
     4321 ttgtgcacct ccagatatgt gtgatgcggc acatgcagtt ctagtaggct cctcacttcc
     4381 tcttgttgaa agtgtccatg tgaacctgga gcaggcgctc agcatcttca caaagcctac
     4441 tatcaatgct gtcttaaaac actttaaaac tgttgttgac tggtatactt caaaaacctt
     4501 tagtgatgaa gattactatc agttccaaca tattttgctt gaaatttatg ggttcatgca
     4561 tgatcatctg agtgaaggga aggattcttt taaagccttg aagtttccat gggtttggac
     4621 tggcaaaaac ttttgtcctc ttgcccaggc tgtgataaag ccaacccatg atctggatct
     4681 tcagccttat ttatataatg tgcctaaaac catggcaaaa ttccaccagc tgttcaaggc
     4741 ttgtggctca atagaagagt tgacatcaga tcatatttcc atggtcattc agaaagttta
     4801 tctcaaaagt gaccaggagt tgagtgaaga agaaagtaaa caaaatcttc atctcatgtt
     4861 gaatattatg agatggctct atagcaatca gattccagca agccctaata caccagttcc
     4921 tatttatcac agcagaaatc cttccaaact tgtcatgaag ccaattcatg aatgctgtta
     4981 ttgtgacatc aaagttgatg acctcaatga cttgcttgaa gattcagtgg aaccaattat
     5041 cttggtacat gaagatatac ccatgaaaac tgcagaatgg ctaaaagttc cgtgccttag
     5101 tacaagactg atcaatcctg aaaacatggg gtttgagcag tcagggcaaa gagagcctct
     5161 tactgtaagg attaaaaata ttttggaaga atacccttcc gtgtcagata tttttaaaga
     5221 gctacttcaa aatgctgatg atgcaaatgc cacagaatgc agcttcatga ttgatatgag
     5281 aaggaatatg gacatacggg aaaatctcct ggacccaggg atggcagctt gtcatggacc
     5341 tgctctgtgg tcattcaaca attctgaatt ctcagattca gatttcttaa acataacgag
     5401 gttaggagag tctttaaaaa ggggagaagt tgacaaggtt gggaaatttg gtcttggttt
     5461 taattctgtg taccacatca ctgacattcc catcattatg agcagagaat ttatgataat
     5521 gtttgatcca aacataaatc atatcagcaa acacattaaa gatagatcga atcctggaat
     5581 caaaattaat tggagtaagc agcagaaaag acttaggaag ttccccaacc agttcaaacc
     5641 atttatagat gtatttggct gtcagttacc tttggctgtt gaagctcctt acagctacaa
     5701 tggaactctt ttccgactgt cctttagaac acagcaggaa gcaaaagtga gtgaagttag
     5761 cagtacttgc tacaatactg cggatattta ctccctagtg gatgaattta gtctttgtgg
     5821 gcacagactt atcattttta ctcagagtgt aaactcgatg tatttgaaat acttgaaaat
     5881 tgaagaaacc aatcctagct tagcacaaga tacaatcata attaagaaaa aagtttgccc
     5941 ctccaaagca ttgaatgcac cagttttaag tgttttaaaa gaagctgcta aactcatgaa
     6001 gacttgtagc agcagcaaca agaagcttcc cacggatgtg ccaaagtcat cttgcattct
     6061 tcagatcaca gtcgaagaat tccaccatgt gtttaggagg attgctgact tacagtcacc
     6121 actatttcga ggtccagatg atgacccagc tactctcttt gaaatggcta aatctggcca
     6181 atcaaaaaag ccatcagatg agttgccaca aaagacagta gattgtacca catggcttat
     6241 atgcacatgc atggatacag gagaagctct caagttttcc ttgaatgaaa gtggaagaag
     6301 attagggctg gttccttgtg gggcagtagg ggttctcttg catgaaaccc aggaacagaa
     6361 gtggaccgtg aaaccacaca taggagaagt gttttgctat ttacctctac gaatcaaaac
     6421 agggttgcca attcacatca atgggtgctt tgctgttact tcaaatagga aagaaatctg
     6481 gaagacagat acaaaaggtc gatggaatac cacattcatg aggcatgtca ttgtgaaagc
     6541 ttacttacaa gccctcagtg tcttacggga cctagccatt ggtggtgagc tgactgatta
     6601 tacttactat gcagtgtggc ctgatcctga tctagttcat gatgacttct ctgtgatctg
     6661 taaaggattt tatgaagaca ttgctcatgg gaaggggaag gagttgacca gagtcttctc
     6721 tgatgggtct atgtgggttt ccatgaagaa tgtgaggttt ctggatgact ctatacttca
     6781 aaggaaagat gttggttcag cagccttcaa gatatttctg aagtacctca agaaaacagg
     6841 atccaaaaac ctctgtgctg ttgagcttcc ttcttcagta aaagcaggat ttgaagaggc
     6901 tggctgtaaa cagatactgc tggaaaatac attttcagag aaacagttct tttcagaagt
     6961 cttctttcct aatatccagg aaattgaagc agaacttaga gatcctctga tgaattttgt
     7021 cctaaatgaa aaacttgatg agttctcagg aattcttcgt gttacccctt gtgttccttg
     7081 ctccttggag ggccatcctt tggttttgcc ttcaagattg atccatcctg aaggacgagt
     7141 tgcaaagtta tttgatacta aagatggaag attcccttat ggttccacac aggattacct
     7201 caatcctatt atcttgatta agctcgttca gttaggcatg gcaaaagatg atattttgtg
     7261 ggatgacatg ctagagcgtg cagagtctgt agctgagatt aataaaagtg accatgctgc
     7321 tgcctgctta aggagtagta ttctgctaag ccttattgat gagaagctaa aaataaagga
     7381 tcctagagca aaggattttg ctgcaaaata tcaaacaatt cccttcctcc catttctaac
     7441 aaagccagca ggtttttctt tagaatggaa agggaacagc tttaagcctg aaaccatgtt
     7501 tgcagcaact gacatttaca cagctgaata tcaagatata gtctgtcttt tgcaaccaat
     7561 tcttaatgaa aattcccatt cctttagagg ctgtggttca gtgtctttgg ctgttaagga
     7621 gtttttgggt ttactaaaga agccaacagt tgatctggta ataaaccagt tgaagcaagt
     7681 tgcaaaatca gttgatgatg gcattacatt gtaccaggaa aatatcacca acgcttgcta
     7741 caaatacctc catgaagcag tattgcagaa tgaaatggcc aaggcaacaa ttattgagaa
     7801 gctaaagcca ttttgtttca ttctagttga gaatgtatat gttgagtcag aaaaggtttc
     7861 ttttcacttg aactttgaag cagcaccata cctttatcag ttacctaaca agtataaaaa
     7921 taatttccgt gagctttttg aaagtgtggg tgtgcgacag tcatttactg ttgaagactt
     7981 tgccctagtt ttggagtcta ttgatcaaga gagaggaaaa aaacaaataa cagaagagaa
     8041 ttttcagctt tgccgacgaa taatcagtga aggcatctgg agtctcatta gagaaaagag
     8101 acaagaattt tgtgagaaaa attatggcaa aatattactg ccagacacta acctgctgct
     8161 gctccctgct aagtcattat gctacaatga ctgtccctgg ataaaagtaa aggactccac
     8221 tgtcaagtat tgccatgccg acataccccg ggaagtagct gtaaaacttg gtgcaatacc
     8281 aaagagacat aaagcattag aaagatatgc atccaacatc tgtttcacag ctctaggtac
     8341 agaatttggg cagaaagaaa aactgaccag cagaattaag agcattctca atgcctatcc
     8401 ttcagaaaag gaaatgctga aagagcttct tcaaaatgct gatgatgcaa aggccacaga
     8461 gatctgcttt gtgtttgatc ctagacagca tcctgttgac cgaatatttg atgataagtg
     8521 ggccccactg caagggccag cactgtgtgt ttacaacaac cagccattta cagaagatga
     8581 tgttagagga attcagaatc ttgggaaagg caccaaagaa ggaaatcctt gcaaaacagg
     8641 acaatatgga atcggattca attccgttta tcatattaca gactgccctt cttttatttc
     8701 tggcaatgac atcctgtgta tttttgatcc ccatgccaga tatgcaccag gagccacatc
     8761 agttagccct ggacgcatgt ttagagattt ggatgcagac tttagaaccc agttctcaga
     8821 tgttctagat ctgtacttgg gaaaccactt taaactggac aattgtacaa tgtttagatt
     8881 tcctctgcgt aatgcagaga tggcacaagt ttcagaaatt tcttccgttc catcatcaga
     8941 cagaatggtc cagaatcttt tggacaagtt acggtctgat ggggcagaac ttctaatgtt
     9001 tctcaaccac atggagaaaa tatctatttg tgaaatagat aaggccacag gaggtctgaa
     9061 tgtgctctat tcagtaaaag gcaagatcac tgatggagac cgattgaaaa ggaagcaatt
     9121 ccacgcctct gtaattgaca gtgttactaa aaagagacag ctcaaggaca taccagttca
     9181 acaaataacc tacactatgg atactgagga ttctgaagga aatctgacca catggctcat
     9241 ctgtaataga tcaggatttt caagtatgga aaaagtatcc aagagtgtaa tatcagctca
     9301 caagaaccaa gatatcaccc ttttcccacg tggtggagta gcagcctgca ttactcacaa
     9361 ttataaaaag ccccacagag ccttctgctt tctgcctctc tctttggaga cagggctgcc
     9421 atttcatgtg aatggccact ttgctttaga ttcagccaga agaaacttgt ggcgtgatga
     9481 taatggggtt ggtgttcgaa gtgactggaa taatagttta atgacagcat taatagcacc
     9541 tgcatatgtt gagttactaa tccagttaaa aaaacggtat ttccctggtt ctgacccaac
     9601 attatcagtt ttacagaaca cacccattca tgtcgtaaag gacacattaa agaagtttct
     9661 gtccttcttt ccagttaaca ggctggatct gcagccggac ttatattgct tagtaaaagc
     9721 actttacagt tgcattcatg aagacatgaa gcgtcttttg cctgttgttc gggctccaaa
     9781 tattgatggc tcagatttgc actctgcagt cataattact tggatcaata tgtctacttc
     9841 aaataaaact agaccatttt ttgataactt actacaggat gaattacagc accttaaaaa
     9901 tgcagattat aacatcacaa ctcgaaaaac agtcgcagag aatgtctaca gactgaagca
     9961 cctgctctta gaaattggtt tcaacttggt ttataactgt gatgaaactg ctaaccttta
    10021 ccattgcctt gtagatgcag atatccctgt cagctatgtg actcctgctg atgttaggtc
    10081 cttcttaatg actttctctt ctcctgacac taattgccat attgggaagc tgccttgtcg
    10141 tcttcagcag actaacctaa aactttttca cagtttaaaa cttttagttg attactgttt
    10201 taaagatgct gaagaaagtg agtttgaagt tgagggactg cccctactca ttacactgga
    10261 cagtgtcttg cagatttttg atggtaaacg acccaagttt ctaacaacat accatgaatt
    10321 aattccatcg cgtaaagact tgtttatgaa caccttatac ttgaaataca gtagtgtttt
    10381 gttgaactgc aaagttgcaa aagtgtttga catttccagc tttgctgact tactctcttc
    10441 tgtgttgcct cgtgagtaca agaccaaaaa ctgtgcaaag tggaaagaca attttgccag
    10501 tgaatcttgg cttaagaacg catggcattt tatcagtgaa tcagtaagtg taacggatga
    10561 tcaggaagaa ccaaagccag catttgatgt cattgttgac atccttaaag actgggcatt
    10621 gcttccagga acaaagttca ctgtgtcaac cagtcagctt gtggttcctg agggagacgt
    10681 gttgattccc ctgagcctca tgcacattgc tgtgttccca aatgctcaga gtgataaggt
    10741 ttttcacgct ctgatgaaag ctggctgtat tcagctggct ttgaacaaaa tctgctctaa
    10801 agacagcgca ttagttcctc tgttgtcatg ccacacagca aacatagata gccctgcaag
    10861 catcttgaag gctgtgcatt atatggttca gacgtcaaca tttagaactg aaaaactaat
    10921 ggaaaatgac tttgaagcac ttttgatgta tttcaactgt aatttgagtc acttgatgtc
    10981 ccaagatgac ataaaaattt taaagtccct cccatgctac aaatccatca gtggccgcta
    11041 tatgagcatt gcaaaatttg gaacgtgcta tgtgcttacc aaaagtattc cttcagctga
    11101 agtggaaaaa tggacacagt catcctcttc cgcgtttctt gaagaaaagg tgcatttaaa
    11161 agaactctat gaggtgcttg gctgtgtgcc agtagatgat ctggaggtgt atttgaaaca
    11221 tcttctgcca aaaattgaaa atctctctta tgatgcaaag ttggagcacc tgatttatct
    11281 gaagaataga ctggcaagca tcgaggaacc gtcagagatt aaggagcaac tttttgaaaa
    11341 actggaaagc ttattgatta tccacgatgc caacaatcga ctaaagcaag caaaacattt
    11401 ctatgacaga actgtgagag tttttgaagt tatgcttcct gaaaaattgt ttattcctaa
    11461 ggagttcttt aaaaaattgg aacaagtaat caaacctaaa aatcaagctg catttatgac
    11521 gtcctgggtg gaattcttga gaaatattgg actgaagtac gcgctctccc agcagcagtt
    11581 gttacagttt gccaaggaaa tcagtgtgag ggcaaataca gaaaactggt ctaaagaaac
    11641 cctgcaaagt acagttgaca tccttctcca tcacatattc caagaacgaa tggatttgtt
    11701 atctggaaat tttctgaaag aactgtcctt aataccattc ttgtgtcctg aacgggcccc
    11761 cgctgagtac attcggtttc accctcagta ccaggaggta aacggaacac ttcctcttat
    11821 aaagttcaat ggagcacaag tgaatccaaa gttcaagcaa tgtgatgtac tccagctgct
    11881 gtggacatct tgccctattc ttccagagaa agccacaccg ttgagcatta aagaacaaga
    11941 aggcagtgac ctcgctccac aggaacagct tgaacaagtt ttaaatatgc ttaatgttaa
    12001 cctggacccc cctcttgata aggtcattaa taattgcaga aacatatgca acataacaac
    12061 tttggatgag gaaatggtaa aaactagagc aaaggtccta aggagcatat atgaatttct
    12121 gagtgcagaa aaacgagagt tccgttttca gcttcggggt gtggcctttg taatggtaga
    12181 agacggatgg aaacttctga agcctgagga agtagtgata aacctggagt atgaggctga
    12241 ttttaaacct tatctgtaca agctgccttt agagcttggc acttttcatc agctgttcaa
    12301 acatttaggt actgaagata tcatttccac taagcaatat gttgaagtgt taagccgaat
    12361 attcaaaagc tctgaaggaa agcagctaga ccctaatgaa atgcgtacag ttaagagagt
    12421 ggtttctggc ctattcaaga gtctacaaaa tgattcagtc aaggtgagga gtgacctgga
    12481 gaatgcccgg gacctcgcac tctaccttcc aagccaggat gggaagttgg tgaagtcaag
    12541 catcttggtg ttcgatgatg cgccacatta taaaagtagg atccagggga atattggcgt
    12601 gcagatgcta gttgatctta gccagtgcta cttagggaaa gaccatggat ttcacactaa
    12661 gctgataatg ctctttcctc aaaagcttcg acctcgtctg ctgagcagta tacttgaaga
    12721 gcagcttgat gaggagaccc ctaaagtgtg ccagtttggc gcattgtgct ctcttcaggg
    12781 aagactgcag cttctcttgt cttcagagca gttcatcaca ggactcattc gaatcatgaa
    12841 gcatgaaaat gataatgctt tcctggccaa tgaagaaaaa gccataagac tttgcaaagc
    12901 tctaagagaa gggctgaaag tttcctgttt tgagaagctt cagacaacat taagggttaa
    12961 aggttttaat cctattcccc atagcaggag tgaaactttc gcttttctaa agcgatttgg
    13021 caatgcagtc atcttgctct acatccaaca ttcagacagc aaagacatta actttctgct
    13081 agccttagcg atgacactta aatcagcaac tgacaatttg atttctgaca cgtcatactt
    13141 aattgctatg ctgggatgca atgacattta caggatcagt gagaagcttg acagtttagg
    13201 ggtgaaatac gactcctctg agccatcaaa actggaactc cccatgcctg gcacaccaat
    13261 acccgctgag atccattaca cgctacttat ggatccaatg aatgtttttt atcctgggga
    13321 atatgttggt taccttgtgg atgctgaagg tggtgatatc tatgggtcat accagccaac
    13381 atacacatac gcaattattg tgcaagaagt tgaaagagaa gatgctgaca atactagttt
    13441 cttaggaaag atctatcaga tcgatattgg ctacagtgaa tataagatag tcagctctct
    13501 tgatctgtac aagttctcaa ggcctgatga aagctcccaa aacagagaca gtgctcccac
    13561 cacaccaaca agccccaccg aattcctgac tcctggtctg agaagcatcc ctcctctttt
    13621 ctctggcaag gagagccaca agtctccctc caccaaacac cattccccca gaaagctcaa
    13681 ggtgaatgct ttaccagaaa tcttaaaaga agtgacatca gtggtggagc aagcttggaa
    13741 gcttccagaa tcagagcgga aaaagatcat tagacgcttg tatttgaagt ggcaccctga
    13801 caaaaatcca gaaaatcatg atattgctaa tgaagtgttc aagcacctgc agaatgaaat
    13861 caacagatta gaaaaacagg cttttctgga tcaaaatgca gacagagctt caagaagaac
    13921 attttcaacc tctgcatctc gatttcagtc agacaagtac tcatttcaaa gattttacac
    13981 ttcgtggaat caagaagcca caagtcataa atctgaaagg caacagcaaa gcaaagagaa
    14041 atgccctcct tctgctggac agacatactc tcaaaggttc tttgttcctc ccaccttcaa
    14101 gtcagtgggc aatccagtgg aagcccggag atggttaaga caagccagag caaacttctc
    14161 agctgccagg aatgaccttc acaaaaatgc caatgaatgg gtgtgcttca agtgttacct
    14221 ttccaccaag ctggctttga ttgcagccga ctatgctgtc agggggaaat ctgataaaga
    14281 tgtaaagcca actgcacttg cacaaaagat agaggagtac agtcagcagc tggaaggact
    14341 gacaaacgat gtgcacacat tggaagctta tggtgtagac agcttgaaaa caaggtaccc
    14401 tgatttgctt ccttttccgc agattcccaa tgacaggttc acatctgagg ttgccatgag
    14461 ggtgatggaa tgcactgcct gtatcatcat aaaacttgaa aattttatac aacagaaggt
    14521 gtgaacgtaa agaaaacagc agagccagct cttgaatgtg ttatagcaca aacacgaatc
    14581 gctacactcc attcagcttc attcccagta tctaggaatt gtgaagcaca cagcagagtg
    14641 ttctggaagc atttggaagc tgtatgactc ttaacagaaa ccgtaacaca aatgaaacct
    14701 gattttgaag ttaacagtga gctgcagagt ttctaggtgt gtttaaacaa ttgggtggca
    14761 cattattgaa ctgcacttta tgtaaccaaa gcttagcagt ttgttagata agattctgca
    14821 catgtctctg gttaggaggg agttaatttt atgtttttaa acatgttttt gaagtagtta
    14881 aaggaacact ggacagactg atttatttgg acatgtgagg ggaattttta agtggacact
    14941 tttagatacg ttattttctt atcagctgga tctgattatg gatttgttca gtttcccatc
    15001 tttcgttgga catttaaagt ggtacagtat tcaaccctga ctattacttg actacgagtg
    15061 tgaagatggg ccttggagcg cgctggacgc actttccatc cttgttttga gtttttagac
    15121 cttgtgtttg tgggcttcct gactcgtgaa gataaccgat ggaagtctca gagtgctgcc
    15181 tcacactacc agatattgct tctaaaaatg cttcccaaca tgatatttag caaaagagca
    15241 ttggagtttg tgtacatatt ttccacagat gacataattt gtatagtgtg gctgaacagg
    15301 atgcaatctt ttgtctaaag gtgctgcagt gaaaaaaaaa aaaccaaact gtctttcaat
    15361 atggcactta gtgggaattt aaacattttt accttatgca cattaaaatt gctcaaattg
    15421 ttgaggtgat agacagaagt ttacaaaggg aattatcagc ttgtactgtc ccccacgaat
    15481 gattgagaac tgacatttaa ttttcataat gttcaaaaga tctaacatac ataatttaac
    15541 atattctttt gcataaagtc aaagaaagga aataatagct tatgtaagta cactggctgt
    15601 aaatgatgct aaatatattt tatgcagtta agggcttaca tacagaacat gattttttta
    15661 ttttatttgt aaaagggaat gttaattgct tctgaatgtg aatcatgaat atttctgctg
    15721 ttaatattat gtgccatgat tttaataaaa aatgtatata gaaaatca
//
