LOCUS       NM_030233               3660 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus serum amyloid A-like 1 (Saal1), transcript variant 1,
            mRNA.
ACCESSION   NM_030233 XM_620495 XM_917891
VERSION     NM_030233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Sato,T., Fujii,R., Konomi,K., Yagishita,N., Aratani,S., Araya,N.,
            Aono,H., Yudoh,K., Suzuki,N., Beppu,M., Yamano,Y., Nishioka,K. and
            Nakajima,T.
  TITLE     Overexpression of SPACIA1/SAAL1, a newly identified gene that is
            involved in synoviocyte proliferation, accelerates the progression
            of synovitis in mice and humans
  JOURNAL   Arthritis Rheum 63 (12), 3833-3842 (2011)
   PUBMED   22127701
  REMARK    GeneRIF: Overexpression of SPACIA1/SAAL1, a newly identified gene
            that is involved in synoviocyte proliferation, accelerates the
            progression of synovitis in mice and humans.
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 3660)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090122.26.
            
            On Mar 28, 2023 this sequence version replaced NM_030233.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132193.1, AK033202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC090122.26        88145-88308
            165-278             AC090122.26        89829-89942
            279-362             AC090122.26        91730-91813
            363-442             AC090122.26        94713-94792
            443-502             AC090122.26        96126-96185
            503-618             AC090122.26        96289-96404
            619-799             AC090122.26        96845-97025
            800-882             AC090122.26        99088-99170
            883-1071            AC090122.26        99254-99442
            1072-1268           AC090122.26        105831-106027
            1269-1361           AC090122.26        108911-109003
            1362-3660           AC090122.26        109351-111649
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.48 cM"
     gene            1..3660
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="serum amyloid A-like 1"
                     /db_xref="GeneID:78935"
                     /db_xref="MGI:MGI:1926185"
     exon            1..164
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1454
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SAAL1; synoviocyte proliferation-associated in
                     collagen-induced arthritis 1; synoviocyte
                     proliferation-associated in collagen-induced arthritis
                     protein 1"
                     /codon_start=1
                     /product="protein SAAL1 isoform 1"
                     /protein_id="NP_084509.1"
                     /db_xref="CCDS:CCDS52253.1"
                     /db_xref="GeneID:78935"
                     /db_xref="MGI:MGI:1926185"
                     /translation="MDRNPSPPPPTCGSEDEEDLGGGDRIGSTVYSKHWLFGVLSGLI
                     QIVTPESGTSGSADEEEQADLAEEMENEICRVWDMSMDEDVALFLQEFKAPDIFMGVL
                     AKSPCPRLREICVGILGNMACFREICESISKNEDHGQVLLQCLCDSDPPTLLETCRLL
                     LTCLSQTEVASVWVRRIREHPSVYANVCFIMSSSTNVDLLVKVGEVVDKLFDLDEKLM
                     LEWIRKGATRLPGQPHEDSEEQPVFSIVPCVLEAAKQVRSENLEGLDVYMRILQLLTT
                     VDDGVQAIVQCPDTGNDTWRLLFDLVCHEFCQPDDPPVILQEQKTVLASVFSVLSAIS
                     ASRAEQEHLKIEEGDLPLIDSLIRVLQNMEHCQKKPENPSESDTEEPTICGPTQDDFH
                     MKILKDISCEFLSNIFQVLTKEKVAQGLKEGQLSKQKCSCAFQSLLPLYGPAVEDFVK
                     VVREVDEALADDLEDSFPSVKAQT"
     exon            165..278
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..362
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..442
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..502
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..618
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..799
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..882
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1071
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1268
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1361
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..3660
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="major polyA site"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: AATGAA"
     polyA_site      1560
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     polyA_site      1692
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: AATATA"
     polyA_site      2219
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: TATAAA"
     polyA_site      2925
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     polyA_site      2943
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     regulatory      3002..3007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: GATAAA"
     polyA_site      3021
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
                     /note="hexamer: AAGAAA"
     polyA_site      3660
                     /gene="Saal1"
                     /gene_synonym="5031425D22Rik; SPACIA1"
ORIGIN      
        1 ggcttccggt actgttggcg cgcatcggca tggatcgaaa cccgtctcct ccgccgccta
       61 cctgtggttc ggaggatgaa gaggacctgg gtgggggaga ccgcatcggg agcacggtct
      121 acagcaagca ctggctcttc ggcgtcctca gcgggctcat ccagattgtc acacctgaaa
      181 gtggcacatc tggctcagct gatgaggaag aacaggcaga tcttgctgaa gaaatggaga
      241 atgagatttg cagagtctgg gatatgtcca tggacgagga tgtggcttta tttctccaag
      301 aatttaaggc tcctgacata ttcatgggag tgctggccaa atccccgtgt ccccgattaa
      361 gagaaatctg tgtgggaatt ttagggaata tggcttgttt ccgggagata tgcgagtcca
      421 tcagcaagaa cgaggatcat gggcaggtgc tgctgcagtg tttgtgtgac tcagacccac
      481 ccaccctgct ggaaacttgc aggttgttgc ttacttgcct ttcccagaca gaagtggcca
      541 gtgtctgggt tagaaggatc cgggaacacc catctgtcta cgctaacgtt tgcttcatca
      601 tgtccagttc aacaaacgtt gacttgctgg tgaaggtcgg ggaggtcgtg gacaaactct
      661 ttgacttaga tgaaaaactc atgttggaat ggattagaaa gggggctacc cggcttccag
      721 gccaacccca cgaggactct gaagagcagc cagtgttttc cattgtaccc tgtgtgctgg
      781 aagctgccaa acaagtgcgc tctgaaaacc tggaggggct ggatgtttac atgcgcatct
      841 tacagctgct caccacggtg gatgacggcg tgcaagccat cgtgcagtgt cctgatactg
      901 gaaacgacac gtggcgttta ctctttgacc tggtgtgcca tgaattctgc cagcctgatg
      961 acccgcctgt catactgcag gaacagaaga cagtgctagc gtctgtcttc tcagtgctgt
     1021 cagccatcag tgcctcacgg gccgaacagg agcacctgaa gatagaagaa ggggatcttc
     1081 ctctaattga cagcctaatt cgggtattac aaaatatgga acattgtcag aagaaaccag
     1141 agaacccctc agagtctgat acagaagagc ctacgatctg tggtcccacc caagacgact
     1201 tccatatgaa gatcttgaag gacatttcat gtgaattcct ttctaatatt tttcaggtgt
     1261 taacaaagga aaaggtggct cagggactga aggagggcca gttaagcaag cagaagtgct
     1321 cctgcgcctt tcagagcctc ctgcccctct acggccctgc agtggaagac ttcgttaaag
     1381 tcgtacgtga ggtcgatgag gctcttgctg atgacctaga agacagcttc ccaagtgtga
     1441 aggcacagac ttaagaccca agttggagct tctgctgtcc aaggaataaa ctttgtgttt
     1501 tctatggttc gaagttggca tcgggatgat ggtgtgaatg aacattgtat cagaccttga
     1561 tttcgtagtc tgccctgatg cccgtctcct cccacttgtg tttgtaccag acgctggttt
     1621 accactgtca cccccctctc ctctgcattg agcgcatgtt actgatgctt ggttgaagaa
     1681 gaggaaatcc aagcttgttg tcacagttaa ggtgctgctg ggaaaagacc ccatggccat
     1741 gacaactctt acaaaggatg acgtttaact gggcctggct tccaggttca ttatcctgga
     1801 gggaagcatg gcagggtgca ggcaccgtaa ggctggagaa ggagctgaga gcgctacatc
     1861 ttgatttgca ggcagcagaa ggcacactgg gcaaagctct agcctaggag acctcaaagc
     1921 ctgcccccta cagtgacact tactccaata aggccacaca tcctagtagt gccagtcccc
     1981 atgggctatg cattcaagca cccgagtcta tgcatcacca tatttgtcag agcaaaggtt
     2041 ctttttccaa tattgagttg taaggttgtc ttcataatct ttacttgggc ttttatgtga
     2101 gaattttgta ttcattacaa gtacatttag ttgcagtgac agaaactcct catatggtag
     2161 cttcctccag tatccttgtg tatttcatac aatatatgca gagacaagtg cagaccgggg
     2221 aaccgtctgc ctcctttccc tgtctcagtg gcctaccatg cagacctttg cacacacaca
     2281 cttatttgta acagtgaggc ctgcgctgtg tcttccatcc acattcaggg gtgaaacaaa
     2341 agaggcaaag aggcgctcta ggaagttctg ccagccttcc ctgacctcct ctgttatgcg
     2401 ttgtatctaa agtccaggtc ctgctcactc tccataagag ggaaggtgta actaacttag
     2461 gcttggagag ccagcctgct agcatacagt agctgctctg agcctcaggt gtgctagctc
     2521 tcagcatcag ctgtgtggac tcctccagat tgtcagtaac aacctggaag cagtacttcc
     2581 tgtgccgtgg ttccacttgc actttcctgt ttcacagacg gaagagagac agacactggc
     2641 gttcagtgtg agtgcgttgg cgagactgtt ttcagcatga gtcggcagtt gtgcttcaga
     2701 acatgatttg cttgagaaga ttttaagtaa gatgagggac tgccacagcc tctctcgtct
     2761 gtgactccct ggtgcttcct cgctgtcccc agtgcttctt gatgaagaca ttcctggaac
     2821 catccaggca cttagcatcc agtctgcatt acttcacaca ccaaccagaa ttctttctcg
     2881 tttaaagaga ttctcagtta ccacaaagcc agctttataa acccattcca gtttccccca
     2941 gaatcttttt taacgtaagg gattggtctc catttatact tttccttaaa cgatttttat
     3001 tgataaaaca cagattctgt attgggggga taagaactca ctttctgatc tctagatgtt
     3061 gctgaaaagg attggagaac aggagcgcac actcaaactt gacctgagtg gcggatttac
     3121 cttatatacc ttcctgttct tggggctaac tgtaatgcta gactgtaagg ttatgtgttt
     3181 gtagttaggg accagctctt atgtgtgcca cactggatag gaattccgaa tcctgtgtcc
     3241 tctgtgactg actcggggtt tcagcagcgt gttgaagtca ctcatgctaa gacgaggtgt
     3301 tgtctcatgt agaagatgaa gcctgctgca cacggaatag cacttggatc tcttgctttt
     3361 gcttaccgtt gtgcatgcat gtttcatgtt gcttttatga gaacacactt tgagaacaca
     3421 aggacttctc agggtgaggc tgcccctcag aggacaagtt ctagagggag aggaaaaagg
     3481 gtgtggcgta agggccaaca tgctgtttcc tgcttcttga ttctggctgg ccccttacta
     3541 tttactctgt tggttctgtt tttcaggcac tacaaacttc acattggttt gatatgcatg
     3601 aaaacatcct gagtctgtaa aactagagaa atgtaaaaga aaacatggtc agggctaaaa
//
