LOCUS       NM_011316               2100 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serum amyloid A 4 (Saa4), mRNA.
ACCESSION   NM_011316 XM_001002620
VERSION     NM_011316.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Liu,Y., Liu,J., Liu,A., Yin,H., Burd,I. and Lei,J.
  TITLE     Maternal siRNA silencing of placental SAA2 mitigates preterm birth
            following intrauterine inflammation
  JOURNAL   Front Immunol 13, 902096 (2022)
   PUBMED   36211368
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Alldred,M.J., Lee,S.H., Petkova,E. and Ginsberg,S.D.
  TITLE     Expression profile analysis of vulnerable CA1 pyramidal neurons in
            young-Middle-Aged Ts65Dn mice
  JOURNAL   J Comp Neurol 523 (1), 61-74 (2015)
   PUBMED   25131634
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   de Beer,M.C., de Beer,F.C., Gerardot,C.J., Cecil,D.R., Webb,N.R.,
            Goodson,M.L. and Kindy,M.S.
  TITLE     Structure of the mouse Saa4 gene and its linkage to the serum
            amyloid A gene family
  JOURNAL   Genomics 34 (1), 139-142 (1996)
   PUBMED   8661036
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Butler,A. and Whitehead,A.S.
  TITLE     Mapping of the mouse serum amyloid A gene cluster by long-range
            polymerase chain reaction
  JOURNAL   Immunogenetics 44 (6), 468-474 (1996)
   PUBMED   8824159
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Butler,A., Rochelle,J.M., Seldin,M.F. and Whitehead,A.S.
  TITLE     The gene encoding the mouse serum amyloid A protein, apo-SAA5, maps
            to proximal chromosome 7
  JOURNAL   Immunogenetics 42 (2), 153-155 (1995)
   PUBMED   7607707
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   de Beer,M.C., Kindy,M.S., Lane,W.S. and de Beer,F.C.
  TITLE     Mouse serum amyloid A protein (SAA5) structure and expression
  JOURNAL   J Biol Chem 269 (6), 4661-4667 (1994)
   PUBMED   8308037
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   de Beer,M.C., de Beer,F.C., Beach,C.M., Carreras,I. and Sipe,J.D.
  TITLE     Mouse serum amyloid A protein. Complete amino acid sequence and
            mRNA analysis of a new isoform
  JOURNAL   Biochem J 283 (Pt 3) (Pt 3), 673-678 (1992)
   PUBMED   1590757
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   de Beer,M.C., Beach,C.M., Shedlofsky,S.I. and de Beer,F.C.
  TITLE     Identification of a novel serum amyloid A protein in BALB/c mice
  JOURNAL   Biochem J 280 (Pt 1) (Pt 1), 45-49 (1991)
   PUBMED   1741755
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Stearman,R.S., Lowell,C.A., Peltzman,C.G. and Morrow,J.F.
  TITLE     The sequence and structure of a new serum amyloid A gene
  JOURNAL   Nucleic Acids Res 14 (2), 797-809 (1986)
   PUBMED   3003697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134068.1 and AC090122.26.
            
            On Sep 8, 2016 this sequence version replaced NM_011316.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02554.1, CJ134068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-651               CJ134068.1         2-652
            652-2100            AC090122.26        69366-70814
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.53 cM"
     gene            1..2100
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="serum amyloid A 4"
                     /db_xref="GeneID:20211"
                     /db_xref="MGI:MGI:98224"
     exon            1..173
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /inference="alignment:Splign:2.1.0"
     exon            174..268
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..570
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="serum amyloid A-4 protein; amyloid A-5 protein"
                     /codon_start=1
                     /product="serum amyloid A-4 protein precursor"
                     /protein_id="NP_035446.1"
                     /db_xref="CCDS:CCDS21283.1"
                     /db_xref="GeneID:20211"
                     /db_xref="MGI:MGI:98224"
                     /translation="MRLATVIVLCSLFLGVSGDGWYSFFREAVQGTWDLWRAYRDNLE
                     ANYQNADQYFYARGNYEAQQRGSGGIWAAKIISTSRKYFQGLLNRYYFGIRNHGLETL
                     QATQKAEEWGRSGKNPNHFRPEGLPEKF"
     exon            269..407
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /inference="alignment:Splign:2.1.0"
     exon            408..2100
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      698..703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="hexamer: ATTAAA"
     polyA_site      717
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="major polyA site"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="hexamer: ATTAAA"
     polyA_site      2096
                     /gene="Saa4"
                     /gene_synonym="Saa-4; Saa-5"
                     /note="major polyA site"
ORIGIN      
        1 attaatgtta aagccaggag agagaaagca gcaggcactc catggagaga aggtcctaac
       61 ggtcccaatt cctctgaaac ttccaccaga gaaagggcca tccatcgatg tcacacttct
      121 ccagggaggt cttgctcgtg attcactcct gagatccgtt tcatatagag tcgcatcatg
      181 aggcttgcca ccgtcattgt cctctgttct ttgttcctgg gagtcagtgg tgatggctgg
      241 tattcattct tcagggaagc cgtacaaggg acttgggact tgtggagagc ctatcgggac
      301 aacctagaag ctaattacca aaatgcagac caatacttct atgctcgtgg gaactacgag
      361 gcccaacaga ggggctctgg gggcatctgg gctgctaaaa taatcagcac cagcaggaaa
      421 tacttccagg gcctcctaaa ccgatattat tttggaatca ggaaccatgg attggaaacc
      481 ctgcaggcta cccagaaagc cgaggaatgg ggccgcagtg gcaaaaaccc caatcacttc
      541 cgacccgagg gccttcctga gaagttctga gtctgccact cagacagcac tcagtggact
      601 aggctgtgag ccacaagcct ctctctgtga tagtcactca gcttggtgtc cacaagaagc
      661 acggagaagc tagagatgcc cagtaaacac tttgccaatt aaatttgtcg atggaaacag
      721 ggaactctca gaaatacttt ctggggagaa agagttgcta tggatcacag aaaataagca
      781 gaggaaaaag gtgtgaccac caggtaatgg cctcaaacca tgaaggtccc tcacacaacc
      841 ccagcagatc tgctctagcc tttaaccaca ccaacgtctg ctaagcaggc ttgagctagc
      901 aaagcattgc ccaccatgca ggggcttctc tgaaaagtgg agtttgctct gagataagcc
      961 ctgggaacct gcccatcaac ttctcccctg gacactggtc aggtgtctcc ctaccccacc
     1021 atcttctggt cacaaccggt ctctgtttta ttggtactgg tgtacctctg ccttatcaat
     1081 catgccctct tcactaactg caggccttgt cccctgcgac ctctttcaag tagggaacgc
     1141 tatgtcgaga atgcctcatc ttagccttgg gaactctaac ttggaaactg cactggggac
     1201 cagggatatc gtttggtata gtgcttgcta agcgtgcatg cataggtaga ttctcagaac
     1261 tgcataaatc tggtgatggt atacatttat aatcctagca ctggggaggc agacagaggc
     1321 tgacagacca gaagttcaag gccagccctg gctatgtatt gaatttgaat ttgaggtcag
     1381 tttgggatac atgagaccct ctgtccccat aaagtgtaca cacacacaca cacacacaca
     1441 cacacacaca cacacacaca cacacaccac actcccacat acaccatgac ccccacacac
     1501 accaacacac acacacacca acacacacac acacacacac acacacacac acacacacac
     1561 acacaccaca ccacaccaca ccagtgccta gctcagctca ggttctaact agtcttggcc
     1621 aacactacct aagaagtggc gatcgcatca ctctttcttg gctttattct cattgtcttt
     1681 tgatcgaaac aaaagtctgc tttccgctct agaagggaag caagacacaa catcactgag
     1741 cgggagtaaa tgaattggtt ccctcataaa gcaaaggcat tcttctagag aaggccagtc
     1801 tggtttgtag ggacgagaag gcacggatga agacggagat tctagtcata cgggagcaac
     1861 tgctatgcca aagccaggtc cctaggcgga agactaactc cacaggagca gagaaagaaa
     1921 cgtggggagg atggatggag cctgtgggat ggaggatgag gaacttggga ttcatcctgc
     1981 tcttgtcaca tgttgtcaca tgttgccact ttcagagtgt ggcatacttc actatattgg
     2041 cccatctgcc tatctgtctg cagggaaaat atattaaaaa agccaaagga taaagatgtc
//
