LOCUS       NM_011315                531 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus serum amyloid A 3 (Saa3), mRNA.
ACCESSION   NM_011315
VERSION     NM_011315.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 531)
  AUTHORS   Huang,S., Jiang,Y., Li,J., Mao,L., Qiu,Z., Zhang,S., Jiang,Y.,
            Liu,Y., Liu,W., Xiong,Z., Zhang,W., Liu,X., Zhang,Y., Bai,X. and
            Guo,B.
  TITLE     Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism
            of Cholesterol
  JOURNAL   Adv Sci (Weinh) 11 (24), e2307818 (2024)
   PUBMED   38613835
  REMARK    GeneRIF: Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic
            Metabolism of Cholesterol.
REFERENCE   2  (bases 1 to 531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 531)
  AUTHORS   Ji,A., Trumbauer,A.C., Noffsinger,V.P., Meredith,L.W., Dong,B.,
            Wang,Q., Guo,L., Li,X., De Beer,F.C., Webb,N.R., Tannock,L.R.,
            Starr,M.E., Waters,C.M. and Shridas,P.
  TITLE     Deficiency of Acute-Phase Serum Amyloid A Exacerbates
            Sepsis-Induced Mortality and Lung Injury in Mice
  JOURNAL   Int J Mol Sci 24 (24), 17501 (2023)
   PUBMED   38139330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 531)
  AUTHORS   Ji,A., Trumbauer,A.C., Noffsinger,V.P., de Beer,F.C., Webb,N.R.,
            Tannock,L.R. and Shridas,P.
  TITLE     Serum amyloid A augments the atherogenic effects of cholesteryl
            ester transfer protein
  JOURNAL   J Lipid Res 64 (5), 100365 (2023)
   PUBMED   37004910
REFERENCE   5  (bases 1 to 531)
  AUTHORS   Baumann,K.K., Liang,W.S., Quaranta,D.V., Wilson,M.L., Asrat,H.S.,
            Thysell,J.A., Sarchi,A.V., Banks,W.A. and Erickson,M.A.
  TITLE     Effects of Ozone on Sickness and Depressive-like Behavioral and
            Biochemical Phenotypes and Their Regulation by Serum Amyloid A in
            Mice
  JOURNAL   Int J Mol Sci 24 (2), 1612 (2023)
   PUBMED   36675130
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 531)
  AUTHORS   Meek,R.L., Eriksen,N. and Benditt,E.P.
  TITLE     Murine serum amyloid A3 is a high density apolipoprotein and is
            secreted by macrophages
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 7949-7952 (1992)
   PUBMED   1518819
REFERENCE   7  (bases 1 to 531)
  AUTHORS   Shimizu,H., Mitomo,K. and Yamamoto,K.
  TITLE     Regulation of mouse serum amyloid A3 gene expression during acute
            phase reaction
  JOURNAL   Folia Histochem Cytobiol 30 (4), 141-142 (1992)
   PUBMED   1303890
REFERENCE   8  (bases 1 to 531)
  AUTHORS   Rienhoff,H.Y. Jr. and Groudine,M.
  TITLE     Regulation of amyloid A gene expression in cultured cells
  JOURNAL   Mol Cell Biol 8 (9), 3710-3716 (1988)
   PUBMED   3221863
REFERENCE   9  (bases 1 to 531)
  AUTHORS   Lowell,C.A., Potter,D.A., Stearman,R.S. and Morrow,J.F.
  TITLE     Structure of the murine serum amyloid A gene family. Gene
            conversion
  JOURNAL   J Biol Chem 261 (18), 8442-8452 (1986)
   PUBMED   3013853
REFERENCE   10 (bases 1 to 531)
  AUTHORS   Stearman,R.S., Lowell,C.A., Peltzman,C.G. and Morrow,J.F.
  TITLE     The sequence and structure of a new serum amyloid A gene
  JOURNAL   Nucleic Acids Res 14 (2), 797-809 (1986)
   PUBMED   3003697
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC090122.26.
            
            On Nov 17, 2006 this sequence version replaced NM_011315.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055885.1, BE306167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC090122.26        83130-83159
            31-125              AC090122.26        83702-83796
            126-264             AC090122.26        86079-86217
            265-531             AC090122.26        86542-86808
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.51 cM"
     gene            1..531
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /note="serum amyloid A 3"
                     /db_xref="GeneID:20210"
                     /db_xref="MGI:MGI:98223"
     exon            1..30
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            31..125
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..264
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /inference="alignment:Splign:2.1.0"
     exon            265..531
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      511..516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /note="hexamer: AATAAA"
     polyA_site      531
                     /gene="Saa3"
                     /gene_synonym="l7R3; Saa-3"
                     /note="major polyA site"
ORIGIN      
        1 tggggtccca gaaggagctc gcagcacgag caggatgaag ccttccattg ccatcattct
       61 ttgcatcttg atcctgggag ttgacagcca aagatgggtc cagttcatga aagaagctgg
      121 tcaagggtct agagacatgt ggcgagccta ctctgacatg aagaaagcta actggaaaaa
      181 ctcagacaaa tacttccatg ctcgggggaa ctatgatgct gcccggaggg gtcccggggg
      241 agcctgggct gctaaagtca tcagcgatgc cagagaggct gttcagaagt tcacgggaca
      301 tggagcagag gactcaagag ctgaccagtt tgccaatgag tggggccgga gtggcaaaga
      361 ccccaaccac ttccgacctg ctggcctgcc taaaagatac tgagttttct cttcctgttg
      421 ttcccagtca tgctgccccc cgagaagagg agcaactact gggttgagat attttctaaa
      481 atctggatcc ctaaacatcc caatgtgctg aataaatact tgtgaaatgc a
//
