LOCUS       NM_011314                609 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serum amyloid A 2 (Saa2), transcript variant 1, mRNA.
ACCESSION   NM_011314
VERSION     NM_011314.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 609)
  AUTHORS   Lang,Y., Wang,Q., Sheng,Q., Lu,S., Yang,M., Kong,Z., Gao,Y.,
            Fan,X., Shen,N., Wang,R. and Lv,Z.
  TITLE     FTO-mediated m6A modification of serum amyloid A2 mRNA promotes
            podocyte injury and inflammation by activating the NF-kappaB
            signaling pathway
  JOURNAL   FASEB J 38 (2), e23409 (2024)
   PUBMED   38193628
  REMARK    GeneRIF: FTO-mediated m6A modification of serum amyloid A2 mRNA
            promotes podocyte injury and inflammation by activating the
            NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 609)
  AUTHORS   Ma,J., Pang,X., Wang,T., Ning,M., Liang,Y., Li,X., Tian,X., Mo,Y.,
            Laher,I. and Li,S.
  TITLE     Acute aerobic exercise regulation of myocardial calcium homeostasis
            involves CASQ1, CASQ2, and TRDN
  JOURNAL   J Appl Physiol (1985) 135 (4), 707-716 (2023)
   PUBMED   37589058
  REMARK    GeneRIF: Acute aerobic exercise regulation of myocardial calcium
            homeostasis involves CASQ1, CASQ2, and TRDN.
REFERENCE   3  (bases 1 to 609)
  AUTHORS   He,C., Konishi,R., Harata,A., Nakamura,Y., Mizuno,R., Yoda,M.,
            Toi,M., Kawaguchi,K. and Kawaoka,S.
  TITLE     Serum amyloid alpha 1-2 are not required for liver inflammation in
            the 4T1 murine breast cancer model
  JOURNAL   Front Immunol 14, 1097788 (2023)
   PUBMED   36817472
  REMARK    GeneRIF: Serum amyloid alpha 1-2 are not required for liver
            inflammation in the 4T1 murine breast cancer model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 609)
  AUTHORS   Baumann,K.K., Liang,W.S., Quaranta,D.V., Wilson,M.L., Asrat,H.S.,
            Thysell,J.A., Sarchi,A.V., Banks,W.A. and Erickson,M.A.
  TITLE     Effects of Ozone on Sickness and Depressive-like Behavioral and
            Biochemical Phenotypes and Their Regulation by Serum Amyloid A in
            Mice
  JOURNAL   Int J Mol Sci 24 (2), 1612 (2023)
   PUBMED   36675130
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 609)
  AUTHORS   Liu,Y., Liu,J., Liu,A., Yin,H., Burd,I. and Lei,J.
  TITLE     Maternal siRNA silencing of placental SAA2 mitigates preterm birth
            following intrauterine inflammation
  JOURNAL   Front Immunol 13, 902096 (2022)
   PUBMED   36211368
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 609)
  AUTHORS   de Beer,M.C., de Beer,F.C., Beach,C.M., Carreras,I. and Sipe,J.D.
  TITLE     Mouse serum amyloid A protein. Complete amino acid sequence and
            mRNA analysis of a new isoform
  JOURNAL   Biochem J 283 (Pt 3) (Pt 3), 673-678 (1992)
   PUBMED   1590757
REFERENCE   7  (bases 1 to 609)
  AUTHORS   Rienhoff,H.Y. Jr. and Groudine,M.
  TITLE     Regulation of amyloid A gene expression in cultured cells
  JOURNAL   Mol Cell Biol 8 (9), 3710-3716 (1988)
   PUBMED   3221863
REFERENCE   8  (bases 1 to 609)
  AUTHORS   Yamamoto,K., Goto,N., Kosaka,J., Shiroo,M., Yeul,Y.D. and Migita,S.
  TITLE     Structural diversity of murine serum amyloid A genes. Evolutionary
            implications
  JOURNAL   J Immunol 139 (5), 1683-1688 (1987)
   PUBMED   3624868
REFERENCE   9  (bases 1 to 609)
  AUTHORS   Lowell,C.A., Potter,D.A., Stearman,R.S. and Morrow,J.F.
  TITLE     Structure of the murine serum amyloid A gene family. Gene
            conversion
  JOURNAL   J Biol Chem 261 (18), 8442-8452 (1986)
   PUBMED   3013853
REFERENCE   10 (bases 1 to 609)
  AUTHORS   Yamamoto,K., Shiroo,M. and Migita,S.
  TITLE     Diverse gene expression for isotypes of murine serum amyloid A
            protein during acute phase reaction
  JOURNAL   Science 232 (4747), 227-229 (1986)
   PUBMED   3456645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090122.26.
            
            On Mar 28, 2020 this sequence version replaced NM_011314.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11130.1, CB593624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC090122.26        46942-46973         c
            33-127              AC090122.26        46425-46519         c
            128-266             AC090122.26        45250-45388         c
            267-609             AC090122.26        44493-44835         c
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.56 cM"
     gene            1..609
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /note="serum amyloid A 2"
                     /db_xref="GeneID:20209"
                     /db_xref="MGI:MGI:98222"
     exon            1..32
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..127
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..405
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /note="serum amyloid A-2 protein; serum amyloid A 1"
                     /codon_start=1
                     /product="serum amyloid A-2 protein preproprotein"
                     /protein_id="NP_035444.1"
                     /db_xref="CCDS:CCDS21285.1"
                     /db_xref="GeneID:20209"
                     /db_xref="MGI:MGI:98222"
                     /translation="MKLLTSLVFCSLLLGVCHGGFFSFIGEAFQGAGDMWRAYTDMKE
                     AGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR
                     HGRSGKDPNYYRPPGLPAKY"
     exon            128..266
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..609
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      586..591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /note="hexamer: AATAAA"
     polyA_site      609
                     /gene="Saa2"
                     /gene_synonym="Saa-2; Saa1"
                     /note="major polyA site"
ORIGIN      
        1 atagaccacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc
       61 ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttat tggggaggct
      121 ttccaagggg ctggagacat gtggcgagcc tacactgaca tgaaggaagc tggctggaaa
      181 gatggagaca aatacttcca tgctcggggg aactatgatg ctgcccaaag gggtcccggg
      241 ggagtctggg ctgctgagaa aatcagtgat gcaagagaga gctttcagga attcttcggc
      301 agaggacacg aggacaccat ggctgaccag gaagccaaca gacatggccg cagtggcaaa
      361 gaccccaatt actacagacc tcctggactg cctgccaaat actgagagtc ctcctattag
      421 ttcagaaggc tgtgttgggg tcctgagggt ggggtctggg cttcctatct aggaacactg
      481 aagatgctct ctggggcaac atagtatacc tctcatgtgt gtatcccaca agggtttcag
      541 aatggagtta ctcgagcagt agtaactgct tgaggaggag agggtaataa acaggaactt
      601 ggaagtgga
//
