LOCUS       NM_001357493             612 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus serum amyloid A 1 (Saa1), transcript variant 2, mRNA.
ACCESSION   NM_001357493 XM_006540726
VERSION     NM_001357493.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 612)
  AUTHORS   Wang,Q., Li,H., Lu,H., Wang,S., Li,Y., Zhang,Z., Han,J., Yang,Z.,
            Yang,Y. and Hong,Y.
  TITLE     SAA1 exacerbates pancreatic beta-cell dysfunction through
            activation of NF-kappaB signaling in high-fat diet-induced type 2
            diabetes mice
  JOURNAL   Mol Cell Endocrinol 576, 112043 (2023)
   PUBMED   37574124
  REMARK    GeneRIF: SAA1 exacerbates pancreatic beta-cell dysfunction through
            activation of NF-kappaB signaling in high-fat diet-induced type 2
            diabetes mice.
REFERENCE   2  (bases 1 to 612)
  AUTHORS   Xiao,Y., Ni,L., Shi,H., Yang,K., Yang,J., Zhao,J., Liu,J. and
            Luo,P.
  TITLE     SAA1 deficiency alleviates cardiac remodeling by inhibiting
            NF-kappaB/p38/JNK and TGFbeta/Smad pathways
  JOURNAL   FASEB J 37 (5), e22911 (2023)
   PUBMED   37022639
  REMARK    GeneRIF: SAA1 deficiency alleviates cardiac remodeling by
            inhibiting NF-kappaB/p38/JNK and TGFbeta/Smad pathways.
REFERENCE   3  (bases 1 to 612)
  AUTHORS   He,C., Konishi,R., Harata,A., Nakamura,Y., Mizuno,R., Yoda,M.,
            Toi,M., Kawaguchi,K. and Kawaoka,S.
  TITLE     Serum amyloid alpha 1-2 are not required for liver inflammation in
            the 4T1 murine breast cancer model
  JOURNAL   Front Immunol 14, 1097788 (2023)
   PUBMED   36817472
  REMARK    GeneRIF: Serum amyloid alpha 1-2 are not required for liver
            inflammation in the 4T1 murine breast cancer model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 612)
  AUTHORS   Baumann,K.K., Liang,W.S., Quaranta,D.V., Wilson,M.L., Asrat,H.S.,
            Thysell,J.A., Sarchi,A.V., Banks,W.A. and Erickson,M.A.
  TITLE     Effects of Ozone on Sickness and Depressive-like Behavioral and
            Biochemical Phenotypes and Their Regulation by Serum Amyloid A in
            Mice
  JOURNAL   Int J Mol Sci 24 (2), 1612 (2023)
   PUBMED   36675130
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 612)
  AUTHORS   Liu,Y., Liu,J., Liu,A., Yin,H., Burd,I. and Lei,J.
  TITLE     Maternal siRNA silencing of placental SAA2 mitigates preterm birth
            following intrauterine inflammation
  JOURNAL   Front Immunol 13, 902096 (2022)
   PUBMED   36211368
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 612)
  AUTHORS   Rienhoff,H.Y. Jr. and Groudine,M.
  TITLE     Regulation of amyloid A gene expression in cultured cells
  JOURNAL   Mol Cell Biol 8 (9), 3710-3716 (1988)
   PUBMED   3221863
REFERENCE   7  (bases 1 to 612)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   8  (bases 1 to 612)
  AUTHORS   Lowell,C.A., Potter,D.A., Stearman,R.S. and Morrow,J.F.
  TITLE     Structure of the murine serum amyloid A gene family. Gene
            conversion
  JOURNAL   J Biol Chem 261 (18), 8442-8452 (1986)
   PUBMED   3013853
REFERENCE   9  (bases 1 to 612)
  AUTHORS   Yamamoto,K., Shiroo,M. and Migita,S.
  TITLE     Diverse gene expression for isotypes of murine serum amyloid A
            protein during acute phase reaction
  JOURNAL   Science 232 (4747), 227-229 (1986)
   PUBMED   3456645
REFERENCE   10 (bases 1 to 612)
  AUTHORS   Johnson,P.M., Husby,G., Natvig,J.B., Anders,R.F. and Linder,E.
  TITLE     Identification in human placentae of antigenic activity related to
            the amyloid serum protein SAA
  JOURNAL   Scand J Immunol 6 (4), 319-325 (1977)
   PUBMED   67636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090122.26.
            
            On Oct 28, 2017 this sequence version replaced XM_006540726.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB949542.1, CB949918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC090122.26        55826-55857
            33-127              AC090122.26        56280-56374
            128-266             AC090122.26        57412-57550
            267-612             AC090122.26        57964-58309
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.54 cM"
     gene            1..612
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /note="serum amyloid A 1"
                     /db_xref="GeneID:20208"
                     /db_xref="MGI:MGI:98221"
     exon            1..32
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /inference="alignment:Splign:2.1.0"
     exon            33..127
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..405
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /note="serum amyloid A-1 protein; serum amyloid A 2"
                     /codon_start=1
                     /product="serum amyloid A-1 protein precursor"
                     /protein_id="NP_001344422.1"
                     /db_xref="CCDS:CCDS21284.1"
                     /db_xref="GeneID:20208"
                     /db_xref="MGI:MGI:98221"
                     /translation="MKLLTSLVFCSLLLGVCHGGFFSFVHEAFQGAGDMWRAYTDMKE
                     ANWKNSDKYFHARGNYDAAQRGPGGVWAAEKISDGREAFQEFFGRGHEDTIADQEANR
                     HGRSGKDPNYYRPPGLPDKY"
     exon            128..266
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..612
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      589..594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /note="hexamer: AATAAA"
     polyA_site      612
                     /gene="Saa1"
                     /gene_synonym="Saa-1; Saa2"
                     /note="major polyA site"
ORIGIN      
        1 atagatcacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc
       61 ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttgt tcacgaggct
      121 ttccaagggg ctggggacat gtggcgagcc tacactgaca tgaaggaagc taactggaaa
      181 aactcagaca aatacttcca tgctcggggg aactatgatg ctgctcaaag gggtcccggg
      241 ggagtctggg ctgctgagaa aatcagtgat ggaagagagg cctttcagga attcttcggc
      301 agaggacatg aggacaccat tgctgaccag gaagccaaca gacatggccg cagtggcaaa
      361 gaccccaatt actacagacc tcctggactg cctgacaaat actgagcgtc ctcctattag
      421 ctcagtaggt tgtgctgggg gcctgagggt ggggtctggg cttcttccta cctaggaaca
      481 ctgaagatgc tctctgggga aacattgtat atctctcatg tgtgtatccc acaagggttt
      541 cagaactgag ttactcttgc agtagtaact gcttgaggag gagagggtaa taaacagaaa
      601 cttggaagtg ga
//
