LOCUS       NM_001309847            2313 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus synaptojanin 2 binding protein Cox16 readthrough
            (S2bpcox16), transcript variant 1, mRNA.
ACCESSION   NM_001309847
VERSION     NM_001309847.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Tsuchida,K., Nakatani,M., Matsuzaki,T., Yamakawa,N., Liu,Z.,
            Bao,Y., Arai,K.Y., Murakami,T., Takehara,Y., Kurisaki,A. and
            Sugino,H.
  TITLE     Novel factors in regulation of activin signaling
  JOURNAL   Mol Cell Endocrinol 225 (1-2), 1-8 (2004)
   PUBMED   15451561
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Matsuzaki,T., Hanai,S., Kishi,H., Liu,Z., Bao,Y., Kikuchi,A.,
            Tsuchida,K. and Sugino,H.
  TITLE     Regulation of endocytosis of activin type II receptors by a novel
            PDZ protein through Ral/Ral-binding protein 1-dependent pathway
  JOURNAL   J Biol Chem 277 (21), 19008-19018 (2002)
   PUBMED   11882656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154908.4, AK148649.1 and AC132391.3.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring Synj2bp (synaptojanin 2
            binding protein) and Cox16 (cytochrome c oxidase assembly protein
            16) genes on chromosome 12. The readthrough transcripts encode
            fusion proteins that share sequence similarity with each individual
            gene product. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jun
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148649.1, SRR7345562.262961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 24071, 66272
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC154908.4         86635-86663         c
            30-496              AK148649.1         3-469
            497-497             AC132391.3         14341-14341
            498-869             AK148649.1         471-842
            870-870             AC132391.3         23230-23230
            871-2313            AK148649.1         844-2286
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 37.6 cM"
     gene            1..2313
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="synaptojanin 2 binding protein Cox16 readthrough"
                     /db_xref="GeneID:105940408"
                     /db_xref="MGI:MGI:5141963"
     exon            1..196
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..681
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activin receptor-interacting protein 2a; Synj2bp-cox16
                     readthrough; Synaptojanin-2-binding protein; Activin
                     receptor-interacting protein 2; Activin
                     receptor-interacting protein 4; Mitochondrial outer
                     membrane protein 25"
                     /codon_start=1
                     /product="Synj2bp-cox16 protein isoform 1"
                     /protein_id="NP_001296776.1"
                     /db_xref="GeneID:105940408"
                     /db_xref="MGI:MGI:5141963"
                     /translation="MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYV
                     SRIKEDGAAAQDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGCAVSLRVQHRLLV
                     VGGSFGLREFSQIRYDAVTIKIDPELEKKLKVNKITLESEYEKIKDSTFENWKNIRGP
                     RPWEDPQLLQGRNPETLKPKTT"
     exon            197..333
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     exon            334..429
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     exon            430..501
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     exon            502..564
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     exon            565..2313
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="hexamer: ATTAAA"
     polyA_site      823
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="major polyA site"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="hexamer: AATAAA"
     regulatory      1091..1096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
                     /note="hexamer: TATAAA"
     polyA_site      1096
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
     polyA_site      1113
                     /gene="S2bpcox16"
                     /gene_synonym="Arip2; ARIP2a; Gm20498; Omp25; Synj2bp;
                     Synj2bp-cox16"
ORIGIN      
        1 ggtttccttt tccggtctga ccgctgagga aactgtaaaa gctatgctgg ggaggcagcg
       61 cggagcttga ttcaccttca cctgctctgg ccacccgctg acccggggtt tccggccgga
      121 gagcagtcag atatgaacgg acgggtggat tatttagtca cggaggaaga gatcaacctg
      181 acgagaggac cttcggggct gggcttcaac atcgtcggtg ggacagatca acagtatgtc
      241 tccaacgaca gtggcatcta cgtcagccgt atcaaagagg atggggctgc ggcccaggat
      301 gggcggctcc aggagggtga taagatcctc tcggtaaatg gccaagatct gaagaacctg
      361 ctgcaccaag atgctgtaga cctcttccgt aatgcgggat gtgctgtgtc cctgagagta
      421 cagcacaggt tgctggttgt tggaggttct tttggtcttc gtgaattttc acaaatccgg
      481 tacgatgctg tgacaattaa gattgatcct gaattggaga aaaaattgaa agtgaataaa
      541 ataactttag agtcagagta tgagaaaata aaggactcca cttttgaaaa ctggaagaat
      601 attcgaggtc cgaggccttg ggaagatcct caactcctcc aaggacgaaa cccagaaact
      661 cttaagccta agacaacctg actgtgctca attttttgtt ttgttttgtt tttttcaatg
      721 aaatgttctc atcttgatat gtaggaagaa gattccagac ctgtggaaac ctggatgtga
      781 atagtatgat ggcagaaatt tttgattaaa aagtcaagta taagtctgta tgcttttcag
      841 tctacttgca aatgaaaata gtagtgttga acacacacac acacacacac acacacacac
      901 actccactac caatctataa aaaaaatgtg actactactt ccataacatg ccatgaattc
      961 tactttccta ttacccactc atactctttc tagtcactgg aatatttttg ctatctcagt
     1021 ttggtttctg atgaaaatca taggcataga tccagatttt cccaataaaa tggtgacttt
     1081 atgttaagct tataaataag tgatcataat ctagtaatgg tcttatattt tattcctaat
     1141 actttataac tcagcctctg aaacctgttc atatgtagtg catgatggta agaagatgtg
     1201 acatttttgt tgaggttatg aaaaggctgt gttgtgcagt agcataatct gggagttggt
     1261 tctagtttgt ttgttagatc tcctgtagtc tgatccttaa acaaaatggt aggaaaggta
     1321 agagttttgt ttttaaaacc agtagctcat tttcttcttt tacttctgtt taggcagtct
     1381 caattctcta ccttgtgtaa tctcagtact gaattctaaa tacctgaagt tttagctgaa
     1441 atattcccac tataactatt ccaaatgata aaaacacccc acttttctct caatcaattt
     1501 taattaattt caacacatta gttttagtga tcttagaata ttacttaatg gataattaca
     1561 aactgacttc aaagttagtg gcttagttat ttttctgttg ctgtgataaa acactgacca
     1621 aaagcaactt ggaaaataaa gggtttattt tgcttacact cttagtcagg gtaggaactc
     1681 aaggcaggga ctgatgcatt ggccatggag gaacatggct tcctggcttg cttcccattt
     1741 cttcctcaac ttcctttctt atacggccga ggatcactcc ggatagcacc atctacaatg
     1801 ggcagttctc ctacatcaat cattgttcag aaaaattacc tgtagacttg cctacaaaat
     1861 catatagatg ttttctggat tatgattcct tcttctcaga tgaccctagg ttgtatctat
     1921 ttgatatgaa aaccaaccat aataatctac ccattgtcaa tttgacacag catttcctaa
     1981 gccacaaccc ttcttgtttg tccatggtgt catgctaatg tcatatgaca gtgtgaaaca
     2041 ttccaatttt taaaagtccc atagttttta aatttttcaa cactttaagt gtccagtttt
     2101 ctttttatat agtacctaat ctctttcaaa atacaaaggc tctttaagtc cccaaattta
     2161 tctgaaatac taaaagtctc tctaactgtg ggctcctgta agacaaaaca agaacaaaac
     2221 taaagacaaa gaagttaaag actttttttt accctgggag ggaagaacta gggcatgcat
     2281 agtcacaatc aaataaagtc aaaatccaaa tcc
//
