LOCUS       NM_053190               2512 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sphingosine-1-phosphate receptor 5 (S1pr5), mRNA.
ACCESSION   NM_053190
VERSION     NM_053190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Delconte,R.B., Owyong,M., Santosa,E.K., Srpan,K., Sheppard,S.,
            McGuire,T.J., Abbasi,A., Diaz-Salazar,C., Chun,J., Rogatsky,I.,
            Hsu,K.C., Jordan,S., Merad,M. and Sun,J.C.
  TITLE     Fasting reshapes tissue-specific niches to improve NK cell-mediated
            anti-tumor immunity
  JOURNAL   Immunity 57 (8), 1923-1938 (2024)
   PUBMED   38878769
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Behrangi,N., Heinig,L., Frintrop,L., Santrau,E., Kurth,J.,
            Krause,B., Atanasova,D., Clarner,T., Fragoulis,A., Joksch,M.,
            Rudolf,H., Meuth,S.G., Joost,S. and Kipp,M.
  TITLE     Siponimod ameliorates metabolic oligodendrocyte injury via the
            sphingosine-1 phosphate receptor 5
  JOURNAL   Proc Natl Acad Sci U S A 119 (40), e2204509119 (2022)
   PUBMED   36161894
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Skoug,C., Martinsson,I., Gouras,G.K., Meissner,A. and Duarte,J.M.N.
  TITLE     Sphingosine 1-Phoshpate Receptors are Located in Synapses and
            Control Spontaneous Activity of Mouse Neurons in Culture
  JOURNAL   Neurochem Res 47 (10), 3114-3125 (2022)
   PUBMED   35781853
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Eckes,T., Patyna,S., Koch,A., Oftring,A., Gauer,S., Obermuller,N.,
            Schwalm,S., Schaefer,L., Chun,J., Grone,H.J. and Pfeilschifter,J.
  TITLE     Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates
            Adenine-Induced Nephropathy
  JOURNAL   Int J Mol Sci 23 (7), 3952 (2022)
   PUBMED   35409312
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Evrard,M., Wynne-Jones,E., Peng,C., Kato,Y., Christo,S.N.,
            Fonseca,R., Park,S.L., Burn,T.N., Osman,M., Devi,S., Chun,J.,
            Mueller,S.N., Kannourakis,G., Berzins,S.P., Pellicci,D.G.,
            Heath,W.R., Jameson,S.C. and Mackay,L.K.
  TITLE     Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral
            retention of tissue-resident lymphocytes
  JOURNAL   J Exp Med 219 (1) (2022)
   PUBMED   34677611
  REMARK    GeneRIF: Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the
            peripheral retention of tissue-resident lymphocytes.
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   McGiffert,C., Contos,J.J., Friedman,B. and Chun,J.
  TITLE     Embryonic brain expression analysis of lysophospholipid receptor
            genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in
            angiogenesis
  JOURNAL   FEBS Lett 531 (1), 103-108 (2002)
   PUBMED   12401212
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Ishii,I., Ye,X., Friedman,B., Kawamura,S., Contos,J.J.,
            Kingsbury,M.A., Yang,A.H., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Marked perinatal lethality and cellular signaling deficits in mice
            null for the two sphingosine 1-phosphate (S1P) receptors,
            S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3
  JOURNAL   J Biol Chem 277 (28), 25152-25159 (2002)
   PUBMED   12006579
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Brinkmann,V., Davis,M.D., Heise,C.E., Albert,R., Cottens,S.,
            Hof,R., Bruns,C., Prieschl,E., Baumruker,T., Hiestand,P.,
            Foster,C.A., Zollinger,M. and Lynch,K.R.
  TITLE     The immune modulator FTY720 targets sphingosine 1-phosphate
            receptors
  JOURNAL   J Biol Chem 277 (24), 21453-21457 (2002)
   PUBMED   11967257
  REMARK    GeneRIF: The immune modulator FTY720 targets sphingosine
            1-phosphate receptors.
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Im,D.S., Clemens,J., Macdonald,T.L. and Lynch,K.R.
  TITLE     Characterization of the human and mouse sphingosine 1-phosphate
            receptor, S1P5 (Edg-8): structure-activity relationship of
            sphingosine1-phosphate receptors
  JOURNAL   Biochemistry 40 (46), 14053-14060 (2001)
   PUBMED   11705398
  REMARK    GeneRIF: The molecular identity, functional properties, and
            expression profile of the S1P5 (Edg-8) receptor have been
            characterized.
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Ishii,I., Friedman,B., Ye,X., Kawamura,S., McGiffert,C.,
            Contos,J.J., Kingsbury,M.A., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Selective loss of sphingosine 1-phosphate signaling with no obvious
            phenotypic abnormality in mice lacking its G protein-coupled
            receptor, LP(B3)/EDG-3
  JOURNAL   J Biol Chem 276 (36), 33697-33704 (2001)
   PUBMED   11443127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY736639.1, AK081126.1, AI848371.1 and AI852113.1.
            
            On Nov 15, 2007 this sequence version replaced NM_053190.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY736639.1, BI329992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-716               BY736639.1         1-716
            717-2162            AK081126.1         396-1841
            2163-2195           AI848371.1         320-352             c
            2196-2512           AI852113.1         1-317               c
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.75 cM"
     gene            1..2512
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /note="sphingosine-1-phosphate receptor 5"
                     /db_xref="GeneID:94226"
                     /db_xref="MGI:MGI:2150641"
     exon            1..51
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..208
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /inference="alignment:Splign:2.1.0"
     exon            209..2495
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1486
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /note="S1P receptor 5; S1P receptor Edg-8;
                     lysophospholipid receptor B4; sphingosine 1-phosphate
                     receptor Edg-8; endothelial differentiation
                     G-protein-coupled receptor 8; endothelial differentiation,
                     sphingolipid G-protein-coupled receptor, 8;
                     sphingosine-1-phosphate receptor LPB4"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 5"
                     /protein_id="NP_444420.1"
                     /db_xref="CCDS:CCDS22898.1"
                     /db_xref="GeneID:94226"
                     /db_xref="MGI:MGI:2150641"
                     /translation="MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCL
                     AVCAFIVLENLAVLLVLVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLR
                     LSPALWFAREGGVFVALAASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWG
                     ASLLLGLLPALGWNCLGRLETCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQ
                     VRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDV
                     ACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSS
                     NSLQRSPSAAGPSGGGLRRCLPPTLDRSSSPSEHLSPQQDGVDTSCSTGSPGVATANR
                     SLVPTATD"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /note="hexamer: AATAAA"
     polyA_site      2183
                     /gene="S1pr5"
                     /gene_synonym="Edg8; lpB4; S1P5"
                     /note="major polyA site"
ORIGIN      
        1 agtgttccca ggcgcaccgc ctagggcaca cgaccggacc caggcgcaag ggcctcgaac
       61 ttactgtgta gagaacgata accttgaagt cctgatcctc cgctggcaat tgctggggaa
      121 ccggtgtaca ccaaatgccc agcttactcc ccccagattt ccaatagccg ctctcctgtg
      181 tctgcttctg gagtgccggt tacaggagac ttttgcacag tgctccagtg gacgaccggc
      241 aggacacagc agcgacatct ccgcggcggg cggcgggcag cccatggagc ccgggctgct
      301 gcggccggcg ccggtgagtg aggttattgt ccttcactac aactacaccg gcaagctccg
      361 cggggcgcgc taccagcccg gcgccggcct gcgcgcagac gccgcagtgt gtctggctgt
      421 gtgtgccttc attgtgctgg agaacttggc tgtgctcttg gtgctggtcc gccaccctcg
      481 cttccatgcg cccatgtttc tgctccttgg cagcctcact ttgtcggacc tgctcgccgg
      541 ggcggcctac gccaccaaca tcctactgtc cgggccgctc acgctgcgcc tgtcgcctgc
      601 gctttggttt gcgcgtgagg ggggcgtctt cgtggcgctc gccgcgtcgg tgctgagcct
      661 cttggccatt gctttagagc gccaccttac catggcccgt cgtggacccg cacccgccgc
      721 cagtcgcgct cgcacgctgg cgatggcggt ggccgcctgg ggcgcgtcgc tattgctcgg
      781 gctgctaccc gcgctgggct ggaactgctt aggacgcctg gaaacctgct ccaccgtgct
      841 gccgctctac gccaaggcct atgtgctctt ctgcgtgctg gccttcctgg gcatcctggc
      901 tgccatctgt gcgctctatg caaggattta ctgtcaggtg cgggccaacg cgcgtcgcct
      961 gcgggcgggt cctgggtccc gcagggccac ctcgtcctcg cgatcccggc acacgccgcg
     1021 gtcgctggcc ctgcttcgta cccttagcgt ggtgctcctg gccttcgtgg cctgctgggg
     1081 accgctgttt ctcttgctat tactggatgt cgcgtgccca gcccgcgcgt gtcccgtgct
     1141 cctgcaggcc gatcccttcc tgggtctagc catggctaac tcgctgctga atcccatcat
     1201 ctacaccttc accaaccgag atctgcgcca cgcgctcctg cggctgctct gctgtggccg
     1261 cggaccctgc aaccaagact cctccaacag cttgcagcga tcccccagtg ctgccgggcc
     1321 ttccggtggt ggcctgcgac gctgcctgcc accaaccttg gatcgcagct ctagcccatc
     1381 agaacacttg tctccccagc aggacggggt ggacaccagc tgctccaccg gcagtcctgg
     1441 agtagcaacc gccaaccgga gcctggtgcc tactgctaca gactgacgct tcccaaccct
     1501 ttgcaagaac agactgactc gccaaataag cgcatcatct gtaggaaata gccagcgacg
     1561 gagggggaca tacaagaaag aagggaaagt gattgatcac cccataacaa gaacagacaa
     1621 aaatgcactc gggatctgag atggacaata agggaaagaa gaaagtgatg agaaggtatc
     1681 caggtagtgg aacctaagct gggaagccct gaaggagagc cattccatat ggctgcagca
     1741 gaaattgagg agcaggagat gaaagggcag gttgtgggga agtcttgttg gttctgagga
     1801 agtccttagg tttggctctg agtgaagtgg gagccataga gaattctaaa caaaggaggg
     1861 actctcctgg attcagacct ccacaggtac cctgtgacta ccaaagttca aggggaatgg
     1921 ctaaaagatg aagggataaa ggagagcggg gctccaagaa tgctcagaac caggtgatgt
     1981 ctagataaga gtgtgctaag ggctggcagg agtagtggct ggctacagag gaaacagagc
     2041 tgtggacaaa ggtaagccta ggtctggaaa tttggctctg gagactgtca gatatcagct
     2101 gccaaacttc cagagtgtgg acaggttctt catacaaatt acaaccacaa taaaaacaat
     2161 tcaaggagtt gtccttactg ggatctttca gaatctattc attcatctat tgattttttt
     2221 ttttaatttt cccccagaaa gttgtaacta tcctctttaa aagtgtttat ttattggggt
     2281 tggagagatg gctcagcagt taagaacact tgttaccctt gcaggggacc tgtgttccat
     2341 tcccagcacc caagtggtga ttctggcaac ttcagttcca aggttatctg atgccctcat
     2401 ctgacctctg agggcaccag gcatgcacat ggtacaaaga ttgaatgcag gcaaaactct
     2461 catacaaaca agctaaataa atcttttaaa atgttaaaaa aaaaaaaaaa aa
//
