LOCUS       NM_010102               2393 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus sphingosine-1-phosphate receptor 4 (S1pr4), mRNA.
ACCESSION   NM_010102
VERSION     NM_010102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Luker,A.J., Wukitch,A., Kulinski,J.M., Ganesan,S., Kabat,J.,
            Lack,J., Frischmeyer-Guerrerio,P., Metcalfe,D.D. and Olivera,A.
  TITLE     Sphingosine-1-Phosphate Receptor 4 links neutrophils and early
            local inflammation to lymphocyte recruitment into the draining
            lymph node to facilitate robust germinal center formation
  JOURNAL   Front Immunol 15, 1427509 (2024)
   PUBMED   39188715
  REMARK    GeneRIF: Sphingosine-1-Phosphate Receptor 4 links neutrophils and
            early local inflammation to lymphocyte recruitment into the
            draining lymph node to facilitate robust germinal center formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Kurano,M., Uranbileg,B. and Yatomi,Y.
  TITLE     Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis
            through activating S1P1 and S1P4
  JOURNAL   Biomed Pharmacother 166, 115400 (2023)
   PUBMED   37657263
  REMARK    GeneRIF: Apolipoprotein M bound sphingosine 1-phosphate suppresses
            NETosis through activating S1P1 and S1P4.
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Wang,S., Tian,Z., Lu,Y., Huang,Z., Fan,Y., Li,B., Zheng,H., Wu,X.,
            Wang,M., Zhao,J. and Xie,J.
  TITLE     Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway
            Inflammation in Experimental Asthma via Repressing Proinflammatory
            Macrophage Activation
  JOURNAL   Int J Biol Sci 19 (5), 1597-1615 (2023)
   PUBMED   37056936
  REMARK    GeneRIF: Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic
            Airway Inflammation in Experimental Asthma via Repressing
            Proinflammatory Macrophage Activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Riese,J., Hahnel,C., Menz,J., Hannemann,M., Khabipov,A., Luhrs,F.
            and Schulze,T.
  TITLE     S1PR4 deficiency results in reduced germinal center formation but
            only marginally affects antibody production
  JOURNAL   Front Immunol 13, 1053490 (2022)
   PUBMED   36532028
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Skoug,C., Martinsson,I., Gouras,G.K., Meissner,A. and Duarte,J.M.N.
  TITLE     Sphingosine 1-Phoshpate Receptors are Located in Synapses and
            Control Spontaneous Activity of Mouse Neurons in Culture
  JOURNAL   Neurochem Res 47 (10), 3114-3125 (2022)
   PUBMED   35781853
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Edsbagge,J., Johansson,J.K., Esni,F., Luo,Y., Radice,G.L. and
            Semb,H.
  TITLE     Vascular function and sphingosine-1-phosphate regulate development
            of the dorsal pancreatic mesenchyme
  JOURNAL   Development 132 (5), 1085-1092 (2005)
   PUBMED   15689381
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   McGiffert,C., Contos,J.J., Friedman,B. and Chun,J.
  TITLE     Embryonic brain expression analysis of lysophospholipid receptor
            genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in
            angiogenesis
  JOURNAL   FEBS Lett 531 (1), 103-108 (2002)
   PUBMED   12401212
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Contos,J.J., Ye,X., Sah,V.P. and Chun,J.
  TITLE     Tandem genomic arrangement of a G protein (Gna15) and G
            protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene
  JOURNAL   FEBS Lett 531 (1), 99-102 (2002)
   PUBMED   12401211
  REMARK    GeneRIF: s1p(4) maps to mouse chromosome 10 and has similar tissue
            distribution to mouse Gna15; transcription of the two genes may be
            under control of the same enhancer elements
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Ishii,I., Friedman,B., Ye,X., Kawamura,S., McGiffert,C.,
            Contos,J.J., Kingsbury,M.A., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Selective loss of sphingosine 1-phosphate signaling with no obvious
            phenotypic abnormality in mice lacking its G protein-coupled
            receptor, LP(B3)/EDG-3
  JOURNAL   J Biol Chem 276 (36), 33697-33704 (2001)
   PUBMED   11443127
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Graler,M.H., Bernhardt,G. and Lipp,M.
  TITLE     EDG6, a novel G-protein-coupled receptor related to receptors for
            bioactive lysophospholipids, is specifically expressed in lymphoid
            tissue
  JOURNAL   Genomics 53 (2), 164-169 (1998)
   PUBMED   9790765
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159474.9.
            
            On Feb 24, 2010 this sequence version replaced NM_010102.1.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family. The encoded protein is a receptor for the
            lysophospholipid sphingosine 1-phosphate. The encoded protein is
            one of the predominant sphingosine 1-phosphate G-protein coupled
            receptors expressed in T cells, and it plays a role in suppression
            of T cell proliferation, generation of cytokines, and potentially
            other aspects of immune activation. [provided by RefSeq, Feb 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ006074.1, AK154242.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2393              AC159474.9         75739-78131
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2393
                     /gene="S1pr4"
                     /gene_synonym="Edg6; Lpc1; S1p4"
                     /note="sphingosine-1-phosphate receptor 4"
                     /db_xref="GeneID:13611"
                     /db_xref="MGI:MGI:1333809"
     exon            1..2393
                     /gene="S1pr4"
                     /gene_synonym="Edg6; Lpc1; S1p4"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..1660
                     /gene="S1pr4"
                     /gene_synonym="Edg6; Lpc1; S1p4"
                     /note="S1p receptor 4; sphingosine 1-phosphate receptor
                     Edg-6; lysophospholipid receptor C1; endothelial
                     differentiation G-protein-coupled receptor 6; S1P receptor
                     Edg-6"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 4"
                     /protein_id="NP_034232.1"
                     /db_xref="CCDS:CCDS24059.1"
                     /db_xref="GeneID:13611"
                     /db_xref="MGI:MGI:1333809"
                     /translation="MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSE
                     DGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAY
                     VVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATK
                     TSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALIL
                     VAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLAD
                     IFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLR
                     GPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST"
     regulatory      2370..2375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr4"
                     /gene_synonym="Edg6; Lpc1; S1p4"
                     /note="hexamer: ATTAAA"
     polyA_site      2391
                     /gene="S1pr4"
                     /gene_synonym="Edg6; Lpc1; S1p4"
                     /note="major polyA site"
ORIGIN      
        1 tttttcgaga cagggtttct ctgtgtagcc ctggctgtcc tggaactcac tttatagacc
       61 aggctggcct cgaactcaga aatccgcctg cctctgccta tggcacgctt tctgtgtaca
      121 gttgacaaat acttattagg cacctgctgt atatataagc atacagttgg aacagttggg
      181 cacaaggggg tgggcagagg gatcttggat gccaggctat gcccattgtc cagtagtgac
      241 tccccatcta gtgcttgcct cccatccaaa gagggaaatt tggtcctggg tggggtgcca
      301 tgagagatca tgctctctag ctcagagccc ccagagtcac acccacagtt gctcaggatg
      361 cccctccctg ccctggcctc acccccaccc actctggggc accttgagca taacaggaaa
      421 tttcaaacaa caggaaaccc aggccaggca gtgactccac cctgcggagg cctctctcag
      481 tctgtccccg ggggaggcca tgaacatcag tacctggtcc acgctggtga ccccagagtc
      541 ctgccaccgg ctggcagcca gcggccacag cctcctcatt gtcctgcact acaatcacag
      601 cggcaggctg gccagccgcg ggggctctga ggacggtgga gggctaggga tgctgagggg
      661 gccgtcggtg gccgcaggtt gcctggtggt gctggagaac gccatggtgc tggccgccat
      721 cgccatctac atgcggtccc gccgctgggt gtactactgc ctgctgaaca tcacactgag
      781 tgacctgctc acaggcctgg cctacgtggt caacgtgctg ctgtcaggga ctcgtacctt
      841 ccagctgtca ccggtgcact ggttcctgcg ggagggcctg ctcttcatgg ccttggccgc
      901 atccaccttc agtctgctct tcacggccgg cgagcgcttc gccaccatgg tgcgggtggc
      961 tgagagtggg gccaccaaga ccagccgtgt gtatggctgc atcggtctgt gctggctact
     1021 ggcagctatc ctgggcctgc tgcccctgct gggctggaac tgtgtgtgcg ccttcccacg
     1081 ctgctccagc ctgctgcccc tctactccaa gggctatgtg ctcttttgtg tggtggtctt
     1141 cgccctcatc ctagtggcta tcctgagcct ctacggggcc atctttagag tggtccgagc
     1201 caatgggcag aagtctccac gtcctcctgc ccgccgcaag tcccgcaggc tactcaacac
     1261 cgtgctgatg atcttggtgg cctttgtggt gtgctggggt cccctgtttg gcctgctcct
     1321 ggctgacatc tttggttcta atgtctgggc ccaggagtac ctgcgtggca tggactggat
     1381 cctggccctg gccgtgttca actcagccat taatcctctc atctactcct tccgcagccg
     1441 tgaggtgcag cgcgctgtgc tggccttcct gtgctgcggc tgtctctggc taggtctgcg
     1501 aggtccagga gactgcctga cccggatcac cgaggcccac tccggtgcat ccaccactga
     1561 cagctccctg aggcccaggg acagttttcg gacttctcgg tcactcagct tcaggatgag
     1621 agagccgctg tccagcattt ccagcgtccg cagcacctag agcttggacc agccagttgc
     1681 ccactgagca ggccctccca gacgaggtga gaagggacag gacacaagaa ccttgcctga
     1741 tggtgactga gaacatgaca gcaagccccg ggttccttcc acaaaattcc ccgtgatgaa
     1801 tgtttggcag agagtggctg gagccagagc cagtgagtct gggccttgaa gggcccctcc
     1861 cccccgccca ggcagcaaag gggatgtgcc atgtccgagg ccatggacag gacagagctt
     1921 tgtggttctg tcttagtcac atgtgttcag gtcaatgccc aggctactgt aatgtgtctc
     1981 ctggtcatac ccactggtat acagtgcttt gggggtgtgc tgggatgggg gtggacctgc
     2041 accatttgtt tgagggcaac ttgacgtgtt taagaatgaa agggggcctg gagggcacac
     2101 cagtctgtca tccacccctc ttctcaatga cttctacatt gggacaagca gcctgccccc
     2161 gatggcctcc ctcctccagt tcaggttctc tgtctctgtg tggggaggat agagccaccc
     2221 actccaggtc tggggcaatc tcaactggtc ctgtaacccc gcagcctcgc ccttcctgtt
     2281 ctgaatcacg gagatatgct gtggcaggga gctgtggacc ctaccatgtg atagtgcagc
     2341 tgcaagccat gcatggctgc ataaaattca ttaaaatgaa cgaaacctcc aca
//
