LOCUS       NM_010101               4484 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus sphingosine-1-phosphate receptor 3 (S1pr3), mRNA.
ACCESSION   NM_010101
VERSION     NM_010101.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4484)
  AUTHORS   Piao,J., Su,Z., He,J., Zhu,T., Fan,F., Wang,X., Yang,Z., Zhan,H.
            and Luo,D.
  TITLE     SphK1 deficiency ameliorates the development of atherosclerosis by
            inhibiting the S1P/S1PR3/Rhoa/ROCK pathway
  JOURNAL   Cell Signal 121, 111252 (2024)
   PUBMED   38852936
  REMARK    GeneRIF: SphK1 deficiency ameliorates the development of
            atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
REFERENCE   2  (bases 1 to 4484)
  AUTHORS   Peng,J., Tang,R., He,J., Yu,Q., Wang,D. and Qi,D.
  TITLE     S1PR3 inhibition protects against LPS-induced ARDS by inhibiting
            NF-kappaB and improving mitochondrial oxidative phosphorylation
  JOURNAL   J Transl Med 22 (1), 535 (2024)
   PUBMED   38840216
  REMARK    GeneRIF: S1PR3 inhibition protects against LPS-induced ARDS by
            inhibiting NF-kappaB and improving mitochondrial oxidative
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4484)
  AUTHORS   Velagapudi,S., Wang,D., Poti,F., Feuerborn,R., Robert,J.,
            Schlumpf,E., Yalcinkaya,M., Panteloglou,G., Potapenko,A.,
            Simoni,M., Rohrer,L., Nofer,J.R. and von Eckardstein,A.
  TITLE     Sphingosine-1-phosphate receptor 3 regulates the transendothelial
            transport of high-density lipoproteins and low-density lipoproteins
            in opposite ways
  JOURNAL   Cardiovasc Res 120 (5), 476-489 (2024)
   PUBMED   38109696
  REMARK    GeneRIF: Sphingosine-1-phosphate receptor 3 regulates the
            transendothelial transport of high-density lipoproteins and
            low-density lipoproteins in opposite ways.
REFERENCE   4  (bases 1 to 4484)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4484)
  AUTHORS   Skoug,C., Martinsson,I., Gouras,G.K., Meissner,A. and Duarte,J.M.N.
  TITLE     Sphingosine 1-Phoshpate Receptors are Located in Synapses and
            Control Spontaneous Activity of Mouse Neurons in Culture
  JOURNAL   Neurochem Res 47 (10), 3114-3125 (2022)
   PUBMED   35781853
REFERENCE   6  (bases 1 to 4484)
  AUTHORS   Nofer,J.R., van der Giet,M., Tolle,M., Wolinska,I., von Wnuck
            Lipinski,K., Baba,H.A., Tietge,U.J., Godecke,A., Ishii,I.,
            Kleuser,B., Schafers,M., Fobker,M., Zidek,W., Assmann,G., Chun,J.
            and Levkau,B.
  TITLE     HDL induces NO-dependent vasorelaxation via the lysophospholipid
            receptor S1P3
  JOURNAL   J Clin Invest 113 (4), 569-581 (2004)
   PUBMED   14966566
  REMARK    GeneRIF: Data identify HDL as a carrier of bioactive
            lysophospholipids that regulate vascular tone via S1P3-mediated
            nitric oxide release.
REFERENCE   7  (bases 1 to 4484)
  AUTHORS   McGiffert,C., Contos,J.J., Friedman,B. and Chun,J.
  TITLE     Embryonic brain expression analysis of lysophospholipid receptor
            genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in
            angiogenesis
  JOURNAL   FEBS Lett 531 (1), 103-108 (2002)
   PUBMED   12401212
  REMARK    GeneRIF: s1p(1-3) influence angiogenesis in the developing brain
REFERENCE   8  (bases 1 to 4484)
  AUTHORS   Ishii,I., Ye,X., Friedman,B., Kawamura,S., Contos,J.J.,
            Kingsbury,M.A., Yang,A.H., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Marked perinatal lethality and cellular signaling deficits in mice
            null for the two sphingosine 1-phosphate (S1P) receptors,
            S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3
  JOURNAL   J Biol Chem 277 (28), 25152-25159 (2002)
   PUBMED   12006579
  REMARK    GeneRIF: mice null for both EDG-5 and EDG-3 show marked perinatal
            lethality and cellular signaling defect
REFERENCE   9  (bases 1 to 4484)
  AUTHORS   Ishii,I., Friedman,B., Ye,X., Kawamura,S., McGiffert,C.,
            Contos,J.J., Kingsbury,M.A., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Selective loss of sphingosine 1-phosphate signaling with no obvious
            phenotypic abnormality in mice lacking its G protein-coupled
            receptor, LP(B3)/EDG-3
  JOURNAL   J Biol Chem 276 (36), 33697-33704 (2001)
   PUBMED   11443127
REFERENCE   10 (bases 1 to 4484)
  AUTHORS   Zhang,G., Contos,J.J., Weiner,J.A., Fukushima,N. and Chun,J.
  TITLE     Comparative analysis of three murine G-protein coupled receptors
            activated by sphingosine-1-phosphate
  JOURNAL   Gene 227 (1), 89-99 (1999)
   PUBMED   9931453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159104.2 and AK084944.1.
            
            On Jan 26, 2010 this sequence version replaced NM_010101.3.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family. The encoded protein is a receptor for the
            lysophospholipid sphingosine 1-phosphate. The gene product
            functions in endothelial cells and is involved in vascular and
            heart development. The gene product mediates HDL and HDL-associated
            lysophospholipid-induced vasorelaxation, and it coordinates with
            other lysophospholipid receptors in the process of angiogenesis.
            [provided by RefSeq, Jan 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084944.1, AK081919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC159104.2         161467-161612       c
            147-4484            AK084944.1         2-4339
FEATURES             Location/Qualifiers
     source          1..4484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.12 cM"
     gene            1..4484
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /note="sphingosine-1-phosphate receptor 3"
                     /db_xref="GeneID:13610"
                     /db_xref="MGI:MGI:1339365"
     exon            1..328
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..4484
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..1608
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /note="lysophospholipid receptor B3; S1p receptor 3;
                     endothelial differentiation sphingolipid G-protein-coupled
                     receptor 3; S1P receptor Edg-3; sphingosine 1-phosphate
                     receptor Edg-3; endothelial differentiation G-protein
                     coupled receptor 3"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 3"
                     /protein_id="NP_034231.1"
                     /db_xref="CCDS:CCDS26512.1"
                     /db_xref="GeneID:13610"
                     /db_xref="MGI:MGI:1339365"
                     /translation="MATTHAQGHQPVLGNDTLREHYDYVGKLAGRLRDPPEGGTLITT
                     ILFLVTCSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGR
                     KTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIG
                     MCWLIAFSLGALPILGWNCLENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYAR
                     IYCLVKSSSRRVANHNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSI
                     LFKSQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDP
                     SRSKSSSSNNSSHSPKVKEDLPRVATSSCIIDKNRSFQNGVLCK"
     regulatory      3788..3793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /note="hexamer: AATAAA"
     polyA_site      3817
                     /gene="S1pr3"
                     /gene_synonym="Edg3; Lpb3; S1p3"
                     /note="major polyA site"
ORIGIN      
        1 gcggggacgt ggctgggaac cagggcgtat ctggggacca gcccgcgaag ctctgaagct
       61 tgggttaggg gcggcaggag gcggggtgag tttgggcccc gccccggagg gcagtggcaa
      121 aagtttgcct tcggattctc tggggcagag tctgggagaa caagttcagg ggcaggcgac
      181 aaggtccggg tgctgagcaa ggtggctgga caagcctagc gggagagaaa cctgaggcca
      241 cgagcgacct ccggaggagc ccctagacgg gagtcttagc tgagacacgg cagcatgcaa
      301 ccagcccaga tgcgccttgc agaacgagag cctattttca acactcttcc cgcagtcggg
      361 cctgcacgcc ttcaggaacc caccaccact ctcccaattg ttccctgaaa tgaacgttcc
      421 tggcgcgccc tctcgtggac tgttgaagta accatctgtc tctaggaagc catggcaacc
      481 acgcatgcgc agggccacca gccagtcttg ggaaatgaca ctctccggga acattacgat
      541 tacgtgggga aactggcagg caggctgcgg gacccccctg agggtggcac cctcatcacc
      601 accatcctct tcttggtcac ctgtagcttc atcgtcttgg agaacctgat ggttttgatt
      661 gccatctgga aaaacaataa atttcacaac cgcatgtact ttttcatcgg caacttggct
      721 ctctgcgacc tgctggccgg catagcatac aaggtcaata ttcttatgtc cggcaggaag
      781 acgttcagtc tgtctccaac agtgtggttc ctcagggagg gcagtatgtt cgtagccctg
      841 ggcgcatcca cctgcagctt actggccatt gccattgagc gacacctgac catgatcaag
      901 atgaggccat atgatgccaa caagaagcac cgcgtgttcc ttctgattgg gatgtgctgg
      961 ctaattgcct tctcgctggg tgccctgcca atcctgggct ggaactgcct ggagaacttt
     1021 cccgactgct ctaccatctt gcccctctac tccaagaaat acatcgcctt cctcatcagt
     1081 atcttcaccg ccattctggt gaccatcgtc atcttgtatg cgcgcatcta ctgcctggtc
     1141 aagtccagca gccgcagggt ggccaaccac aactctgaga gatccatggc ccttctgcgg
     1201 accgtagtga ttgtggtgag tgtgttcatt gcctgttggt ccccactttt tatcctcttc
     1261 ctcatcgacg tggcctgcag ggcaaaggag tgctccatcc tcttcaagag tcagtggttc
     1321 atcatgctgg ctgtcctcaa ctcggccatg aaccctgtca tctacacgct ggccagcaaa
     1381 gagatgaggc gcgccttctt ccggttggtg tgcggctgtc tagtcaaggg caaggggacc
     1441 caggcctcac ccatgcagcc tgccctcgac ccaagcagaa gtaagtcaag ctccagtaac
     1501 aacagcagcc actctccgaa ggtcaaggaa gacctgcccc gcgtggctac ttcttcctgc
     1561 atcattgaca aaaacaggtc gtttcagaac ggggtcctct gcaagtgacg gtctcaacag
     1621 ggcaagctct gcagccacac ctatttattg catgcatcac ttccacgtgg ggccttaaga
     1681 gatcttaact ctggaggtct gcttgctgtg gccagactgt gtggtatctc ctgaggagga
     1741 gacccaagga gtcaccaacg catttcagcc tggacttgga tgtgacttat ctgttgcggg
     1801 ctccatcctt ctgaatgtac caagctgctg acacggtgca ctgccttcgg atgccgctac
     1861 ccctggtcca gggaaggcag gtggtgatgt gctatgcaca tgcacattgg gatgatgtct
     1921 ccctgcgttc acactacatt tattttccat agaatgggtg ctcatgtgtg tgtgtgtgtg
     1981 tgtgtgtgtt cgttgctgtg ttgtacagga tgtatacgat tgattttccc aggtggaacc
     2041 cattacaaag tgtcagtctt ccacacatca ttggtccaaa cctgcccaca ctgctgtccc
     2101 aggttcagca tgtgataagg tcatgtcccc ttcccagtgc ccttgcactg gtgttctaac
     2161 tcatagctgt gaaaagttac taaagtattc tgtattctca aaagcctcac ccaagagcag
     2221 cccaggtgtg tgggtcttac ccttacattc ctgcacccct cctccctctt gggtcccttg
     2281 cgtaagctta ggtacaccta agagccaaat tatgcgatca ttgaggcatt tctgaaagcc
     2341 acagaaaagc cagccgggat ctctcggaat gcaggcacca ctaaaggaag aactcctaag
     2401 gagaggcaag gtgctctcca ctgtgggcaa tctttctagg ggactgcagt ctgtctgctg
     2461 catgtagaga gtttccagca gtgacgttca caagccagcc cttcatctgt atggtcctga
     2521 gttcaagtct atagagagaa gcttgaggct gcttgtcccc tttgctgtca ccctttgctg
     2581 gcaaggagct ggagctgtca gcaaagcttc tcaactccct cagttatgga ccctgtccag
     2641 gactattcag tgagaggatt ccgccaggct gggaggcgtg atgtagttat ttgtgtgctc
     2701 tttagagaga accattccaa ttcccatatg atggacactc cagccactct cctccgcttg
     2761 gacctgcgtt catttgtcca tcctgtaaag aaaatgcgta gaagacacct ctgaacatcc
     2821 cctccccaag gattccgccc acagggcaca cagatgaaag gtgggtgcgt tggagagtgg
     2881 ccagcatcca tgctcccaga acagccttcg gaaagactct catttgagga aacgtcatgt
     2941 caaggctccc cataagttga ttagtctcag agactgttgc cttatgaacc ctggaagagc
     3001 agcctttaca cactcatggg cctttttaaa actgattttt ttttccctct tggtggttac
     3061 ctgatggcat ttgctcttgt ttagggacat ttttctgggc cttaggtaac cctggtctga
     3121 ctaactaaag acttcccctc atgtcactcc tggtgtatat aggtcactgc caagaagttc
     3181 tgctccatca ttggccttgc ccttctctat gtcaccaaga aaatgtcacc gtgttgacaa
     3241 aacccatggc atttctggaa aaggaaagca tacaagtgct gggttaaggg aaaaataaat
     3301 agcagagcag tgtgtagggg agttgaggtg gaaagagaac agggcttgtg ggcacgctct
     3361 ttcatgattg caaggctttg aggccgtggg tctaggtcac tgatattaat cacacattgt
     3421 acaggattct ggcttctcca tttcctcctg tgtctgcttt cacacaacag cccttgtgga
     3481 gggccaggcc caccatcccc agctaggagg tgacatttgt agcatgacag actgccaagc
     3541 aactgaaaat aaaaatacac taaaacccaa ttgcgctcac ttgatgtatg cccagtggat
     3601 ccgtcgaccg tgatgccagt gtgcacacct ttccctagct agcctccgag acagcactga
     3661 gacatcgggt gcatccaacc ctcaccctga aggtcaaagg tcggaaacca gtgacaccag
     3721 agaccctggg gctcgcccaa ggtagtgagc aaccttggct acttgcagtt tatgtttgtt
     3781 aataataaat aaaaccaaaa gcctgtataa aaacccatcc tggaggcctg tgtggtatgt
     3841 tctattgttt tggaatagac actcgggggg tgtagtgggg tggtcttgct tctctcccta
     3901 gaacctgatc tcacagcatt acaggcataa actacatttg atgcccaatc actaagtccc
     3961 ttttatcccc cagggccatc ttgtagatga tgttagattg aagctttagc gtactggatg
     4021 ctactgatac aggtctgggt agatgctgtt ttactggtgg tggtggtggt ggtggtggta
     4081 gcggtggtga gtgtgtgtat gtgtgtgccc acccatgtac actattgtgc atgcaggaga
     4141 ggccagaggt taatgttgga tctctctctc tctctctatg ctctccatct tggttttttt
     4201 gttgttgttt tgttgttgtt gttgttgttt tgttgtttgt ttttttgaga caccatttct
     4261 cactgaaccc gaagctgcca gctttggcta gattgactga ccaacaattc cccccaggac
     4321 ctgtgttcct cctgtcatgg ttataggcac aaactgccct ctgtggcatt tacgtaggca
     4381 cagggcatcc caggggagcc atttcccagc agatcctatg atttgaagaa tggtaatagc
     4441 ccctctgtag ggaagaaatt ataaaataaa aatgtcatcc aacc
//
