LOCUS       NM_010333               2815 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sphingosine-1-phosphate receptor 2 (S1pr2), mRNA.
ACCESSION   NM_010333 XM_134731
VERSION     NM_010333.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Pagella,P., Lai,C.F., Pirenne,L., Cantu,C., Schwab,M.E. and
            Mitsiadis,T.A.
  TITLE     An unexpected role of neurite outgrowth inhibitor A as regulator of
            tooth enamel formation
  JOURNAL   Int J Oral Sci 16 (1), 60 (2024)
   PUBMED   39426966
  REMARK    Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi:
            10.1038/s41368-024-00330-y.. PMID: 39511159]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Duan,Y., Li,Q., Wu,J., Zhou,C., Liu,X., Yue,J., Chen,X., Liu,J.,
            Zhang,Q., Zhang,Y. and Zhang,L.
  TITLE     A detrimental role of endothelial S1PR2 in cardiac
            ischemia-reperfusion injury via modulating mitochondrial
            dysfunction, NLRP3 inflammasome activation, and pyroptosis
  JOURNAL   Redox Biol 75, 103244 (2024)
   PUBMED   38909407
  REMARK    GeneRIF: A detrimental role of endothelial S1PR2 in cardiac
            ischemia-reperfusion injury via modulating mitochondrial
            dysfunction, NLRP3 inflammasome activation, and pyroptosis.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Lin,T., Peng,M., Zhu,Q. and Pan,X.
  TITLE     S1PR2 participates in intestinal injury in severe acute
            pancreatitis by regulating macrophage pyroptosis
  JOURNAL   Front Immunol 15, 1405622 (2024)
   PUBMED   38827741
  REMARK    GeneRIF: S1PR2 participates in intestinal injury in severe acute
            pancreatitis by regulating macrophage pyroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Shrestha,A.P., Stiles,M., Grambergs,R.C., Boff,J.M., Madireddy,S.,
            Mondal,K., Rajmanna,R., Porter,H., Sherry,D.M., Proia,R.L.,
            Vaithianathan,T. and Mandal,N.
  TITLE     The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina
            Light Responses
  JOURNAL   Biomolecules 13 (12), 1691 (2023)
   PUBMED   38136563
  REMARK    GeneRIF: The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse
            Retina Light Responses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Ishii,I., Friedman,B., Ye,X., Kawamura,S., McGiffert,C.,
            Contos,J.J., Kingsbury,M.A., Zhang,G., Brown,J.H. and Chun,J.
  TITLE     Selective loss of sphingosine 1-phosphate signaling with no obvious
            phenotypic abnormality in mice lacking its G protein-coupled
            receptor, LP(B3)/EDG-3
  JOURNAL   J Biol Chem 276 (36), 33697-33704 (2001)
   PUBMED   11443127
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   MacLennan,A.J., Carney,P.R., Zhu,W.J., Chaves,A.H., Garcia,J.,
            Grimes,J.R., Anderson,K.J., Roper,S.N. and Lee,N.
  TITLE     An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine
            1-phosphate receptor in neuronal excitability
  JOURNAL   Eur J Neurosci 14 (2), 203-209 (2001)
   PUBMED   11553273
REFERENCE   8  (bases 1 to 2815)
  AUTHORS   Katsuma,S., Shiojima,S., Hirasawa,A., Suzuki,Y., Takagaki,K.,
            Murai,M., Kaminishi,Y., Hada,Y., Koba,M., Muso,E., Miyawaki,S.,
            Ohgi,T., Yano,J. and Tsujimoto,G.
  TITLE     Genomic analysis of a mouse model of immunoglobulin A nephropathy
            reveals an enhanced PDGF-EDG5 cascade
  JOURNAL   Pharmacogenomics J 1 (3), 211-217 (2001)
   PUBMED   11908758
  REMARK    GeneRIF: Enhanced EDG5 signaling plays an important role in the
            proliferation of kidney mesangial cells and the progression of
            immunoglobulin A nephropathy.
REFERENCE   9  (bases 1 to 2815)
  AUTHORS   Zhang,G., Contos,J.J., Weiner,J.A., Fukushima,N. and Chun,J.
  TITLE     Comparative analysis of three murine G-protein coupled receptors
            activated by sphingosine-1-phosphate
  JOURNAL   Gene 227 (1), 89-99 (1999)
   PUBMED   9931453
REFERENCE   10 (bases 1 to 2815)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY095108.1 and AK151062.1.
            
            On Nov 15, 2007 this sequence version replaced NM_010333.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170436.1, AK085114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BY095108.1         1-65
            66-2815             AK151062.1         2-2751
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.68 cM"
     gene            1..2815
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /note="sphingosine-1-phosphate receptor 2"
                     /db_xref="GeneID:14739"
                     /db_xref="MGI:MGI:99569"
     exon            1..196
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..2815
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1295
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /note="endothelial differentiation, sphingolipid
                     G-protein-coupled receptor, 5; G-protein coupled receptor
                     13; lysophospholipid receptor B2; sphingosine-1-phosphate
                     receptor S1P(2); S1P receptor 2; S1P receptor Edg-5;
                     sphingosine 1-phosphate receptor Edg-5; endothelial
                     differentiation G-protein coupled receptor 5"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 2"
                     /protein_id="NP_034463.2"
                     /db_xref="CCDS:CCDS22888.1"
                     /db_xref="GeneID:14739"
                     /db_xref="MGI:MGI:99569"
                     /translation="MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILC
                     CAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTP
                     VQWFAREGSAFITLSASVFSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISL
                     ILGGLPILGWNCLNQLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRS
                     SHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAF
                     ATLNSLLNPVIYTWRSRDLRREVLRPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLE
                     RGMHMPTSPTFLEGNTVV"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="S1pr2"
                     /gene_synonym="1100001A16Rik; Edg5; Gpcr13; H218; LPb2;
                     S1P2"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggagg gcggggcgag cagggagttg gggccggagg cagcggctct gcccgcctct
       61 ctcttgtcct gggtccccaa ctccgggaca tagaccgagc acagccaaca gtctccaaaa
      121 ccaaccactg gctgtcccgg ggcgcagacg ccaaggccac tcaggccagg gcagggaccc
      181 cggccggcct agccagtgct cagccccatg gccccagccg gccactgagc cccaccatgg
      241 gcggcttata ctcagagtac ctcaatcctg agaaggttct ggaacactac aattacacca
      301 aggagacgct ggacatgcag gagaccacct cccgcaaggt ggcctcggcc ttcatcatca
      361 tcttgtgctg cgccatcgtg gtggagaatc ttctggtgct cattgcagtg gccaggaaca
      421 gcaagttcca ctcagcaatg tacctgttcc ttggcaacct ggcagcctct gacctgctgg
      481 caggcgtggc cttcgtggcc aacaccttac tctcagggca tgtcactctg tccttaactc
      541 ccgtgcagtg gtttgcccga gagggttccg ccttcatcac gctctccgcc tcggtcttta
      601 gcctcctggc catcgccatc gagagacaag tggccctcgc caaggtcaag ctctacggca
      661 gtgacaaaag ctgccgaatg ctgatgctca tcggggcctc ttggctgata tcgctgattc
      721 tgggtggctt gcccatcctg ggctggaatt gtctgaacca gctggaggcc tgctccaccg
      781 tgctgcctct ctatgctaag cactacgtgc tctgcgtggt caccatcttc tccgtcatct
      841 tactggctat cgtggctctg tacgtccgaa tctactttgt agtccgctcc agccacgcgg
      901 atgttgctgg tcctcagacg ctagccctgc tcaagacggt caccatcgta ctgggtgttt
      961 tcatcatctg ctggctgccg gcttttagca tccttctctt agactccacc tgtcccgttc
     1021 gggcctgccc tgtcctctac aaagcccact atttttttgc ctttgccacc cttaactcac
     1081 tgctcaatcc tgtcatctat acgtggcgta gccgggacct tcggagggag gtgctgcggc
     1141 ccctgcagtg ctggcggaga gggaagggag tgacgggacg cagaggtggg aaccctggtc
     1201 accgactcct gcctctccgc agctccagct ccctggagag aggcatgcat atgcctacat
     1261 caccgacatt tctggagggt aacacagtgg tctgaaggga aaatgtgaac tgatagttaa
     1321 ccaagccaca gagagctctg tggggagaga ccaggtgacc tcatgatgtc cctcagtgct
     1381 gcaggtctgg agaaactgac cacagctcat aggtcaggtg accaacggag gcactgacta
     1441 atcagattgt agtactgtga ctgtggggat cattaagggt ctagggtgac cgcaggctgg
     1501 agcttagggc tagacatttg ccacttgata caaagggtgt cagcattctg tctgtcctat
     1561 cttccagccc ccctggttcc cgtcctgccg cctccttttt agggcctctc tacatagcct
     1621 tgactggctt gaactttcta tgcagaccgg gctgacctgg agctcacagc agtctatcta
     1681 cctgtctgtg ttctgagggt tgggtagcag ctcacccagc tcctgccccc ttccataaac
     1741 aaccttaggc ctctgaagga aatgctgtct gcagcggacc caaggcttct tccctgtctt
     1801 tctgaggcct aaatccacag cttccccaat ttcatcaact gctgcttctt ctctttcctt
     1861 tcatattcgg ggaaaggaaa ccactgtggg ggcagggagg aggcctggca tcccagtctt
     1921 tattttcaga tctcactggc cactcgcttt attggtgagc cgagagggat caggtgaggc
     1981 agtatggggc agctgttgag gagactttgg gctctcactc tcggggaggt gatggtcatt
     2041 cctggaactc ctccccccac acccagcctt tctccccatg agctcatcac ctcttcatcc
     2101 tatcccaggt accacggccc ttaaggcagg gcagccttga gctggatgtg gctgcttgca
     2161 acttgtctgt gctgtttttt aaaattggga cagggtctca tgtagcccag gttggtctcc
     2221 agctcactgt gtagccaaga ctggctgtgg acttccgatc ctcctgcctc cacttctgga
     2281 gtgccagtat ctgtatcaca ggggtgtacc accaccacct gtcttgaaaa ttgccatgaa
     2341 tgacatagtt cacatagcca tgggtggcca aggacactcc tgggtactct tactgcatct
     2401 tcccttgaag gactttgcta aatcctgtgg agaaatagaa aaatccaata cggtacaaac
     2461 tgtatttata tgtgtctgtg tgtcaatgtg gggtctgtga cctcctatcc cagtgtgggt
     2521 gctgtctgac ctcttctgtg cacatctgta tcaagactgc tagaaagata gacaggggtg
     2581 gggtgtgtct gtgggggtct ggccatgatc aggcctcctg ggaattgctg attcatctct
     2641 cccacgcata gaaacctctt ccttgaagaa atatgtgaaa gaaaaggctg aagaagggga
     2701 gatttgggag gcaaggagcc tgtcgggagt gtgtctcccc tcatatagct tcccagatgt
     2761 cctccttgtg ctggaaaccc agatctgggc caataaacag ttcaatttct cttgc
//
