LOCUS       NM_007901               3029 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA.
ACCESSION   NM_007901 XM_986946
VERSION     NM_007901.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3029)
  AUTHORS   Burrows,K., Ngai,L., Chiaranunt,P., Watt,J., Popple,S., Forde,B.,
            Denha,S., Olyntho,V.M., Tai,S.L., Cao,E.Y., Tejeda-Garibay,S.,
            Koenig,J.F.E., Mayer-Barber,K.D., Streutker,C.J., Hoyer,K.K.,
            Osborne,L.C., Liu,J., O'Mahony,L. and Mortha,A.
  TITLE     A gut commensal protozoan determines respiratory disease outcomes
            by shaping pulmonary immunity
  JOURNAL   Cell 188 (2), 316-330 (2025)
   PUBMED   39706191
REFERENCE   2  (bases 1 to 3029)
  AUTHORS   Engesser,J., Wang,H., Kapffer,S., Kaffke,A., Peters,A., Paust,H.J.,
            Geissen,M., Krebs,C.F., Panzer,U. and Asada,N.
  TITLE     S1PR1 mediates Th17 cell migration from the thymus to the skin in
            health and disease
  JOURNAL   Front Immunol 15, 1473130 (2024)
   PUBMED   39380990
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3029)
  AUTHORS   Burg,N., Malpass,R., Alex,L., Tran,M., Englebrecht,E., Kuo,A.,
            Pannelini,T., Minett,M., Athukorala,K., Worgall,T., Faust,H.J.,
            Goodman,S., Mehta,B., Brenner,M., Vestweber,D., Wei,K., Blobel,C.,
            Hla,T. and Salmon,J.E.
  TITLE     Endothelial cell sphingosine 1-phosphate receptor 1 restrains
            VE-cadherin cleavage and attenuates experimental inflammatory
            arthritis
  JOURNAL   JCI Insight 9 (11), e171467 (2024)
   PUBMED   38855867
  REMARK    GeneRIF: Endothelial cell sphingosine 1-phosphate receptor 1
            restrains VE-cadherin cleavage and attenuates experimental
            inflammatory arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3029)
  AUTHORS   Bassila,C., Kluck,G.E.G., Thyagarajan,N., Chathely,K.M.,
            Gonzalez,L. and Trigatti,B.L.
  TITLE     Ligand-dependent interactions between SR-B1 and S1PR1 in
            macrophages and atherosclerotic plaques
  JOURNAL   J Lipid Res 65 (5), 100541 (2024)
   PUBMED   38583587
  REMARK    GeneRIF: Ligand-dependent interactions between SR-B1 and S1PR1 in
            macrophages and atherosclerotic plaques.
REFERENCE   5  (bases 1 to 3029)
  AUTHORS   Guo,Y., Wu,D., Li,X., Wang,J., Li,H., Li,Y., Luo,D., Yi,F. and
            Zhang,D.
  TITLE     Proximal tubular MBD2 promotes autophagy to drive the progression
            of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis
  JOURNAL   FASEB J 38 (7), e23562 (2024)
   PUBMED   38578557
  REMARK    GeneRIF: Proximal tubular MBD2 promotes autophagy to drive the
            progression of AKI caused by vancomycin via regulation of
            miR-597-5p/S1PR1 axis.
REFERENCE   6  (bases 1 to 3029)
  AUTHORS   Hobson,J.P., Rosenfeldt,H.M., Barak,L.S., Olivera,A., Poulton,S.,
            Caron,M.G., Milstien,S. and Spiegel,S.
  TITLE     Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced
            cell motility
  JOURNAL   Science 291 (5509), 1800-1803 (2001)
   PUBMED   11230698
REFERENCE   7  (bases 1 to 3029)
  AUTHORS   Contos,J.J., Fukushima,N., Weiner,J.A., Kaushal,D. and Chun,J.
  TITLE     Requirement for the lpA1 lysophosphatidic acid receptor gene in
            normal suckling behavior
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13384-13389 (2000)
   PUBMED   11087877
REFERENCE   8  (bases 1 to 3029)
  AUTHORS   Liu,Y., Wada,R., Yamashita,T., Mi,Y., Deng,C.X., Hobson,J.P.,
            Rosenfeldt,H.M., Nava,V.E., Chae,S.S., Lee,M.J., Liu,C.H., Hla,T.,
            Spiegel,S. and Proia,R.L.
  TITLE     Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate,
            is essential for vascular maturation
  JOURNAL   J Clin Invest 106 (8), 951-961 (2000)
   PUBMED   11032855
REFERENCE   9  (bases 1 to 3029)
  AUTHORS   Zhang,G., Contos,J.J., Weiner,J.A., Fukushima,N. and Chun,J.
  TITLE     Comparative analysis of three murine G-protein coupled receptors
            activated by sphingosine-1-phosphate
  JOURNAL   Gene 227 (1), 89-99 (1999)
   PUBMED   9931453
REFERENCE   10 (bases 1 to 3029)
  AUTHORS   Liu,C.H. and Hla,T.
  TITLE     The mouse gene for the inducible G-protein-coupled receptor edg-1
  JOURNAL   Genomics 43 (1), 15-24 (1997)
   PUBMED   9226368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126932.4 and AK004591.2.
            
            On Jan 22, 2010 this sequence version replaced NM_007901.4.
            
            Summary: This gene encodes a G-protein-coupled receptor bound by
            the lysophospholipid, sphingosine 1-phosphate. The gene product
            functions in endothelial cells and is involved in vascular and
            heart development. This receptor is highly expressed in T and B
            lymphocytes, and it plays a role in T cell and B cell export from
            peripheral lymphoid organs. This protein is bound and downregulated
            by FTY720, an exogenous immunosuppressant drug studied in mouse
            disease models for multiple sclerosis in humans. [provided by
            RefSeq, Jan 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004591.2, BC049094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC126932.4         127972-127979
            9-1923              AK004591.2         2-1916
            1924-3029           AC126932.4         131489-132594
FEATURES             Location/Qualifiers
     source          1..3029
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.0 cM"
     gene            1..3029
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /note="sphingosine-1-phosphate receptor 1"
                     /db_xref="GeneID:13609"
                     /db_xref="MGI:MGI:1096355"
     exon            1..347
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..3029
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..1667
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /note="lysophospholipid receptor B1; S1P receptor 1; S1P
                     receptor Edg-1; sphingosine 1-phosphate receptor Edg-1;
                     endothelial differentiation G-protein coupled receptor 1;
                     endothelial differentiation sphingolipid G-protein-coupled
                     receptor 1"
                     /codon_start=1
                     /product="sphingosine 1-phosphate receptor 1"
                     /protein_id="NP_031927.2"
                     /db_xref="CCDS:CCDS17781.1"
                     /db_xref="GeneID:13609"
                     /db_xref="MGI:MGI:1096355"
                     /translation="MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHG
                     IKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANL
                     LLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRS
                     FLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIV
                     ILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILL
                     LLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNG
                     DSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /note="hexamer: AATAAA"
     polyA_site      2888
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
     regulatory      3007..3012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /note="hexamer: AATAAA"
     polyA_site      3029
                     /gene="S1pr1"
                     /gene_synonym="Edg1; Lpb1; S1p; S1p1"
                     /note="major polyA site"
ORIGIN      
        1 tctgccccag atctttctgg gaggctgctt cttagcagcc cagaccctga ggggccccct
       61 gccgctggca gagggcggag gagttaaaag cattaacccc tcccagtccc ttcctagagg
      121 agccacccag cctcggcggg gcgctcagag acttcgtctt gcaaaagtgg tgcgggcagc
      181 gcaggcaggg ctggccattg gagtgcaccg ctgaggaggg aggggacccc agctcaggga
      241 actttgcgag tgagctggtc gccgtcagtc gccgacagca gcaagatgcg gatcgcgcgg
      301 tgtagaccca gagtcctgcg gacgcagctt cgtccggctt gagcgaggct gctgtttctc
      361 ggaggcctct ccagccaagg aaaagctcca taaaagaaaa aagcattgga ttgctcgctg
      421 acctggcttt gctgtaactg aaggctcact caacctcgcc ctctagcgtt tgcctggaga
      481 aataccaccc caggctcctg gggacacaat tagcagctat ggtgtccact agcatcccgg
      541 aggttaaagc tctccgcagc tcagtctctg actatgggaa ctatgatatc atagtccggc
      601 attacaacta cacaggcaag ttgaacatcg gggcggagaa ggaccatggc attaaactga
      661 cttcagtggt gttcattctc atctgctgct tcatcatcct agagaatata tttgtcttgc
      721 taactatttg gaaaaccaag aagttccacc ggcccatgta ctatttcata ggcaacctag
      781 ccctctcgga cctattagca ggcgtggctt acacagctaa cctgctgttg tctggggcca
      841 ccacttacaa gctcacacct gcccagtggt ttctgcggga agggagtatg tttgtggctc
      901 tctctgcatc agtcttcagc ctccttgcca tcgccattga gcgctacatc accatgctga
      961 agatgaaact acacaacggg agcaacagct cgcgctcctt tctgctgatc agcgcctgct
     1021 gggtcatctc cctcatcctg gggggcctgc ccatcatggg ctggaactgc atcagctcgc
     1081 tgtctagctg ctccaccgtg ctcccgctct accacaagca ctatattctc ttctgcacca
     1141 ccgtcttcac tctgctcctg ctttccatcg tcatcctcta ctgcaggatc tactccttgg
     1201 tcaggactcg aagccgccgc ctgaccttcc gcaagaacat ctccaaggcc agtcgcagtt
     1261 ctgagaagtc tctggccttg ctgaagacgg tgatcattgt cctgagtgtc ttcattgcct
     1321 gctgggcccc tctcttcatc ctactactgt tagatgtggg ctgcaaggcg aagacctgtg
     1381 acatcctgta caaagcagag tacttcctgg ttctggctgt gctgaactca ggtaccaacc
     1441 ccatcatcta cactctgacc aacaaggaga tgcgccgggc cttcatccgg atcgtatctt
     1501 gttgcaaatg ccccaacgga gactctgctg gcaaattcaa gaggcccatc atcccaggca
     1561 tggaatttag ccgcagcaaa tcagacaact cctctcaccc ccagaaggac gatggggaca
     1621 acccagagac cattatgtcg tctggaaacg tcaattcttc ttcctaaagc ctgaagaagc
     1681 tgttgatact gagggaagca ttctgacttg atcacccact accccagcat ttcaaaaatg
     1741 tctctcgctc tccactgctg caaggaagga gcaactggga gcctgagaga gggagggaag
     1801 ggagaatgtg cggcctggtg ataccatgat gtaggtaggt agtaattgtg aacaatgcac
     1861 tgggaagggt ggagatcagg tctggcctgc agtgggtttc ctgccccccc ctcccccgta
     1921 ccctggagct ttgattttgc actgagccaa aggtctagca ttgtcaagct cccagagggc
     1981 tcatctggtc cctcctcaaa gactaaggtc ccaagagaaa gtgttgtgat ctctcactgt
     2041 aatgtcaaag tgagtatgtg ccctttagct tggttgggtg gtgtacatgt ccccaccctc
     2101 cggtttcttc tcaccctgtc tccccttacc accccttctt tatatcgtaa ctgcctgact
     2161 tttgttcatc agaaggaggt tgtggagggg tctatttctt gattatagtg agcaagctat
     2221 ttgctgggaa ggctatttgc tgaggccaaa gtttccatgt aaactgggtc aagttgttgg
     2281 gaatttggta ggccatcttt aagatgaaaa tgtgttcctt ttttgtcaca tgttccttat
     2341 tcccattaca accacaatgg ttgtgaatga agagtaacaa agaataacga agtctacttt
     2401 atttgaatta tactgggcag aatcttagat gatacgggaa aagcaaaaaa caaacaaaca
     2461 aacaaacaaa caaacaaaaa tctacagcat gaggtgaaat gtgagagtta agtcgtgcag
     2521 accaagagct gtttcttgct gtctttctct aacccctaca gcacctttgg cacttttatt
     2581 gatgatttca gaatgttgtg tgatccattt caaccaactg ggggagagtt gtattttgtt
     2641 taaagaacat tttctgattt tcgaatgtat ttgtttcttt gaggtcatct tattgaactt
     2701 cttcctaacc cgtgttaaca ccactgaatg tgtagttctt aagaaagtgt catccttttg
     2761 taccccccac tccccaaaag cattacttta actgacaggg aacatcagga attctttatt
     2821 tcggctgtca ctaggtattg atgatggtta taaatgttac agagaataaa aatatattag
     2881 tctctttagt ctggtgttca gtgagtgcaa ttaagccaag aaatgtcttt tttaaaaaat
     2941 agtatttaat aggttcctga cttttgtgga tcattttgca catagcttta tcaactttta
     3001 aacattaata aactgatttt tttaaaaga
//
