LOCUS       NM_001379590            4296 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus S100P binding protein (S100pbp), transcript variant 6,
            mRNA.
ACCESSION   NM_001379590 XM_006503445
VERSION     NM_001379590.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4296)
  AUTHORS   Srivastava,K., Lines,K.E., Jach,D. and Crnogorac-Jurcevic,T.
  TITLE     S100PBP is regulated by mutated KRAS and plays a tumour suppressor
            role in pancreatic cancer
  JOURNAL   Oncogene 42 (46), 3422-3434 (2023)
   PUBMED   37794133
  REMARK    GeneRIF: S100PBP is regulated by mutated KRAS and plays a tumour
            suppressor role in pancreatic cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606977.28.
            
            On Apr 9, 2020 this sequence version replaced XM_006503445.4.
            
            Transcript Variant: This variant (6), as well as variants 1, 4, 5,
            7, and 8, encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.558873.1,
                                           SRR7974084.13507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL606977.28        135956-135993       c
            39-155              AL606977.28        130015-130131       c
            156-946             AL606977.28        128156-128946       c
            947-1029            AL606977.28        126603-126685       c
            1030-1121           AL606977.28        124655-124746       c
            1122-1206           AL606977.28        101839-101923       c
            1207-4296           AL606977.28        94416-97505         c
FEATURES             Location/Qualifiers
     source          1..4296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.96 cM"
     gene            1..4296
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="S100P binding protein"
                     /db_xref="GeneID:74648"
                     /db_xref="MGI:MGI:1921898"
     exon            1..38
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            39..155
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            156..946
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1348
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="S100P-binding protein isoform 1"
                     /protein_id="NP_001366519.1"
                     /db_xref="GeneID:74648"
                     /db_xref="MGI:MGI:1921898"
                     /translation="MTCSLLPSEQSSGASFLPKSNASFPWGSLDEDELDDSLLEFSDG
                     EEDDGHFSFTEEEIEMLLKDDDGGHNEYRPRKSQILPDIPQENSLYSLGPAAETPGFL
                     KLPQLSTSVGHGPTPSKSLNRHFVLEKNLIKVTVVAPFNPTVCDPVLDKDKIDSSKET
                     ENPASLREQTREDDPQPNESKRCTEPEGVSPNTSAWDGPLLSSPSNNNIEQTASDKNI
                     PESKKPTPVFSQISNHSEVPNRKNSGSHKSGCEVRIPVVSSSSNRHAFDKDSGEAKGE
                     RRLGKVIPVLQTRTRMFSQSELEKQKDIYLSKVIAHIEDPGDSNQGTLGELDALMDQV
                     HMQHPDWQHPSDLTTRNYARFRQRPLQRYSLSQWVDRNKRSHHRFQRLPDFSYSPYVS
                     SHQQ"
     exon            947..1029
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1121
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1206
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..4296
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4274..4279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="hexamer: AATAAA"
     polyA_site      4296
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="major polyA site"
ORIGIN      
        1 gctgccgctc gcccaggctt ttggcccggc ttccggagga aggtgggagt caatcacttt
       61 gacaagtctc ctggaaggaa cagccagcgg gagttgaaac ctttttccat ttggtctcgt
      121 ggcaaaggca gagattgctc cagcagctcc acacaatatg acgtgttcac tcttgccctc
      181 tgaacagtct tctggtgcct cttttctgcc taaaagcaat gcctcatttc cttggggttc
      241 cttggatgaa gatgagttgg atgactcctt gttggagttt tctgatggag aagaagatga
      301 tggccatttc agtttcacag aggaagagat tgagatgctc ttgaaggacg atgatggtgg
      361 gcataatgag tatagaccaa gaaagagtca aattctacct gatattcctc aagaaaattc
      421 tttgtacagc ttgggaccag cagctgaaac ccctggcttc ctaaaactac ctcaactaag
      481 tacatcagtt ggtcatggac ctactcctag taaatcatta aacagacact ttgtacttga
      541 aaagaatctt ataaaagtaa ctgttgtcgc accatttaat ccaacagttt gtgatcctgt
      601 gcttgataaa gacaagatcg attcctccaa agaaacggaa aatcctgcct cccttcggga
      661 acagacgaga gaagatgacc ctcaacctaa tgagagtaaa cgttgcactg agcctgaagg
      721 ggtcagtccc aatacctctg cttgggatgg gcccctgctt tcttctcctt caaacaataa
      781 catcgaacaa actgcctctg ataaaaatat acctgaaagt aagaaaccta cccctgtgtt
      841 ctctcagatc tccaaccatt cagaggtccc caacaggaaa aacagtggct cacataaatc
      901 aggttgtgaa gtgagaattc cagttgtgtc cagttcatca aacagacatg cctttgacaa
      961 ggattctggg gaggcgaaag gtgagagaag actaggcaaa gtcattcctg ttctacaaac
     1021 tagaaccagg atgttttcac aatcagagct agaaaaacag aaggacattt atctcagcaa
     1081 agtcattgct catatagaag atccagggga ctctaaccaa ggtaccttgg gagagctaga
     1141 tgccctgatg gatcaagttc atatgcagca cccagactgg cagcatcctt cagatcttac
     1201 cacacgaaac tacgcccggt tccgacagag gcctctgcag aggtacagtc tgagtcagtg
     1261 ggttgacaga aacaagcgga gccaccatcg gttccagcgt ctcccagact tctcctacag
     1321 tccatatgtc tcatcccatc aacagtgaca gttcctgcca agggtcccgt ccagagcagc
     1381 atcacatttt cctctgctat ttttgtttgt atattttgag ttttatttca caagattttt
     1441 atttaaagaa tttgtcacct tttggaaatg cccattactg tcttgaattt ttgtttttta
     1501 atgagggcca ccccccaccc ctgatttgta tgtctgtctg gtgaatatgt ttcagcagtg
     1561 ttaagtattg tttttctgtt tgttcactgt tgttgttgtt gttgctgttt ttaaatttta
     1621 aatgaaggta attctctttt gaaggcctgc attaagtcag aacagtcagg ctttgagtaa
     1681 aataccagct gtaagggcag gcagactcac cttccagtct actgtaagga agaggctgtt
     1741 ttgcaagcta agagccggta ttattattgt tgacttgtga atagatagaa gtcactttta
     1801 acgacccctc tttttaaatt tgagtttctt gaatacttgt cagtatttta atgttgccaa
     1861 ttcagtacat ttgaaatagg agaaggagaa aagtcctgtt gaagggctag attaaaagtg
     1921 taaatcctct cctttctgta cctattagct gcctttttaa aaaattatta gtggcttttt
     1981 tcactctcta ttagatatat ttcgttcata atgtttgaaa tcttacacat cttaactgac
     2041 agaagacagc tgaataaccc ttgttcaata ctctgtggtc ttgtgactgg ttggtttctc
     2101 tgccccattg ttttcttttc cttttcccac tcccagtgac cggttagtcc tgaagctttg
     2161 cagtaagtgt tcttatgtcc tgttagactg agacatggct ctcaggtgcc ctctgtctgc
     2221 tgaagaaatc ctgtcagaat cctgactgtc gttaggccgg cacagaatcc tgactgttgt
     2281 taggccagca caattgggat gtctaggaat cttcagttct gtcttcggaa cccgagttta
     2341 tgtgttgctg ctgttcaagg aaccttcgtc ctatgaaatc cttgggagag tcactggcct
     2401 ctcccgttgg ttacaggtac ccttataccc tggatgttag cgttgtagtt gtagcattgg
     2461 gtccattgtt tcacattagt gtttgagcat cttgggaaag tacgattgag cccgtgcacc
     2521 gcaccaccac catgcaccgc gtaaggtgtg gtgttccaac caaagcgcta ggctctgtgt
     2581 actgtcttaa tggatgtcct aaaagatctg tatttcttac aggcagctct agagatcatt
     2641 ctgagagggt ttacaatatg acactcctgc tgctgcagtc actgtgggag tgattcatag
     2701 ttgcctagcc tctgtctcat tttatatgtg gctaacccac cctgaatagt ctactctgcc
     2761 tcagaaaaat gatctttttg ttctgttttg tttttgcttt tcaagacagg gtttctttgt
     2821 atactcctgg ctgtcctgga actcgctctt agactgggct ggccttaact cacagagctc
     2881 tgcctacctt gccttctcac tgctgggagt aaaaggatga atcaccattg ttggactgaa
     2941 aaagtgactg tgattaggaa aatcttgatt ttgtttgttt tgttttgttt tgttttcaag
     3001 cctttaatag gtttggataa atgttcccaa gtgtgtgtta gttttatcta gtgaaagttt
     3061 tttcttcttt ccttcctttt ttgcggcagg gtctcctata aagcctaggc tagccatcaa
     3121 cacactattt aacccaagat ggtcttgcac ttctgatttt tctctccctc cagcccctca
     3181 cccctcagac aggttttttt tttatgtagc cctcctgtct gggtagacca ggctggcctc
     3241 aggactcaca gagattcacc tgcctctgcc ttcttagtgc tgggattaaa ggtgtgcacc
     3301 accactccct gcttttgaca tccccccccc cgccccaccc gccaccccca gaaagacttt
     3361 tctatttctt agttatttgg tttagattct gggaccagac tttgaaaggc agtagtccag
     3421 tcacctctct tgatgggcac gcttgttgtt gacctcagtt gacttgtcca agatgctgtg
     3481 agttagcctg ttagactgag atatgccaaa caacccacct atgggaccaa aacaaagtgc
     3541 agattagcta ccgctggagt agctagcatt ggggctgaat ggttcccacg gggagcccag
     3601 ggagtggagg gacagcaaag ctcctgctct cctgctacca ggaggaatta agactgaatg
     3661 tataatggga gtgctgcctc tgtcagagca gatgagtgac aggttaacta gaaaatgtga
     3721 caatcacatt tcctctagcg cagataattc tgtttttcca aagtgttagc agctaattaa
     3781 atctggtgga ctgggggagg agagagctgt tctgtactgg ttaacatggt attctttaag
     3841 gagaaaaaag ccaaagaaaa ctcatccggc atgttagcct taaagatggt actggccaga
     3901 agccggggct taatctcttc agagctgcat atctcttatg tttgggtttg gcctctaagt
     3961 cttgtagatt aaattaattc ttgctgtatt tttaaatttg agtaagggtt atgtgcattt
     4021 aactgtgttc ctgtctttta tcatccctgg ggacgttctt accatagggg tcttgacaaa
     4081 gcaaagctaa aatgtgttgt tgataaatag ttcctgtgta ggtcaggagc cgaaataaca
     4141 atagctctgc agctcatcgg gctctgattt actcgagttg ttgtcggggt cgattatgaa
     4201 actgaagttt ggtgcctcct tttttatcat gtttttcccc ttgtagcagt tgtgtttaat
     4261 gtcattaaaa agaaataaaa gttctcgtca gtggca
//
