LOCUS       NM_001361317            4062 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus S100P binding protein (S100pbp), transcript variant 3,
            mRNA.
ACCESSION   NM_001361317
VERSION     NM_001361317.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Srivastava,K., Lines,K.E., Jach,D. and Crnogorac-Jurcevic,T.
  TITLE     S100PBP is regulated by mutated KRAS and plays a tumour suppressor
            role in pancreatic cancer
  JOURNAL   Oncogene 42 (46), 3422-3434 (2023)
   PUBMED   37794133
  REMARK    GeneRIF: S100PBP is regulated by mutated KRAS and plays a tumour
            suppressor role in pancreatic cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606977.28.
            
            On Apr 9, 2020 this sequence version replaced NM_001361317.1.
            
            Transcript Variant: This variant (3), as well as variant 11,
            encodes isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030636.1, SRR17253014.4778275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL606977.28        135956-135993       c
            39-155              AL606977.28        130015-130131       c
            156-479             AL606977.28        128623-128946       c
            480-613             AL606977.28        128381-128514       c
            614-712             AL606977.28        128156-128254       c
            713-795             AL606977.28        126603-126685       c
            796-887             AL606977.28        124655-124746       c
            888-972             AL606977.28        101839-101923       c
            973-4062            AL606977.28        94416-97505         c
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 62.96 cM"
     gene            1..4062
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="S100P binding protein"
                     /db_xref="GeneID:74648"
                     /db_xref="MGI:MGI:1921898"
     exon            1..38
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            39..155
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            156..479
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1114
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="S100P-binding protein isoform 3"
                     /protein_id="NP_001348246.1"
                     /db_xref="CCDS:CCDS89830.1"
                     /db_xref="GeneID:74648"
                     /db_xref="MGI:MGI:1921898"
                     /translation="MTCSLLPSEQSSGASFLPKSNASFPWGSLDEDELDDSLLEFSDG
                     EEDDGHFSFTEEEIEMLLKDDDGGHNEYRPRKSQILPDIPQENSLYSLGPAAETPGFL
                     KLPQLICDPVLDKDKIDSSKETENPASLREQTREDDPQPNESKRCTEPEGISNHSEVP
                     NRKNSGSHKSGCEVRIPVVSSSSNRHAFDKDSGEAKGERRLGKVIPVLQTRTRMFSQS
                     ELEKQKDIYLSKVIAHIEDPGDSNQGTLGELDALMDQVHMQHPDWQHPSDLTTRNYAR
                     FRQRPLQRYSLSQWVDRNKRSHHRFQRLPDFSYSPYVSSHQQ"
     exon            480..613
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            614..712
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            713..795
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            796..887
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            888..972
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     exon            973..4062
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="S100pbp"
                     /gene_synonym="4930429A08Rik; S100pbpr"
                     /note="major polyA site"
ORIGIN      
        1 gctgccgctc gcccaggctt ttggcccggc ttccggagga aggtgggagt caatcacttt
       61 gacaagtctc ctggaaggaa cagccagcgg gagttgaaac ctttttccat ttggtctcgt
      121 ggcaaaggca gagattgctc cagcagctcc acacaatatg acgtgttcac tcttgccctc
      181 tgaacagtct tctggtgcct cttttctgcc taaaagcaat gcctcatttc cttggggttc
      241 cttggatgaa gatgagttgg atgactcctt gttggagttt tctgatggag aagaagatga
      301 tggccatttc agtttcacag aggaagagat tgagatgctc ttgaaggacg atgatggtgg
      361 gcataatgag tatagaccaa gaaagagtca aattctacct gatattcctc aagaaaattc
      421 tttgtacagc ttgggaccag cagctgaaac ccctggcttc ctaaaactac ctcaactaat
      481 ttgtgatcct gtgcttgata aagacaagat cgattcctcc aaagaaacgg aaaatcctgc
      541 ctcccttcgg gaacagacga gagaagatga ccctcaacct aatgagagta aacgttgcac
      601 tgagcctgaa gggatctcca accattcaga ggtccccaac aggaaaaaca gtggctcaca
      661 taaatcaggt tgtgaagtga gaattccagt tgtgtccagt tcatcaaaca gacatgcctt
      721 tgacaaggat tctggggagg cgaaaggtga gagaagacta ggcaaagtca ttcctgttct
      781 acaaactaga accaggatgt tttcacaatc agagctagaa aaacagaagg acatttatct
      841 cagcaaagtc attgctcata tagaagatcc aggggactct aaccaaggta ccttgggaga
      901 gctagatgcc ctgatggatc aagttcatat gcagcaccca gactggcagc atccttcaga
      961 tcttaccaca cgaaactacg cccggttccg acagaggcct ctgcagaggt acagtctgag
     1021 tcagtgggtt gacagaaaca agcggagcca ccatcggttc cagcgtctcc cagacttctc
     1081 ctacagtcca tatgtctcat cccatcaaca gtgacagttc ctgccaaggg tcccgtccag
     1141 agcagcatca cattttcctc tgctattttt gtttgtatat tttgagtttt atttcacaag
     1201 atttttattt aaagaatttg tcaccttttg gaaatgccca ttactgtctt gaatttttgt
     1261 tttttaatga gggccacccc ccacccctga tttgtatgtc tgtctggtga atatgtttca
     1321 gcagtgttaa gtattgtttt tctgtttgtt cactgttgtt gttgttgttg ctgtttttaa
     1381 attttaaatg aaggtaattc tcttttgaag gcctgcatta agtcagaaca gtcaggcttt
     1441 gagtaaaata ccagctgtaa gggcaggcag actcaccttc cagtctactg taaggaagag
     1501 gctgttttgc aagctaagag ccggtattat tattgttgac ttgtgaatag atagaagtca
     1561 cttttaacga cccctctttt taaatttgag tttcttgaat acttgtcagt attttaatgt
     1621 tgccaattca gtacatttga aataggagaa ggagaaaagt cctgttgaag ggctagatta
     1681 aaagtgtaaa tcctctcctt tctgtaccta ttagctgcct ttttaaaaaa ttattagtgg
     1741 cttttttcac tctctattag atatatttcg ttcataatgt ttgaaatctt acacatctta
     1801 actgacagaa gacagctgaa taacccttgt tcaatactct gtggtcttgt gactggttgg
     1861 tttctctgcc ccattgtttt cttttccttt tcccactccc agtgaccggt tagtcctgaa
     1921 gctttgcagt aagtgttctt atgtcctgtt agactgagac atggctctca ggtgccctct
     1981 gtctgctgaa gaaatcctgt cagaatcctg actgtcgtta ggccggcaca gaatcctgac
     2041 tgttgttagg ccagcacaat tgggatgtct aggaatcttc agttctgtct tcggaacccg
     2101 agtttatgtg ttgctgctgt tcaaggaacc ttcgtcctat gaaatccttg ggagagtcac
     2161 tggcctctcc cgttggttac aggtaccctt ataccctgga tgttagcgtt gtagttgtag
     2221 cattgggtcc attgtttcac attagtgttt gagcatcttg ggaaagtacg attgagcccg
     2281 tgcaccgcac caccaccatg caccgcgtaa ggtgtggtgt tccaaccaaa gcgctaggct
     2341 ctgtgtactg tcttaatgga tgtcctaaaa gatctgtatt tcttacaggc agctctagag
     2401 atcattctga gagggtttac aatatgacac tcctgctgct gcagtcactg tgggagtgat
     2461 tcatagttgc ctagcctctg tctcatttta tatgtggcta acccaccctg aatagtctac
     2521 tctgcctcag aaaaatgatc tttttgttct gttttgtttt tgcttttcaa gacagggttt
     2581 ctttgtatac tcctggctgt cctggaactc gctcttagac tgggctggcc ttaactcaca
     2641 gagctctgcc taccttgcct tctcactgct gggagtaaaa ggatgaatca ccattgttgg
     2701 actgaaaaag tgactgtgat taggaaaatc ttgattttgt ttgttttgtt ttgttttgtt
     2761 ttcaagcctt taataggttt ggataaatgt tcccaagtgt gtgttagttt tatctagtga
     2821 aagttttttc ttctttcctt ccttttttgc ggcagggtct cctataaagc ctaggctagc
     2881 catcaacaca ctatttaacc caagatggtc ttgcacttct gatttttctc tccctccagc
     2941 ccctcacccc tcagacaggt ttttttttta tgtagccctc ctgtctgggt agaccaggct
     3001 ggcctcagga ctcacagaga ttcacctgcc tctgccttct tagtgctggg attaaaggtg
     3061 tgcaccacca ctccctgctt ttgacatccc cccccccgcc ccacccgcca cccccagaaa
     3121 gacttttcta tttcttagtt atttggttta gattctggga ccagactttg aaaggcagta
     3181 gtccagtcac ctctcttgat gggcacgctt gttgttgacc tcagttgact tgtccaagat
     3241 gctgtgagtt agcctgttag actgagatat gccaaacaac ccacctatgg gaccaaaaca
     3301 aagtgcagat tagctaccgc tggagtagct agcattgggg ctgaatggtt cccacgggga
     3361 gcccagggag tggagggaca gcaaagctcc tgctctcctg ctaccaggag gaattaagac
     3421 tgaatgtata atgggagtgc tgcctctgtc agagcagatg agtgacaggt taactagaaa
     3481 atgtgacaat cacatttcct ctagcgcaga taattctgtt tttccaaagt gttagcagct
     3541 aattaaatct ggtggactgg gggaggagag agctgttctg tactggttaa catggtattc
     3601 tttaaggaga aaaaagccaa agaaaactca tccggcatgt tagccttaaa gatggtactg
     3661 gccagaagcc ggggcttaat ctcttcagag ctgcatatct cttatgtttg ggtttggcct
     3721 ctaagtcttg tagattaaat taattcttgc tgtattttta aatttgagta agggttatgt
     3781 gcatttaact gtgttcctgt cttttatcat ccctggggac gttcttacca taggggtctt
     3841 gacaaagcaa agctaaaatg tgttgttgat aaatagttcc tgtgtaggtc aggagccgaa
     3901 ataacaatag ctctgcagct catcgggctc tgatttactc gagttgttgt cggggtcgat
     3961 tatgaaactg aagtttggtg cctccttttt tatcatgttt ttccccttgt agcagttgtg
     4021 tttaatgtca ttaaaaagaa ataaaagttc tcgtcagtgg ca
//
