LOCUS       NM_009115               1676 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus S100 protein, beta polypeptide, neural (S100b), mRNA.
ACCESSION   NM_009115
VERSION     NM_009115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Zhang,Y., Li,D., Cai,Y., Zou,R., Zhang,Y., Deng,X., Wang,Y.,
            Tang,T., Ma,Y., Wu,F. and Xie,Y.
  TITLE     Astrocyte allocation during brain development is controlled by
            Tcf4-mediated fate restriction
  JOURNAL   EMBO J 43 (21), 5114-5140 (2024)
   PUBMED   39300210
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Bansal,P., Banda,E.C., Glatt-Deeley,H.R., Stoddard,C.E.,
            Linsley,J.W., Arora,N., Deleschaux,C., Ahern,D.T., Kondaveeti,Y.,
            Massey,R.E., Nicouleau,M., Wang,S., Sabariego-Navarro,M.,
            Dierssen,M., Finkbeiner,S. and Pinter,S.F.
  TITLE     A dynamic in vitro model of Down syndrome neurogenesis with trisomy
            21 gene dosage correction
  JOURNAL   Sci Adv 10 (23), eadj0385 (2024)
   PUBMED   38848354
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Shimizu,A., Sakai,Y., Ohno,K., Masaki,S., Kuwano,R., Takahashi,Y.,
            Miyashita,N. and Watanabe,T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   MacDonald,G., Chu,M.L. and Cox,D.R.
  TITLE     Fine structure physical mapping of the region of mouse chromosome
            10 homologous to human chromosome 21
  JOURNAL   Genomics 11 (2), 317-323 (1991)
   PUBMED   1837533
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Naruse,I., Kato,K., Asano,T., Suzuki,F. and Kameyama,Y.
  TITLE     Developmental brain abnormalities accompanied with the retarded
            production of S-100 beta protein in genetic polydactyly mice
  JOURNAL   Brain Res Dev Brain Res 51 (2), 253-258 (1990)
   PUBMED   2323034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX205737.1, BC061178.1, AK135083.1 and AW456919.1.
            
            On Oct 4, 2007 this sequence version replaced NM_009115.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX205737.1, AK135083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CX205737.1         1-17
            18-439              BC061178.1         1-422
            440-1619            AK135083.1         423-1602
            1620-1676           AW456919.1         1-57                c
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.76 cM"
     gene            1..1676
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="S100 protein, beta polypeptide, neural"
                     /db_xref="GeneID:20203"
                     /db_xref="MGI:MGI:98217"
     exon            1..123
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /inference="alignment:Splign:2.1.0"
     exon            124..269
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..410
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="S-100 protein beta chain; S-100 protein subunit
                     beta; S100 calcium-binding protein B"
                     /codon_start=1
                     /product="protein S100-B"
                     /protein_id="NP_033141.1"
                     /db_xref="CCDS:CCDS35943.1"
                     /db_xref="GeneID:20203"
                     /db_xref="MGI:MGI:98217"
                     /translation="MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHF
                     LEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVAMVTTACHEFFEHE"
     exon            270..1661
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="hexamer: AATAAA"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="hexamer: ATTAAA"
     polyA_site      1479
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="major polyA site"
     polyA_site      1504
                     /gene="S100b"
                     /gene_synonym="Bpb"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="S100b"
                     /gene_synonym="Bpb"
ORIGIN      
        1 gtggactgcg ccaagcccac acccagttct ctctgcagga agaataagaa gctgttctgt
       61 ctacactcct gttactcgga cactgaagcc agagaggact ccagcagcaa aggtgaccag
      121 gagctcccgg gatgtccgag ctggagaagg ccatggttgc cctcattgat gtcttccacc
      181 agtactccgg gcgagagggt gacaagcaca agctgaagaa gtcagaactg aaggagctta
      241 tcaacaacga gctctctcac ttcctggagg aaatcaagga gcaggaagtg gtggacaaag
      301 tgatggagac gctggacgaa gatggggatg gggagtgtga cttccaggag ttcatggcct
      361 tcgtcgccat ggtgaccacg gcctgccatg agttctttga acatgagtga gaccaaaaaa
      421 aaaaaaaaaa aaaaaaaaag tagctgagct gtttctgcaa cagacatgag ggtcacaaga
      481 ggaggcacag caaaggctca tgggctcgaa ggagctgagc tctctagaca cacataacta
      541 attaggaagc ttggtttgct ttggggatga aaccccaacc cccttcccag gggctgcttt
      601 aagttagcac atcatgattt ctgctaggct aggcattccc gtgagctgac tggtcccagg
      661 aactgttggt aagggtcact taggggatga gatcaacgct ctgttgataa aacacgtgtt
      721 gctgaccacc atgcccctgt agaagagtca cctgtaagaa tcaaggcaga ctaccaacag
      781 tacttccgtc agtcagcttt cttagatgta tgcttcccat acatctacag acccacagct
      841 ggatctgctg ccacccgaag aggttgctca tccttacacc tgcttgccat ctgcctgagc
      901 aaatgatgct ccagaaagta gacagactga tcgcctacac ccttccccag ctcagaggag
      961 cacagccaca cttaagtctc ttcttccaca gtgtgcagtg attcgttact aagtaaatat
     1021 ttaatgccaa cagttctaac tggggaaaca attagatctc acaaactaag tatgaacatt
     1081 ctaactcagg accgagaatc aaaattctgc tcggcagact tctcctttca ggatgatcgc
     1141 tttgttcctg gaggacagag gaggggaatg gccagagtct ttttctagtt agttgtatct
     1201 tccttgctcc ctctgctgtc cataatgtga gtggctgcgg aagttgagat tcacaggacg
     1261 agctgatggg gaattaaggg tctctgaggt gtgtccttta gctgctggga gccatgtctg
     1321 acctgctggt gcctagggcc tgcttagccc ttggtgaggc tgagagtcga ggactgtggg
     1381 aagctggact tgaggctttc taacttgcat attcaaatag cgacgtttta aataatccaa
     1441 gttacattta aataaaaact gcattgcaaa tattaaaaag ccattctagg agaattctaa
     1501 attaccctta cccatctcta ttttgttttg ttttgttttg ttttcagaga agagacttag
     1561 aagttcatta agtcaactga acaatgcctt cgcataaaat aaaagcattg tgaaaattct
     1621 ccatcaccac tgaagaagaa ataaatataa agtacttgtg aaaaaaaaaa aaaaaa
//
