LOCUS       NM_001281852             537 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus S100 calcium binding protein A9 (calgranulin B)
            (S100a9), transcript variant 1, mRNA.
ACCESSION   NM_001281852
VERSION     NM_001281852.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 537)
  AUTHORS   Franz,S., Torregrossa,M., Anderegg,U., Ertel,A. and Saalbach,A.
  TITLE     Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic
            Wounds
  JOURNAL   Int J Mol Sci 25 (18), 9980 (2024)
   PUBMED   39337466
  REMARK    GeneRIF: Dysregulated S100A9 Expression Impairs Matrix Deposition
            in Chronic Wounds.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 537)
  AUTHORS   Chang,N., Liu,Y., Li,W., Ma,Y., Zhou,X., Zhao,X., Yang,L. and Li,L.
  TITLE     Neutrophil-secreted S100A8/A9 participates in fatty liver injury
            and fibrosis by promoting myofibroblast migration
  JOURNAL   J Mol Med (Berl) 102 (9), 1117-1133 (2024)
   PUBMED   38995368
  REMARK    GeneRIF: Neutrophil-secreted S100A8/A9 participates in fatty liver
            injury and fibrosis by promoting myofibroblast migration.
REFERENCE   3  (bases 1 to 537)
  AUTHORS   Liu,X., Wang,J., Jin,J., Hu,Q., Zhao,T., Wang,J., Gao,J. and Man,J.
  TITLE     S100A9 deletion in microglia/macrophages ameliorates brain injury
            through the STAT6/PPARgamma pathway in ischemic stroke
  JOURNAL   CNS Neurosci Ther 30 (8), e14881 (2024)
   PUBMED   39107960
  REMARK    GeneRIF: S100A9 deletion in microglia/macrophages ameliorates brain
            injury through the STAT6/PPARgamma pathway in ischemic stroke.
REFERENCE   4  (bases 1 to 537)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 537)
  AUTHORS   Yuan,Y.P., Shen,Z.Y., Teng,T., Xu,S.C., Kong,C.Y., Zeng,X.F., A
            Hofmann Bowman,M. and Yan,L.
  TITLE     S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes Cardiac
            Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth Factor 23)
            in Mice
  JOURNAL   J Am Heart Assoc 13 (10), e028006 (2024)
   PUBMED   38726894
  REMARK    GeneRIF: S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes
            Cardiac Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth
            Factor 23) in Mice.
REFERENCE   6  (bases 1 to 537)
  AUTHORS   Donato,R.
  TITLE     Functional roles of S100 proteins, calcium-binding proteins of the
            EF-hand type
  JOURNAL   Biochim Biophys Acta 1450 (3), 191-231 (1999)
   PUBMED   10395934
  REMARK    Review article
REFERENCE   7  (bases 1 to 537)
  AUTHORS   Lichanska,A.M., Browne,C.M., Henkel,G.W., Murphy,K.M.,
            Ostrowski,M.C., McKercher,S.R., Maki,R.A. and Hume,D.A.
  TITLE     Differentiation of the mononuclear phagocyte system during mouse
            embryogenesis: the role of transcription factor PU.1
  JOURNAL   Blood 94 (1), 127-138 (1999)
   PUBMED   10381505
REFERENCE   8  (bases 1 to 537)
  AUTHORS   Ridinger,K., Ilg,E.C., Niggli,F.K., Heizmann,C.W. and Schafer,B.W.
  TITLE     Clustered organization of S100 genes in human and mouse
  JOURNAL   Biochim Biophys Acta 1448 (2), 254-263 (1998)
   PUBMED   9920416
REFERENCE   9  (bases 1 to 537)
  AUTHORS   Raftery,M.J., Harrison,C.A., Alewood,P., Jones,A. and Geczy,C.L.
  TITLE     Isolation of the murine S100 protein MRP14 (14 kDa
            migration-inhibitory-factor-related protein) from activated spleen
            cells: characterization of post-translational modifications and
            zinc binding
  JOURNAL   Biochem J 316 (Pt 1) (Pt 1), 285-293 (1996)
   PUBMED   8645219
REFERENCE   10 (bases 1 to 537)
  AUTHORS   Lagasse,E. and Weissman,I.L.
  TITLE     Mouse MRP8 and MRP14, two intracellular calcium-binding proteins
            associated with the development of the myeloid lineage
  JOURNAL   Blood 79 (8), 1907-1915 (1992)
   PUBMED   1373330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122425.5, AK143826.1, BC027635.1 and BF732133.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX521503.1, BG072801.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC122425.5         68630-68659         c
            31-518              AK143826.1         2-489
            519-519             BC027635.1         468-468
            520-537             BF732133.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.91 cM"
     gene            1..537
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /note="S100 calcium binding protein A9 (calgranulin B)"
                     /db_xref="GeneID:20202"
                     /db_xref="MGI:MGI:1338947"
     exon            1..54
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /inference="alignment:Splign:2.1.0"
     exon            55..219
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..408
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /note="leukocyte L1 complex heavy chain; migration
                     inhibitory factor-related protein 14; S100 calcium-binding
                     protein A9"
                     /codon_start=1
                     /product="protein S100-A9"
                     /protein_id="NP_001268781.1"
                     /db_xref="CCDS:CCDS17543.1"
                     /db_xref="GeneID:20202"
                     /db_xref="MGI:MGI:1338947"
                     /translation="MANKAPSQMERSITTIIDTFHQYSRKEGHPDTLSKKEFRQMVEA
                     QLATFMKKEKRNEALINDIMEDLDTNQDNQLSFEECMMLMAKLIFACHEKLHENNPRG
                     HGHSHGKGCGK"
     exon            220..524
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      500..505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /note="hexamer: AATAAA"
     polyA_site      519
                     /gene="S100a9"
                     /gene_synonym="60B8Ag; BEE22; Cagb; GAGB; L1Ag; MRP14;
                     p14"
                     /note="major polyA site"
ORIGIN      
        1 tataaatact gggcttacac tgctcttacc aacatctgtg actctttagc cttgaagagc
       61 aagaagatgg ccaacaaagc accttctcag atggagcgca gcataaccac catcatcgac
      121 accttccatc aatactctag gaaggaagga caccctgaca ccctgagcaa gaaggaattc
      181 agacaaatgg tggaagcaca gttggcaacc tttatgaaga aagagaagag aaatgaagcc
      241 ctcataaatg acatcatgga ggacctggac acaaaccagg acaatcagct gagctttgag
      301 gagtgtatga tgctgatggc aaagttgatc tttgcctgtc atgagaagct gcatgagaac
      361 aacccacgtg ggcatggcca cagtcatggc aaaggctgtg ggaagtaatt aagaggtcag
      421 ccatgtgaca gctgcccaac caagtctaaa gggaatggct tactcaatgg cctttgttct
      481 gggaaatgat aagataaata ataaataagt ctttatccat tccaaaaaaa aaaaaaa
//
