LOCUS       NM_013650                392 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus S100 calcium binding protein A8 (calgranulin A)
            (S100a8), mRNA.
ACCESSION   NM_013650
VERSION     NM_013650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 392)
  AUTHORS   Chang,N., Liu,Y., Li,W., Ma,Y., Zhou,X., Zhao,X., Yang,L. and Li,L.
  TITLE     Neutrophil-secreted S100A8/A9 participates in fatty liver injury
            and fibrosis by promoting myofibroblast migration
  JOURNAL   J Mol Med (Berl) 102 (9), 1117-1133 (2024)
   PUBMED   38995368
  REMARK    GeneRIF: Neutrophil-secreted S100A8/A9 participates in fatty liver
            injury and fibrosis by promoting myofibroblast migration.
REFERENCE   2  (bases 1 to 392)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 392)
  AUTHORS   Gatti,D.M., Tyler,A.L., Mahoney,J.M., Churchill,G.A., Yener,B.,
            Koyuncu,D., Gurcan,M.N., Niazi,M.K., Tavolara,T., Gower,A.,
            Dayao,D., McGlone,E., Ginese,M.L., Specht,A., Alsharaydeh,A.,
            Tessier,P.A., Kurtz,S.L., Elkins,K.L., Kramnik,I. and Beamer,G.
  TITLE     Systems genetics uncover new loci containing functional gene
            candidates in Mycobacterium tuberculosis-infected Diversity Outbred
            mice
  JOURNAL   PLoS Pathog 20 (6), e1011915 (2024)
   PUBMED   38861581
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 392)
  AUTHORS   Ding,L., Lu,L., Zheng,S., Zhang,Z., Huang,X., Ma,R., Zhang,M.,
            Xu,Z., Chen,M., Guo,Z., Zhu,S., Gong,J., Mao,H., Zhang,W. and Xu,P.
  TITLE     Usp14 deficiency removes alpha-synuclein by regulating S100A8/A9 in
            Parkinson's disease
  JOURNAL   Cell Mol Life Sci 81 (1), 232 (2024)
   PUBMED   38780644
  REMARK    GeneRIF: Usp14 deficiency removes alpha-synuclein by regulating
            S100A8/A9 in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 392)
  AUTHORS   Yuan,Y.P., Shen,Z.Y., Teng,T., Xu,S.C., Kong,C.Y., Zeng,X.F., A
            Hofmann Bowman,M. and Yan,L.
  TITLE     S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes Cardiac
            Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth Factor 23)
            in Mice
  JOURNAL   J Am Heart Assoc 13 (10), e028006 (2024)
   PUBMED   38726894
  REMARK    GeneRIF: S100a8/9 (S100 Calcium Binding Protein a8/9) Promotes
            Cardiac Hypertrophy Via Upregulation of FGF23 (Fibroblast Growth
            Factor 23) in Mice.
REFERENCE   6  (bases 1 to 392)
  AUTHORS   Nacken,W., Manitz,M.P. and Sorg,C.
  TITLE     Molecular characterisation of the genomic locus of the mouse MRP8
            gene
  JOURNAL   Biochim Biophys Acta 1315 (1), 1-5 (1996)
   PUBMED   8611640
REFERENCE   7  (bases 1 to 392)
  AUTHORS   Iismaa,S.E., Hu,S., Kocher,M., Lackmann,M., Harrison,C.A.,
            Thliveris,S. and Geczy,C.L.
  TITLE     Recombinant and cellular expression of the murine chemotactic
            protein, CP-10
  JOURNAL   DNA Cell Biol 13 (2), 183-192 (1994)
   PUBMED   8179823
REFERENCE   8  (bases 1 to 392)
  AUTHORS   Lackmann,M., Rajasekariah,P., Iismaa,S.E., Jones,G., Cornish,C.J.,
            Hu,S., Simpson,R.J., Moritz,R.L. and Geczy,C.L.
  TITLE     Identification of a chemotactic domain of the pro-inflammatory S100
            protein CP-10
  JOURNAL   J Immunol 150 (7), 2981-2991 (1993)
   PUBMED   8454868
REFERENCE   9  (bases 1 to 392)
  AUTHORS   Lackmann,M., Cornish,C.J., Simpson,R.J., Moritz,R.L. and Geczy,C.L.
  TITLE     Purification and structural analysis of a murine chemotactic
            cytokine (CP-10) with sequence homology to S100 proteins
  JOURNAL   J Biol Chem 267 (11), 7499-7504 (1992)
   PUBMED   1559987
REFERENCE   10 (bases 1 to 392)
  AUTHORS   Lagasse,E. and Weissman,I.L.
  TITLE     Mouse MRP8 and MRP14, two intracellular calcium-binding proteins
            associated with the development of the myeloid lineage
  JOURNAL   Blood 79 (8), 1907-1915 (1992)
   PUBMED   1373330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157837.1 and AV007095.1.
            
            On Sep 2, 2006 this sequence version replaced NM_013650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX639728.1, BY226706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AK157837.1         2-388
            388-392             AV007095.1         331-335
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.9 cM"
     gene            1..392
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /note="S100 calcium binding protein A8 (calgranulin A)"
                     /db_xref="GeneID:20201"
                     /db_xref="MGI:MGI:88244"
     exon            1..32
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /inference="alignment:Splign:2.1.0"
     exon            33..196
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..325
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /note="chemotactic S100 protein; MRP-8; calgranulin-A;
                     chemotactic cytokine CP-10; pro-inflammatory S100
                     cytokine; S100 calcium-binding protein A8; leukocyte L1
                     complex light chain; migration inhibitory factor-related
                     protein 8"
                     /codon_start=1
                     /product="protein S100-A8"
                     /protein_id="NP_038678.1"
                     /db_xref="CCDS:CCDS38507.1"
                     /db_xref="GeneID:20201"
                     /db_xref="MGI:MGI:88244"
                     /translation="MPSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPQ
                     FVQNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE"
     exon            197..392
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      369..374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /note="hexamer: AATAAA"
     polyA_site      388
                     /gene="S100a8"
                     /gene_synonym="60B8Ag; B8Ag; Caga; CFAg; CP-10; MRP8; p8"
                     /note="major polyA site"
ORIGIN      
        1 atcctttgtc agctccgtct tcaagacatc gtttgaaagg aaatctttcg tgacaatgcc
       61 gtctgaactg gagaaggcct tgagcaacct cattgatgtc taccacaatt attccaatat
      121 acaaggaaat caccatgccc tctacaagaa tgacttcaag aaaatggtca ctactgagtg
      181 tcctcagttt gtgcagaata taaatatcga aaacttgttc agagaattgg acatcaatag
      241 tgacaatgca attaacttcg aggagttcct tgcgatggtg ataaaagtgg gtgtggcatc
      301 tcacaaagac agccacaagg agtagcagag cttctggcct agggctgggt ccctggatat
      361 gtctacagaa taaagtcatc atatctcagg tc
//
