LOCUS       NM_199422                741 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus S100 calcium binding protein A7A (S100a7a), mRNA.
ACCESSION   NM_199422 XM_355449
VERSION     NM_199422.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 741)
  AUTHORS   Harrison,S.A., Naretto,A., Balakrishnan,S., Perera,Y.R. and
            Chazin,W.J.
  TITLE     Comparative analysis of the physical properties of murine and human
            S100A7: Insight into why zinc piracy is mediated by human but not
            murine S100A7
  JOURNAL   J Biol Chem 299 (11), 105292 (2023)
   PUBMED   37769710
REFERENCE   2  (bases 1 to 741)
  AUTHORS   Gui,J., Gober,M., Yang,X., Katlinski,K.V., Marshall,C.M.,
            Sharma,M., Werth,V.P., Baker,D.P., Rui,H., Seykora,J.T. and
            Fuchs,S.Y.
  TITLE     Therapeutic Elimination of the Type 1 Interferon Receptor for
            Treating Psoriatic Skin Inflammation
  JOURNAL   J Invest Dermatol 136 (10), 1990-2002 (2016)
   PUBMED   27369778
REFERENCE   3  (bases 1 to 741)
  AUTHORS   Hau,C.S., Kanda,N., Noda,S., Tatsuta,A., Kamata,M., Shibata,S.,
            Asano,Y., Sato,S., Watanabe,S. and Tada,Y.
  TITLE     Visfatin enhances the production of cathelicidin antimicrobial
            peptide, human beta-defensin-2, human beta-defensin-3, and S100A7
            in human keratinocytes and their orthologs in murine
            imiquimod-induced psoriatic skin
  JOURNAL   Am J Pathol 182 (5), 1705-1717 (2013)
   PUBMED   23499548
  REMARK    GeneRIF: visfatin enhances CAMP, hBD-2, hBD-3, and S100A7
            production in human keratinocytes and their orthologs in murine
            imiquimod-treated psoriatic skin.
REFERENCE   4  (bases 1 to 741)
  AUTHORS   Nasser,M.W., Qamri,Z., Deol,Y.S., Ravi,J., Powell,C.A., Trikha,P.,
            Schwendener,R.A., Bai,X.F., Shilo,K., Zou,X., Leone,G., Wolf,R.,
            Yuspa,S.H. and Ganju,R.K.
  TITLE     S100A7 enhances mammary tumorigenesis through upregulation of
            inflammatory pathways
  JOURNAL   Cancer Res 72 (3), 604-615 (2012)
   PUBMED   22158945
  REMARK    GeneRIF: Data show that hS100A7 and mS100a7a15 overexpression
            induce proliferation and expression of inflammatory
            cytokines/chemokines.
REFERENCE   5  (bases 1 to 741)
  AUTHORS   Wolf,R., Mascia,F., Dharamsi,A., Howard,O.M., Cataisson,C.,
            Bliskovski,V., Winston,J., Feigenbaum,L., Lichti,U., Ruzicka,T.,
            Chavakis,T. and Yuspa,S.H.
  TITLE     Gene from a psoriasis susceptibility locus primes the skin for
            inflammation
  JOURNAL   Sci Transl Med 2 (61), 61ra90 (2010)
   PUBMED   21148126
REFERENCE   6  (bases 1 to 741)
  AUTHORS   Marenholz,I., Lovering,R.C. and Heizmann,C.W.
  TITLE     An update of the S100 nomenclature
  JOURNAL   Biochim Biophys Acta 1763 (11), 1282-1283 (2006)
   PUBMED   16938360
REFERENCE   7  (bases 1 to 741)
  AUTHORS   Wolf,R., Voscopoulos,C.J., FitzGerald,P.C., Goldsmith,P.,
            Cataisson,C., Gunsior,M., Walz,M., Ruzicka,T. and Yuspa,S.H.
  TITLE     The mouse S100A15 ortholog parallels genomic organization,
            structure, gene expression, and protein-processing pattern of the
            human S100A7/A15 subfamily during epidermal maturation
  JOURNAL   J Invest Dermatol 126 (7), 1600-1608 (2006)
   PUBMED   16528363
  REMARK    GeneRIF: The regulation, expression pattern and crosslinking of
            mS100A15 are consistent with the characteristics of the human
            orthologs, providing a valid surrogate model to study changes in
            these proteins associated with cutaneous pathologies.
REFERENCE   8  (bases 1 to 741)
  AUTHORS   Webb,M., Emberley,E.D., Lizardo,M., Alowami,S., Qing,G.,
            Alfia'ar,A., Snell-Curtis,L.J., Niu,Y., Civetta,A., Myal,Y.,
            Shiu,R., Murphy,L.C. and Watson,P.H.
  TITLE     Expression analysis of the mouse S100A7/psoriasin gene in skin
            inflammation and mammary tumorigenesis
  JOURNAL   BMC Cancer 5, 17 (2005)
   PUBMED   15717926
  REMARK    GeneRIF: These results support the hypothesis that the mouse S100A7
            gene is structurally and functionally similar to human S100A7 and
            may offer a relevant model system for studying its normal
            biological function and putative role in tumor progression. S00A7
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 741)
  AUTHORS   Marenholz,I., Heizmann,C.W. and Fritz,G.
  TITLE     S100 proteins in mouse and man: from evolution to function and
            pathology (including an update of the nomenclature)
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1111-1122 (2004)
   PUBMED   15336958
  REMARK    Review article
REFERENCE   10 (bases 1 to 741)
  AUTHORS   Ravasi,T., Hsu,K., Goyette,J., Schroder,K., Yang,Z., Rahimi,F.,
            Miranda,L.P., Alewood,P.F., Hume,D.A. and Geczy,C.
  TITLE     Probing the S100 protein family through genomic and functional
            analysis
  JOURNAL   Genomics 84 (1), 10-22 (2004)
   PUBMED   15203200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY465109.1.
            
            On Jan 9, 2004 this sequence version replaced XM_355449.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY465109.1, BC107307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6xC3H"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.82 cM"
     gene            1..741
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /note="S100 calcium binding protein A7A"
                     /db_xref="GeneID:381493"
                     /db_xref="MGI:MGI:2687194"
     exon            1..40
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..260
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..437
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /note="S100 calcium binding protein A15; S100
                     calcium-binding protein A15A; S100 calcium binding protein
                     A7-like 1"
                     /codon_start=1
                     /product="protein S100-A15A"
                     /protein_id="NP_955454.1"
                     /db_xref="CCDS:CCDS17541.1"
                     /db_xref="GeneID:381493"
                     /db_xref="MGI:MGI:2687194"
                     /translation="MPDTPVEDSLFQIIHCFHHYAAREGDKETLSLEELKALLLDSVP
                     RFMDTLGRRQPYYITELFRAADKNKDNQICFDEFLYILGKLVKDYHLQFHRQLCAHYC
                     TEHSLY"
     exon            261..741
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      615..620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /note="hexamer: AGTAAA"
     polyA_site      621
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /note="major polyA site"
     polyA_site      646
                     /gene="S100a7a"
                     /gene_synonym="Gm1020; S100a15; S100a15a; S100a17l1;
                     S100A7f; S100A7L1"
                     /note="major polyA site"
ORIGIN      
        1 aggctgtgga tgctgagcag ccctgcacca agagcaacag actctccgct gtcccagagc
       61 ctcctcctct gctctgcaga tctgcctgta ccctgaaggg tccatcagtc atgccagaca
      121 caccagtgga ggactccctc ttccaaatca tacactgctt ccatcactat gctgcccggg
      181 aaggggacaa ggagaccttg tccctggagg agttgaaagc tctgctcttg gatagtgtgc
      241 ctcgcttcat ggacaccttg ggccgcaggc agccatacta catcacagag ctgttccggg
      301 cagctgacaa aaacaaggac aaccagatct gctttgatga gttcctgtac atcttgggca
      361 agctggtgaa ggactaccat ctccagttcc accggcagtt gtgtgcacac tactgtactg
      421 agcacagcct ctactagagg gaggacaggc agtctctcat caccagaacc tctcccgaga
      481 catggcctga tcatgaacag tgtacagaac tcagcaatgt atttcttctt aggtgtgtgc
      541 acatgcatac aaacaatatc acaaatattt ctgggaagta ctcaggtcat ggttctgggt
      601 atcccttaat gttcagtaaa agaagtttag tttttattat caggaacatc gttttgggca
      661 gaagacatgg ctcctgcctt cagtgatacc ttgcttgaat accgggggga ataccggcct
      721 tgaatccaaa gtgccagccg g
//
