LOCUS       NM_001417972             586 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus S100 calcium binding protein A6 (calcyclin) (S100a6),
            transcript variant 4, mRNA.
ACCESSION   NM_001417972
VERSION     NM_001417972.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 586)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 586)
  AUTHORS   Otake,S., Saito,K., Chiba,Y., Yamada,A. and Fukumoto,S.
  TITLE     S100a6 knockdown promotes the differentiation of dental epithelial
            cells toward the epidermal lineage instead of the odontogenic
            lineage
  JOURNAL   FASEB J 38 (7), e23608 (2024)
   PUBMED   38593315
  REMARK    GeneRIF: S100a6 knockdown promotes the differentiation of dental
            epithelial cells toward the epidermal lineage instead of the
            odontogenic lineage.
REFERENCE   3  (bases 1 to 586)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 586)
  AUTHORS   Du,Q., Zhu,T., Wen,G., Jin,H., An,J., Xu,J., Xie,R., Zhu,J.,
            Yang,X., Zhang,T., Liu,Q., Yao,S., Yang,X., Tuo,B. and Ma,X.
  TITLE     The S100 calcium-binding protein A6 plays a crucial role in hepatic
            steatosis by mediating lipophagy
  JOURNAL   Hepatol Commun 7 (9), e0232 (2023)
   PUBMED   37655980
  REMARK    GeneRIF: The S100 calcium-binding protein A6 plays a crucial role
            in hepatic steatosis by mediating lipophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 586)
  AUTHORS   Derk,J., Como,C.N., Jones,H.E., Joyce,L.R., Kim,S., Spencer,B.L.,
            Bonney,S., O'Rourke,R., Pawlikowski,B., Doran,K.S. and
            Siegenthaler,J.A.
  TITLE     Formation and function of the meningeal arachnoid barrier around
            the developing mouse brain
  JOURNAL   Dev Cell 58 (8), 635-644 (2023)
   PUBMED   36996816
REFERENCE   6  (bases 1 to 586)
  AUTHORS   Korsmeyer,S.J.
  TITLE     Bcl-2 initiates a new category of oncogenes: regulators of cell
            death
  JOURNAL   Blood 80 (4), 879-886 (1992)
   PUBMED   1498330
  REMARK    Review article
REFERENCE   7  (bases 1 to 586)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   8  (bases 1 to 586)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   9  (bases 1 to 586)
  AUTHORS   Poirier,F., Chan,C.T., Timmons,P.M., Robertson,E.J., Evans,M.J. and
            Rigby,P.W.
  TITLE     The murine H19 gene is activated during embryonic stem cell
            differentiation in vitro and at the time of implantation in the
            developing embryo
  JOURNAL   Development 113 (4), 1105-1114 (1991)
   PUBMED   1811930
REFERENCE   10 (bases 1 to 586)
  AUTHORS   Thordarson,G., Southard,J.N. and Talamantes,F.
  TITLE     Purification and characterization of mouse decidual calcyclin: a
            novel stimulator of mouse placental lactogen-II secretion
  JOURNAL   Endocrinology 129 (3), 1257-1265 (1991)
   PUBMED   1874170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160552.13.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK794115.1, SRR17253014.925851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC160552.13        172864-173062
            200-361             AC160552.13        173423-173584
            362-586             AC160552.13        173871-174095
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.35 cM"
     gene            1..586
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /note="S100 calcium binding protein A6 (calcyclin)"
                     /db_xref="GeneID:20200"
                     /db_xref="MGI:MGI:1339467"
     exon            1..199
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /inference="alignment:Splign:2.1.0"
     exon            200..361
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..493
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /note="isoform 1 is encoded by transcript variant 4;
                     calcium binding protein A6 (calcyclin); protein S100-A6;
                     S100 calcium-binding protein A6; prolactin
                     receptor-associated protein"
                     /codon_start=1
                     /product="protein S100-A6 isoform 1"
                     /protein_id="NP_001404901.1"
                     /db_xref="GeneID:20200"
                     /db_xref="MGI:MGI:1339467"
                     /translation="MACPLDQAIGLLVAIFHKYSGKEGDKHTLSKKELKELIQKELTI
                     GSKLQDAEIARLMDDLDRNKDQEVNFQEYVAFLGALALIYNEALK"
     exon            362..586
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      559..564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /note="hexamer: AATAAA"
     polyA_site      586
                     /gene="S100a6"
                     /gene_synonym="2A9; 5B10; Cacy; CALCYCLIN; PRA"
                     /note="major polyA site"
ORIGIN      
        1 atcccctcga ccactccttt ggcgcttcgc tgtcgaccgt gcggtgagct ctcgctgggg
       61 ggtccctcta gggtctttct gctcctgggc aaggggttaa gccacttcct tcccccgtca
      121 gcctctgcag gctcagtggg tggaatgcat tgggatccaa gttttcggag cccagggagg
      181 cagggagagc catgattagc ttcttctagc ccagtgatca gtcatggcat gccctctgga
      241 tcaggccatt ggccttctcg tggccatctt ccacaagtac tctggcaagg aaggtgacaa
      301 gcacaccctg agcaagaagg agctgaagga gttgatccag aaggagctca ccattggctc
      361 caagctgcag gatgctgaaa ttgcaaggct gatggatgat ctggaccgta acaaggatca
      421 ggaagtaaac ttccaggagt atgtcgcctt cctgggggcc ttggctttga tctacaatga
      481 agctctgaaa taaaatggga ccgttgagat gacttccggg ggcctctctc ggtcaaatcc
      541 agtggtgggt agttatacaa taaatatttc gtttttgtta tgccta
//
