LOCUS       NM_001410571             568 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus S100 calcium binding protein A4 (S100a4), transcript
            variant 2, mRNA.
ACCESSION   NM_001410571 XM_006501178
VERSION     NM_001410571.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 568)
  AUTHORS   Jingjing,H., Tongqian,W., Shirong,Y., Lan,M., Jing,L., Shihui,M.,
            Haijian,Y. and Fang,Y.
  TITLE     S100A4 promotes experimental autoimmune encephalomyelitis by
            impacting microglial inflammation through TLR4/NF-kappaB signaling
            pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 112849 (2024)
   PUBMED   39241524
  REMARK    GeneRIF: S100A4 promotes experimental autoimmune encephalomyelitis
            by impacting microglial inflammation through TLR4/NF-kappaB
            signaling pathway.
REFERENCE   2  (bases 1 to 568)
  AUTHORS   Chen,X., Wang,J., Yang,P., Liu,H.Y., Zhong,S., Lu,C., Gao,M.,
            Liu,D., Zhang,J., Wang,J., Ma,S., Wang,W., Zhu,H., Zhang,X. and
            Liu,Y.
  TITLE     SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of
            FSP1
  JOURNAL   Redox Biol 75, 103267 (2024)
   PUBMED   39025016
  REMARK    GeneRIF: SENP3 sensitizes macrophages to ferroptosis via
            de-SUMOylation of FSP1.
REFERENCE   3  (bases 1 to 568)
  AUTHORS   Hu,Y., Zou,W., Zhang,L., Zhang,S., Hu,L., Song,Z., Kong,S., Gao,Y.,
            Zhang,J., Yang,Y. and Zheng,J.
  TITLE     TRPV3 facilitates lipolysis and attenuates diet-induced obesity via
            activation of the NRF2/FSP1 signaling axis
  JOURNAL   Free Radic Biol Med 221, 155-168 (2024)
   PUBMED   38777204
  REMARK    GeneRIF: TRPV3 facilitates lipolysis and attenuates diet-induced
            obesity via activation of the NRF2/FSP1 signaling axis.
REFERENCE   4  (bases 1 to 568)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   5  (bases 1 to 568)
  AUTHORS   Wang,Y.F., Zhang,W.L., Li,Z.X., Liu,Y., Tan,J., Yin,H.Z.,
            Zhang,Z.C., Piao,X.J., Ruan,M.H., Dai,Z.H., Wang,S.J., Mu,C.Y.,
            Yuan,J.H., Sun,S.H., Liu,H. and Yang,F.
  TITLE     METTL14 downregulation drives S100A4+ monocyte-derived macrophages
            via MyD88/NF-kappaB pathway to promote MAFLD progression
  JOURNAL   Signal Transduct Target Ther 9 (1), 91 (2024)
   PUBMED   38627387
  REMARK    GeneRIF: METTL14 downregulation drives S100A4[+] monocyte-derived
            macrophages via MyD88/NF-kappaB pathway to promote MAFLD
            progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 568)
  AUTHORS   Parker,C. and Sherbet,G.V.
  TITLE     Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7
            alter the expression of metastasis-associated genes MTS1 and NM23
            in metastatic variants of the B16 murine melanoma
  JOURNAL   Melanoma Res 2 (5-6), 337-343 (1992)
   PUBMED   1337998
REFERENCE   7  (bases 1 to 568)
  AUTHORS   Tulchinsky,E., Ford,H.L., Kramerov,D., Reshetnyak,E., Grigorian,M.,
            Zain,S. and Lukanidin,E.
  TITLE     Transcriptional analysis of the mts1 gene with specific reference
            to 5' flanking sequences
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9146-9150 (1992)
   PUBMED   1329089
REFERENCE   8  (bases 1 to 568)
  AUTHORS   Dorin,J.R., Emslie,E. and van Heyningen,V.
  TITLE     Related calcium-binding proteins map to the same subregion of
            chromosome 1q and to an extended region of synteny on mouse
            chromosome 3
  JOURNAL   Genomics 8 (3), 420-426 (1990)
   PUBMED   2149559
REFERENCE   9  (bases 1 to 568)
  AUTHORS   Tulchinsky,E.M., Grigorian,M.S., Ebralidze,A.K., Milshina,N.I. and
            Lukanidin,E.M.
  TITLE     Structure of gene mts1, transcribed in metastatic mouse tumor cells
  JOURNAL   Gene 87 (2), 219-223 (1990)
   PUBMED   2332170
REFERENCE   10 (bases 1 to 568)
  AUTHORS   Ebralidze,A., Tulchinsky,E., Grigorian,M., Afanasyeva,A., Senin,V.,
            Revazova,E. and Lukanidin,E.
  TITLE     Isolation and characterization of a gene specifically expressed in
            different metastatic cells and whose deduced gene product has a
            high degree of homology to a Ca2+-binding protein family
  JOURNAL   Genes Dev 3 (7), 1086-1093 (1989)
   PUBMED   2550322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160552.13.
            
            On Aug 10, 2022 this sequence version replaced XM_006501178.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2055771.1,
                                           SRR17253014.1582403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC160552.13        164330-164438
            110-265             AC160552.13        164677-164832
            266-568             AC160552.13        165420-165722
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.27 cM"
     gene            1..568
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /note="S100 calcium binding protein A4"
                     /db_xref="GeneID:20198"
                     /db_xref="MGI:MGI:1330282"
     exon            1..109
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /inference="alignment:Splign:2.1.0"
     exon            110..265
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..430
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /note="protein 18A2; protein Mts1; metastatic cell
                     protein; placental calcium-binding protein; calvasculin;
                     Fibroblast-specific protein 1"
                     /codon_start=1
                     /product="protein S100-A4"
                     /protein_id="NP_001397500.1"
                     /db_xref="GeneID:20198"
                     /db_xref="MGI:MGI:1330282"
                     /translation="MARPLEEALDVIVSTFHKYSGKEGDKFKLNKTELKELLTRELPS
                     FLGKRTDEAAFQKVMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK"
     exon            266..568
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      549..554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /note="hexamer: AATAAA"
     polyA_site      568
                     /gene="S100a4"
                     /gene_synonym="18A2; 42a; Capl; FSp1; metastasin; Mts1;
                     PeL98; pk9a"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtggtt gagctgtggg agtgagtaag ctgatggaaa actgctgttg ttgaggccag
       61 gactgagagg cacagaaagg tgctggcatg gatctccaga gtttgagggg tctcaacggt
      121 taccatggca agacccttgg aggaggccct ggatgtaatt gtgtccacct tccacaaata
      181 ctcaggcaaa gagggtgaca agttcaagct gaacaagaca gagctcaagg agctactgac
      241 cagggagctg cctagcttcc tggggaaaag gacagatgaa gctgcattcc agaaggtgat
      301 gagcaacttg gacagcaaca gggacaatga agttgacttc caggagtact gtgtcttcct
      361 gtcctgcatt gccatgatgt gcaatgaatt ctttgagggc tgcccagata aggagccccg
      421 gaagaagtga agactcctca gatgaagtgt tggggtgtag tttgccagtg ggggatcttc
      481 cctgttggct gtgagcatag tgccttactc tggcttcttc gcacatgtgc acagtgctga
      541 gcaaattcaa taaaaggttt tgaaacta
//
