LOCUS       NM_001356605            1145 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus S100 calcium binding protein A16 (S100a16), transcript
            variant 1, mRNA.
ACCESSION   NM_001356605 XM_006501948
VERSION     NM_001356605.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1145)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1145)
  AUTHORS   Wang,D., Zhang,R., Qin,X., Wang,J., Hu,Y., Lu,S., Kan,J., Ge,Y.,
            Jin,K., Zhang,W.S. and Liu,Y.
  TITLE     S100a16 Deficiency Prevents Alcohol-induced Fatty Liver Injury via
            Inducing MANF Expression in Mice
  JOURNAL   Int J Biol Sci 19 (16), 5074-5088 (2023)
   PUBMED   37928262
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1145)
  AUTHORS   Hu,Y., Zhang,R., Lu,S., Zhang,W., Wang,D., Ge,Y., Jiang,F., Qin,X.
            and Liu,Y.
  TITLE     S100 Calcium Binding Protein A16 Promotes Cell Proliferation by
            triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to
            inhibit Hippo pathway in Glioma development
  JOURNAL   Int J Biol Sci 19 (7), 2034-2052 (2023)
   PUBMED   37151881
  REMARK    GeneRIF: S100 Calcium Binding Protein A16 Promotes Cell
            Proliferation by triggering LATS1 ubiquitin degradation mediated by
            CUL4A ligase to inhibit Hippo pathway in Glioma development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1145)
  AUTHORS   Zhang,W.S., Zhang,R., Ge,Y., Wang,D., Hu,Y., Qin,X., Kan,J. and
            Liu,Y.
  TITLE     S100a16 deficiency prevents hepatic stellate cells activation and
            liver fibrosis via inhibiting CXCR4 expression
  JOURNAL   Metabolism 135, 155271 (2022)
   PUBMED   35914619
REFERENCE   5  (bases 1 to 1145)
  AUTHORS   Liu,Y., Zhang,R., Xin,J., Sun,Y., Li,J., Wei,D. and Zhao,A.Z.
  TITLE     Identification of S100A16 as a novel adipogenesis promoting factor
            in 3T3-L1 cells
  JOURNAL   Endocrinology 152 (3), 903-911 (2011)
   PUBMED   21266506
  REMARK    GeneRIF: This study showed that S100A16 protein is a novel
            adipogenesis-promoting factor and that increased expression of
            S100A16 in 3T3-L1 adipocytes can have a negative impact on insulin
            sensitivity.
REFERENCE   6  (bases 1 to 1145)
  AUTHORS   Sturchler,E., Cox,J.A., Durussel,I., Weibel,M. and Heizmann,C.W.
  TITLE     S100A16, a novel calcium-binding protein of the EF-hand superfamily
  JOURNAL   J Biol Chem 281 (50), 38905-38917 (2006)
   PUBMED   17030513
  REMARK    GeneRIF: In situ hybridization analysis and immunohistochemistry
            revealed a widespread distribution in the mouse brain. Furthermore,
            S100A16 expression was found to be astrocyte-specific
REFERENCE   7  (bases 1 to 1145)
  AUTHORS   Marenholz,I., Lovering,R.C. and Heizmann,C.W.
  TITLE     An update of the S100 nomenclature
  JOURNAL   Biochim Biophys Acta 1763 (11), 1282-1283 (2006)
   PUBMED   16938360
REFERENCE   8  (bases 1 to 1145)
  AUTHORS   Marenholz,I., Heizmann,C.W. and Fritz,G.
  TITLE     S100 proteins in mouse and man: from evolution to function and
            pathology (including an update of the nomenclature)
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1111-1122 (2004)
   PUBMED   15336958
  REMARK    Review article
REFERENCE   9  (bases 1 to 1145)
  AUTHORS   Ravasi,T., Hsu,K., Goyette,J., Schroder,K., Yang,Z., Rahimi,F.,
            Miranda,L.P., Alewood,P.F., Hume,D.A. and Geczy,C.
  TITLE     Probing the S100 protein family through genomic and functional
            analysis
  JOURNAL   Genomics 84 (1), 10-22 (2004)
   PUBMED   15203200
REFERENCE   10 (bases 1 to 1145)
  AUTHORS   Marenholz,I. and Heizmann,C.W.
  TITLE     S100A16, a ubiquitously expressed EF-hand protein which is
            up-regulated in tumors
  JOURNAL   Biochem Biophys Res Commun 313 (2), 237-244 (2004)
   PUBMED   14684152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160552.13, CK623434.1 and AI841112.1.
            
            On Oct 12, 2017 this sequence version replaced XM_006501948.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI691962.1, AK167006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC160552.13        96934-97025
            93-741              CK623434.1         1-649
            742-1129            AC160552.13        102443-102830
            1130-1145           AI841112.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.25 cM"
     gene            1..1145
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /note="S100 calcium binding protein A16"
                     /db_xref="GeneID:67860"
                     /db_xref="MGI:MGI:1915110"
     exon            1..164
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     exon            165..343
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..565
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /codon_start=1
                     /product="protein S100-A16"
                     /protein_id="NP_001343534.1"
                     /db_xref="CCDS:CCDS17536.1"
                     /db_xref="GeneID:67860"
                     /db_xref="MGI:MGI:1915110"
                     /translation="MADCYTELEKAVVVLVENFYKYVSKHSLVKNKISKSSFRKMLQR
                     ELNHMLTDTGNRKAADKLIQNLDANHDGRICFDEYWTMIGGITSPMANLIRQQECQQE
                     SQQECQQESQQESQQESQQGSS"
     exon            344..1130
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /note="hexamer: AATAAA"
     polyA_site      1130
                     /gene="S100a16"
                     /gene_synonym="2300002L21Rik; DT1P1A7; S100F"
                     /note="major polyA site"
ORIGIN      
        1 ttcccacagc cagctcagcc aggcaaggcc gggagggagt gggacagatt ctgggagtgc
       61 agtggggagg agtcctggct ccgctgagca ggagctgctt ggctgtcagt gccagagccc
      121 aggcctcaga gccctgctgg aggaggtgga ctcacaggag gcaggcccag agaggagctg
      181 aggcagtgag atggctgact gctatacaga gctggagaag gcagttgttg tcctggtgga
      241 aaacttttat aaatatgtat ccaagcacag cctggtcaaa aacaagatca gcaagtccag
      301 cttccgaaag atgctccaga gagagttgaa ccacatgctg acggacacag ggaaccgaaa
      361 ggcagctgac aagctcatcc agaacctgga tgccaaccac gacgggcgca tctgctttga
      421 cgaatactgg accatgattg gtggaatcac cagccccatg gccaacctca tccgccaaca
      481 ggagtgccag caggagagcc agcaggagtg ccagcaggag agccagcagg agagccagca
      541 ggagagccag cagggcagca gctagaggcc cctcgtgggc cccttttcat gtcctgaccc
      601 atgtcctgcc agtgttcttt ccatgcttta agttgactct ttcttcctcc cttctccctc
      661 cagacctgtt cctacccttg ctgaacagca caagatgggt gggtcggggg ctatcaaggc
      721 cactgtggta gtgcttccct gagcattcaa tccctggatc ctgtaggccc tgggaggggg
      781 tcccctttgt gaaatatcaa tgctgtttgg ggccctcccc ccaagacttc tctcacttgt
      841 tgagtctgtg tgctctcgca atgttcctgt ctaattcttg actgattctg ggtctgtcct
      901 gacctctaga ggtgagcttg ctgcttgagg tctcccagct cctgactgtg gcagctgtgg
      961 tagtggcagt accagaatta gccgcttctt ttcctcccaa cctcttagcc gggtagagag
     1021 gcattcccag gggctcctgt ccagctgtct ctgtctggga atgatctaac ctgggttgag
     1081 cctcctctct gctctgccac cgaaataaac gttgaatttg gagtttgtaa aaaaaaaaaa
     1141 aaaaa
//
