LOCUS       NM_025393               1080 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus S100 calcium binding protein A14 (S100a14), transcript
            variant 2, mRNA.
ACCESSION   NM_025393
VERSION     NM_025393.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Li,X., Ding,F., Wang,L., Chen,H. and Liu,Z.
  TITLE     Disruption of enhancer-driven S100A14 expression promotes
            esophageal carcinogenesis
  JOURNAL   Cancer Lett 545, 215833 (2022)
   PUBMED   35917972
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Zhu,H., Gao,W., Li,X., Yu,L., Luo,D., Liu,Y. and Yu,X.
  TITLE     S100A14 promotes progression and gemcitabine resistance in
            pancreatic cancer
  JOURNAL   Pancreatology 21 (3), 589-598 (2021)
   PUBMED   33579599
  REMARK    GeneRIF: S100A14 promotes progression and gemcitabine resistance in
            pancreatic cancer.
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Li,X., Wang,M., Gong,T., Lei,X., Hu,T., Tian,M., Ding,F., Ma,F.,
            Chen,H. and Liu,Z.
  TITLE     A S100A14-CCL2/CXCL5 signaling axis drives breast cancer metastasis
  JOURNAL   Theranostics 10 (13), 5687-5703 (2020)
   PUBMED   32483412
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Sugino,T., Ichikawa-Tomikawa,N., Tanaka,M., Shishito,N., Miura,T.,
            Abe,M., Muramatsu,K., Oishi,T., Kakuda,Y., Kawata,T. and Akiyama,Y.
  TITLE     Identification of S100A14 as a metastasis-promoting molecule in a
            murine organotropic metastasis model
  JOURNAL   Clin Exp Metastasis 36 (4), 411-422 (2019)
   PUBMED   31263990
  REMARK    GeneRIF: S100A14 enhanced scattering, motility and invasiveness of
            mouse tumor cells.
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Marenholz,I., Lovering,R.C. and Heizmann,C.W.
  TITLE     An update of the S100 nomenclature
  JOURNAL   Biochim Biophys Acta 1763 (11), 1282-1283 (2006)
   PUBMED   16938360
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Marenholz,I., Heizmann,C.W. and Fritz,G.
  TITLE     S100 proteins in mouse and man: from evolution to function and
            pathology (including an update of the nomenclature)
  JOURNAL   Biochem Biophys Res Commun 322 (4), 1111-1122 (2004)
   PUBMED   15336958
  REMARK    Review article
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Ravasi,T., Hsu,K., Goyette,J., Schroder,K., Yang,Z., Rahimi,F.,
            Miranda,L.P., Alewood,P.F., Hume,D.A. and Geczy,C.
  TITLE     Probing the S100 protein family through genomic and functional
            analysis
  JOURNAL   Genomics 84 (1), 10-22 (2004)
   PUBMED   15203200
REFERENCE   10 (bases 1 to 1080)
  AUTHORS   Pietas,A., Schluns,K., Marenholz,I., Schafer,B.W., Heizmann,C.W.
            and Petersen,I.
  TITLE     Molecular cloning and characterization of the human S100A14 gene
            encoding a novel member of the S100 family
  JOURNAL   Genomics 79 (4), 513-522 (2002)
   PUBMED   11944983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160552.13, AK019075.1, AK003669.1 and EH105802.1.
            
            On Jun 19, 2010 this sequence version replaced NM_025393.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI150889.1, AK003669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC160552.13        86529-86557
            30-540              AK019075.1         1-511
            541-1076            AK003669.1         521-1056
            1077-1080           EH105802.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.25 cM"
     gene            1..1080
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /note="S100 calcium binding protein A14"
                     /db_xref="GeneID:66166"
                     /db_xref="MGI:MGI:1913416"
     exon            1..51
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /inference="alignment:Splign:2.1.0"
     exon            52..173
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /inference="alignment:Splign:2.1.0"
     exon            174..320
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1080
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /note="hexamer: AATAAA"
     polyA_site      1075
                     /gene="S100a14"
                     /gene_synonym="1110013O05Rik; S100a15; S114"
                     /note="major polyA site"
ORIGIN      
        1 gcagagctca ggtgagctgg ctcctccatc ctgtctccca gctgccagca ggtagatcat
       61 gatccatcag ctcctgtggg gcaggctata ggacagacga caaaactcaa ctcacagaag
      121 gaaggaccag tgtaccagga acgatgggac agtgtcggtc agccaatgct gaggatgccc
      181 aagaattcag tgatgtagag agggccattg agacactcat caagaacttc cataaatact
      241 ctgtggcggg taaaaaggaa acactgaccc ctgctgagct tcgagacctg gttacccagc
      301 agctgccaca cctcatgccg agcaactgtg ggttagaaga gaaaattgcc aacctgggca
      361 actgtaatga ctcgaaactg gagtttggaa gcttctggga gttgattgga gaagcagcca
      421 agagtgtgaa gatggagagg cctgttactc ggagctgagg acttctactt ggaacttgtt
      481 gggggtgttg gggatagggg agttttagag gcactggaaa taaaaccctc aatgcccacc
      541 acccccttcc ccagcctgca cctctcctca ttgctgcaat gttcacgttc aggacaggct
      601 tccctgtggg ctccatggag ctcctgggtc cagaagtcct catctcaagg gagctcaggg
      661 ggtgggttgg ggctggagag gatatgcagg gatcctggaa gggtaagggc caagcaattt
      721 ggtagtaggg gaagggcaga aaggaactgg gttatggaag tgatccaaag agcagggatg
      781 ggaatctggc tgcatatttg gtcctgaaaa gggtgtctga gaacctaccc ccttctaatc
      841 ttgtcccacc taaactgtag ttgtctgccc tgtgctatcc ttgctgcttc cagctctgcc
      901 ccatcctcct tccagtgtct gttcctgagt aggggcaggg gaaataggag cagagttgca
      961 aaagaggctg aggagggcat gacttcatca ctttggggtg agaggaccag ctagatgctt
     1021 gggcatttat ggtagttatt ttatatcatt tgattaataa aaatattgga aaatgtaaaa
//
