LOCUS       NM_011309                615 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus S100 calcium binding protein A1 (S100a1), mRNA.
ACCESSION   NM_011309
VERSION     NM_011309.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   Seitz,A., Busch,M., Kroemer,J., Schneider,A., Simon,S.,
            Jungmann,A., Katus,H.A., Most,P. and Ritterhoff,J.
  TITLE     S100A1's single cysteine is an indispensable redox switch for the
            protection against diastolic calcium waves in cardiomyocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (1), H000 (2024)
   PUBMED   38819384
  REMARK    GeneRIF: S100A1's single cysteine is an indispensable redox switch
            for the protection against diastolic calcium waves in
            cardiomyocytes.
REFERENCE   2  (bases 1 to 615)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 615)
  AUTHORS   Qasrawi,F., Meuser,M., Lehnhoff,F., Schulte,M. and Kispert,A.
  TITLE     S100A1 expression characterizes terminally differentiated
            superficial cells in the urothelium of the murine bladder and
            ureter
  JOURNAL   Histochem Cell Biol 158 (4), 389-399 (2022)
   PUBMED   35648290
  REMARK    GeneRIF: S100A1 expression characterizes terminally differentiated
            superficial cells in the urothelium of the murine bladder and
            ureter.
REFERENCE   4  (bases 1 to 615)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   5  (bases 1 to 615)
  AUTHORS   Li,R., Cai,Y., Lin,H., Dong,L., Tang,M., Lang,Y., Qi,Y., Peng,Y.,
            Zhou,B., Yang,G., Teng,Y. and Yang,X.
  TITLE     Generation of an Ihh-mKate2-Dre knock-in mouse line
  JOURNAL   Genesis 60 (6-7), e23488 (2022)
   PUBMED   35765931
REFERENCE   6  (bases 1 to 615)
  AUTHORS   Du,X.J., Cole,T.J., Tenis,N., Gao,X.M., Kontgen,F., Kemp,B.E. and
            Heierhorst,J.
  TITLE     Impaired cardiac contractility response to hemodynamic stress in
            S100A1-deficient mice
  JOURNAL   Mol Cell Biol 22 (8), 2821-2829 (2002)
   PUBMED   11909974
REFERENCE   7  (bases 1 to 615)
  AUTHORS   Kiewitz,R., Lyons,G.E., Schafer,B.W. and Heizmann,C.W.
  TITLE     Transcriptional regulation of S100A1 and expression during mouse
            heart development
  JOURNAL   Biochim Biophys Acta 1498 (2-3), 207-219 (2000)
   PUBMED   11108964
REFERENCE   8  (bases 1 to 615)
  AUTHORS   Tarabykina,S., Kriajevska,M., Scott,D.J., Hill,T.J., Lafitte,D.,
            Derrick,P.J., Dodson,G.G., Lukanidin,E. and Bronstein,I.
  TITLE     Heterocomplex formation between metastasis-related protein S100A4
            (Mts1) and S100A1 as revealed by the yeast two-hybrid system
  JOURNAL   FEBS Lett 475 (3), 187-191 (2000)
   PUBMED   10869553
REFERENCE   9  (bases 1 to 615)
  AUTHORS   Donato,R.
  TITLE     Functional roles of S100 proteins, calcium-binding proteins of the
            EF-hand type
  JOURNAL   Biochim Biophys Acta 1450 (3), 191-231 (1999)
   PUBMED   10395934
  REMARK    Review article
REFERENCE   10 (bases 1 to 615)
  AUTHORS   Ridinger,K., Ilg,E.C., Niggli,F.K., Heizmann,C.W. and Schafer,B.W.
  TITLE     Clustered organization of S100 genes in human and mouse
  JOURNAL   Biochim Biophys Acta 1448 (2), 254-263 (1998)
   PUBMED   9920416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012578.1 and AK168822.1.
            
            On Sep 2, 2006 this sequence version replaced NM_011309.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012578.1, CD766077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AK012578.1         1-99
            100-615             AK168822.1         36-551
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.24 cM"
     gene            1..615
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /note="S100 calcium binding protein A1"
                     /db_xref="GeneID:20193"
                     /db_xref="MGI:MGI:1338917"
     exon            1..130
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /inference="alignment:Splign:2.1.0"
     exon            131..284
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..428
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /note="S-100 protein alpha chain; S-100 protein subunit
                     alpha"
                     /codon_start=1
                     /product="protein S100-A1"
                     /protein_id="NP_035439.1"
                     /db_xref="CCDS:CCDS38503.1"
                     /db_xref="GeneID:20193"
                     /db_xref="MGI:MGI:1338917"
                     /translation="MGSELESAMETLINVFHAHSGKEGDKYKLSKKELKDLLQTELSG
                     FLDVQKDADAVDKVMKELDENGDGEVDFKEYVVLVAALTVACNNFFWETS"
     exon            285..615
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      591..596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /note="hexamer: AATAAA"
     polyA_site      614
                     /gene="S100a1"
                     /gene_synonym="S100; S100a"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgttg gggaggaggt cggtagggaa agacgactaa aagacaggtc tcctcacacc
       61 ggtccagtgg ccacatttgc agcgtgccct tctgtcgaga atctgttccg acgtcaggcc
      121 gaggccaacc gtgtgctgct gaaatgggct ctgagctgga gagtgccatg gagaccctca
      181 tcaatgtgtt ccatgcccat tcgggcaagg aaggggacaa atataagctg agcaagaaag
      241 aactgaaaga cctgctacaa actgaacttt ctggcttcct ggatgtccag aaggatgcag
      301 atgctgtgga caaggtaatg aaggaactgg atgaaaacgg agatggggaa gtggacttca
      361 aggagtatgt tgtgctggtg gctgctctca cagtggcttg taacaacttc ttctgggaga
      421 ccagttgagc acagtctgtg agcagtgccc ttcctctccc acttgtcaag atttcccctt
      481 tagcgtgctt gctcctcacc ccacctgtac ctccctatgt ccccatcctt gcccagtctc
      541 gacgtgcacc aagggcacaa gagtggcagt ccagatctgc cacttgtttt aataaagcct
      601 tctctctcac cagct
//
