LOCUS       NM_001319156           15456 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus ryanodine receptor 3 (Ryr3), mRNA.
ACCESSION   NM_001319156
VERSION     NM_001319156.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15456)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15456)
  AUTHORS   Torres,R.F. and Kerr,B.
  TITLE     Spatial Learning Is Associated with Antagonist Outcomes for DNA
            Methylation and DNA Hydroxymethylation in the Transcriptional
            Regulation of the Ryanodine Receptor 3
  JOURNAL   Neural Plast 2021, 9930962 (2021)
   PUBMED   34434232
  REMARK    GeneRIF: Spatial Learning Is Associated with Antagonist Outcomes
            for DNA Methylation and DNA Hydroxymethylation in the
            Transcriptional Regulation of the Ryanodine Receptor 3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15456)
  AUTHORS   Ichinose,M., Suzuki,N., Wang,T., Kobayashi,H., Vrbanac,L., Ng,J.Q.,
            Wright,J.A., Lannagan,T.R.M., Gieniec,K.A., Lewis,M., Ando,R.,
            Enomoto,A., Koblar,S., Thomas,P., Worthley,D.L. and Woods,S.L.
  TITLE     The BMP antagonist gremlin 1 contributes to the development of
            cortical excitatory neurons, motor balance and fear responses
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34184027
REFERENCE   4  (bases 1 to 15456)
  AUTHORS   Tedoldi,A., Ludwig,P., Fulgenzi,G., Takeshima,H., Pedarzani,P. and
            Stocker,M.
  TITLE     Calcium-induced calcium release and type 3 ryanodine receptors
            modulate the slow afterhyperpolarising current, sIAHP, and its
            potentiation in hippocampal pyramidal neurons
  JOURNAL   PLoS One 15 (6), e0230465 (2020)
   PUBMED   32559219
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15456)
  AUTHORS   Martynova,E., Zhao,Y., Xie,Q., Zheng,D. and Cvekl,A.
  TITLE     Transcriptomic analysis and novel insights into lens fibre cell
            differentiation regulated by Gata3
  JOURNAL   Open Biol 9 (12), 190220 (2019)
   PUBMED   31847788
REFERENCE   6  (bases 1 to 15456)
  AUTHORS   Takeshima,H., Yamazawa,T., Ikemoto,T., Takekura,H., Nishi,M.,
            Noda,T. and Iino,M.
  TITLE     Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking
            the type-1 ryanodine receptor
  JOURNAL   EMBO J 14 (13), 2999-3006 (1995)
   PUBMED   7621815
REFERENCE   7  (bases 1 to 15456)
  AUTHORS   Ayabe,T., Kopf,G.S. and Schultz,R.M.
  TITLE     Regulation of mouse egg activation: presence of ryanodine receptors
            and effects of microinjected ryanodine and cyclic ADP ribose on
            uninseminated and inseminated eggs
  JOURNAL   Development 121 (7), 2233-2244 (1995)
   PUBMED   7635066
REFERENCE   8  (bases 1 to 15456)
  AUTHORS   Giannini,G., Conti,A., Mammarella,S., Scrobogna,M. and
            Sorrentino,V.
  TITLE     The ryanodine receptor/calcium channel genes are widely and
            differentially expressed in murine brain and peripheral tissues
  JOURNAL   J Cell Biol 128 (5), 893-904 (1995)
   PUBMED   7876312
REFERENCE   9  (bases 1 to 15456)
  AUTHORS   Mattei,M.G., Giannini,G., Moscatelli,F. and Sorrentino,V.
  TITLE     Chromosomal localization of murine ryanodine receptor genes RYR1,
            RYR2, and RYR3 by in situ hybridization
  JOURNAL   Genomics 22 (1), 202-204 (1994)
   PUBMED   7959768
REFERENCE   10 (bases 1 to 15456)
  AUTHORS   Steck,T.L.
  TITLE     The organization of proteins in the human red blood cell membrane.
            A review
  JOURNAL   J Cell Biol 62 (1), 1-19 (1974)
   PUBMED   4600883
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ060048.1, AK082701.1, AL732316.10, AL672250.8, AL691423.14 and
            AI851294.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CJ060048.1         14-34
            22-144              AK082701.1         2-124
            145-264             AL732316.10        92123-92242         c
            265-372             AL732316.10        60127-60234         c
            373-447             AL732316.10        30700-30774         c
            448-526             AL732316.10        27880-27958         c
            527-639             AL732316.10        21685-21797         c
            640-739             AL732316.10        20747-20846         c
            740-833             AL732316.10        17842-17935         c
            834-908             AL732316.10        12637-12711         c
            909-1065            AL732316.10        10386-10542         c
            1066-1239           AL672250.8         187554-187727       c
            1240-1361           AL672250.8         183176-183297       c
            1362-1530           AL672250.8         172986-173154       c
            1531-1666           AL672250.8         171139-171274       c
            1667-1762           AL672250.8         170647-170742       c
            1763-1881           AL672250.8         169144-169262       c
            1882-2015           AL672250.8         163329-163462       c
            2016-2257           AL672250.8         161551-161792       c
            2258-2450           AL672250.8         147243-147435       c
            2451-2667           AL672250.8         135685-135901       c
            2668-2772           AL672250.8         129756-129860       c
            2773-2876           AL672250.8         128026-128129       c
            2877-2960           AL672250.8         126778-126861       c
            2961-3120           AL672250.8         124488-124647       c
            3121-3268           AL672250.8         122544-122691       c
            3269-3474           AL672250.8         121074-121279       c
            3475-3649           AL672250.8         120398-120572       c
            3650-3858           AL672250.8         110229-110437       c
            3859-4034           AL672250.8         108152-108327       c
            4035-4071           AL672250.8         106855-106891       c
            4072-4235           AL672250.8         105375-105538       c
            4236-4401           AL672250.8         102568-102733       c
            4402-4488           AL672250.8         97423-97509         c
            4489-4715           AL672250.8         96789-97015         c
            4716-5508           AL672250.8         94281-95073         c
            5509-5709           AL672250.8         91779-91979         c
            5710-5812           AL672250.8         87407-87509         c
            5813-5950           AL672250.8         86544-86681         c
            5951-6224           AL672250.8         65332-65605         c
            6225-6339           AL672250.8         63912-64026         c
            6340-6469           AL672250.8         62054-62183         c
            6470-6573           AL672250.8         60736-60839         c
            6574-6709           AL672250.8         55209-55344         c
            6710-6890           AL672250.8         41730-41910         c
            6891-6999           AL672250.8         40711-40819         c
            7000-7120           AL672250.8         38958-39078         c
            7121-7290           AL672250.8         36408-36577         c
            7291-7511           AL672250.8         33431-33651         c
            7512-7602           AL672250.8         26990-27080         c
            7603-7743           AL672250.8         25317-25457         c
            7744-7907           AL672250.8         24275-24438         c
            7908-7986           AL672250.8         22223-22301         c
            7987-8076           AL672250.8         18363-18452         c
            8077-8223           AL672250.8         17259-17405         c
            8224-8286           AL672250.8         17002-17064         c
            8287-8362           AL672250.8         15836-15911         c
            8363-8486           AL672250.8         15598-15721         c
            8487-8602           AL672250.8         13767-13882         c
            8603-8670           AL672250.8         12521-12588         c
            8671-8792           AL672250.8         11538-11659         c
            8793-8842           AL691423.14        208591-208640       c
            8843-8903           AL691423.14        208135-208195       c
            8904-9142           AL691423.14        205472-205710       c
            9143-9224           AL691423.14        204013-204094       c
            9225-9355           AL691423.14        193165-193295       c
            9356-9676           AL691423.14        187386-187706       c
            9677-9917           AL691423.14        184236-184476       c
            9918-10005          AL691423.14        161971-162058       c
            10006-10098         AL691423.14        161741-161833       c
            10099-10113         AL691423.14        156901-156915       c
            10114-10284         AL691423.14        153543-153713       c
            10285-10344         AL691423.14        153202-153261       c
            10345-10476         AL691423.14        150999-151130       c
            10477-10589         AL691423.14        150435-150547       c
            10590-10686         AL691423.14        147401-147497       c
            10687-10793         AL691423.14        145753-145859       c
            10794-10845         AL691423.14        145348-145399       c
            10846-10902         AL691423.14        144397-144453       c
            10903-11002         AL691423.14        143211-143310       c
            11003-11082         AL691423.14        142983-143062       c
            11083-11159         AL691423.14        141492-141568       c
            11160-11233         AL691423.14        138435-138508       c
            11234-11251         AL691423.14        138156-138173       c
            11252-11332         AL691423.14        137668-137748       c
            11333-11421         AL691423.14        136783-136871       c
            11422-11550         AL691423.14        135212-135340       c
            11551-11655         AL691423.14        131666-131770       c
            11656-11737         AL691423.14        129605-129686       c
            11738-13065         AL691423.14        127625-128952       c
            13066-13124         AL691423.14        125278-125336       c
            13125-13296         AL691423.14        124439-124610       c
            13297-13383         AL691423.14        123478-123564       c
            13384-13584         AL691423.14        122085-122285       c
            13585-13715         AL691423.14        120346-120476       c
            13716-13758         AL691423.14        116719-116761       c
            13759-13886         AL691423.14        116177-116304       c
            13887-13947         AL691423.14        115779-115839       c
            13948-14094         AL691423.14        115306-115452       c
            14095-14229         AL691423.14        113252-113386       c
            14230-14386         AL691423.14        111694-111850       c
            14387-14451         AL691423.14        110923-110987       c
            14452-14552         AL691423.14        110475-110575       c
            14553-14604         AL691423.14        108237-108288       c
            14605-15442         AL691423.14        106547-107384       c
            15443-15456         AI851294.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..15456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.2 cM"
     gene            1..15456
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /note="ryanodine receptor 3"
                     /db_xref="GeneID:20192"
                     /db_xref="MGI:MGI:99684"
     exon            1..144
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..14700
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /note="calcium release channel; type 3 ryanodine receptor;
                     brain-type ryanodine receptor; brain ryanodine
                     receptor-calcium release channel"
                     /codon_start=1
                     /product="ryanodine receptor 3"
                     /protein_id="NP_001306085.1"
                     /db_xref="CCDS:CCDS50661.2"
                     /db_xref="GeneID:20192"
                     /db_xref="MGI:MGI:99684"
                     /translation="MAEAGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLG
                     NRLCFLEPTSEAKYIPPDLCVCNFVLEQSLSVRALQEMLANTVENGGEGAAQGGGHRT
                     LLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRS
                     EGEKVRIGDDLILVSVSSERYLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYL
                     LGGHVVRLFHGHDECLTIPSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGS
                     NIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSH
                     KRDMEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMD
                     DGLTLQRCQQEESQAARIIRNTTALFSQFVSGNNRTTAPVALPTEEVLQTLQDLIAYF
                     QPPEDEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIVREE
                     SGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCIL
                     IESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLL
                     PRRNLLLQTRLINDVTSIRPNIFLGVAEGSPQYKKWYFELIIDQVEPFLTAEPTHLRV
                     GWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLKSDD
                     VVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEF
                     KFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGTTQFLSQASFIPCPIDT
                     SQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTYGKVRDDNKRQHPCLVEFSKLPET
                     EKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSD
                     VKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTK
                     KSNRDSLREAVRTFVGYGYNIEPSDQELADPTVEKVSIDKIRFFRVERSYAVKSGKWY
                     FEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGD
                     VVGCMINLDDASMVFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLG
                     TDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRIDGT
                     MDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI
                     LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV
                     HESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELGTCYQ
                     VEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPTPQCPPRLDVQT
                     IQPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQE
                     DLMQFHYHTLRLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLL
                     ISIHLANAKERKLMMKNEYIIPITSATRNIRLYPDESKRHGLPGVGLRTCLKPGFRFS
                     TPCFVVTSEDHQKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVL
                     KLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGETEEGVEKEVTHAEEKAVEAGEKA
                     CKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKF
                     RYNELMQALNMSAALTARKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHE
                     DLLVHCGVPLEEEEEEEEDTSWTGKLCALVYKIKGPPKPEKEQPTEEEKPYPTTLKEL
                     VSQTMIRWAQENQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINL
                     LAALGQIRSLLSVRMGREEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVN
                     VLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRG
                     STPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLLARGYPDVGWNPIE
                     GERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIK
                     ISENPALDLPSQGYKTEVTQDDGEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQT
                     GKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMV
                     LFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSAVLPL
                     LTRCAPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSML
                     QQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEK
                     LFWGIFDSLSHKKYDLDLFRMALPCLSAIAGALPPDYLDTRITATLEKQVSVDADGNF
                     DPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYGISLDENVKTHPLIRP
                     FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRCVSQTNQGN
                     SYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTL
                     TAKEKFRDREKAQDLFKFLQVNGILVSRGMKDLELDASSMEKRFAYKFLKKILKYVDA
                     AQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSS
                     SGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGS
                     ELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSI
                     FEHIAQHQFGVDLLLSDVQVSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI
                     PVAFLEPSLNRHNPLSVFNTKTPRERSILGMPDKVEDMCPDIPQLEGLMKEINDLAES
                     GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILK
                     IINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQL
                     KTDGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDPDSDQLFRM
                     VAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKK
                     TKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHL
                     RNNLHLQEKSDDPAVKWQLNLYKDVLRNDEPSNPEKTVERVQSISAALFHLEQVEQPL
                     RSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAHFFEE
                     KLVQDLAKSPRVEDEEEEETERQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMM
                     AKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMS
                     PMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFER
                     QNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQM
                     GNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSL
                     TEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDM
                     VVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYD
                     PDGKGIISRKEFQKAMEGLKQYTQSEIDFLLSCTEADENDMFNYVDFVERFHEPAKDI
                     GFNVAVLLTNLSEHMPNDSRLKSLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEI
                     SESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESD
                     STDRPEEEEEEDEDSAYSIETEGEEEEKSFESASAFTMACVSVKRNVTKFLKRATLKN
                     LRKQYRNVKKMSAKELVKVFFSFFWMLFVGLFQLLFTIFGGIFQILWNTVFGGGLVEG
                     AKNIRVTKILGDMPDPTQFGIHDDVIETDRAEVTEPGVTTELVHFVKGEAGDTDIMSD
                     LFGIHSKKEGGLKQGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQAAEMKAVHEAEG
                     KAESEKADMEDREKEDKIKEEGQTDYLWADVTVKKTRRRGQKAEKPEAFMANFFKGLE
                     IYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFND
                     DDEEEAMVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLKVPLVVFKREKEIA
                     RKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAER
                     IAELLGLDKNALDFSPVEEAKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWY
                     TTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTV
                     VAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEM
                     YRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD
                     TTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC
                     FRKQYEDQLG"
     exon            145..264
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            265..372
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..447
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..526
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            527..639
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..739
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..833
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..908
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1065
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1239
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1361
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1530
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1666
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1762
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1881
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2015
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2257
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2450
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2667
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2772
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2876
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2960
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3120
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3268
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3474
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3649
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3858
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..4034
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4071
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4235
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4401
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4488
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4715
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..5508
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5509..5709
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5710..5812
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5813..5950
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            5951..6224
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6225..6339
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6340..6469
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6470..6573
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6574..6709
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6710..6890
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            6891..6999
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7000..7120
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7121..7290
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7291..7511
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7512..7602
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7603..7743
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7744..7907
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7908..7986
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            7987..8076
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8077..8223
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8224..8286
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8287..8362
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8363..8486
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8487..8602
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8603..8670
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8671..8792
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8793..8842
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8843..8903
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            8904..9142
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9143..9224
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9225..9355
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9356..9676
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9677..9917
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            9918..10005
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10006..10098
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10099..10113
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10114..10284
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10285..10344
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10345..10476
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10477..10589
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10590..10686
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10687..10793
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10794..10845
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10846..10902
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            10903..11002
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11003..11082
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11083..11159
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11160..11233
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11234..11251
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11252..11332
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11421
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11422..11550
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11551..11655
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11656..11737
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            11738..13065
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13066..13124
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13125..13296
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13297..13383
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13384..13584
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13585..13715
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13716..13758
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13759..13886
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13887..13947
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            13948..14094
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14095..14229
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14230..14386
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14387..14451
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14452..14552
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14553..14604
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            14605..15443
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15410..15415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /note="hexamer: AATAAA"
     polyA_site      15443
                     /gene="Ryr3"
                     /gene_synonym="C230090H21; RYR-3"
                     /note="major polyA site"
ORIGIN      
        1 aaagagcagc ggcagagcag cagtcagcgc acgccgctgc ctaggggaaa cagaggcgcc
       61 cgaggctggg gcgcagcgca cgccctggga gccatggccg aagcgggaga aggaggcgag
      121 gatgagatcc agttcctgag gactgaggat gaagttgtac tccagtgcat tgcaaacatt
      181 cacaaggagc agcggaagtt ctgcctggca gccgagggac ttgggaatcg cctgtgcttc
      241 ttggaaccca cctcagaagc caagtacatt cctccagatc tctgtgtctg caatttcgtg
      301 ctggaacagt ccttatctgt cagagcactg caagaaatgc ttgccaacac cgttgaaaat
      361 ggcggagaag gggcggcaca agggggtggc cacaggaccc tgctctacgg gcatgcaatt
      421 ctcctgcggc actctttcag tggaatgtat ctaacgtgct tgaccacgtc aagatcccag
      481 acagataaac ttgcctttga tgtaggtctg cgggaacatg ccacaggaga agcctgttgg
      541 tggactatac atcctgcttc caaacaaagg tctgaaggag agaaagtacg aattggagat
      601 gaccttatcc tcgtcagtgt gtcctctgaa agatatcttc atctctcgat atcaaatggt
      661 agcatccaag tggatgcctc ctttatgcaa acactctgga acgtacatcc tacctgctca
      721 ggaagtagca ttgaagaagg atacttactc ggtggccatg tagttcgtct tttccacggt
      781 catgatgaat gtttgacgat accatctaca gatcagaatg attctcagca caggagggtg
      841 ttctatgaag ctggaggagc tgggaccaga gccaggtctc tatggagagt ggaacccctt
      901 cggataagct ggagtggcag taacatcagg tggggccagg ccttccgact ccggcatctt
      961 accacaggcc actacttggc cttgacagaa gaccaaggcc ttcttctaca agaccgggga
     1021 aaatccgaca ccaaatccac agccttctcc ttccgagcat caaaggaaat caaggagaaa
     1081 ttagattcca gtcacaaaag agatatggaa ggcatgggag ttccagaaat caagtacggg
     1141 gattctgtct gctttgttca gcatgtagcc agtggccttt gggtcaccta caaagcacaa
     1201 gatgccaaaa cttcccgcct gggacctctg aaaagaaagg tcatactcca tcaggaaggc
     1261 cacatggatg acggattaac actgcagagg tgccagcagg aagagtccca ggctgctcgc
     1321 atcatccgga acacaaccgc cttattcagc cagtttgtca gtggaaacaa tcgcacaact
     1381 gcccctgtcg ccttgccaac agaagaggtt ctgcagaccc tgcaagactt gatagcctac
     1441 ttccagccac cagaggacga gatgcaacat gaagacaaac agaataagct ccgctctcta
     1501 aagaacagac aaaatctttt caaggaggag gggatgctgg ccctcgtatt gaattgcatt
     1561 gatcgattaa acatctacaa tagtgtagca cactttgcag ggatcgtaag ggaagagagt
     1621 ggcatggcct ggaaagaaat tctgaacctg ctatacaaat tactagccgc tctcatacgt
     1681 ggaaacagaa acaattgtgc tcaattctcc aataaccttg attggttaat tagtaagttg
     1741 gacagactag aatcttcctc aggtatcttg gaggtcttgc actgcatctt gattgaaagc
     1801 ccagaagcct taaacctaat agcagagggc cacatcaagt ctatcatctc cctactggat
     1861 aagcatgggc ggaatcacaa ggttctcgat gtcctgtgct ccctctgtct ctgcaatggg
     1921 gttgcagtaa gagccaacca gaatctgatc tgtgacaacc tactaccccg gaggaacctg
     1981 cttctgcaga cacgactaat taatgatgtc accagcatcc ggccaaacat cttcctggga
     2041 gttgctgaag gttcaccaca gtacaagaag tggtactttg agttaattat cgaccaggtg
     2101 gagcctttcc taacagcaga gcctacacat ctgcgagtgg gctgggcctc ctcttcaggc
     2161 tatgccccgt accctggtgg tggagaagga tggggaggca atggtgtcgg tgatgatctg
     2221 tactcctatg gctttgatgg gcttcatctg tggtcaggac ggatacccag agctgtggct
     2281 tccatcaacc agcatctgct caagtcagac gatgtggtga gctgctgcct tgaccttgga
     2341 gtacccagca tttctttccg aatcaatgga caacctgtgc aggggatgtt tgagaatttc
     2401 aacacagatg gactcttctt ccctgtgatg agtttttcag ctggtgtcaa agtacgcttc
     2461 ctgatgggtg gtcggcatgg agaatttaag ttcctgcctc cctcaggcta tgccccttgc
     2521 tatgaagcct tacttcctaa ggagaagatg agattggagc ctgtcaaaga atataagcgt
     2581 gatgctgatg gtgtgagaga tctattgggt accacacagt tcctctccca agcctctttc
     2641 atcccatgtc ccatagatac cagtcaggtt gttttgccac ttcacctaga gaagatccga
     2701 gacagactgg ctgagaacat ccacgagctt tgggggatga acaaaataga actcggctgg
     2761 acttatggca aagtgcggga tgacaacaaa aggcagcatc cctgccttgt ggagttttca
     2821 aagctccctg aaactgagaa gaattataac ctgcagatgt caacggaaac cttgaaaacc
     2881 ttgctggccc tggggtgcca cattgctcat gttaacccag ctgcggaaga ggatctaaag
     2941 aaagtcaagc ttcccaaaaa ctatatgatg tccaatggct ataagccagc ccctttggat
     3001 ttatctgatg tgaagctgtt accacctcaa gaaattttag tggataagct tgcagaaaat
     3061 gctcacaatg tttgggcaaa ggacagaatt aaacaaggtt ggacctatgg tattcaacag
     3121 gatctgaaga ataaaagaaa tccccgcctg gtgccatatg cattactaga tgagcgcacc
     3181 aagaaatcaa acagggacag cctacgtgaa gctgtacgga catttgttgg ttatgggtat
     3241 aacattgagc cttcagacca agaactagct gatcctactg tcgagaaggt cagcatagac
     3301 aagatccggt ttttccgagt agaacggtca tatgctgtaa agtctggaaa gtggtacttt
     3361 gaatttgaag tggtaactgg aggagacatg cgtgttggct gggccaggcc aggctgtcgt
     3421 cctgacattg agctgggggc tgatgatcaa gccttcgtgt ttgaaggaag caggggtcag
     3481 cgttggcatc aaggcagtgg gtattttgga cgaacttggc agccaggaga tgtggtcggg
     3541 tgcatgatta acctggatga tgcctccatg gtcttcacac tgaatgggga actgctcatc
     3601 accaacaaag gttctgaact tgccttcgca gactatgaga ttgagaacgg ttttgtgccc
     3661 atttgctctc tggggctatc ccagattggc cgcatgaatc ttgggacaga tgccagtacc
     3721 ttcaagtttt ataccatgtg tggactccag gagggctttg agccttttgc ggtaaatatg
     3781 aaccgagatg ttgcagtgtg gtttagcaag cgcctcccaa catttgtgaa tgtgcctaag
     3841 gatcatcccc acatagaggt tgtgagaatt gatggcacca tggacagccc tccatgcctc
     3901 aaggtgaccc acaagacctt cggcacacag aacagcaatg ccaacatgat ctactgccgc
     3961 ctgagcatgc ctgttgaatg tcattcctct ttcagtcaca gtccctgtct agacagtgaa
     4021 gccttccaaa aaaggaaaca gatgcaagaa atactatctc acacaacaac acaatgctac
     4081 tatgctatcc gcatttttgc tgggcaggac ccatcatgtg tctgggttgg atgggtgact
     4141 ccggactacc atttatacag tgaaaagttt gacctgaata aaaactgcac tgtgactgtc
     4201 accctgggag atgaaagagg ccgggtccat gaaagtgtga aacgcagcaa ctgctacatg
     4261 gtctggggtg gggatattgt agccagttcc caaagatcaa gtcggagcaa tgtagacctg
     4321 gagattggct gccttctaga tctggcaatg ggcatgttgt ccttctcagc taatgggaag
     4381 gaacttggca cctgctacca ggtggagcct aacaccaaag tgttccctgc agtcttcctt
     4441 cagcctacca gcacgtcctt gtttcagttt gaacttggaa aactgaagaa tgcaatgcct
     4501 ctgtcagcag ccatatttaa gagtgaagag aagaacccca ccccacagtg tccacctcgg
     4561 ctggatgtcc aaaccatcca gcctgtactc tggagtcgaa tgcccagcag cttcctcaaa
     4621 gtggagacag agcgggtgag cgagcgccat ggctgggtgg tgcagtgcct agaacccctg
     4681 cagatgatgg cactccacat ccctgaggag aacaggtgtg tggacatcct cgagctctgt
     4741 gagcaggagg acctgatgca gttccattac cacacactga gactttacag cgctgtgtgc
     4801 gctctgggaa atagccgagt ggcttctgcc ctgtgcagcc acgtggacct ctcacagctc
     4861 ttctacgcca ttgacaacaa gtacttgcct ggcctccttc ggtctggctt ctatgacctg
     4921 ctcattagca tccacctggc caatgctaag gagaggaagc tgatgatgaa gaatgagtac
     4981 atcattccta tcaccagcgc caccaggaat atccgcctat acccggatga gtccaagaga
     5041 cacggattgc ctggggtggg cctgaggaca tgcctcaagc caggcttcag gttctccacc
     5101 ccttgctttg tggtgacgag tgaggaccat cagaagcaga gccctgagat tcccttgcag
     5161 attctcaaga caaaagccct gagcatgcta accgaggccg tgcactgtag cggggcccac
     5221 atccgagacc ctgtcggggg ttctgtggag ttccagttcg tgcctgtgct gaaactcatt
     5281 ggaaccttgt tagtcatggg ggttttcgac gacgatgatg ttcgccagat tctcctcctg
     5341 attgatccct ctgtgtttgg ggagcacagt ggggagacgg aagaaggggt ggaaaaagaa
     5401 gtgacccacg cagaggaaaa ggcagtggag gctggagaaa aggcctgcaa ggaggctcca
     5461 gtcaaaggct tgctgcagac ccgattgcct gagtctgtca agctgcagat gtgcgaactc
     5521 ctcagctacc tctgtgactg cgaactgcag caccgagtag aggctattgt ggcatttggt
     5581 gacatttacg tgtccaagct gcaggcaaat cagaagttcc gctacaatga gctcatgcag
     5641 gccctgaaca tgtctgcagc cctaactgcc agaaagacaa gagagttccg ctcaccgccc
     5701 caggagcaga tcaacatgct tctcaacttt cacctgggag agaactgccc ctgcccagag
     5761 gagatccgag aggagctgta tgacttccat gaggaccttc tggttcactg cggggttccc
     5821 ttggaggaag aggaagagga ggaggaggat acttcctgga caggaaaact gtgtgctctg
     5881 gtgtataaga tcaagggtcc acccaagcct gagaaggagc agccaacaga ggaagagaaa
     5941 ccgtatccta caacactgaa ggaactagtt tcacagacaa tgatccgctg ggcccaggag
     6001 aaccaaatcc aggatgcgga actggtgagg atgatgttca acctccttcg gagacagtat
     6061 gacagcattg gggagttgct ccaggctctg cggaagacct acaccatcag ccaggcctct
     6121 gtgaatgaca ctatcaacct gctggctgcc ctgggccaga ttcggtccct gcttagtgtc
     6181 aggatgggca gagaagagga gctcctcatg atcaacgggc taggggacat aatgaacaac
     6241 aaggtgtttt accagcaccc caacctgatg agagtcctcg gcatgcatga gactgtgatg
     6301 gaagtgatgg tcaatgtgct gggtactgag aagtcgcaga ttgccttccc aaagatggtt
     6361 gctagctgct gtcgcttcct ttgctatttc tgtcgaatta gccggcaaaa tcagaaggcc
     6421 atgtttgagc atctaagtta cctgctggag aacagtagtg tgggtctagc gtccccatcg
     6481 atgagggggt ccaccccact ggatgtggca gcctcctctg tgatggacaa taatgaacta
     6541 gcactgggct tagaagaacc ggatcttgag aaggtcgtaa cctacttggc aggctgtggc
     6601 cttcagagct gccccatgct tctggccaga ggctaccctg acgttggctg gaaccccatc
     6661 gaaggggagc gctacctgtc cttcctgagg tttgccgtct tcgtaaacag cgaaagtgtg
     6721 gaagaaaatg ccagcgttgt ggtcaaactg ctcatcagac gtcccgagtg cttcggccca
     6781 gctctgaggg gtgaaggagg caacggactg ctggcggcta tgcagggtgc tattaagatc
     6841 tcagagaacc ctgccctcga cctcccttcc cagggttaca agacagaagt cacacaggat
     6901 gatggagagg aggaagagat tgtgcatatg ggcaatgcaa ttatgtcatt ttattcagcg
     6961 cttatagatc tattgggccg ctgtgctccc gaaatgcatc tcatccaaac agggaaaggg
     7021 gaagccatcc ggatccggtc catcctgcgc tccctggtcc ccacggaaga cctggttggg
     7081 atcatcagca tccccctcaa actgccctcc ctaaacaaag atggttcagt cagcgagcca
     7141 gacatggcgg ccaacttctg ccctgaccac aaggcaccca tggtgctgtt cttggaccgt
     7201 gtttatggca ttaaagatca aactttcctg ctccacttgc tggaagttgg gtttttacct
     7261 gacttacggg cttctgcatc tctagataca gtgtccctca gcaccacaga ggctgcgctg
     7321 gcgctgaata ggtatttatg ttcggctgtg ctcccactcc tcactagatg cgcccctctc
     7381 ttttctggga cagaacactg tacttctctg attgattcta cactgcagac aatatacagg
     7441 ctttccaaag gacgctccct caccaaggca cagagggaca ccatagaaga atgtttgcta
     7501 gccatttgca atcatttgag accttccatg ttacagcaac tcctgcgtcg tctggttttt
     7561 gacgtgccac agctcagcga gtactgcaag atgcccctta agcttctgac aaatcactac
     7621 gagcagtgct ggaagtatta ctgcctgcct tcgggatggg ggagctatgg gctggctgtg
     7681 gaggaggagc tgcacctcac tgagaagctc ttctggggga tctttgactc cctctcccac
     7741 aagaaatatg acctggacct tttccgaatg gccctgcctt gtctcagtgc tattgctggg
     7801 gccttgccac cagactattt agatacgaga attacagcca cattggagaa gcaggtctca
     7861 gtggatgcag atggaaactt tgaccccaaa cctatcaaca ccatgaattt ttccttgcct
     7921 gaaaaattgg aatacattgt caccaagtat gctgagcatt ctcatgataa atgggcttgt
     7981 gacaagagtc acagtggatg gaaatatggg atttctctgg atgaaaatgt gaagacacac
     8041 ccactaatac ggcccttcaa gacattaaca gagaaggaga aggaaattta tcgctggcct
     8101 gccagagagt ccctgaaaac catgctggct gtgggctgga cagtggaaag gaccaaagaa
     8161 ggagaagcct tggttcaaca aagagagaat gagaagcttc gatgtgtgtc ccagaccaat
     8221 cagggcaata gttacagccc cgcccctctg gatctctcaa atgttgtgct gtccagggag
     8281 cttcagggaa tggtggaggt ggtggctgag aactatcaca atatctgggc caagaagaag
     8341 aagctggagc tggaaagcaa gggtggtggc agccacccgc ttttggtacc atatgacacc
     8401 ttgactgcca aggaaaagtt cagggatcga gagaaggccc aggacctgtt caaattcctc
     8461 caagtgaatg gcattctagt ttctagaggc atgaaggact tggagctgga tgcctcctcc
     8521 atggagaaga gatttgccta caagtttttg aagaagatcc tgaagtatgt tgacgctgct
     8581 caagagttta ttgctcactt ggaagccatt gtcagcagtg ggaagacaga aaagtctccc
     8641 catgaccagg agatcaaatt ctttgccaaa gttctcctcc cactggtcga ccagtacttc
     8701 accaaccacc gcctgtattt cctgtcgtct cctctgaagc cgctcagcag cagtgggtat
     8761 gcttcccata aagagaaaga aatggtggcc agcctattct gcaagctggc cgctcttgtt
     8821 agacacagga tttcactctt tgggagcgat tcaactacaa tggtgagctg tcttcatatc
     8881 ttagctcaga cacttgacac aaggacagtg atgaagtcag gctcagagct ggtgaaagcc
     8941 gggctgcgag cattctttga aaatgctgct gaagacttag agaagacctc cgaaaacctg
     9001 aagctgggga agtttaccca ttcccgaacg cagatcaaag gtgtttctca gaatattaac
     9061 tacaccacag tggctctgct tcccatcctg acatccatct ttgagcacat cgctcagcat
     9121 cagtttgggg tggatctact cttgagcgac gtgcaggttt catgctacca cattctgtgc
     9181 agcctctact cccttgggac tgggaaaaac atctatgttg aaaggcaacg tcctgctctt
     9241 ggagaatgtc tggcttccct agcagctgct atccctgtgg cctttctgga gcccagcctt
     9301 aaccgccaca atcccctctc agtcttcaac accaaaaccc ccagggagcg ctctattctg
     9361 gggatgccag acaaggtgga ggacatgtgt cctgacatcc ctcagctgga aggcctgatg
     9421 aaggaaatca atgacttggc cgagtcaggt gcccggtaca ctgagatgcc ccatgtcatt
     9481 gaagtgatct tgcccatgct ctgcaactac ctgtcctact ggtgggagcg gggacctgag
     9541 aacctgcccc ccagcacagg accctgctgc accaaggtca catctgaaca cctcagcctc
     9601 atcctgggca acatcctgaa aatcatcaac aacaacctgg gcattgatga ggcctcctgg
     9661 atgaagcgca tcgcagtgta tgcccagcca attatcagca aagccaggcc cgacctgctt
     9721 cgaagccact tcatccccac cctggagaag ctaaagaaga aggcggtgaa gactgtgcag
     9781 gaggaggagc agctgaagac cgatggcaag ggggacaccc aggaggctga gctcctcatc
     9841 ctagatgagt ttgctgtcct ctgcagggac ctctatgcct tctaccccat gctgatccgc
     9901 tatgtggaca acaacagatc taactggctc aaaagcccag atcctgattc tgaccagctc
     9961 ttccgcatgg tggccgaggt cttcattctg tggtgtaaat ctcataactt caagagggaa
    10021 gagcaaaatt ttgtgattca aaatgaaatt aataacttgg catttttaac tggagacagc
    10081 aaaagcaaga tgtcaaaagc catgcaagta aagtctggag gacaggacca ggaacggaag
    10141 aagacaaaga ggcgaggaga cttgtattcc atccagacgt cccttatcgt ggctgcgctc
    10201 aagaaaatgc tgcccattgg tctgaacatg tgtactccag gcgaccagga gctcatctca
    10261 ctcgcaaaat cacgatacag ctgtagggac actgatgaag aagtcaagga acatcttcgg
    10321 aataacctgc acctgcagga gaagtctgat gacccagctg tgaaatggca actgaacctc
    10381 tacaaggacg ttctgaggaa tgacgagcct tctaatccag aaaagacggt ggagcgggtg
    10441 cagagcattt cggcagctct cttccacctt gagcaggtgg aacagccttt gaggtccaaa
    10501 aaggctgtat ggcacaaatt gttgtcaaag caacggaaac gggcagtggt ggcctgtttc
    10561 aggatggctc ccctctacaa tctgcccagg caccgctcta ttaacctctt cctccatggc
    10621 tatcagagat tctggataga aacagaggcg catttctttg aagagaaact agtacaggat
    10681 ctggctaaat ctcccagggt tgaagatgag gaagaagagg agacagagag gcaacctgac
    10741 ccacttcacc agatcattct gcattttagt cgcaacgcgc tcacggagag gagcaaattg
    10801 gaagatgatc cattgtacac ttcctattcc agcatgatgg ccaagagctg tcagagtggt
    10861 gaggatgaag aagaagaaga agacaaggaa aaaacctttg aagagaagga gatggagaag
    10921 caaaaaacac tgtatcaaca agcaaggctg cacgagcgtg gtgctgcaga gatggtcctt
    10981 cagatgataa gtgccagcaa aggtgagatg agccccatgg tggttgagac actgaagctg
    11041 gggattgcca ttctgaacgg aggcaatgct ggtgtgcaac agaaaatgct agattactta
    11101 aaggagaaaa aagatgctgg attctttcaa agcctctctg gtcttatgca gtcctgcagt
    11161 gtccttgatt tgaatgcatt tgagagacag aataaagctg aaggcctggg gatggttaca
    11221 gaagaaggga cactcattgt tcgtgagcgt ggtgaaaagg tactccagaa tgatgaattc
    11281 acacaagatc tctttagatt cctacagttg ctttgtgaag gacataacag tgactttcag
    11341 aacttcctga ggactcagat gggcaacacc actactgtga acatcatcat tagcactgtg
    11401 gactaccttc tgcgtctgca ggaatcaatc agcgatttct attggtacta ttcaggaaag
    11461 gacatcattg atgaatctgg acagcataat ttctctaaag ctctggcagt caccaagcaa
    11521 atttttaatt ctcttacaga gtacatccag ggcccttgca tcgggaacca gcaaagcctg
    11581 gctcacagta ggctgtggga tgcagtagtc gggttcctcc atgtatttgc taacatgcag
    11641 atgaagcttt ctcaggattc cagtcagatc gagctgctga aggaactctt ggatctcctt
    11701 caggacatgg tggtgatgct tctgtccctc ctggaaggaa atgtggtaaa tgggactatc
    11761 ggaaagcaga tggttgacac gctggtagaa tcatccacta atgtagagat gatcttgaaa
    11821 ttctttgaca tgtttttgaa acttaaagac ttaaccagct cagacacctt caaagaatat
    11881 gacccagatg gcaaagggat catctctcga aaagaatttc agaaggccat ggaaggtcta
    11941 aagcaatata cacagtcaga gatcgacttt ctcctttcat gtacagaggc tgatgagaac
    12001 gacatgttta attatgtgga ttttgtagag aggttccatg agccagccaa ggacataggg
    12061 ttcaatgtgg cagtgttatt gacaaatctc tctgaacata tgcccaacga ttcccgtctc
    12121 aagagtctgt tggacccagc agaaagtgtg ctaaattact tcgagccata cctgggtcga
    12181 attgagatca tgggtggggc caagaaaatt gagcgtgttt attttgagat cagtgaatcc
    12241 agtcgaactc agtgggaaaa acctcaagtg aaggaatcta agcgacagtt catcttcgat
    12301 gttgtcaatg aaggcgggga gcaagagaag atggaattgt ttgtgaactt ctgtgaggat
    12361 acaatctttg agatgcaatt agcatctcag atctcagaat ctgactcaac tgacaggccg
    12421 gaagaggaag aggaagagga tgaagactct gcttattcta tagaaaccga gggggaggag
    12481 gaagagaaat cttttgagtc tgcctctgct tttactatgg cctgtgtctc agtaaagaga
    12541 aatgtcacca agtttctgaa gagggcaacc ttgaagaacc tcaggaaaca atacaggaat
    12601 gtaaaaaaga tgagtgcaaa ggaactggtc aaggtgttct tctccttctt ctggatgctg
    12661 tttgtgggcc tctttcagtt gctcttcaca atctttggag gaatctttca gatcctctgg
    12721 aacacagtgt ttggaggggg ccttgtcgaa ggggcaaaga acatcagagt gactaagatc
    12781 ctaggtgaca tgcccgaccc cactcagttt gggatccatg atgatgtaat agaaactgac
    12841 agggcagaag tgactgagcc aggtgtcacc actgagctgg tccactttgt aaagggtgag
    12901 gcaggagata cagacatcat gtcagacctc tttggaatcc actccaagaa agaaggtggc
    12961 ttaaagcaag ggcctgaagt gggattaggt gacctctctg aaattatcgg caaggacgaa
    13021 cccccaacat tagagagtac tgtgcggaag aaaagaaaag cacaggcagc agagatgaaa
    13081 gcagtgcatg aagctgaagg aaaagctgaa tctgagaagg ccgacatgga agacagagaa
    13141 aaggaagaca aaatcaagga ggaggggcaa acagactacc tgtgggcaga cgtgacagta
    13201 aagaagacga gacggcgcgg tcagaaggct gagaagccag aagcctttat ggccaacttc
    13261 ttcaaagggc tggagattta tcagaccaag ttattgcact acctggccag gaatttctac
    13321 aacctgaggt tccttgctct gtttgtagcc ttcgctatca acttcatcct gcttttttat
    13381 aaggtcactg aagaaccttt agaggaagag acagaggatg ttgcaaacct gtggaactca
    13441 ttcaatgatg atgacgagga agaagcgatg gtgttctttg ttcttcagga gagcactggt
    13501 tatatggcac caacactgcg tgctttggcc attgtccaca ccatcatctc tctggtctgt
    13561 gtggtgggct attactgcct gaaggtacct ttggtggtat tcaaaaggga gaaagaaatt
    13621 gccaggaagc tggagtttga tggcctctat atcactgaac agccatctga ggatgacatc
    13681 aaggggcagt gggaccgctt ggtaatcaac acgccatctt ttcctaataa ctactgggac
    13741 aagtttgtga agagaaaggt gatcaacaag tatggagatc tctatggagc agagcgcatc
    13801 gctgaactcc tgggtttgga caaaaatgcc cttgacttta gcccagtaga agaggccaaa
    13861 gcagaggcag catctctggt gtcatggcta agttccatcg acatgaagta ccatatttgg
    13921 aagctagggg tggttttcac tgacaactcc tttctctacc ttgcctggta cacaaccatg
    13981 tctgtcctgg gccactacaa caacttcttc tttgctgctc atctgttgga tattgcaatg
    14041 ggctttaaga ccttgaggac gatcctgtca tctgtaactc acaatggcaa acagctggtt
    14101 ctgaccgttg gcctcctggc tgtggttgtt tacctctata ctgtggtggc tttcaacttc
    14161 ttccgaaagt tctacaacaa aagtgaagat gacgatgagc cggatatgaa gtgtgacgac
    14221 atgatgacgt gctacctctt ccacatgtac gtgggcgtaa gagcaggtgg aggcattggt
    14281 gatgaaattg aagaccccgc tggtgaccct tatgaaatgt atcgcatcgt ctttgatatt
    14341 accttcttct tcttcgtcat tgtcatcttg ctggccatca ttcaaggtct tattattgat
    14401 gcttttggag agctgcggga ccagcaggag caagtacggg aagacatgga gaccaagtgc
    14461 ttcatctgcg gcattggcaa tgactacttt gacacgaccc ctcatggttt tgaaacacat
    14521 acactgcaag agcacaactt agccaattat ctattctttc tgatgtattt gattaacaag
    14581 gatgaaacag aacatacggg ccaggaatcc tatgtgtgga agatgtacca ggaaaggtgt
    14641 tgggacttct tcccagctgg agactgcttt cggaagcaat atgaagatca gctcgggtaa
    14701 acctgagttc acgacaagct acagttctga acagccacct tctaatgcaa cagagtccgt
    14761 cttttacact ttaacaacaa aaaatagatt tggtaattaa cttggctttt gtgcacgaag
    14821 gatggcaaag tgtcaaggaa tccacctgac tgctaacgga gctctcgttt ctacaaactt
    14881 agtagttttt caccgacatg gttcagagag aaatgcgaaa tcttgaacac ctgaacgtca
    14941 tgtaagagga cccttgccag ggactgatgg gcagaactac acaaaatcat gttcaactca
    15001 tgttaccttc gatctaattt ttccatggta cttgctagtg actgtctcca gaatcagctt
    15061 gaaaagcttt aagcagctaa agaaatagaa aacaaacact ttgtcgaaac tgaaatatcg
    15121 attaagtgcc ttaaaaaatc tctttagata tagctatgca agttttttat gtttgtgttc
    15181 cagaaggaca actccattaa acagctgtgc tgctcctctg tcttacgtca tgacactgca
    15241 cttgcaggtt attcacgtca tttcttcagt aacagcttgt cacctgctgt tatctggaga
    15301 aaggcactgt actgaaattt cagaaaaaat ctcaatctta taccaaactt gagtgatgca
    15361 atatggtccc atgtaagtag tggagctgcc atgttttagg tcaatctcca ataaaaagaa
    15421 gtgcccactg caataaagta aaaaaaaaaa aaaaaa
//
