LOCUS       NM_023868              16813 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ryanodine receptor 2, cardiac (Ryr2), mRNA.
ACCESSION   NM_023868
VERSION     NM_023868.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 16813)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16813)
  AUTHORS   Lu,F., Liou,C., Ma,Q., Wu,Z., Xue,B., Xia,Y., Xia,S.,
            Trembley,M.A., Ponek,A., Xie,W., Shani,K., Bortolin,R.H.,
            Prondzynski,M., Berkson,P., Zhang,X., Naya,F.J., Bedi,K.C.,
            Margulies,K.B., Zhang,D., Parker,K.K. and Pu,W.T.
  TITLE     Virally delivered CMYA5 enhances the assembly of cardiac dyads
  JOURNAL   Nat Biomed Eng (2024) In press
   PUBMED   39237710
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 16813)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 16813)
  AUTHORS   Asghari,P., Scriven,D.R.L., Shahrasebi,S., Valdivia,H.H.,
            Alsina,K.M., Valdivia,C.R., Navarro-Garcia,J.A., Wehrens,X.H.T. and
            Moore,E.D.W.
  TITLE     Phosphorylation of RyR2 simultaneously expands the dyad and
            rearranges the tetramers
  JOURNAL   J Gen Physiol 156 (4) (2024)
   PUBMED   38385988
  REMARK    GeneRIF: Phosphorylation of RyR2 simultaneously expands the dyad
            and rearranges the tetramers.
REFERENCE   5  (bases 1 to 16813)
  AUTHORS   Bansal,V., Winkelmann,B.R., Dietrich,J.W. and Boehm,B.O.
  TITLE     Whole-exome sequencing in familial type 2 diabetes identifies an
            atypical missense variant in the RyR2 gene
  JOURNAL   Front Endocrinol (Lausanne) 15, 1258982 (2024)
   PUBMED   38444585
  REMARK    GeneRIF: Whole-exome sequencing in familial type 2 diabetes
            identifies an atypical missense variant in the RyR2 gene.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16813)
  AUTHORS   Takeshima,H., Yamazawa,T., Ikemoto,T., Takekura,H., Nishi,M.,
            Noda,T. and Iino,M.
  TITLE     Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking
            the type-1 ryanodine receptor
  JOURNAL   EMBO J 14 (13), 2999-3006 (1995)
   PUBMED   7621815
REFERENCE   7  (bases 1 to 16813)
  AUTHORS   Ayabe,T., Kopf,G.S. and Schultz,R.M.
  TITLE     Regulation of mouse egg activation: presence of ryanodine receptors
            and effects of microinjected ryanodine and cyclic ADP ribose on
            uninseminated and inseminated eggs
  JOURNAL   Development 121 (7), 2233-2244 (1995)
   PUBMED   7635066
REFERENCE   8  (bases 1 to 16813)
  AUTHORS   Giannini,G., Conti,A., Mammarella,S., Scrobogna,M. and
            Sorrentino,V.
  TITLE     The ryanodine receptor/calcium channel genes are widely and
            differentially expressed in murine brain and peripheral tissues
  JOURNAL   J Cell Biol 128 (5), 893-904 (1995)
   PUBMED   7876312
REFERENCE   9  (bases 1 to 16813)
  AUTHORS   Mattei,M.G., Giannini,G., Moscatelli,F. and Sorrentino,V.
  TITLE     Chromosomal localization of murine ryanodine receptor genes RYR1,
            RYR2, and RYR3 by in situ hybridization
  JOURNAL   Genomics 22 (1), 202-204 (1994)
   PUBMED   7959768
REFERENCE   10 (bases 1 to 16813)
  AUTHORS   Steck,T.L.
  TITLE     The organization of proteins in the human red blood cell membrane.
            A review
  JOURNAL   J Cell Biol 62 (1), 1-19 (1974)
   PUBMED   4600883
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059061.1, AF295105.1, AC131329.13, BB387101.1, BU921357.1,
            AC159208.2 and U23755.1.
            
            On Feb 3, 2007 this sequence version replaced NM_023868.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF295105.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-772               BC059061.1         1-772
            773-793             AF295105.1         274-294
            794-3565            BC059061.1         773-3544
            3566-3594           AF295105.1         3067-3095
            3595-3595           AC131329.13        87982-87982
            3596-4056           AF295105.1         3097-3557
            4057-4057           AC131329.13        98241-98241
            4058-4493           AF295105.1         3559-3994
            4494-4598           AC131329.13        107098-107202
            4599-4669           AF295105.1         4100-4170
            4670-4671           BB387101.1         55-56
            4672-4733           AF295105.1         4173-4234
            4734-4805           BB387101.1         119-190
            4806-4869           AF295105.1         4307-4370
            4870-4908           BB387101.1         255-293
            4909-4968           AF295105.1         4410-4469
            4969-5015           AC131329.13        112226-112272
            5016-5277           AF295105.1         4517-4778
            5278-5323           BU921357.1         55-100
            5324-5452           AF295105.1         4825-4953
            5453-5917           AC131329.13        119472-119936
            5918-6383           AF295105.1         5419-5884
            6384-6384           AC131329.13        122453-122453
            6385-6546           AF295105.1         5886-6047
            6547-6547           AC131329.13        127494-127494
            6548-6864           AF295105.1         6049-6365
            6865-6865           AC131329.13        131024-131024
            6866-7026           AF295105.1         6367-6527
            7027-7027           AC131329.13        133665-133665
            7028-7294           AF295105.1         6529-6795
            7295-7797           AF295105.1         6799-7301
            7798-7798           AC159208.2         188976-188976       c
            7799-8093           AF295105.1         7303-7597
            8094-8094           AC159208.2         184958-184958       c
            8095-8637           AF295105.1         7599-8141
            8638-8638           AC159208.2         180364-180364       c
            8639-10014          AF295105.1         8143-9518
            10015-10073         AC159208.2         142685-142743       c
            10074-10149         AF295105.1         9578-9653
            10150-10150         AC159208.2         139114-139114       c
            10151-11097         AF295105.1         9655-10601
            11098-11101         AC159208.2         126615-126618       c
            11102-11436         AF295105.1         10606-10940
            11437-11437         AC159208.2         117173-117173       c
            11438-11877         AF295105.1         10942-11381
            11878-11878         AC159208.2         96291-96291         c
            11879-13143         AF295105.1         11383-12647
            13144-13144         AC159208.2         72095-72095         c
            13145-13911         AF295105.1         12649-13415
            13912-13918         AC159208.2         68077-68083         c
            13919-13983         AF295105.1         13423-13487
            13984-13996         AC159208.2         65003-65015         c
            13997-14358         AF295105.1         13501-13862
            14359-14359         AC159208.2         62259-62259         c
            14360-14562         AF295105.1         13864-14066
            14563-14563         AC159208.2         54604-54604         c
            14564-14829         AF295105.1         14068-14333
            14830-14830         AC159208.2         43748-43748         c
            14831-14901         AF295105.1         14335-14405
            14902-14984         U23755.1           20-102
            14985-15400         AF295105.1         14489-14904
            15401-16813         AC159208.2         29904-31316         c
FEATURES             Location/Qualifiers
     source          1..16813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 4.38 cM"
     gene            1..16813
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /note="ryanodine receptor 2, cardiac"
                     /db_xref="GeneID:20191"
                     /db_xref="MGI:MGI:99685"
     exon            1..547
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..15400
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /note="ryanodine receptor type 2; calcium release channel;
                     type 2 ryanodine receptor; cardiac muscle ryanodine
                     receptor; cardiac muscle ryanodine receptor-calcium
                     release channel"
                     /codon_start=1
                     /product="ryanodine receptor 2"
                     /protein_id="NP_076357.2"
                     /db_xref="CCDS:CCDS49206.1"
                     /db_xref="GeneID:20191"
                     /db_xref="MGI:MGI:99685"
                     /translation="MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGN
                     RLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMM
                     KTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWW
                     TIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPIS
                     SGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWR
                     LETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSS
                     KEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQRKAI
                     MHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKLPTIDLPIE
                     SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVY
                     SSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLE
                     ASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVA
                     VRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHT
                     EPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIART
                     VSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGI
                     KVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVS
                     LTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQ
                     HPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQL
                     TSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNP
                     RLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGERFRIF
                     RAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWH
                     QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPV
                     CSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVP
                     SNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNNNTDIMFYRLSMPIECAEVFSKSVAG
                     GLPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQ
                     EKPSRLKQRFLLRRTKPDYSTGHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQ
                     EPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESM
                     SPGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPN
                     VFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVS
                     RISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCAL
                     GNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEF
                     IVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFP
                     LDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKH
                     ILQLIEPSVFKEAAVPEEEGGTPEKEISIEDAKLEGEEEAKGGKRPKEGLLQMKLPEP
                     VKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTA
                     RKTREFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSL
                     DGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVASDSRKCSSLQQLISETMVRWAQESVI
                     EDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVR
                     MGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPK
                     MVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMD
                     NNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVF
                     CNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPT
                     SGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSIL
                     RSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQ
                     DFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTE
                     HHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVP
                     LLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQK
                     KYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITI
                     PEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIY
                     RWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMS
                     NVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAKDRE
                     KAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG
                     GSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEM
                     VTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFL
                     DNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGE
                     DLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDK
                     HNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMM
                     EVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEG
                     AWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEA
                     ELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKS
                     HNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIV
                     AALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIR
                     WQMALYKDLPNRTEDPSDPERTVERVLGIANVLFHLEQKSKYTGRGYFSLVEHPQRSK
                     KAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLI
                     EDLAKPGAELPEEDEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSC
                     HDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAA
                     TLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAE
                     GLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS
                     TVDYLLRVQESISDFYWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGN
                     QQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGN
                     VVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRD
                     FHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNL
                     SEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKP
                     QVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERLANKEES
                     EKERPEEQAPRMGFFSLLTIQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKMTVKDM
                     VLAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANMPDP
                     TQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIP
                     HNPNAGLSDLMTNPVPVPEVQEKFQEQKAKEEKEEKEETKSEPEKAEGEDGEKEEKAK
                     DEKSKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFA
                     INFILLFYKVSTSSVVEGKELPTRTSSDTAKVTNSLDSSPHRIIAVHYVLEESSGYME
                     PTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIK
                     GQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREK
                     KKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHL
                     LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDT
                     PDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL
                     AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN
                     YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN"
     exon            548..667
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..772
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            773..793
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..808
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..883
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..962
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1075
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1175
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1272
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1347
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1504
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1669
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1791
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1975
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2111
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2207
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2326
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2460
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2702
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2895
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3112
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3217
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3321
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3405
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3565
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3713
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3922
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4097
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4306
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4659
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..4774
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4935
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5098
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5099..5185
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5186..5412
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            5413..6211
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6212..6412
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6413..6518
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6519..6662
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6663..6936
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            6937..7051
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7052..7184
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7185..7288
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7289..7424
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7425..7611
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7612..7717
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7718..7838
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            7839..8008
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8009..8229
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8230..8320
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8321..8461
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8462..8625
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8626..8704
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8705..8794
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8795..8932
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            8933..9010
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9011..9086
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9087..9210
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9211..9326
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9327..9391
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9392..9513
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9514..9563
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9564..9624
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9625..9863
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9864..9945
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            9946..10076
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10077..10397
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10398..10638
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10639..10726
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10727..10819
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10820..10990
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            10991..11050
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11051..11185
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11186..11221
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11222..11334
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11335..11431
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11432..11535
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11536..11587
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11588..11641
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11642..11741
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11742..11821
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11822..11898
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11899..11972
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            11973..12053
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12054..12142
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12143..12271
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12272..12376
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12377..12458
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            12459..13756
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13757..13821
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13822..13969
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            13970..14056
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14057..14278
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14279..14409
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14410..14452
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14453..14586
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14587..14647
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14648..14794
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14795..14929
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            14930..15086
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15087..15151
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15152..15252
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15253..15304
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            15305..16813
                     /gene="Ryr2"
                     /gene_synonym="9330127I20Rik; RYR-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcggattac ctgcagcagc cggggctggc agctcctccc cgcccgcccc cagcccgccc
       61 ccgccgctgc actagcccgg ctccgcgggc tccgggcact cgctggcggg agccggggcc
      121 gagcgcgccg ggcagtgggg cctcctccct gcgtcctcac gccgggctgc cctcctcccg
      181 caccgtgcgg cgcagggagg ccccgcgcct cggccgcccc cgcgtgcccg cctccgccgc
      241 gctgcagggg gaccgaccgc tgggctctcg gcaccagcag cgcggccccc cgggtgcctc
      301 gggctcctgg ctgtggccgc cgcaggggca gcgacccgag tagcagccgt tggagcccct
      361 agaacatcct ggttagcagt gactagagcg tccagagaag ccgcagcagc agcttcagca
      421 gtagcagcag cagcataagt ggccgcggtc gtggggctcc gccgggctcc ggagccggcc
      481 gggccaggag cgcggagcca tggctgatgc gggcgaaggc gaggatgaga tccagttcct
      541 gagaactgat gatgaggtgg ttctgcagtg cacggcgacc atccacaaag aacagcagaa
      601 gctgtgcttg gcagcagaag gatttggcaa cagactttgt tttttggagt ctacttccaa
      661 ttccaagaat gttcccccgg acctgtctat ctgcaccttt gtgctggagc agtccctgtc
      721 agtacgggcc ctgcaggaga tgctggccaa cacagtggaa aagtcagaag ggcaggtgga
      781 tgtggaaaag tggaagttca tgatgaagac tgctcaaggt ggaggccacc ggacactcct
      841 ctatggacac gccatattgc tacgccattc ctacagtggt atgtatcttt gctgtctctc
      901 cacctcccgg tcttccactg acaaactggc cttcgatgtt ggccttcaag aggataccac
      961 aggggaggct tgctggtgga ccatacatcc tgcctctaag cagagatcag aaggagaaaa
     1021 agtgcgtgtt ggagatgatc tcatcttggt cagcgtgtcc tcagaaaggt acttgcactt
     1081 gtcatatggc aacagcagct ggcatgtgga tgctgccttc cagcagaccc tctggagcgt
     1141 ggcccctatc agctcaggaa gtgaagcagc ccaaggctat ctcattggcg gtgatgttct
     1201 ccggctgctg catgggcaca tggatgaatg tctcactgtc ccttcaggag agcatggtga
     1261 agaacagcgg agaacagttc attatgaagg tggtgccgta tcagttcatg cccgctccct
     1321 ctggagacta gagaccctaa gagtcgcgtg gagtggaagc cacataagat ggggccagcc
     1381 attccgactc cggcatgtca cgacaggaaa atacttaagc ctcatggaag acaagaacct
     1441 cctactcatg gacaaagaga aagcagatgt aaaatcaaca gcgtttgcct tccggtcttc
     1501 caaggaaaaa ttggacgtgg gggtgaggaa agaagtcgat ggcatgggaa cctcagaaat
     1561 caagtatgga gactccattt gctacataca acatgtggat acaggcctgt ggctaaccta
     1621 ccaggctgtg gatgtgaaat cagcacgaat gggatccatc cagcgtaagg ctatcatgca
     1681 ccacgaaggc cacatggacg atggtttgaa cttatccaga tcacagcatg aggagtcccg
     1741 cactgcccgc gtcattcgga gcacagtgtt cctctttaat aggttcataa ggggcctgga
     1801 tgctctcagc aagaaagtaa agctgcccac cattgacttg cccatcgagt ctgtgagcct
     1861 gagtttgcag gacctcatcg gctacttcca ccccccagat gagcacttgg agcatgagga
     1921 caagcagaac aggctgcgag ccctgaagaa caggcagaat ctcttccagg aagagggaat
     1981 gatcaacctg gttctggagt gcatcgaccg cctgcatgtc tacagcagtg cagcccactt
     2041 tgcagatgtc gcaggacgag aagcaggaga gtcttggaaa tccatcctga attctctgta
     2101 tgagttgctg gcggccctaa ttagaggaaa tcgtaaaaac tgtgctcagt tttctggttc
     2161 cctcgactgg ctgatcagca gactggaaag actggaagca tcctcaggta tcctggaggt
     2221 cctccactgt gtgttagtgg agagcccaga agctctgaat atcatcaaag aagggcatat
     2281 caagtccatt atctcgcttt tagacaagca tgggagaaac cacaaggtcc tggatgtgct
     2341 gtgttctctc tgtgtatgcc atggagttgc tgtccgctct aatcagcacc tcatctgtga
     2401 taatctcctg ccaggacgag atctcttact gcagacccgt cttgtgaatc atgtcagcag
     2461 catgaggcct aatattttcc tgggtgtcag cgaaggatca gcacagtata agaagtggta
     2521 ctacgagctc atggtggacc acacggaacc ctttgtgacg gcagaagcca ctcacctgcg
     2581 agtgggctgg gcttccactg aagggtattc tccataccca ggtgggggtg aagagtgggg
     2641 tggcaatggc gttggtgacg acctcttctc ctatgggttt gatggccttc acctctggtc
     2701 aggttgtata gctcggaccg tgagctcccc caaccagcac ctgctgagaa ctgacgatgt
     2761 catcagttgt tgtttagatc taagtgcccc cagcatctcg tttcgcatta atggacaacc
     2821 ggtgcaaggg atgtttgaga acttcaatat cgatggcctg ttctttccag ttgtcagttt
     2881 ctctgcagga ataaaggttc gctttttgct tggggggaga catggagaat tcaagtttct
     2941 ccctccacct ggctatgcag cttgctatga agctgtacta cccaaagaga aattgaaggt
     3001 ggaacacagc cgagaatata agcaggagag gacatacaca cgagacctgc tggggcctac
     3061 agtgtccctg acccaagctg ccttcacacc tgttcctgtg gacaccagcc agattgtgtt
     3121 gcctcctcac ctggaaagga taagagaaag actggcagag aatatccatg agctctgggt
     3181 tatgaataaa attgagcttg gctggcagta tggtccggtt agagatgaca acaagagaca
     3241 gcacccatgt ctggtggagt tctgcaagct tccagaacag gaacgcaact ataatttgca
     3301 gatgtcgctt gaaaccctca agactttgct ggcattggga tgtcacgtgg gtatagctga
     3361 tgaacatgct gaagagaagg tgaagaaaat gaaactgcct aagaattacc agctgaccag
     3421 cggatacaag cctgccccaa tggatctgag ctttataaaa ctaaccccgt ctcaggaagc
     3481 aatggtggac aagttggctg aaaatgctca caatgtgtgg gcccgggacc gaatccggca
     3541 aggctggact tacggcatcc agcaggatgt aaagaataga agaaaccctc gtctcgtccc
     3601 ctacactctt ctggatgaca gaaccaagaa gtccaacaaa gacagtctcc gagaggcagt
     3661 gcgcacactg ctgggctacg gctaccacct ggaagctcct gatcaggacc atgcctcgag
     3721 agccgaggtg tgcagcggta ctggggagag gttccgcatc ttcagggcag agaagaccta
     3781 tgcggtgaag gctgggcgct ggtactttga atttgaggct gtcactgctg gagacatgcg
     3841 ggtgggctgg agcaggccag gctgccaacc agatctagaa ctgggttctg atgaccgtgc
     3901 ctttgctttt gatggcttta aggcacagcg gtggcaccag ggcaatgaac actacgggcg
     3961 ctcatggcaa gctggtgacg tcgtgggctg catggttgat atgaatgaac acaccatgat
     4021 gttcactctg aacggcgaga tcctgctgga tgattcaggc tctgagctgg cattcaagga
     4081 ctttgatgtt ggtgatggat tcatccctgt gtgtagcctc ggggtggcac aagtaggcag
     4141 gatgaacttt ggaaaggacg tcagcacttt gaaatatttt accatctgtg gcttacaaga
     4201 aggctatgag ccatttgccg ttaatacaaa tagggacatc accatgtggc tgagcaagcg
     4261 gcttcctcag ttcctccagg tcccatcaaa ccacgaacac attgaggtga ccagaataga
     4321 tggtaccata gacagttctc catgtctgaa ggtcactcag aagtcctttg gttctcagaa
     4381 caacaacact gacatcatgt tttaccgcct gagtatgccc attgaatgtg ccgaggtctt
     4441 ctcaaagtcg gtggcgggag ggcttcctgg tgccggcttc tacgggccca agaatgattt
     4501 ggaggacttt gatgtggact ctgactttga ggttctgatg aagacagctc atggtcatct
     4561 tgtgcctgac cgcatcgaca aggacaaaga gacccctaag ccagagttca ataaccacaa
     4621 agattatgct caggaaaagc cctcacgact aaagcaaaga ttcttactta gaaggaccaa
     4681 gccagattac agcacaggcc actctgcaag actcactgaa gatgtccttg ctgatgaccg
     4741 ggatgactac gagtacctga tgcagacgtc cacatactat tactcggtga ggatctttcc
     4801 tggacaagaa ccagctaatg tctgggtggg ctggattaca tctgacttcc accagtacga
     4861 cacaggcttt gatttggaca gagtgcgcac agtgacggtc accctaggag atgaaaaagg
     4921 aaaagtgcat gagagcatca aacgcagcaa ctgctatatg gtgtgtgcag gagagagcat
     4981 gagccccggg caaggacgaa acaacagcaa cgggctggag attggctgtg tggtggatgc
     5041 tgccagtggg ctgctcacat tcatagccaa tggcaaggag ctaagcactt actatcaggt
     5101 ggagccaagc acaaagctct ttcctgcggt tttcgcgcaa gctacgagtc ccaatgtttt
     5161 ccagtttgag ttgggcagaa taaagaatgt aatgcctctc tccgcgggac tgtttaagag
     5221 cgagcacaaa aaccccgtgc cccagtgtcc tccacgtctg catgtgcagt tcctgtccca
     5281 tgtcctgtgg agccggatgc ccaaccagtt cttgaaggtg gacgtctctc gaatcagtga
     5341 acgccaaggc tggctggtgc agtgtctaga tcctctgcag ttcatgtccc tccatatacc
     5401 tgaggagaac agatctgttg acatcttaga gctgacagag caggaggagt tgttgcagtt
     5461 tcactatcac accctccgcc tctactctgc tgtctgcgcc cttgggaatc atcgggtggc
     5521 tcacgccctg tgcagccacg tggacgaacc tcagctgctc tacgccattg agaacaagta
     5581 catgcctggc ttgctgcgag ctggctacta tgacctgctg attgacatcc acctcagctc
     5641 ctatgccacc gccaggctca tgatgaacaa cgaattcatc gtccctatga cagaggagac
     5701 aaagagcatc accctcttcc ctgatgagaa taagaaacat ggcctcccag gcataggcct
     5761 tagcacctcc ctccggcctc ggatgcgttt ttcctccccg agtttcgtga gcattagcaa
     5821 cgactgttat cagtacagtc ccgagtttcc tctggacatc ctcaaggcca agaccatcca
     5881 gatgctcaca gaagccgtga aggagggcag cctccacgct cgggatcctg tgggtgggac
     5941 cacggagttc ctctttgtgc ccctcatcaa gctgttctac accctgctca tcatgggcat
     6001 ctttcacaat gaggatttga aacacatcct gcagttgatc gagcccagtg tgtttaagga
     6061 agctgccgtt ccagaggagg aaggaggcac cccggagaag gagatcagta tagaagacgc
     6121 caagctggaa ggcgaagaag aagccaaagg gggtaaaagg cccaaggaag gcttgctcca
     6181 gatgaaactc ccggagccag ttaaactaca gatgtgcctc ttgcttcagt acctctgtga
     6241 ctgccaggtt aggcaccgga tcgaagccat tgtagccttt tcagatgact ttgtagctaa
     6301 actccaagac aaccaacggt tcaggtataa tgaagtcatg caagccttaa acatgtctgc
     6361 cgcactcact gccaggaaaa ccagggagtt ccggtcacca ccgcaggagc agattaacat
     6421 gcttctcaat tttaaggatg acaaaagtga atgcccctgc cctgaagaaa tccgagacca
     6481 actcctagat ttccacgagg acctgatgac tcactgtgga attgaactgg acgaggatgg
     6541 atccctagat ggaagcaatg acttaacaat cagaggacgt ctgttgtctc tggtagaaaa
     6601 ggtgacctac ctgaagaaga agcaagctga aaaaccagtt gcaagtgact ccagaaagtg
     6661 ctccagcctc cagcaactca tttctgagac tatggtacgg tgggctcaag agtctgtcat
     6721 tgaggaccct gagctggtga gggccatgtt tgtgctgcta catcggcagt atgatggcat
     6781 cgggggtcta gtccgagcgc tgccaaagac ctacactatc aacggggtct ctgtggagga
     6841 caccatcaat ctgcttgctt cgctcggtca gatccgatct ctgctgagtg tgaggatggg
     6901 caaagaagag gagaagctga tgatccgtgg actaggggat atcatgaata acaaagtgtt
     6961 ttaccagcat cccaatctca tgcgggccct tgggatgcat gagacagtga tggaagtcat
     7021 ggtgaatgtc cttggaggtg gcgagtccaa ggaaatcacc ttccccaaga tggtggccaa
     7081 ctgctgccgt tttctctgtt acttctgtcg tataagtaga cagaatcaaa aagccatgtt
     7141 tgatcatctc agttacttac tggaaaacag cagtgttggt cttgcatcac cagccatgag
     7201 aggttcaact cctttagacg tggccgcagc ttcagtgatg gataacaatg agcttgccct
     7261 tgctctacga gagccggatc tggagaaggt agttcgctat ctggctggct gtggtctgca
     7321 gagctgtcag atgctggtgt ctaagggtta cccagacatt gggtggaatc cagttgaagg
     7381 agagcgatac cttgactttc tcagatttgc agtcttctgt aacggggaga gtgtggaaga
     7441 gaatgcaaat gttgtggtga ggctgctcat ccggagaccc gagtgctttg gtcctgcctt
     7501 gagaggagaa ggtggtaatg gtctccttgc agccatggaa gaagccataa aaatagctga
     7561 ggatccttct agagatggtc cctctccaac cagtggctcc agcaaaaccc ttgatataga
     7621 agaggaggaa gatgatacca tccacatggg gaacgcgatc atgaccttct acgcagcttt
     7681 gattgacctg cttggtcgct gtgctcctga aatgcacttg attcatgctg gaaagggaga
     7741 agccatccga attaggtcca ttttgcgatc tctgattcca ttgggagact tggtgggcgt
     7801 catcagcatt gcatttcaga tgccaacaat agccaaagat gggaaggtgg tggagcctga
     7861 catgtccgcg gggttttgcc cagatcacaa ggcagccatg gttttgttcc ttgacagggt
     7921 ctatggaatt gaggtgcaag atttcctcct ccatctcctt gaggttggct ttctgccaga
     7981 tcttcgagct gctgcctctc tagacacggc tgcactaagt gctacagaca tggccttggc
     8041 cctcaaccgg tacctctgca cagctgtcct acctttgtta acgaggtgtg ctcccctgtt
     8101 tgctggaaca gagcaccatg cttccctcat tgactctctg ctacacactg tatatagact
     8161 ctctaaggga tgctccctta ccaaagctca gcgggactcc atagaagtgt gcctgctctc
     8221 tatatgtggc caactgagac catctatgat gcaacaccta ctccgaaggc tggtgtttga
     8281 tgttccactg ttgaatgagc atgcaaagat gcctctgaag ctgctgacca atcattatga
     8341 aagatgctgg aaatattatt gcctccctgg agggtggggc aactttggtg ctgcctcgga
     8401 agaagaactt catttatcaa gaaaattatt ttggggcatc tttgatgctt tgtctcaaaa
     8461 gaaatatgaa caagaacttt tcaaactggc cctgccttgc ctgagtgcag ttgcgggagc
     8521 tttacctcca gactacatgg agtcaaacta tgtcagtatg atggaaaaac agtcatccat
     8581 ggattctgaa gggaacttta acccacaacc tgttgatacc tcaaacatta caattccaga
     8641 gaagttggaa tacttcatta acaaatatgc agaacattcc catgataaat ggtccatgga
     8701 caagttggcg aatggatgga tttatgggga aatatattca gactcttcta agatccaacc
     8761 gctaatgaag ccatataaac tcttgtctga aaaggaaaaa gaaatttatc gttggccaat
     8821 caaggagtct ttgaaaacga tgctggcttg gggttggaga attgagagaa cacgggaggg
     8881 ggacagcatg gccctttata accggactcg acgaatttct cagacaagcc aggtgtctat
     8941 agatgctgca catggataca gcccccgtgc tattgacatg agtaatgtga cactctctcg
     9001 agacctgcat gctatggcag agatgatggc tgaaaactac cacaacatat gggccaagaa
     9061 aaagaaactg gagctggaat ccaaaggagg aggaaaccac cccctcctgg tgccttatga
     9121 cacactgaca gccaaggaga aagccaagga cagagaaaaa gcccaagaca tcttcaagtt
     9181 cctacagatc agtggttatg tggtatccag agggttcaaa gacctggatc tagatacacc
     9241 ttcgattgag aagcgatttg cctatagttt cctgcagcag ctgatccgat acgtggatga
     9301 ggcgcatcag tacatcctgg agtttgatgg tggcagcaga agcaaaggag aacacttccc
     9361 gtacgagcaa gaaatcaagt tctttgccaa agttgttctt cctttaattg atcagtattt
     9421 caaaaaccac cgcctgtact tcttgtctgc tgcaagcagg cctctctgca ctggaggaca
     9481 tgcatccaac aaagagaagg agatggtgac aagcctgttc tgcaaacttg gagttcttgt
     9541 caggcatagg atctcactgt ttgggaatga tgccacctca attgtgaact gtctgcacat
     9601 tttgggtcag actttggatg caaggactgt gatgaagacg ggcctagaca gtgtgaaaag
     9661 tgctcttagg gcctttctgg acaatgctgc agaggatttg gaaaagacaa tggaaaacct
     9721 gaagcagggc cagtttactc acaccaggag ccagcccaag ggggtgactc agatcatcaa
     9781 ctacaccact gtggctctcc tgcccatgct ctcctccctg tttgaacaca tcggccagca
     9841 tcagtttgga gaagatctga tattggagga tgtacaggtg tcttgttata gaatcctgac
     9901 cagcttgtat gccctgggaa ccagcaagag catctacgtg gagaggcaac gatctgcact
     9961 tggggaatgc ttagctgcct ttgctggtgc cttccctatc gcctttttgg aaacccacct
    10021 ggacaaacat aacgtttact ccatctacaa caccagatct tcacgagaaa gagcagctct
    10081 cagtttacct gcaaatgtgg aggatgtctg cccaaatata ccatccctgg agaagcttat
    10141 gactgagata atagagctgg cagagtcagg aatccgctac actcagatgc catacatgat
    10201 ggaggttgta ctgcccatgt tatgcagcta catgtcaagg tggtgggaac acggtcctga
    10261 gaaccatcca gagagggctg agatgtgctg cacagccctc aactcagagc acatgaacac
    10321 gctgctgggc aacattctca aaatcatcta caacaacctg gggattgatg aaggagcctg
    10381 gatgaagcgc ttggccgtgt tttcacagcc tatcatcaac aaagtgaaac ctcagctctt
    10441 gaaaactcat ttcttaccct tgatggagaa gctaaagaaa aaggctgcta tggtagtgtc
    10501 tgaggaagac cacctgaaag ccgaagccag aggggacatg tctgaggccg agctgctcat
    10561 tctagatgag ttcaccacac tggccaggga tctctatgcc ttctacccac tcctgatccg
    10621 atttgtggac tataacaggg caaagtggct gaaggagccc aacccagaag cagaggagct
    10681 atttcgaatg gtggctgaag tcttcatcta ctggtccaaa tcccataatt tcaaaagaga
    10741 agaacagaac tttgtggtgc agaatgaaat caacaacatg tccttcctca tcactgacac
    10801 aaagtccaag atgtccaagg cagccatttc tgatcaagaa aggaagaaaa tgaagcgcaa
    10861 aggggaccgg tattctatgc agacatcttt gatcgtggca gctctgaaga gattactacc
    10921 cattgggctg aacatctgtg cccctggtga ccaagagctc attgctttgg ccaaaaatag
    10981 atttagcttg aaagacaccg aggaggaagt acgtgatata atccgcagta atatacactt
    11041 acaaggcaag ctggaagacc ctgcaatcag gtggcagatg gctctctaca aagacttgcc
    11101 aaacaggaca gaagacccct cagacccaga gaggacagtc gagcgtgtcc tgggtatagc
    11161 aaatgtgctt tttcaccttg agcagaaatc taagtatact ggccggggat atttcagcct
    11221 ggtggaacat cctcaaagat caaagaaagc tgtgtggcac aaactactct ctaagcagag
    11281 aaaaagagct gttgtggcct gcttccggat ggcccccttg tacaatctgc caaggcatcg
    11341 ggcggtcaat ctttttcttc agggatatga aaagtcttgg attgaaacag aagaacatta
    11401 ctttgaggat aaattgattg aagatttagc gaaaccaggg gctgagctcc cagaagaaga
    11461 tgaagccatg aaaagggttg atcccctcca tcaacttatt cttctgttca gccgcacagc
    11521 cctaacggag aaatgcaaac tggaggaaga ttttctatac atggcgtatg cagacattat
    11581 ggcaaagagt tgtcacgatg aagaagatga tgatggtgaa gaagaagtga agagctttga
    11641 agaaaaggaa atggaaaagc agaaacttct gtaccagcaa gccagactgc atgaccgcgg
    11701 ggcagcagag atggtcctgc agactatcag tgccagcaaa ggtgaaactg gaccaatggt
    11761 ggctgctact ttgaagctgg gcattgcgat tttaaatggt ggcaactcca cggtgcagca
    11821 gaagatgctg gattacctga aggaaaaaaa ggatgtaggc ttcttccaga gtctggcagg
    11881 cctcatgcag tcctgcagtg tcctggacct gaatgcattt gagagacaaa acaaagcaga
    11941 aggacttggg atggtgactg aggaaggatc aggggagaag gttctgcagg atgacgagtt
    12001 cacctgtgac ctcttccgat tcctgcagct gctttgtgag gggcacaact cagactttca
    12061 gaattacctg agaactcaga ccggcaacaa caccacagtt aatatcatca tctctactgt
    12121 ggactacctc cttcgagtgc aggagtccat tagtgatttc tattggtact actctggcaa
    12181 ggacatcata gatgagcagg ggcagcgtaa cttttccaaa gccattcaag tggcgaagca
    12241 ggtgttcaac acgctcacgg agtacatcca gggcccttgt actggaaatc agcagagcct
    12301 ggcacacagc aggctgtggg atgctgttgt gggcttcctt catgtatttg cacacatgca
    12361 aatgaagctg tctcaggatt ccagccagat tgagctctta aaagaactta tggatctcca
    12421 gaaggacatg gtggtcatgc tgctgtctat gctagaaggt aatgtggtga acggaacaat
    12481 aggcaaacag atggtggaca tgcttgtgga gtcgtccaac aacgtggaga tgatcctcaa
    12541 gttctttgac atgtttctga agctgaagga cttaacatcc tctgacacat tcaaagagta
    12601 tgaccctgat ggcaaagggg tcatttccaa gagagacttc cacaaagcca tggagagcca
    12661 caagcactac acccagtcag agactgagtt cctgctgtcc tgtgcagaga cagatgaaaa
    12721 cgagacactt gactatgaag agtttgtcaa gaggttccat gagcctgcca aggacatcgg
    12781 cttcaacgtg gctgttctgc tgaccaacct ctcagagcac atgcccaatg acacgaggct
    12841 gcagaccttc ttggagttgg cagagagtgt cctcaactac ttccaacctt tcctgggtcg
    12901 cattgagatc atgggcagtg ccaagcgcat cgaaagggtc tattttgaga tcagcgaatc
    12961 cagccgaacc cagtgggaga aaccccaggt taaggagtcc aagaggcagt tcatattcga
    13021 tgtggtcaat gagggcgggg agaaggagaa gatggagctc tttgtgaact tctgtgagga
    13081 caccatcttt gagatgcagt tggcagctca gatctcagag tctgatctga atgagaggtt
    13141 ggctaataaa gaagagagtg agaaggagag gccagaggag caggccccac gaatgggctt
    13201 cttctccctc ctcaccatcc agtcagccct gtttgctctc aggtacaatg tcctaaccct
    13261 cgtgaggatg ctcagcctga agagcctgaa gaagcagatg aagaggatga agaagatgac
    13321 agtgaaggac atggtcttgg ccttcttctc atcctactgg agtgtgtttg tcaccctctt
    13381 gcacttcgtg gccagtgtct gcaggggctt ctttcgcatt gtctccagcc tgttgctggg
    13441 gggcagcctg gtggaaggtg ctaagaaaat caaagtggca gaacttctag ctaacatgcc
    13501 agaccccact caggatgagg tgcgaggaga tgaggaggag ggagagagga agcctttaga
    13561 gtcagccctg ccctctgaag acctgacaga cttgaaggaa ctgacagagg agagtgatct
    13621 tctttctgac atattcggct tggatctgaa gagagaagga gggcagtaca aactaattcc
    13681 tcacaaccca aatgccggcc tcagtgacct catgaccaac cctgtccctg tccctgaggt
    13741 acaagaaaag tttcaggagc agaaggcgaa agaggaaaag gaagaaaagg aagaaaccaa
    13801 gtcggaacca gagaaagctg aaggggagga tggagaaaaa gaagaaaaag ccaaagatga
    13861 gaagagcaaa cagaagttga ggcagcttca tacacatcgc tatggggagc cggaagtgcc
    13921 tgagtcagca ttctggaaga aaatcatagc ctaccaacag aagctgctga actattttgc
    13981 tcgcaacttt tacaacatga gaatgctggc cttgtttgtt gccttcgcca tcaatttcat
    14041 cctgctcttc tacaaggtct ccacttcttc tgtggttgaa ggaaaggagc tgcctacccg
    14101 aacctccagc gatactgcta aagtgaccaa cagcctagac agcagccccc acaggatcat
    14161 tgcggttcac tatgtcctgg aggagagcag cggctacatg gaacccaccc tgcgcatctt
    14221 agccatcctc cacaccatca tctccttctt ttgcatcatc ggatactact gcttgaaagt
    14281 ccccttggtt atttttaagc gagagaagga agtggcacgg aagttggagt ttgacggact
    14341 ttatataaca gagcagccat cggaagatga tatcaaaggc cagtgggaca gacttgtgat
    14401 caacacacag tcatttccca ataactactg ggataaattt gtgaaaagaa aggtaatgga
    14461 taaatatgga gagttttatg ggagagacag aatcagtgag ttactgggca tggataaggc
    14521 tgcactagat ttcagcgatg caagagagaa gaagaagccc aagaaagaca gctccttgtc
    14581 tgctgtattg aattctattg acgtgaagta ccagatgtgg aaacttggag tcgtgttcac
    14641 agacaattcc ttcctctacc tagcctggta catgaccatg tctgttcttg gacattataa
    14701 caactttttt tttgctgctc acctccttga catcgcgatg ggattcaaga ccttgagaac
    14761 tatcctgtcc tcagttaccc ataatggcaa acagctcgtg ttaactgttg gcttattggc
    14821 tgttgttgtg tacctgtaca ctgtcgtggc gttcaatttc ttccgaaaat tctacaataa
    14881 aagtgaggat ggtgacacgc cagacatgaa gtgtgatgac atgctgacgt gttacatgtt
    14941 ccacatgtat gtgggcgtcc gtgctggagg gggcattggt gatgaaattg aagacccagc
    15001 aggagacgag tatgagatct accgcatcat ctttgacatc acattcttct tcttcgtgat
    15061 tgtcatcctt ttggctatca tacaaggttt gatcattgat gcttttggag aactcagaga
    15121 ccaacaagag caagtcaagg aagacatgga gaccaagtgc ttcatctgtg ggattggcaa
    15181 cgattatttt gatacagtgc cacatggctt tgaaacccat actttacagg aacacaacct
    15241 ggccaactac ctgttttttc tgatgtatct cataaacaag gatgaaacag aacacacagg
    15301 acaggaatct tacgtctgga agatgtacca agagaggtgt tgggaatttt tcccagcagg
    15361 ggactgtttc cggaaacagt atgaagacca gttaaattag catcatacct tgattgtctc
    15421 tgaaaaccaa aagcaatctc tctctcaatc tctctctctc tctatctcag tctctcctct
    15481 ctctctctct ctctctctct ctctctctct ctctctctct ctctctcccc ctccctccct
    15541 ccctccctcc ctctcccccc ccaccttgga aacacctact catattttcc actaaccagc
    15601 atcttgtgct gatgcacgga tgctcagtct cagaggacct gactgttctc cccccacctc
    15661 atgtatcttc attgagaaac aaagaccgaa gaacaatcca aataagcatt cagactaacc
    15721 aggaactctg gaaaggaatt catcatggat actctaccat aacacccatg gacagcttcc
    15781 cctgaagggt catggagtct ccacaagctg ccagacctgt gcagccaagc acggcagtca
    15841 cactcaccca ggctctttat tttgccatcc cagaaggaag tgtctgaggg tcatagagca
    15901 ctgtagcact taacaggttg ccatgcaaag ggaaatagtg ccttactata agtgggttga
    15961 gctatgcaga agataatgtg catgacaaac acctttattt tctttacatc aaccttgttt
    16021 tcttagataa aatggttttg tgattttggt ttctttcttt tttctcccct tttattcttt
    16081 tctttggtgg aggagggtaa gaaaagctat ctgcgctatt ttcaaaagaa gggtggtgtg
    16141 tctcaggaca gaaggaggct cttgtcatcc agctacgtca catttaccct ccccactttg
    16201 gtaaagactc tgatgctaca tggcaactta tgaaatcttt gtatgaaaaa agagactgca
    16261 aaaatacaac tttcaaaaga aataattcat tgcatgttta ttatgcaagt ttaaatgaac
    16321 aaagaaagcc ctcagaaaca agttgatcca catgggagaa ctttcgtgat aattacatcc
    16381 gtagtaacaa agctgtgggc ttcctcatat ttctggagtc agtgtcatcc accgacagtt
    16441 ggaaccatcg ccaatgtgac agtagtcttg ggttttcctc tttcttttgg ccacctgtga
    16501 tcagtcattg gttaaggacg ccttgacagg ccatcttttg atatccaagc tgaagcaata
    16561 tccattcaga gatttcattg gttgcatcat aagacatggg tgaccatgta catcgattca
    16621 ttttatgttt ttcttttttc ttttcttttt atcattttga gtccttttaa atgtaattct
    16681 aatctttaca attaaaaaaa gacaggttca gaatggaagc gaggtcattc tgcgaacatt
    16741 ggagatcttt tattacaagt ctgcttgtta attttagaat tgtaaaacgg ctctaattaa
    16801 actatttaac taa
//
