LOCUS       NM_009109              15362 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus ryanodine receptor 1, skeletal muscle (Ryr1), mRNA.
ACCESSION   NM_009109 XM_355875
VERSION     NM_009109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15362)
  AUTHORS   Sun,Q.A., Grimmett,Z.W., Hess,D.T., Perez,L.G., Qian,Z., Chaube,R.,
            Venetos,N.M., Plummer,B.N., Laurita,K.R., Premont,R.T. and
            Stamler,J.S.
  TITLE     Physiological role for S-nitrosylation of RyR1 in skeletal muscle
            function and development
  JOURNAL   Biochem Biophys Res Commun 723, 150163 (2024)
   PUBMED   38820626
  REMARK    GeneRIF: Physiological role for S-nitrosylation of RyR1 in skeletal
            muscle function and development.
REFERENCE   2  (bases 1 to 15362)
  AUTHORS   Benucci,S., Ruiz,A., Franchini,M., Ruggiero,L., Zoppi,D.,
            Sitsapesan,R., Lindsay,C., Pelczar,P., Pietrangelo,L., Protasi,F.,
            Treves,S. and Zorzato,F.
  TITLE     A novel, patient-derived RyR1 mutation impairs muscle function and
            calcium homeostasis in mice
  JOURNAL   J Gen Physiol 156 (4) (2024)
   PUBMED   38445312
  REMARK    GeneRIF: A novel, patient-derived RyR1 mutation impairs muscle
            function and calcium homeostasis in mice.
REFERENCE   3  (bases 1 to 15362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 15362)
  AUTHORS   Gaglianone,R.B. and Launikonis,B.S.
  TITLE     Muscle fibre mitochondrial [Ca2+ ] dynamics during Ca2+ waves in
            RYR1 gain-of-function mouse
  JOURNAL   Acta Physiol (Oxf) 240 (3), e14098 (2024)
   PUBMED   38240476
  REMARK    GeneRIF: Muscle fibre mitochondrial [Ca[2+] ] dynamics during
            Ca[2+] waves in RYR1 gain-of-function mouse.
REFERENCE   5  (bases 1 to 15362)
  AUTHORS   Thekkedam,C.G., Dutka,T.L., Van der Poel,C., Burgio,G. and
            Dulhunty,A.F.
  TITLE     The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle
            Contractile Properties and RyR1 Ion Channel Gating
  JOURNAL   Int J Mol Sci 25 (1), 434 (2023)
   PUBMED   38203604
  REMARK    GeneRIF: The RyR1 P3528S Substitution Alters Mouse Skeletal Muscle
            Contractile Properties and RyR1 Ion Channel Gating.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15362)
  AUTHORS   Chowdhary,B.P., Harbitz,I., Davies,W. and Gustavsson,I.
  TITLE     Localization of the calcium release channel gene in cattle and
            horse by in situ hybridization: evidence of a conserved synteny
            with glucose phosphate isomerase
  JOURNAL   Anim Genet 23 (1), 43-50 (1992)
   PUBMED   1315127
REFERENCE   7  (bases 1 to 15362)
  AUTHORS   Otsu,K., Khanna,V.K., Archibald,A.L. and MacLennan,D.H.
  TITLE     Cosegregation of porcine malignant hyperthermia and a probable
            causal mutation in the skeletal muscle ryanodine receptor gene in
            backcross families
  JOURNAL   Genomics 11 (3), 744-750 (1991)
   PUBMED   1774073
REFERENCE   8  (bases 1 to 15362)
  AUTHORS   Cavanna,J.S., Greenfield,A.J., Johnson,K.J., Marks,A.R.,
            Nadal-Ginard,B. and Brown,S.D.
  TITLE     Establishment of the mouse chromosome 7 region with homology to the
            myotonic dystrophy region of human chromosome 19q
  JOURNAL   Genomics 7 (1), 12-18 (1990)
   PUBMED   1970795
REFERENCE   9  (bases 1 to 15362)
  AUTHORS   McCarthy,T.V., Healy,J.M., Heffron,J.J., Lehane,M., Deufel,T.,
            Lehmann-Horn,F., Farrall,M. and Johnson,K.
  TITLE     Localization of the malignant hyperthermia susceptibility locus to
            human chromosome 19q12-13.2
  JOURNAL   Nature 343 (6258), 562-564 (1990)
   PUBMED   2300206
REFERENCE   10 (bases 1 to 15362)
  AUTHORS   MacLennan,D.H., Duff,C., Zorzato,F., Fujii,J., Phillips,M.,
            Korneluk,R.G., Frodis,W., Britt,B.A. and Worton,R.G.
  TITLE     Ryanodine receptor gene is a candidate for predisposition to
            malignant hyperthermia
  JOURNAL   Nature 343 (6258), 559-561 (1990)
   PUBMED   1967823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164564.3 and AC165142.3.
            
            On Apr 12, 2007 this sequence version replaced NM_009109.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY268935.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC164564.3         133365-133551
            188-307             AC164564.3         139636-139755
            308-412             AC164564.3         141078-141182
            413-487             AC164564.3         142329-142403
            488-566             AC164564.3         142483-142561
            567-679             AC164564.3         142846-142958
            680-773             AC164564.3         143315-143408
            774-867             AC164564.3         146496-146589
            868-942             AC164564.3         147038-147112
            943-1099            AC164564.3         147515-147671
            1100-1264           AC164564.3         147841-148005
            1265-1386           AC164564.3         148676-148797
            1387-1582           AC164564.3         149121-149316
            1583-1718           AC164564.3         153460-153595
            1719-1814           AC164564.3         153676-153771
            1815-1933           AC164564.3         153854-153972
            1934-2067           AC164564.3         154110-154243
            2068-2309           AC164564.3         154841-155082
            2310-2502           AC164564.3         155517-155709
            2503-2719           AC164564.3         156566-156782
            2720-2824           AC164564.3         158032-158136
            2825-2928           AC164564.3         158319-158422
            2929-3012           AC164564.3         159714-159797
            3013-3320           AC164564.3         161038-161345
            3321-3523           AC164564.3         162237-162439
            3524-3698           AC164564.3         162963-163137
            3699-3907           AC164564.3         163246-163454
            3908-4302           AC164564.3         164246-164640
            4303-4435           AC164564.3         166226-166358
            4436-4596           AC164564.3         167436-167596
            4597-4762           AC164564.3         168289-168454
            4763-4849           AC164564.3         170852-170938
            4850-5076           AC164564.3         171063-171289
            5077-5689           AC164564.3         172192-172804
            5690-5953           AC164564.3         174882-175145
            5954-6154           AC164564.3         175438-175638
            6155-6266           AC164564.3         175972-176083
            6267-6413           AC164564.3         178610-178756
            6414-6687           AC164564.3         179724-179997
            6688-6802           AC164564.3         181379-181493
            6803-6935           AC164564.3         181583-181715
            6936-7030           AC164564.3         182252-182346
            7031-7166           AC164564.3         183217-183352
            7167-7353           AC164564.3         183539-183725
            7354-7462           AC164564.3         183812-183920
            7463-7583           AC165142.3         1134-1254
            7584-7753           AC165142.3         1339-1508
            7754-7974           AC165142.3         2297-2517
            7975-8065           AC165142.3         2614-2704
            8066-8206           AC165142.3         3577-3717
            8207-8370           AC165142.3         4090-4253
            8371-8449           AC165142.3         4363-4441
            8450-8539           AC165142.3         4624-4713
            8540-8680           AC165142.3         5134-5274
            8681-8755           AC165142.3         5629-5703
            8756-8831           AC165142.3         5782-5857
            8832-8955           AC165142.3         6114-6237
            8956-9071           AC165142.3         6557-6672
            9072-9139           AC165142.3         7498-7565
            9140-9261           AC165142.3         7657-7778
            9262-9311           AC165142.3         8648-8697
            9312-9372           AC165142.3         9396-9456
            9373-9611           AC165142.3         9606-9844
            9612-9693           AC165142.3         12049-12130
            9694-9824           AC165142.3         12635-12765
            9825-10157          AC165142.3         14139-14471
            10158-10398         AC165142.3         14564-14804
            10399-10486         AC165142.3         17051-17138
            10487-10579         AC165142.3         17257-17349
            10580-10594         AC165142.3         18025-18039
            10595-10765         AC165142.3         19214-19384
            10766-10825         AC165142.3         20683-20742
            10826-10963         AC165142.3         21074-21211
            10964-11076         AC165142.3         21572-21684
            11077-11173         AC165142.3         21868-21964
            11174-11280         AC165142.3         22153-22259
            11281-11332         AC165142.3         25232-25283
            11333-11407         AC165142.3         25421-25495
            11408-11507         AC165142.3         26718-26817
            11508-11587         AC165142.3         27197-27276
            11588-11664         AC165142.3         27392-27468
            11665-11738         AC165142.3         28596-28669
            11739-11756         AC165142.3         29337-29354
            11757-11837         AC165142.3         30344-30424
            11838-11926         AC165142.3         33380-33468
            11927-12055         AC165142.3         33564-33692
            12056-12160         AC165142.3         33781-33885
            12161-12242         AC165142.3         35845-35926
            12243-12430         AC165142.3         38106-38293
            12431-12772         AC165142.3         49929-50270
            12773-13564         AC165142.3         54007-54798
            13565-13635         AC165142.3         55440-55510
            13636-13786         AC165142.3         56229-56379
            13787-13873         AC165142.3         57103-57189
            13874-14125         AC165142.3         58391-58642
            14126-14256         AC165142.3         60405-60535
            14257-14299         AC165142.3         62035-62077
            14300-14430         AC165142.3         64482-64612
            14431-14491         AC165142.3         64706-64766
            14492-14638         AC165142.3         65072-65218
            14639-14773         AC165142.3         65755-65889
            14774-14930         AC165142.3         68622-68778
            14931-14995         AC165142.3         69426-69490
            14996-15096         AC165142.3         69748-69848
            15097-15148         AC165142.3         70488-70539
            15149-15362         AC165142.3         70720-70933
FEATURES             Location/Qualifiers
     source          1..15362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..15362
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /note="ryanodine receptor 1, skeletal muscle"
                     /db_xref="GeneID:20190"
                     /db_xref="MGI:MGI:99659"
     exon            1..187
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..15244
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /note="skeletal muscle ryanodine receptor; calcium release
                     channel; type 1 ryanodine receptor; skeletal muscle
                     calcium release channel; skeletal muscle-type ryanodine
                     receptor"
                     /codon_start=1
                     /product="ryanodine receptor 1"
                     /protein_id="NP_033135.2"
                     /db_xref="CCDS:CCDS39866.1"
                     /db_xref="GeneID:20190"
                     /db_xref="MGI:MGI:99659"
                     /translation="MGDGGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFG
                     NRLCFLEPTSNAQNVPPDLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTL
                     LYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSE
                     GEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSGCEEGFVTGG
                     HVLRLFHGHMDECLTISPSDSDDQRRLVYYEGGPVCTHARSLWRLEPLRISWSGSHLR
                     WGQPLRIRHVTTGRYLGLTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEG
                     MGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLT
                     RCQQEESQAARMIYSTAGLYNQFIKGLDSFSGKPRGSGPPAGSALPIEGVILSLQDLI
                     GYFEPPSEELQHEEKQTKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEFA
                     GEEAAESWKEIVNLLYELLASLIRGNRTNCALFSTNLDWLVSKLDRLEASSGILEVLY
                     CVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITE
                     NLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVAPFLTAQATH
                     LRVGWALSEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLA
                     PEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVVSFSAGIKVRFLLGGRH
                     GEFKFLPPPGYAPCHEAVLPRERLHLQPIKEYRREGPRGPHLVGPSRCLSHLDFVPCP
                     VDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSL
                     PEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLD
                     LSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDE
                     ATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVDSQSRGDRARIFRAEKSYAVQSGR
                     WYFEFEAVTTGEMRVGWARPELRPDVELGADDLAYVFNGHRGQRWHLGSEPFGRPWQS
                     GDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQVGHLN
                     LGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPHYEVARMD
                     GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPA
                     EDEARAAEPDTDYENLRRSAGGWGEAEGGKDGTAKEGTPGGTAQAGVEAQPARAENEK
                     DATTEKNKKRGFLFKAKKVAMMTQPPSTPALPRLPRDVVPADNRDDPEIILNTTTYYY
                     SVRVFAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCY
                     MVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPA
                     VFVLPTHQNVVQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMP
                     NHFLQVDTRRAGERLGWAVQCQEPLMMMALHIPEENRCMDILELSERLDLQRFHSHTL
                     SLYRSVCALGNNRVAHALCSHVDQAQLLHALEDARLPGPLRAGYYDLLISIHLESACR
                     SRRSMLSEYIVPLTPETRAITLFPPGRSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCF
                     VVALPAAGATEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVP
                     VLKLVSTLLVMGVFSDEDVKQILKMIEPEVFREEEEVEEEGEEEEEDEEEKEEDEEEE
                     AHEKEDEEKEEAEDAAEEEKEELEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVES
                     LAAFAECYVDKMQGNQRGRYGLLMKAFTMSAAETARRTREFRSPPQEQINMLLHFKNG
                     ADEEECPLPEEIRQELVNFHQDLLAHCGIQLEGEEEEPEEESTLGSRLMSLLEKVKLV
                     KKTEEKPEEEPAPEEHKPQSLQELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGL
                     GELLRALPRAYTISVSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNK
                     VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQ
                     RSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGC
                     GLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPEC
                     FGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRRDRRREHFGEEPPEENRVHLGHA
                     IMSFYAALIDLLGRCAPETHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTL
                     GKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLD
                     TATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSL
                     TKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWK
                     YYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRIAMPCLCAIAGALP
                     PDYVDASYSSKTEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFD
                     KIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTVEKAR
                     EGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSVVTLSRELQAMAEQLAENYHNT
                     WGRKKKQELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKD
                     MELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKI
                     LLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT
                     DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQ
                     ARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSL
                     GTTRNPYVEKLRPALGECLARLAAAMPVAFLEPELNEYNACSVYTTKSPRERAILGLP
                     NSVEEMCPDIPVLERLMAEIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEA
                     PPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRA
                     RPELLRSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYA
                     LYPLLIRYVDNNRAHWLTEPNPNAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEIN
                     NMSFLTADNKSKMAKAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLN
                     MCAPTDQDLIVLAKARYALKDTDEEVREFLQNNLNLQGKVEGSPSLRWQMALYRGVPG
                     REEDADDPEKIVRRVQEVSAVLYHLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMT
                     PLYNLPTHRACNMFLESYKASWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDP
                     LHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEEGGEEEEVEVSF
                     EEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAE
                     VQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQ
                     NGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQ
                     ESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRL
                     WDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQ
                     MVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQK
                     QFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPR
                     LRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQF
                     IFDVVNEGGESEKMEMFVSFCEDTIFEMQIAAQISEPEGEPEEDEDEGAEEAEEGAAG
                     SDGSGSAAAAGVWVWLAATAGRTLRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAL
                     VTRAGGAGAGAAAGALRLLWGSLFGGGLVDSAKKVTVTELLAGMPDPTGDEVHGQQPS
                     GAGSDAEGEGEGEGEGDAADGAGDEEAAADQAGTGGADGAVAVADGSPFRPEGAGGLG
                     DMGDTTPVEPPTPEGSPILKRKLGVDGEEEEPPPEPEPEPEPEPEKADTENGEKEVPE
                     PPPEPPKKTPPPPPPKKEEAGGAGLEEFWGELEVQRVKFLNYLSRNFYTLRFLALFLA
                     FAINFILLFYKVSDSPPGEDDIEGSGAGDMSGAGSGDGSGWGSRAGEEVEGDEDENMV
                     YYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGL
                     YITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMD
                     LASLEITAHNERKPDPPPGLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLG
                     HYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFR
                     KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDI
                     TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFE
                     THTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYED
                     QLS"
     exon            188..307
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            308..412
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            413..487
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            488..566
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            567..679
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            680..773
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            774..867
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            868..942
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1099
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1264
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1386
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1582
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1718
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1814
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1933
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2067
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2309
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2502
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2719
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2824
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2928
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3012
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3320
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3523
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3698
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3907
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4302
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4435
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4596
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4762
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            4763..4849
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            4850..5076
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            5077..5689
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            5690..5953
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            5954..6154
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6155..6266
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..6413
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..6687
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6688..6802
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6803..6935
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            6936..7030
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7031..7166
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7167..7353
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7354..7462
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7463..7583
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7584..7753
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7754..7974
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            7975..8065
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8066..8206
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8207..8370
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8371..8449
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8450..8539
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8540..8680
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8681..8755
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8756..8831
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8832..8955
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            8956..9071
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9072..9139
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9140..9261
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9262..9311
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9312..9372
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9373..9611
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9612..9693
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9694..9824
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            9825..10157
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10158..10398
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10399..10486
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10487..10579
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10580..10594
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10595..10765
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10766..10825
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10826..10963
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            10964..11076
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11077..11173
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11174..11280
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11281..11332
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11407
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11408..11507
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11508..11587
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11588..11664
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11665..11738
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11739..11756
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11757..11837
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11838..11926
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            11927..12055
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            12056..12160
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            12161..12242
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            12243..12430
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            12431..12772
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            12773..13564
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            13565..13635
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            13636..13786
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            13787..13873
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            13874..14125
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14126..14256
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14257..14299
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14300..14430
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14431..14491
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14492..14638
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14639..14773
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14774..14930
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14931..14995
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            14996..15096
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            15097..15148
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     exon            15149..15362
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15336..15341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /note="hexamer: AATAAA"
     polyA_site      15359
                     /gene="Ryr1"
                     /gene_synonym="Ryr; RYR-1; skrr"
                     /note="major polyA site"
ORIGIN      
        1 gttccatctc cctcgcgggt gcctctggct tccctagagg tctccgaccc cagcccgccc
       61 tcaggttccc cgccaagcct gcagccccct ctcgccatcc tcagacccta gcccgggaca
      121 cccggggatt gccatcatgg gtgatggagg aggtgaaggc gaggacgagg tccagttttt
      181 gcggacggat gatgaagtgg tcctgcagtg cagcgccacg gtgctcaagg aacagctgaa
      241 gttgtgtctg gccgctgagg ggttcggcaa ccgcctttgc tttctggaac ccaccagcaa
      301 cgcgcagaat gtaccccctg atctggccat ctgctgcttc atcctggagc agtctctgtc
      361 agttcgagcc ctgcaggaga tgctggccaa tactgtggag gccggtgtgg agtcatccca
      421 gggcggggga cacaggacac tcttgtatgg ccacgccatc ctgctccggc acgcacacag
      481 tcgtatgtac ctgagttgcc tcaccacctc ccgatccatg actgacaagt tggcctttga
      541 cgtgggatta caggaagacg caacagggga ggcctgttgg tggacgatgc acccagcctc
      601 aaagcagagg tctgaaggag agaaggttcg agttggggat gaccttatcc ttgtgagtgt
      661 ctcctctgag cgatacctgc acctgtcaac cgcaagtggg gagctccagg ttgacgcctc
      721 ctttatgcag actctgtgga acatgaatcc catctgctct ggctgtgaag aaggctttgt
      781 gactggaggc cacgtcctgc gcctctttca tggacatatg gatgaatgtt tgaccatctc
      841 cccttctgac agtgatgatc aacgcagact tgtctactac gagggagggc ctgtgtgcac
      901 tcatgcccgc tccctatgga ggctagagcc gctgagaatc agctggagtg gaagccatct
      961 ccgctggggc cagccactaa gaatcagaca tgtgaccaca gggaggtacc ttgggctcac
     1021 tgaggaccaa ggccttgtgg tggttgatgc cagcaaggcc cacaccaagg ctacttcctt
     1081 ttgcttccga atctccaagg agaagctgga tgtggccccc aagagagatg tggagggcat
     1141 gggtccccct gagatcaagt atggagagtc gctctgcttt gtacagcatg tggcctcagg
     1201 cctgtggctc acctatgctg ccccagaccc taaggccctg aggcttgggg tactcaagaa
     1261 gaaggccatg ctgcaccagg aaggtcacat ggatgatgcg ttgtcactga cgcgatgcca
     1321 gcaggaggag tcccaggctg cccggatgat atacagcact gccggcctgt acaaccagtt
     1381 cataaagggt ctcgatagct tcagcgggaa gccacggggc tcggggccac cggctgggtc
     1441 agcattgccc atcgagggcg tcatcctgag cctacaggac ctcattggct acttcgagcc
     1501 gccttcagag gagctgcagc acgaggagaa gcagaccaag ctgcgcagcc tgcgcaaccg
     1561 acagagcctc ttccaggagg aggggatgct ctccctggtc ctgaattgca ttgaccgcct
     1621 caacgtctac accaccgctg cccactttgc cgagtttgcg ggagaggagg cagctgaatc
     1681 ttggaaagag attgtgaacc tgctctatga acttctagcc tctctgatcc gtggcaatcg
     1741 caccaactgt gcgctcttct ccacaaactt ggattggctg gtcagcaagc tggatcgtct
     1801 ggaggcctca tctggcatcc tggaggtgtt gtactgtgtc ctgattgaga gtcctgaggt
     1861 gctgaacatc atccaggaga accacatcaa gtctatcatc tccctcttag acaagcatgg
     1921 gcggaatcac aaggtcctgg atgtgctgtg ctcactctgt gtgtgcaatg gtgtggctgt
     1981 acgctccaac caggacctca tcaccgagaa cttgctcccg ggccgagaac ttctgctgca
     2041 gacaaacctc atcaactatg tcaccagcat ccgccccaac atctttgtgg gccgagcaga
     2101 gggctccacg cagtatggca aatggtactt tgaggtgatg gtggatgagg tggctccatt
     2161 tctgacagct caggccaccc acctgagggt gggctgggcc ctcagcgagg gctacagccc
     2221 ctaccccgga ggcggcgagg gctggggcgg caacggggtc ggcgatgatc tctattctta
     2281 cggctttgat gggctgcatc tttggacagg gcatgtggca cgcccagtga cttctccggg
     2341 acaacacctc ttggccccgg aggatgtggt cagctgctgc ctggacctca gcgtcccgtc
     2401 catctccttt cgtatcaacg gctgccccgt gcagggtgtc tttgaatcct tcaacctcga
     2461 tgggctcttc ttccctgtcg tgagcttctc ggctggtatc aaagtgcgct tcctccttgg
     2521 tggccgccat ggtgaattta agttcctgcc cccacctggc tatgctccat gccatgaagc
     2581 tgtgctccct cgggagcggc tccatctcca acccatcaaa gagtatcgca gggaggggcc
     2641 tcgggggccc cacctggtgg gccccagtcg ctgcctctca catctggact ttgtaccctg
     2701 tcctgtggac accatccaga tcgtcttgcc cccccacctg gagcggattc gggagaagct
     2761 ggcagagaac attcatgaac tctgggcact gactcgcatt gagcaaggat ggacctatgg
     2821 tccggtacgg gatgacaaca agaggctgca cccatgtctt gtgaatttcc acagcttgcc
     2881 agaacctgag cggaattaca acttgcagat gtcaggggag acactcaaga ctctgctggc
     2941 cctgggctgc cacgtgggca tggcagatga gaaggcagaa gacaacctga agaagacgaa
     3001 gctgcctaag acgtatatga tgagcaatgg atacaagccg gctcctctgg acctgagcca
     3061 cgtgaggctg acgcctgcac agacaactct ggtggaccgg ctggcagaga acgggcacaa
     3121 tgtctgggcg agagaccgcg tggcacaagg ctggagctac agtgctgtgc aggacatccc
     3181 tgcacgcaga aatcctcgcc tcgtgcccta ccgcctgctg gacgaggcca ccaagcgcag
     3241 caatagggac agcctctgcc aggctgtgcg caccctgctg ggctatggct acaacatcga
     3301 gcctcctgac caggagccca gtcaggtgga cagccagtct cgtggtgacc gggcccgcat
     3361 cttccgggca gagaagtcct atgcagtcca gagcggccgc tggtacttcg agtttgaagc
     3421 agtcaccaca ggagagatgc gagtgggctg ggcaaggcct gagctgagac ctgatgtgga
     3481 gctgggagcg gacgatttgg cctatgtctt caatgggcat cgaggccagc gctggcactt
     3541 gggcagtgag ccatttgggc gcccctggca gtcgggcgat gtcgtcggct gcatgattga
     3601 tctcacagag aacaccatca tcttcaccct caatggcgag gtcctcatgt ctgactcggg
     3661 ctcggaaaca gccttccgtg acattgagat aggggacggc ttcctgccag tctgcagctt
     3721 gggacctggt caggtgggcc acctgaacct gggccaggat gtgagctccc tgaggttttt
     3781 tgccatctgt ggcctccagg aaggctttga gccgttcgcc atcaacatgc aacgcccagt
     3841 taccacctgg tttagcaaga gtcttcctca gtttgagcct gtgcccctcg aacacccgca
     3901 ctatgaggtg gcccgcatgg atggcactgt ggatacaccc ccctgcctgc gcttgaccca
     3961 ccgcacctgg ggttcacaga acagtctggt ggagatgctg tttctccggc taagccttcc
     4021 ggtccagttc caccagcact tccgctgcac cgcaggggcc acacccctgg catcccctgg
     4081 cctgcagcct cctgctgaag atgaggcccg ggcagcagaa ccggatacgg actatgaaaa
     4141 cctgcgccgc tccgctggag gctggggaga ggctgaaggg ggcaaggatg gaactgccaa
     4201 ggaggggaca cccggaggca ctgcccaggc tggggtagag gctcagcctg cgagggcgga
     4261 gaatgagaaa gacgctacca ccgagaagaa caagaagaga gggttcttgt tcaaggccaa
     4321 gaaggttgcc atgatgaccc aaccaccttc cactccggct cttccccgac tccctcgaga
     4381 tgtggtacct gctgacaacc gcgacgaccc tgagatcatc ctcaacacca ccacgtacta
     4441 ttactctgtg agggtcttcg cgggtcagga gcccagctgc gtgtgggtgg gctgggtcac
     4501 tcctgactac catcaacatg acatgagctt cgacctcagc aaagtcaggg cggtgacagt
     4561 gaccatggga gatgaacaag gcaatgtcca cagcagcctc aagtgtagca actgctacat
     4621 ggtgtggggt ggagattttg tgagtcccgg acagcagggc cgaatcagcc acacagacct
     4681 tgtcattggc tgcctggtgg atctggccac cggcttaatg accttcacag ccaatgggaa
     4741 agaaagcaac accttcttcc aggtggaacc caacacgaag ctgtttcctg ctgtcttcgt
     4801 gctgcccacc caccagaacg tggtccagtt tgagctgggg aagcagaaga acatcatgcc
     4861 gctgtcagcc gccatgttcc tgagcgagcg caagaaccca gccccacagt gcccaccaag
     4921 gctggaggtg cagatgctga tgcctgtctc gtggagccga atgcccaacc acttcctaca
     4981 ggtggacacg cggcgtgctg gagagcggct gggctgggca gttcagtgcc aggagccgct
     5041 gatgatgatg gcgctacaca tcccggagga gaacaggtgc atggacatcc tagagctatc
     5101 tgagcggctg gacctacagc gcttccactc acacacgctc tcgctctacc gctcggtgtg
     5161 tgccctgggc aacaaccgcg tggctcatgc cctgtgcagc cacgtggacc aggcacagct
     5221 gttgcatgcg ctggaggatg cgcgcttgcc aggtcctctg cgagcaggct actacgacct
     5281 cctcatcagc atccacctcg aaagcgcctg ccgcagccgt cgctccatgc tctctgagta
     5341 catcgtgcca ctcacgccgg agacccgcgc catcacgctt ttcccacctg ggcgaagtgc
     5401 ggaagatggc ccccgccgcc atggcctgcc tggcgttggg gtcacaacct ccctgagacc
     5461 tccacaccat ttctcacccc cgtgttttgt ggtcgccctg ccagctgctg gggccacaga
     5521 agctccggct cgcctcagcc ctgccatccc tctggaggct ctgcgagaca aggcgctgag
     5581 aatgttgggg gaagccgtgc gtgatggagg acagcatgct cgcgacccgg ttgggggctc
     5641 tgtggagttc cagttcgtcc cggtgctcaa gcttgtgtct accctcctgg tgatgggtgt
     5701 ctttagtgac gaggatgtga agcagatcct gaagatgatt gagcctgaag tcttcaggga
     5761 ggaagaagag gtggaggagg agggagagga ggaagaggaa gatgaggagg agaaagagga
     5821 ggatgaagaa gaagaggcac acgagaagga agatgaggaa aaagaagagg cagaggatgc
     5881 tgcagaagag gagaaggaag agcttgagga ggggctgctg cagatgaagc tgcccgagtc
     5941 tgtgaaatta cagatgtgcc acctcctgga gtatttctgt gaccaagagc tgcagcaccg
     6001 ggtggagtcc ttggcggcct ttgcagagtg ttatgtggac aagatgcagg gcaaccagcg
     6061 gggtcgctac ggcctcctca tgaaagcctt caccatgagc gcagccgaga ccgcaaggcg
     6121 cacccgagag ttccgttctc caccccagga gcagatcaac atgctattgc acttcaaaaa
     6181 tggtgctgat gaggaagagt gtcctctccc tgaagagatc cgacaggagt tagtcaactt
     6241 tcaccaagac ctgctggcac attgtggaat ccagttggag ggagaggagg aggagccaga
     6301 ggaggagagc actctgggaa gccgcctcat gagcttgttg gaaaaagtaa agctggtgaa
     6361 gaagacagag gagaagcctg aggaggagcc ggcacctgag gagcacaagc ctcagtcctt
     6421 gcaggagctg gtgtcccaca cagtggtgcg ctgggcccag gaggacttcg ttcagagccc
     6481 ggagctggtc cgtgccatgt tcagcctcct gcatcggcag tatgacgggc tcggcgagct
     6541 gctgcgtgcc ctgccccggg cctacacaat ctctgtgtcc tcggtggagg ataccatgag
     6601 cctgctggag tgcctgggcc agatccgctc actgctcatt gtgcagatgg gtccccagga
     6661 ggagaacctt atgatccaga gcattgggaa catcatgaat aacaaagtct tctaccaaca
     6721 cccaaacctg atgagagcgc tgggtatgca tgaaacagtc atggaggtta tggtgaacgt
     6781 ccttgggggc ggcgagtcaa aggagatccg cttccccaag atggtgacaa gctgctgccg
     6841 cttcctctgc tacttctgcc gaatcagccg gcagaaccag cgctccatgt ttgaccacct
     6901 gagctacctg ctggagaaca gcggcattgg cctgggcatg cagggctcca cacccttgga
     6961 tgtagctgct gcttctgtca ttgacaacaa cgagctagcc ttggcattac aagagcaaga
     7021 cctggaaaag gttgtgtcat acctggcagg gtgtggctta caaagctgcc ccatgcttct
     7081 ggccaaaggg tatcctgaca tcggatggaa tccctgtggg ggcgaacgct acctcgactt
     7141 cctgcgtttt gctgtctttg tcaacggtga gagcgtggaa gagaacgcta acgtggttgt
     7201 gcggctgttg atccgcaaac ccgagtgctt tggacctgcc ctgaggggtg agggtggctc
     7261 agggctgctg gctgccatcg aagaggccat ccgaatctct gaggatcccg cacgggatgg
     7321 gccgggtgtc cgcagggacc ggcgacgtga gcactttggt gaggagcccc ctgaagaaaa
     7381 ccgggtacac ctgggacatg ccatcatgtc cttctatgct gccttgattg acctgctagg
     7441 acgctgtgca cctgagacgc atttgattca agccggtaag ggtgaggccc tgaggatccg
     7501 tgccatcctt cggtccctcg tgcccttgga tgacctcgtg ggcatcatca gcctcccact
     7561 gcagatcccc accctgggca aagatggcgc actggttcag ccgaagatgt ctgcatcctt
     7621 cgtgcctgac cacaaggcat ccatggtgct tttcctggac cgagtgtatg gcattgagaa
     7681 ccaggacttc ttgctgcatg tgctggatgt ggggttcctt cctgacatga gggcggctgc
     7741 ttcactggac acggctactt tcagcaccac ggagatggcg ctggcactga accgctacct
     7801 ctgtctggct gtgctgccgc tcatcaccaa gtgcgcgcca ctctttgcgg gcaccgagca
     7861 ccgcgccatc atggtggact ccatgctaca cacagtgtac cggctgtcgc ggggccgctc
     7921 gctcaccaaa gcacagcgcg acgtcatcga ggactgcctc atggcgctgt gcaggtatat
     7981 ccgcccgtcc atgctgcagc acctgcttcg acgcctggtg ttcgatgtgc ccatcctcaa
     8041 tgagttcgcc aagatgccac tcaagctcct taccaaccac tatgagcgtt gctggaagta
     8101 ctactgcctc cccacaggct gggccaactt cggggtcacc tctgaggaag agctgcacct
     8161 cacacgcaag ctcttctggg gcatctttga ttctctggcg cataagaaat acgaccagga
     8221 gctttaccga atagccatgc cttgcctgtg tgccatcgcg ggcgcactgc cccctgacta
     8281 cgtggacgcc tcatactcat ccaagacgga gaaaaaagcc acagtggacg ctgaaggcaa
     8341 ctttgatccc cggcctgtgg agaccctcaa cgtcatcatc cccgagaagc tggactcctt
     8401 cattaacaag ttcgcagagt acacccatga gaagtgggcc ttcgacaaga ttcagaacaa
     8461 ttggtcctat ggtgagaaca ttgatgaaga attgaagacc caccccatgc tgagacccta
     8521 caagaccttc tcagagaagg acaaagagat ttaccgttgg cccatcaagg agtctttgaa
     8581 ggccatgatt gcctgggaat ggacagtaga gaaggccagg gaaggcgagg aggagaagac
     8641 ggaaaagaaa aaaacaagaa agatatccca aaccgcccag acatatgacc cccgagaagg
     8701 ctacaatccc cagccaccag acctcagcgt ggttacgttg tcccgggagc tgcaggccat
     8761 ggccgaacaa ctggcagaaa attaccacaa cacttggggg cgaaagaaga agcaagagct
     8821 ggaggctaaa ggaggtgggt ctcatcctct actggttccc tacgacacgc tcacggccaa
     8881 ggagaaggca cgggatcgag agaaggccca ggagttgctg aagtttctgc agatgaatgg
     8941 ctatgctgtc accaggggtc ttaaggacat ggaactggac acatcctcca ttgagaagcg
     9001 atttgccttc ggcttcctgc agcagctgct tcgctggatg gacatctccc aggagttcat
     9061 cgcccacctg gaggctgtgg ttagcagtgg acgggtggag aaatccccac atgaacagga
     9121 gattaaattc tttgctaaga ttctgctgcc tttgatcaac caatacttca ccaaccactg
     9181 tctctacttc ctatccacac cagccaaagt gctgggcagt ggtggccatg cctccaacaa
     9241 ggagaaggaa atgatcacca gcctcttctg taaacttgct gcccttgtcc gccaccgagt
     9301 ctccctcttt gggacggatg ccccagctgt ggtcaactgt cttcacatat tggcacgctc
     9361 tctagatgcc agaacggtga tgaaatcggg ccctgagatc gtaaaggcgg gtctgcgctc
     9421 cttcttcgag agtgcctccg aggacattga gaagatggtg gagaacctgc ggctaggaaa
     9481 ggtgtcgcag gcgcgcacgc aggtgaaggg cgtgggccag aacctcacct acaccacggt
     9541 ggctctgctg cccgtcctca ccaccctctt ccagcacatc gcccagcacc agttcggaga
     9601 cgatgtcatc ctggatgacg tacaagtgtc ttgctaccga acgctctgca gtatctactc
     9661 tctgggaacc accaggaacc cctatgtgga aaaactgcgg ccagccctgg gggaatgcct
     9721 ggcccgcctg gccgcagcca tgccagtggc attcctggag cctgagctga atgaatacaa
     9781 cgcctgctct gtctacacca ccaagtctcc tcgagagcgg gccatcctgg ggcttcccaa
     9841 cagcgtggag gagatgtgtc ctgacatccc agtgctagaa aggctcatgg cagaaatcgg
     9901 ggggctggcc gagtccggag cacgctacac agagatgccg catgtcatcg agattacgtt
     9961 gcctatgctg tgcagctacc tgccccgctg gtgggagcga gggcctgagg cgcccccacc
    10021 agccctgcct gcgggcgccc cgccaccctg tacagcggtc acctccgacc acctcaattc
    10081 cctcctgggg aacatcctcc gaatcattgt gaacaacctg ggcatcgatg aggcctcgtg
    10141 gatgaagcgg ctggccgtgt ttgcccagcc cattgtgagc cgtgccaggc cggagctcct
    10201 acgctcccac ttcatcccta ccatcgggcg attgcgtaag cgggcaggga aggtggtggc
    10261 tgaggaggag cagctgcgcc tggaagccaa ggcagaagct gaggagggtg agctcctggt
    10321 ccgggacgag ttctccgtgc tctgccgcga cctgtatgcc ctctacccac tgctcatccg
    10381 ctacgtagac aacaacaggg cacactggct gacagagccc aaccccaatg cagaggagct
    10441 gttcaggatg gtgggagaaa tcttcatcta ctggtccaag tcccacaact ttaagcgtga
    10501 agaacagaac ttcgtggtcc agaatgaaat caacaacatg tcctttttga cagctgacaa
    10561 taagagcaaa atggccaagg caggagacgt acagtcaggt ggctcagatc aggaacgcac
    10621 caagaagaag cgccgggggg accgctactc cgtgcagaca tccttgatcg tggccacact
    10681 caagaagatg ttgccgatcg gactaaacat gtgtgctccc accgaccagg acctcattgt
    10741 gctggccaaa gcccgctatg ccctgaaaga tacagatgag gaggtccgtg aattccttca
    10801 aaacaacctt aaccttcagg gaaaggtgga aggctcacca tctcttcgct ggcaaatggc
    10861 actgtaccgc ggcgtcccag gccgcgagga agatgccgat gatcccgaga aaatcgtgcg
    10921 cagagttcag gaagtgtccg cagtgctcta tcacctggac cagacggagc atccttacaa
    10981 gtccaagaag gcggtgtggc ataaacttct gtccaagcag cgccggaggg ctgtggtggc
    11041 ctgtttccgc atgacgcccc tgtacaactt gcccacgcac cgagcgtgta acatgttctt
    11101 ggagagctac aaagcctcct ggatcctgac tgaggaccac agtttcgagg accgcatgat
    11161 agatgaccta tcgaaagctg gagagcagga agaagaggag gaagaggtgg aggagaagaa
    11221 gccagacccc ttacaccagt tggtcctaca cttcagccgc acagctctaa ctgaaaagag
    11281 caaactggac gaagactacc tatacatggc ttacgctgac atcatggcaa agagctgcca
    11341 cctggaggag ggcggggaaa atggcgaaga aggaggcgaa gaagaggaag tggaggtgtc
    11401 ctttgaggag aaggagatgg agaaacagag gctcctgtac cagcagtcaa ggctgcacaa
    11461 ccggggtgct gctgagatgg tactgcagat gatcagtgcc tgcaaaggag aaacgggtgc
    11521 catggtgtct tccaccctga agctgggtat ctccatcctt aacggaggga acgctgaagt
    11581 gcagcagaaa atgctggatt acctgaagga caagaaggaa gtgggcttct tccagagtat
    11641 ccaggcgctg atgcaaacgt gcagcgtcct ggacctcaat gccttcgaga ggcagaacaa
    11701 ggcagagggg ctgggcatgg tgaacgagga cggaactgtc atcaatcgcc aaaacggaga
    11761 gaaagtcatg gcggatgacg agttcacaca ggacctgttc cgcttcctgc agctgctctg
    11821 cgaggggcac aacaatgatt tccaaaacta cctacggaca cagactggga acacgaccac
    11881 catcaatatc attatctgca cagtggacta cctcctgcgg ctgcaggaat ccatcagtga
    11941 cttctactgg tattactcgg gcaaggatgt catcgaggaa cagggaaaga gaaacttctc
    12001 caaagccatg tcggtagcta aacaagtgtt caacagcctc accgagtaca tccagggacc
    12061 ctgcaccgga aaccagcaga gtctggcgca cagtcgcctc tgggatgccg tggtgggctt
    12121 cctgcacgtg ttcgcgcaca tgatgatgaa gctggctcag gactccagcc agatagagct
    12181 gctgaaggag ctgctggacc tacagaagga catggtggtg atgctgctgt ccctcctgga
    12241 aggaaacgtg gtgaacggta tgatcgcgcg gcagatggtg gacatgctcg tggagtcttc
    12301 gtccaatgtg gagatgattc tcaagttctt cgacatgttt ctgaaactca aggacatcgt
    12361 aggctctgag gccttccagg actatgtcac agacccccgt ggcctcatct ccaagaagga
    12421 cttccagaag gccatggaca gccagaagca gttcactggc ccagagatcc agttcctgct
    12481 ctcgtgttcc gaagcagatg agaatgagat gatcaactgc gaagagtttg cgaaccgctt
    12541 ccaggaacca gcacgggaca ttggcttcaa cgtggcggtg ctgcttacca acctgtcaga
    12601 gcatgtgccc cacgacccgc gcctgcgcaa cttcctggag ctggctgaga gcatcctgga
    12661 gtacttccgg ccttacctgg gccgcatcga aatcatgggc gcatcgcgtc gcatagaacg
    12721 gatctatttt gagatctcag agaccaaccg tgcccagtgg gagatgcccc aggtgaagga
    12781 gtccaagcgc cagttcatct tcgacgtggt gaacgagggc ggcgagtccg agaagatgga
    12841 gatgttcgtg agtttctgcg aggacacgat ctttgagatg cagatcgcag ctcagatctc
    12901 cgagcctgag ggcgagccgg aggaggacga ggacgagggc gcagaggagg ctgaggaggg
    12961 cgcggcgggt tccgacgggt cgggctctgc agcggctgcg ggcgtgtggg tgtggctggc
    13021 agcgactgcg ggccgaactc tacggggtct gagctaccgg agcctgcggc gacgcgtgcg
    13081 gaggctgcgg cggctgacgg cgcgggaggc tgccacggcg gtggccgcgc tgctctgggc
    13141 gctggtgacc cgcgcggggg gcgcgggcgc gggcgcggca gccggggcgc tgcggctgct
    13201 ctggggctcg ctgtttggcg gtgggctggt agacagcgcc aagaaggtga cagtgacgga
    13261 gctcctggca ggcatgccgg accccaccgg cgacgaggtg cacggccagc agccgagcgg
    13321 cgctggcagc gatgcagagg gcgagggtga gggagaaggc gaaggcgatg ctgccgacgg
    13381 cgccggagat gaagaggctg cagcggacca ggctggcacg ggaggtgccg acggggcggt
    13441 ggccgtggca gatgggagtc ccttccggcc agaaggcgcc ggtggtctcg gggatatggg
    13501 tgacacgacg ccagtggagc cccccacgcc agaaggctcg cctatcctca agaggaagct
    13561 gggggtggat ggagaagagg aggagccgcc cccggagccg gagccagagc cggagcccga
    13621 accggagaaa gctgatacag agaatggaga gaaggaagtc cccgagccac ctccagagcc
    13681 ccccaagaag acaccacctc caccccctcc aaagaaggag gaagctggag gagcaggcct
    13741 ggaagaattc tggggtgaac tggaagtaca gagagtgaaa ttcttgaact acttgtcgag
    13801 gaatttctac acactgcggt tcctggccct cttcctggcc tttgccatca acttcatctt
    13861 actgttttat aaggtctcag actctccacc aggggaggat gacatagaag gttccggtgc
    13921 tggggacatg tcaggggcag ggtctggtga tggctctggc tggggctcca gggccggcga
    13981 ggaggtagag ggcgatgaag atgagaacat ggtgtactac ttcctggagg agagcaccgg
    14041 ctacatggag cctgccctga ggtgcttgag cctgctgcac acgctggtgg cctttctctg
    14101 catcattggc tacaactgtc tcaaggtgcc ccttgtcatc ttcaagcggg agaaggagct
    14161 ggcccggaag ctggagtttg atggcctcta cattacagag cagcccgagg atgatgacgt
    14221 gaagggacag tgggaccgcc tggtgctcaa cacgccgtct ttccctagca actactggga
    14281 caagtttgtc aagcggaagg ttctggacaa acacggggac atctttgggc gggagcggat
    14341 tgcggagctg ctgggcatgg atctggcctc tctggagatc acagcccaca atgagcgcaa
    14401 acctgaccct ccaccgggcc tgctgacatg gatcatgtct atcgatgtca aataccagat
    14461 ctggaagttt ggagtcatct tcacagacaa ctctttcctg tatctgggct ggtacatggt
    14521 gatgtccctc ctggggcact acaataactt cttctttgct gcccacctcc tggacatcgc
    14581 catgggagtc aagacgctcc gcaccatcct ttcatctgtc actcacaatg gaaagcagct
    14641 ggtgatgacc gtagggctcc tggccgtagt ggtctacttg tatacagtgg tggccttcaa
    14701 cttcttccgc aaattctaca acaagagcga agatgaggac gagcctgaca tgaagtgtga
    14761 tgacatgatg acgtgctacc tgttccacat gtatgtgggc gtccgggccg gtggagggat
    14821 cggggacgag atcgaggacc cggccggcga tgaatatgaa ctttaccggg tcgtcttcga
    14881 catcaccttt ttcttcttcg ttatcgtcat tctgctggct atcattcagg gtctgattat
    14941 tgatgctttt ggggagctcc gagaccaaca agagcaagtg aaggaagaca tggagaccaa
    15001 gtgcttcatc tgtggaatag gcagtgacta cttcgacaca accccacatg ggtttgagac
    15061 ccacactcta gaagagcaca acctagccaa ttacatgttt ttcctgatgt atttgataaa
    15121 taaggatgag acagagcaca ctggtcagga gtcgtatgtc tggaagatgt accaggaaag
    15181 gtgctgggat ttcttccctg ctggagactg tttccgcaag cagtatgagg accagcttag
    15241 ctgaggtctg cagctggccc tcccccacct caagtgcctt ctccactgcg agctcctccc
    15301 caggcagctg gggacagatg atcctgaact agaccaataa atcctgtgct acacccccac
    15361 ca
//
