LOCUS       NM_013649               3267 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus receptor-like tyrosine kinase (Ryk), transcript
            variant 1, mRNA.
ACCESSION   NM_013649 XM_135104
VERSION     NM_013649.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Kim,H.T., Panza,P., Kikhi,K., Nakamichi,Y., Atzberger,A.,
            Guenther,S., Ruppert,C., Guenther,A. and Stainier,D.Y.R.
  TITLE     WNT/RYK signaling functions as an antiinflammatory modulator in the
            lung mesenchyme
  JOURNAL   Proc Natl Acad Sci U S A 119 (24), e2201707119 (2022)
   PUBMED   35671428
  REMARK    GeneRIF: WNT/RYK signaling functions as an antiinflammatory
            modulator in the lung mesenchyme.
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Chau,T.C.Y., Baek,S., Coxam,B., Skoczylas,R., Rondon-Galeano,M.,
            Bower,N.I., Wainwright,E.N., Stacker,S.A., Cooper,H.M.,
            Koopman,P.A., Lagendijk,A.K., Harvey,N.L., Francois,M. and
            Hogan,B.M.
  TITLE     Pkd1 and Wnt5a genetically interact to control lymphatic vascular
            morphogenesis in mice
  JOURNAL   Dev Dyn 251 (2), 336-349 (2022)
   PUBMED   34174014
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Feng,B., Freitas,A.E., Gorodetski,L., Wang,J., Tian,R., Lee,Y.R.,
            Grewal,A.S. and Zou,Y.
  TITLE     Planar cell polarity signaling components are a direct target of
            beta-amyloid-associated degeneration of glutamatergic synapses
  JOURNAL   Sci Adv 7 (34) (2021)
   PUBMED   34407949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Hovens,C.M., Stacker,S.A., Andres,A.C., Harpur,A.G., Ziemiecki,A.
            and Wilks,A.F.
  TITLE     RYK, a receptor tyrosine kinase-related molecule with unusual
            kinase domain motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 11818-11822 (1992)
   PUBMED   1334548
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Maminta,M.L., Williams,K.L., Nakagawara,A., Enger,K.T., Guo,C.,
            Brodeur,G.M. and Deuel,T.F.
  TITLE     Identification of a novel tyrosine kinase receptor-like molecule in
            neuroblastomas
  JOURNAL   Biochem Biophys Res Commun 189 (2), 1077-1083 (1992)
   PUBMED   1281989
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Paul,S.R., Merberg,D., Finnerty,H., Morris,G.E., Morris,J.C.,
            Jones,S.S., Kriz,R., Turner,K.J. and Wood,C.R.
  TITLE     Molecular cloning of the cDNA encoding a receptor tyrosine
            kinase-related molecule with a catalytic region homologous to c-met
  JOURNAL   Int J Cell Cloning 10 (5), 309-314 (1992)
   PUBMED   1333503
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Wilks,A.F.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Hanks,S.K., Quinn,A.M. and Hunter,T.
  TITLE     The protein kinase family: conserved features and deduced phylogeny
            of the catalytic domains
  JOURNAL   Science 241 (4861), 42-52 (1988)
   PUBMED   3291115
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L21707.1, L02210.1, AK076449.1, AK144355.1 and BB704205.1.
            
            On Jul 26, 2006 this sequence version replaced NM_013649.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02210.1, L21707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                L21707.1           14-88
            76-2154             L02210.1           51-2129
            2155-2181           AK076449.1         1245-1271
            2182-3265           AK144355.1         1991-3074
            3266-3267           BB704205.1         423-424
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.72 cM"
     gene            1..3267
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="receptor-like tyrosine kinase"
                     /db_xref="GeneID:20187"
                     /db_xref="MGI:MGI:101766"
     exon            1..320
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1921
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tyrosine-protein kinase RYK; growth factor
                     receptor; NYK-R; kinase VIK; met-related kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase RYK isoform 1 precursor"
                     /protein_id="NP_038677.3"
                     /db_xref="CCDS:CCDS40747.1"
                     /db_xref="GeneID:20187"
                     /db_xref="MGI:MGI:101766"
                     /translation="MRAGRGGVPGSGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPA
                     GPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSK
                     VEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLT
                     VNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVG
                     VCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNA
                     TPITSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHG
                     ILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE
                     KPMVVLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIH
                     RDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSS
                     ASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCW
                     ALDPEERPKFQQLVQCLTEFHAALGAYV"
     exon            321..442
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..542
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..677
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            678..731
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..876
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..977
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1112
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1199
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1269
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1402
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1512
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1672
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1809
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..3267
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2197..2202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="hexamer: AATAAA"
     polyA_site      2217
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="major polyA site"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="hexamer: ATTAAA"
     polyA_site      2911
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="major polyA site"
ORIGIN      
        1 cccgttcccg ggcggcgggt ctgaagcggc ggcgcgatga gctggccggc cgcccccggc
       61 tcggggctgt gaggcgctcg gggccggggt gcgcggcggc gcggcgggcg gcggacgctc
      121 ctgctcggcg gcggccatgc gcgcgggccg gggcggcgtc ccggggagcg gcggcctgag
      181 ggccccgccg ccgccgctgc tgctgctgct gctggcgatg ctgcccgccg ccgccccgcg
      241 gtccccggcc ctggccgccg ctcctgcggg acccagcgtg agcctctacc tgagcgagga
      301 cgaggtgcgc cggctgcttg gtcttgatgc agagctttac tatgtgagaa atgacctcat
      361 cagtcactac gctctgtcct ttaacctgct agtgcccagt gagacaaact tcctgcactt
      421 cacttggcat gcaaagtcca aggttgaata taagctggga ttccaagtag acaactttgt
      481 ggctatgggc atgccccagg tcaatatttc tgctcaaggg gaggtcccac gcactttatc
      541 agtgtttcgg gtcgagcttt cttgtaccgg caaagtcgac tctgaagtca tgattctaat
      601 gcagctcaat ctgacagtga attcctcaaa aaattttaca gttttaaatt ttaaacgaag
      661 gaaaatgtgc tacaaaaaac ttgaagaagt aaaaacttca gccttggaca aaaacactag
      721 cagaactatt tatgaccctg tccatgcagc gccaacgact tccacgcgtg tgttttacat
      781 cagtgtaggg gtttgctgtg cagtgatatt tcttgtagca ataatattag ccgttttgca
      841 ccttcatagc atgaaaagga ttgaactgga tgacagcatc agcgccagca gtagttccca
      901 ggggctgtct cagccgtcta cccagacgac ccagtatctg agagctgaca cacccaacaa
      961 tgcaacgcct atcaccagct cctcaggtta tcctaccttg cggatagaga agaacgactt
     1021 gcgaagtgtc actcttctgg aagccaaagc caaggtgaag gatatcgcaa tatccagaga
     1081 aaggatcaca ctgaaagatg tcctccaaga aggtactttt gggcgtattt tccatgggat
     1141 tttagtagat gaaaaagatc caaataaaga gaagcaaaca tttgtaaaaa cagttaaaga
     1201 ccaagcatct gaagttcagg tgacgatgat gctcaccgag agctgcaagc ttcgaggtct
     1261 gcaccacaga aacctccttc ctattactca tgtgtgcata gaagaaggag aaaagcccat
     1321 ggtggtattg ccatacatga attgggggaa tcttaaatta tttcttcggc agtgcaaatt
     1381 agtagaagcc aataatccac aggcaatttc ccagcaagat ctggtccata tggctattca
     1441 gattgcctgc gggatgagct acctggcgag gagagaagtg atccatagag acctggctgc
     1501 taggaactgt gtcatcgacg acactcttca agtcaagatc acagacaatg ccctttccag
     1561 agacttgttt cctatggact accactgcct aggggacaac gagaacaggc cagtgagatg
     1621 gatggctctg gaaagtctgg ttaataatga gttctctagt gctagtgacg tgtgggcctt
     1681 tggagtgacg ctgtgggagc tcatgactct gggccagacg ccctacgtgg acatcgaccc
     1741 ctttgagatg gccgcttacc tgaaagatgg ttaccgaata gcccagccaa tcaactgccc
     1801 tgatgaactg tttgctgtga tggcctgttg ctgggccttg gaccctgagg agaggcctaa
     1861 gttccagcag ctggtccagt gcctcacaga gttccacgct gccctgggag cctacgtctg
     1921 acttctctcc cagctccgcc actcagaaga aagtgcctgt ctgtcacgga tgcccctcgt
     1981 gcagcgcagt gcctgcaggg gcacactgtc tccagatcac ccagccttag cagtgcttcc
     2041 aaacctcagc ttttaacgat gacgtaataa cgcagagtgt tttctagata ccacttttac
     2101 taggttgaac caaaaggggt tttgtacatt ttttggccaa aaattttttt aaaatatagt
     2161 gactttggac tagggggtgc attcttttaa aaaatgaata aacagtttta aaaattattt
     2221 agacacagat atttggaata gctgtcttag tgccaactgc ttttattctt aatgttttac
     2281 ttcattgaag taatgtaggt gactcacctt taaagctatt ttaatatttt ggtcactact
     2341 tttgggagtg gtttgtcttc aaaatgcggt acttttctta ggaaaaacaa cattacgaag
     2401 ttgtctggtt tgccttatac gaagaaagat agtatattag gaaaattgaa aaagtaaaaa
     2461 gaaaaagaaa ttacaaagta aaaataaaaa aaaaaaaaca tatcgccccc gcatggaaaa
     2521 tcgcttgttt agtgaccatg gctctgctca catttgggga agcaggtctg agttcacatc
     2581 tcagtcagct ttcctgtgag ctggaagaag gctggggcag gcttgtggaa aacagtggtg
     2641 accttattta tttttgctct ccggggaagg agaggacaca gttcctgaca gtgacccctc
     2701 tctactgctg cggttccctc tgtgcacgcc tgggcggagc tacgcacaga gccggtgctt
     2761 ctgttgttgt gggtttgggg ggttttagtt ttggtttttg gtttaaattg gtaattttta
     2821 tgcttatctt caaggctggc ttaagtataa atttgttttt ttaaaacact tgaaaaatta
     2881 aaggactcat tttatatgct ggtattcaaa atactgctca cagtgtgtga ctgttggtcg
     2941 tgtcctgaaa gtcttggagt cacattttat cccctgagag tttgactcag gttccaaaac
     3001 cctaacagaa gaacagctga ctctgctcag ccgccagggc ctgttaagaa gttggagtta
     3061 ctcctacaag gacttatcat ggagagagtc cacaaataca tgtatgtagt tacacacagg
     3121 tttggtctac ctaagggatt gtcacctggg cctgtgaagt gactgggcct gcagctactg
     3181 cctctgtgtc tgtcctctca gggatgtgag ggagaacatg ggtctgttct attaaaataa
     3241 gtcttgtgaa taaagagagt atctgaa
//
