LOCUS       NM_001042607            3258 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus receptor-like tyrosine kinase (Ryk), transcript
            variant 2, mRNA.
ACCESSION   NM_001042607 XM_978368
VERSION     NM_001042607.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3258)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3258)
  AUTHORS   Kim,H.T., Panza,P., Kikhi,K., Nakamichi,Y., Atzberger,A.,
            Guenther,S., Ruppert,C., Guenther,A. and Stainier,D.Y.R.
  TITLE     WNT/RYK signaling functions as an antiinflammatory modulator in the
            lung mesenchyme
  JOURNAL   Proc Natl Acad Sci U S A 119 (24), e2201707119 (2022)
   PUBMED   35671428
  REMARK    GeneRIF: WNT/RYK signaling functions as an antiinflammatory
            modulator in the lung mesenchyme.
REFERENCE   3  (bases 1 to 3258)
  AUTHORS   Chau,T.C.Y., Baek,S., Coxam,B., Skoczylas,R., Rondon-Galeano,M.,
            Bower,N.I., Wainwright,E.N., Stacker,S.A., Cooper,H.M.,
            Koopman,P.A., Lagendijk,A.K., Harvey,N.L., Francois,M. and
            Hogan,B.M.
  TITLE     Pkd1 and Wnt5a genetically interact to control lymphatic vascular
            morphogenesis in mice
  JOURNAL   Dev Dyn 251 (2), 336-349 (2022)
   PUBMED   34174014
REFERENCE   4  (bases 1 to 3258)
  AUTHORS   Feng,B., Freitas,A.E., Gorodetski,L., Wang,J., Tian,R., Lee,Y.R.,
            Grewal,A.S. and Zou,Y.
  TITLE     Planar cell polarity signaling components are a direct target of
            beta-amyloid-associated degeneration of glutamatergic synapses
  JOURNAL   Sci Adv 7 (34) (2021)
   PUBMED   34407949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3258)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3258)
  AUTHORS   Hovens,C.M., Stacker,S.A., Andres,A.C., Harpur,A.G., Ziemiecki,A.
            and Wilks,A.F.
  TITLE     RYK, a receptor tyrosine kinase-related molecule with unusual
            kinase domain motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 11818-11822 (1992)
   PUBMED   1334548
REFERENCE   7  (bases 1 to 3258)
  AUTHORS   Maminta,M.L., Williams,K.L., Nakagawara,A., Enger,K.T., Guo,C.,
            Brodeur,G.M. and Deuel,T.F.
  TITLE     Identification of a novel tyrosine kinase receptor-like molecule in
            neuroblastomas
  JOURNAL   Biochem Biophys Res Commun 189 (2), 1077-1083 (1992)
   PUBMED   1281989
REFERENCE   8  (bases 1 to 3258)
  AUTHORS   Paul,S.R., Merberg,D., Finnerty,H., Morris,G.E., Morris,J.C.,
            Jones,S.S., Kriz,R., Turner,K.J. and Wood,C.R.
  TITLE     Molecular cloning of the cDNA encoding a receptor tyrosine
            kinase-related molecule with a catalytic region homologous to c-met
  JOURNAL   Int J Cell Cloning 10 (5), 309-314 (1992)
   PUBMED   1333503
REFERENCE   9  (bases 1 to 3258)
  AUTHORS   Wilks,A.F.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
REFERENCE   10 (bases 1 to 3258)
  AUTHORS   Hanks,S.K., Quinn,A.M. and Hunter,T.
  TITLE     The protein kinase family: conserved features and deduced phylogeny
            of the catalytic domains
  JOURNAL   Science 241 (4861), 42-52 (1988)
   PUBMED   3291115
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L21707.1, L02210.1, AK144355.1 and BB704205.1.
            
            On Jul 28, 2006 this sequence version replaced XM_978368.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032275.1, SRR7345562.971106.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                L21707.1           14-88
            76-977              L02210.1           51-952
            978-2171            AK144355.1         796-1989
            2172-2475           L02210.1           2157-2460
            2476-3256           AK144355.1         2294-3074
            3257-3258           BB704205.1         423-424
FEATURES             Location/Qualifiers
     source          1..3258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.72 cM"
     gene            1..3258
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="receptor-like tyrosine kinase"
                     /db_xref="GeneID:20187"
                     /db_xref="MGI:MGI:101766"
     exon            1..320
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1912
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; tyrosine-protein kinase RYK; growth factor
                     receptor; NYK-R; kinase VIK; met-related kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase RYK isoform 2 precursor"
                     /protein_id="NP_001036072.1"
                     /db_xref="CCDS:CCDS57696.1"
                     /db_xref="GeneID:20187"
                     /db_xref="MGI:MGI:101766"
                     /translation="MRAGRGGVPGSGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPA
                     GPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSK
                     VEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLT
                     VNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVG
                     VCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNA
                     TPITSYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILV
                     DEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPM
                     VVLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDL
                     AARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASD
                     VWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALD
                     PEERPKFQQLVQCLTEFHAALGAYV"
     exon            321..442
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..542
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            543..677
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            678..731
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            732..876
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..977
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1103
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1190
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1260
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1393
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1503
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1663
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1800
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..3258
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="major polyA site"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="hexamer: ATTAAA"
     polyA_site      2902
                     /gene="Ryk"
                     /gene_synonym="ERK-3; Vik"
                     /note="major polyA site"
ORIGIN      
        1 cccgttcccg ggcggcgggt ctgaagcggc ggcgcgatga gctggccggc cgcccccggc
       61 tcggggctgt gaggcgctcg gggccggggt gcgcggcggc gcggcgggcg gcggacgctc
      121 ctgctcggcg gcggccatgc gcgcgggccg gggcggcgtc ccggggagcg gcggcctgag
      181 ggccccgccg ccgccgctgc tgctgctgct gctggcgatg ctgcccgccg ccgccccgcg
      241 gtccccggcc ctggccgccg ctcctgcggg acccagcgtg agcctctacc tgagcgagga
      301 cgaggtgcgc cggctgcttg gtcttgatgc agagctttac tatgtgagaa atgacctcat
      361 cagtcactac gctctgtcct ttaacctgct agtgcccagt gagacaaact tcctgcactt
      421 cacttggcat gcaaagtcca aggttgaata taagctggga ttccaagtag acaactttgt
      481 ggctatgggc atgccccagg tcaatatttc tgctcaaggg gaggtcccac gcactttatc
      541 agtgtttcgg gtcgagcttt cttgtaccgg caaagtcgac tctgaagtca tgattctaat
      601 gcagctcaat ctgacagtga attcctcaaa aaattttaca gttttaaatt ttaaacgaag
      661 gaaaatgtgc tacaaaaaac ttgaagaagt aaaaacttca gccttggaca aaaacactag
      721 cagaactatt tatgaccctg tccatgcagc gccaacgact tccacgcgtg tgttttacat
      781 cagtgtaggg gtttgctgtg cagtgatatt tcttgtagca ataatattag ccgttttgca
      841 ccttcatagc atgaaaagga ttgaactgga tgacagcatc agcgccagca gtagttccca
      901 ggggctgtct cagccgtcta cccagacgac ccagtatctg agagctgaca cacccaacaa
      961 tgcaacgcct atcaccagtt atcctacctt gcggatagag aagaacgact tgcgaagtgt
     1021 cactcttctg gaagccaaag ccaaggtgaa ggatatcgca atatccagag aaaggatcac
     1081 actgaaagat gtcctccaag aaggtacttt tgggcgtatt ttccatggga ttttagtaga
     1141 tgaaaaagat ccaaataaag agaagcaaac atttgtaaaa acagttaaag accaagcatc
     1201 tgaagttcag gtgacgatga tgctcaccga gagctgcaag cttcgaggtc tgcaccacag
     1261 aaacctcctt cctattactc atgtgtgcat agaagaagga gaaaagccca tggtggtatt
     1321 gccatacatg aattggggga atcttaaatt atttcttcgg cagtgcaaat tagtagaagc
     1381 caataatcca caggcaattt cccagcaaga tctggtccat atggctattc agattgcctg
     1441 cgggatgagc tacctggcga ggagagaagt gatccataga gacctggctg ctaggaactg
     1501 tgtcatcgac gacactcttc aagtcaagat cacagacaat gccctttcca gagacttgtt
     1561 tcctatggac taccactgcc taggggacaa cgagaacagg ccagtgagat ggatggctct
     1621 ggaaagtctg gttaataatg agttctctag tgctagtgac gtgtgggcct ttggagtgac
     1681 gctgtgggag ctcatgactc tgggccagac gccctacgtg gacatcgacc cctttgagat
     1741 ggccgcttac ctgaaagatg gttaccgaat agcccagcca atcaactgcc ctgatgaact
     1801 gtttgctgtg atggcctgtt gctgggcctt ggaccctgag gagaggccta agttccagca
     1861 gctggtccag tgcctcacag agttccacgc tgccctggga gcctacgtct gacttctctc
     1921 ccagctccgc cactcagaag aaagtgcctg tctgtcacgg atgcccctcg tgcagcgcag
     1981 tgcctgcagg ggcacactgt ctccagatca cccagcctta gcagtgcttc caaacctcag
     2041 cttttaacga tgacgtaata acgcagagtg ttttctagat accactttta ctaggttgaa
     2101 ccaaaagggg ttttgtacat tttttggcca aaaatttttt taaaatatag tgactttgga
     2161 ctagggggtg cattctttta aaaaatgaat aaacagtttt aaaaattatt tagacacaga
     2221 tatttggaat agctgtctta gtgccaactg cttttattct taatgtttta cttcattgaa
     2281 gtaatgtagg tgactcacct ttaaagctat tttaatattt tggtcactac ttttgggagt
     2341 ggtttgtctt caaaatgcgg tacttttctt aggaaaaaca acattacgaa gttgtctggt
     2401 ttgccttata cgaagaaaga tagtatatta ggaaaattga aaaagtaaaa agaaaaagaa
     2461 attacaaagt aaaaataaaa aaaaaaaaac atatcgcccc cgcatggaaa atcgcttgtt
     2521 tagtgaccat ggctctgctc acatttgggg aagcaggtct gagttcacat ctcagtcagc
     2581 tttcctgtga gctggaagaa ggctggggca ggcttgtgga aaacagtggt gaccttattt
     2641 atttttgctc tccggggaag gagaggacac agttcctgac agtgacccct ctctactgct
     2701 gcggttccct ctgtgcacgc ctgggcggag ctacgcacag agccggtgct tctgttgttg
     2761 tgggtttggg gggttttagt tttggttttt ggtttaaatt ggtaattttt atgcttatct
     2821 tcaaggctgg cttaagtata aatttgtttt tttaaaacac ttgaaaaatt aaaggactca
     2881 ttttatatgc tggtattcaa aatactgctc acagtgtgtg actgttggtc gtgtcctgaa
     2941 agtcttggag tcacatttta tcccctgaga gtttgactca ggttccaaaa ccctaacaga
     3001 agaacagctg actctgctca gccgccaggg cctgttaaga agttggagtt actcctacaa
     3061 ggacttatca tggagagagt ccacaaatac atgtatgtag ttacacacag gtttggtcta
     3121 cctaagggat tgtcacctgg gcctgtgaag tgactgggcc tgcagctact gcctctgtgt
     3181 ctgtcctctc agggatgtga gggagaacat gggtctgttc tattaaaata agtcttgtga
     3241 ataaagagag tatctgaa
//
