LOCUS       NM_019743               4376 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus RING1 and YY1 binding protein (Rybp), mRNA.
ACCESSION   NM_019743
VERSION     NM_019743.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4376)
  AUTHORS   Kokity,L., Czimmerer,Z., Benyhe-Kis,B., Poscher,A., Belai,E.,
            Steinbach,G., Lipinszki,Z. and Pirity,M.K.
  TITLE     Brachyury co-operates with polycomb protein RYBP to regulate
            gastrulation and axial elongation in vitro
  JOURNAL   Front Cell Dev Biol 12, 1498346 (2024)
   PUBMED   39676794
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4376)
  AUTHORS   Liu,Y., Hu,G., Yang,S., Yao,M., Liu,Z., Yan,C., Wen,Y., Ping,W.,
            Wang,J., Song,Y., Dong,X., Pan,G. and Yao,H.
  TITLE     Functional dissection of PRC1 subunits RYBP and YAF2 during neural
            differentiation of embryonic stem cells
  JOURNAL   Nat Commun 14 (1), 7164 (2023)
   PUBMED   37935677
  REMARK    GeneRIF: Functional dissection of PRC1 subunits RYBP and YAF2
            during neural differentiation of embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4376)
  AUTHORS   Liu,C., Sun,L., Tan,Y., Wang,Q., Luo,T., Li,C., Yao,N., Xie,Y.,
            Yi,X., Zhu,Y., Guo,T. and Ji,J.
  TITLE     USP7 represses lineage differentiation genes in mouse embryonic
            stem cells by both catalytic and noncatalytic activities
  JOURNAL   Sci Adv 9 (20), eade3888 (2023)
   PUBMED   37196079
  REMARK    GeneRIF: USP7 represses lineage differentiation genes in mouse
            embryonic stem cells by both catalytic and noncatalytic activities.
REFERENCE   4  (bases 1 to 4376)
  AUTHORS   Henry,S., Kokity,L. and Pirity,M.K.
  TITLE     Polycomb protein RYBP activates transcription factor Plagl1 during
            in vitro cardiac differentiation of mouse embryonic stem cells
  JOURNAL   Open Biol 13 (2), 220305 (2023)
   PUBMED   36751888
  REMARK    GeneRIF: Polycomb protein RYBP activates transcription factor
            Plagl1 during in vitro cardiac differentiation of mouse embryonic
            stem cells.
REFERENCE   5  (bases 1 to 4376)
  AUTHORS   Sutus,E., Henry,S., Adorjan,L., Kovacs,G. and Pirity,M.K.
  TITLE     RYBP regulates Pax6 during in vitro neural differentiation of mouse
            embryonic stem cells
  JOURNAL   Sci Rep 12 (1), 2364 (2022)
   PUBMED   35149723
  REMARK    GeneRIF: RYBP regulates Pax6 during in vitro neural differentiation
            of mouse embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4376)
  AUTHORS   Pirity,M.K., Locker,J. and Schreiber-Agus,N.
  TITLE     Rybp/DEDAF is required for early postimplantation and for central
            nervous system development
  JOURNAL   Mol Cell Biol 25 (16), 7193-7202 (2005)
   PUBMED   16055728
  REMARK    GeneRIF: Rybp/DEDAF is required for early postimplantation and for
            central nervous system development
REFERENCE   7  (bases 1 to 4376)
  AUTHORS   Giangrande,P.H., Zhu,W., Schlisio,S., Sun,X., Mori,S., Gaubatz,S.
            and Nevins,J.R.
  TITLE     A role for E2F6 in distinguishing G1/S- and G2/M-specific
            transcription
  JOURNAL   Genes Dev 18 (23), 2941-2951 (2004)
   PUBMED   15574595
REFERENCE   8  (bases 1 to 4376)
  AUTHORS   Danen-van Oorschot,A.A., Voskamp,P., Seelen,M.C., van
            Miltenburg,M.H., Bolk,M.W., Tait,S.W., Boesen-de Cock,J.G.,
            Rohn,J.L., Borst,J. and Noteborn,M.H.
  TITLE     Human death effector domain-associated factor interacts with the
            viral apoptosis agonist Apoptin and exerts tumor-preferential cell
            killing
  JOURNAL   Cell Death Differ 11 (5), 564-573 (2004)
   PUBMED   14765135
REFERENCE   9  (bases 1 to 4376)
  AUTHORS   Ebling,F.J., Brooks,A.N., Cronin,A.S., Ford,H. and Kerr,J.B.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   10 (bases 1 to 4376)
  AUTHORS   Garcia,E., Marcos-Gutierrez,C., del Mar Lorente,M., Moreno,J.C. and
            Vidal,M.
  TITLE     RYBP, a new repressor protein that interacts with components of the
            mammalian Polycomb complex, and with the transcription factor YY1
  JOURNAL   EMBO J 18 (12), 3404-3418 (1999)
   PUBMED   10369680
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158655.4.
            
            On Mar 21, 2007 this sequence version replaced NM_019743.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053016.1, SRR9219383.124131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC158655.4         7440-7552
            114-239             AC158655.4         8190-8315
            240-416             AC158655.4         61559-61735
            417-515             AC158655.4         61833-61931
            516-4376            AC158655.4         62373-66233
FEATURES             Location/Qualifiers
     source          1..4376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 46.62 cM"
     gene            1..4376
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="RING1 and YY1 binding protein"
                     /db_xref="GeneID:56353"
                     /db_xref="MGI:MGI:1929059"
     exon            1..113
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..768
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="Ring1 interactor Rybp; DED-associated factor; death
                     effector domain-associated factor"
                     /codon_start=1
                     /product="RING1 and YY1-binding protein"
                     /protein_id="NP_062717.2"
                     /db_xref="CCDS:CCDS39579.1"
                     /db_xref="GeneID:56353"
                     /db_xref="MGI:MGI:1929059"
                     /translation="MTMGDKKSPTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSIC
                     DVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKVEKPDKEKPEKDKDISPSV
                     TKKNTNKKTKPKSDILKDPPSEANSIQSANATTKTSETNHTSRPRLKNVDRSTAQQLA
                     VTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKG
                     DMSAVNDESF"
     exon            114..239
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..416
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..515
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..4376
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1041..1046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="hexamer: TATAAA"
     polyA_site      1081
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="major polyA site"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1402
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="major polyA site"
     regulatory      4234..4239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
                     /note="hexamer: AATAAA"
     polyA_site      4261
                     /gene="Rybp"
                     /gene_synonym="2410018J24Rik; DEDAF; YEAF1"
ORIGIN      
        1 ccgctccgcg acgctgcgga ccgcgcttct cctctgagcg gcggcgcgcg cagctgtggg
       61 gcgccggggg ccagcccgtc catgaccatg ggcgacaaga agagcccgac caggccaaaa
      121 agacaagcga aacctgccgc agacgaaggc ttttgggatt gtagcgtctg cacctttagg
      181 aacagcgccg aagcctttaa atgcagcatc tgcgatgtgc ggaaaggcac ctccaccagg
      241 aaacctcgca tcaattctca gctggtggca cagcaggtgg cacagcagta cgccactcca
      301 cctcccccta agaaggagaa gaaggagaag gtcgaaaagc ctgacaaaga aaagccagag
      361 aaagacaagg acattagccc cagtgtcacc aagaaaaaca ccaacaagaa aacaaaacca
      421 aagtctgata ttctgaaaga tcctcctagt gaagctaaca gcatacagtc tgctaacgct
      481 acaacaaaga ccagcgaaac aaaccacacc tcaaggcccc ggctgaagaa tgtggacagg
      541 agcaccgcac agcagttggc agtaactgtg ggcaacgtca ccgtcattat cacagacttt
      601 aaggaaaaga ctcgctcctc ctccacatcc tcttccacag tgacctccag tgcagggtca
      661 gaacagcaga accagagcag ctcgggctca gagagcacag acaaaggctc ctcccgctcc
      721 tccacgccaa agggcgacat gtcagcagtg aatgatgaat ctttctgaga ttgcacatgg
      781 aattgtgaaa ctatgaatca gggtatgaga ttcaaaccct ccacctgccc atgctgcttg
      841 caccctggag agtcttctgt ggacgacctt gtagtgacgc taccaggaga ggttccgctt
      901 gccgtgggca tctggctacc aaggaatttc gtaccctgac agttactctt gacactttta
      961 tgtattccat tgttttatat gattttccta acaatcattt ataattggat gtgctcctga
     1021 atctactttt tatatatata tataaaaaaa atctgctgtg cacaattttc catgtacatt
     1081 acaactggtt ttgtttctgt tttgttgaag agggttggga ggggggaggg aacttttatt
     1141 tattgtgttc acagactcca tcctgtcagc atatcctctt aaatttagtt ctttcttcca
     1201 gctatactct gtactatcag ttttgatata actatatata taaatataaa attatatata
     1261 aagggttatt tgaaaccaat ccatggcaac gctggtgctt gatacactgt gaagtgaata
     1321 caacattgaa cagttgacac agatctggga cagtcccttc tatgaaagtg ctgaaatatc
     1381 attaaaatca gtcttacatg aagtatgttc caacctgcgt gggaacttga ctctctcatc
     1441 tgtctttaga gtactggata atataaaaaa tatatttttt aaacaatgtg atctcaaatt
     1501 taaagactgc tccagatagc ctgcatttgc aatgggctaa ttgacaaatg acaagtggtt
     1561 cagttggagg gctttgacca ttcggaagta acaagactag ctccagaatg ccaagtattc
     1621 gtgtaaatta tggttacatg ttaacattgc tgtttttatt aagcactcat gagaatatgg
     1681 tgttctgtat ctcgaattcc ggcctttttc cagacctctg ctcacgcctg aggtatatct
     1741 agcagctgtc ttagttctag ggttgcggta gtgcatcttt gaatccacac cacccaggga
     1801 agcagtctac atcctctgtg gtgttgcagt ggtggatttt gtgatcatgg cctgttttac
     1861 tcctcctccc gtaccccgtc ctccaaatcc tcaccctacc aatgcagttg ttagtctttc
     1921 ttcttaaaac ctactatggc tcattttatt aaacaagggt tgtcaacctc acatccagac
     1981 ctgacacaga gatcttccag tctctggagt cagttcttag ttccttgtgt gggaaaggat
     2041 cgcaggggtg catgggcgag ttgcggggaa agctcacttc ccaggagagt gaatgaatag
     2101 taggtgttct ttgttgactg aactcttgaa agcttttcat tttcaccatt ttaggggtag
     2161 gagataatga aagaccactg ataatagttt atcatcccat cccaagtctc agtgactctg
     2221 ctttgctctt agattcaggg tatctctcct atctgactta gcttcatgtc caccgagttt
     2281 gtagtgctta agtcacatta agcatgtggt gttaaccttc ctttagttta tcacactcaa
     2341 ggactcatag gagagcgtgt aagggaacac cgactcttgg tggtaaaaga accgggtttg
     2401 cttaataaaa gaatttctat gtgtggaggc aacaagttaa gaacatatta acagcttgaa
     2461 ttgagtagcc aacaggaatg gttccattca catttacatt aaaaccagtc attcgatgcg
     2521 ccggagtctg tccacaaagg cagtgctatt tgtcaatggg ctcctgttct cgacgcatgg
     2581 acaatgctcc cctcttttta aaacagtgct tgtgtctggg atgcaagctg tacttacctt
     2641 tttaaatacc tttttaaagt atttattaat gaaccaaagg aaaccaggtg ctttctgtaa
     2701 gcatcagaat atataataca tagtgatttg actatgaatt ttaaatccac attttaatat
     2761 tagtggggta ttgcaaagac attccttcta aagttttaat attcctttta ttaagggtct
     2821 cagggagggt taattagtca gccatattta ttttccagag gtgtaaggaa ttgctaagtt
     2881 ttttaattaa ctttttaaaa aaaaaattaa atgccaccaa attcatgtgg attgcactgc
     2941 tctttgaacc aataagtgtt ggtatgcact ttgttcagaa acactgtgta ctttttcaaa
     3001 acgagtttca tgtaaagtga ttggaccccc tagattagtg gaaaaggctg atttaccagc
     3061 tcctcatagg ctactaattc attcatcgct ggtgtcttgg gttttcagtt ttgcctccat
     3121 gataaattaa agaatgagga gaggtgaagg gagggaagga ccacttcaga actagtgaac
     3181 ttgccttgag gtagaaactg cagtggtgga gtctaagcag tcagatgttc ctggccgccc
     3241 tgtctcggct gtcgtgggct gcgttgggat agagaggtga taggtgccac acaatgccat
     3301 cctcaggcat gcattctgga aatggaattc ctattagctt cctgcattta cagtttgccc
     3361 tgctatagta ctccgtaggt aaaaacacta gtgtagctta caaagagaca ttaagaggac
     3421 cagaaatact tggtattcag tggcacagaa agaaagcaga ttaaaacaaa aagcacagtg
     3481 ttaaggcttg caagtttccc gtgcgtttag tacatgatct ttcacactcg tgtgcacaca
     3541 cacagctgag ctgacatgct ctgcccgagt catgcagttg ggaaggggga aaagacatct
     3601 tgacacccac gagaatattt taatcaaaac ctttcagttt ggatctggat acttcaaaac
     3661 attggcagac gcttctgtga gtttagctcc actaagatgt ctcgcctgcc ttattaagac
     3721 cattctcagt ctacattttt aagctgccgt atcttaaatt attgagaatt tattaattgc
     3781 tgactatata ataacctttg cttgtatgtt acggaaaatg gtttaagagc caacatttag
     3841 agtgtgacaa tggagctgaa cagtttctaa cgcgcaagca gttctgttct tgtgtatgac
     3901 ttgtaacctt aatttactgt gtaaagatgg ttacattatt tccttagctt tgtttgttgg
     3961 agacagatag cgaatgcttg ttaagtatgt caacataatc tccccttgtg aacttttgtt
     4021 aatgtcttat acgagctctc ttttccattt gcccagaaag gtggcttgta taacgctttg
     4081 gaagtttctg ctccgtccgt cttagagctg acagtctgtt aggtttgttt tctcttcatg
     4141 ctaaagtgtc ggtggttttg tgaactggtc agaaattcac aggtcttaaa tgtttggggg
     4201 aaatttatat tggacactgc tctttgtcta gcaaataaaa gatgttaata tattcctgtt
     4261 attggcatgt gcacgactgt tattagaagc cactttatca ttttcctgct ttaaatagaa
     4321 atgtctattt atgaattctg cttgtagttt tttcacaaat aaaatagtaa aattta
//
