LOCUS       NM_153059               1767 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ribitol xylosyltransferase 1 (Rxylt1), transcript
            variant 1, mRNA.
ACCESSION   NM_153059
VERSION     NM_153059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124763.1, AK075928.1, AK078061.1 and AC158803.11.
            
            On Jun 29, 2018 this sequence version replaced NM_153059.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078061.1, AK043098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BY124763.1         2-79
            79-733              AK075928.1         2-656
            734-1700            AK078061.1         734-1700
            1701-1767           AC158803.11        135411-135477       c
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 70.25 cM"
     gene            1..1767
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /note="ribitol xylosyltransferase 1"
                     /db_xref="GeneID:216395"
                     /db_xref="MGI:MGI:2384919"
     exon            1..271
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1434
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /EC_number="2.4.2.61"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-D-xylose:ribitol-5-phosphate
                     beta1,4-xylosyltransferase; ribitol-5-phosphate
                     xylosyltransferase 1; transmembrane protein 5"
                     /codon_start=1
                     /product="ribitol-5-phosphate xylosyltransferase 1 isoform
                     1"
                     /protein_id="NP_694699.1"
                     /db_xref="CCDS:CCDS24214.1"
                     /db_xref="GeneID:216395"
                     /db_xref="MGI:MGI:2384919"
                     /translation="MRLTRTRLCSLLVALYCLFSIYAAYHVFFGRRRRPLGTTSRNSR
                     KAAAAQAKERRGREQSALESEEWNPWEGDEKNEQRHRVKTNLQILNKSTKEKIEHRVQ
                     IWGKAAIGLYLWEHIFEGTLDPADVTAQWREGQSVVGRTHYSFITGPAVVPGYFSIDV
                     DNVVLVLNGREKAKIFHATQWLIYAQNLMKTQKLQHLAVVLLGNEHCENDWIMQFLKR
                     NGGFVDLLFITYDSPWINGADILQWPLGVATYRQFPVVEASWTMLHDERPYICNFLGT
                     AYENSSRQALMNILKQDGNDKLCWVSAREQWQPQETNESLKNYQDALLHSDLTLCPVG
                     VNTECYRIYEACSFGSIPVVEDVMTAGHCGNTTSQHSAPLQLLKAMGAPFIFIKNWKE
                     LPAILEKEKTISLQEKIQRRKVLLHWYQHFKTELKWKFTKILESSFFINNKV"
     exon            272..427
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            428..530
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..845
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1016
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1767
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /note="hexamer: AATAAA"
     polyA_site      1446
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /note="major polyA site"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /note="hexamer: ATTAAA"
     polyA_site      1586
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
                     /note="hexamer: AATAAA"
     polyA_site      1767
                     /gene="Rxylt1"
                     /gene_synonym="6330415D21Rik; Tmem5"
ORIGIN      
        1 gtctgggctt agcccgcagg gagggcggca acctgggccg gagcttttcc tcacgcccag
       61 ggcggaggcg aggacgccgg gccgggaagc cgcggtggga tgcggctgac gcggacacgg
      121 ctgtgctccc tcctcgtcgc cctgtactgc ctcttctcca tctacgccgc ctaccacgtc
      181 ttcttcgggc gccgccgccg gccgctgggc acgacctctc ggaactccag gaaggcggcg
      241 gcggcgcagg cgaaggagag gcgcggccga gagcagtccg ctttggagag tgaagaatgg
      301 aatccttggg aaggagatga aaaaaacgag cagcgacaca gagttaagac caacctgcaa
      361 atcttaaaca aatccacgaa agaaaaaata gagcataggg tgcaaatctg gggcaaagct
      421 gccattggtc tgtatctctg ggaacatatt tttgaaggca ctcttgatcc tgctgatgtg
      481 actgctcagt ggagggaagg acagtcagtt gtaggaagaa cgcattacag cttcatcaca
      541 ggcccagctg tagttcctgg gtacttctcc atagatgtgg acaatgtggt tcttgtttta
      601 aatggaagag aaaaagcaaa gatctttcat gccacccagt ggttaattta tgcacagaat
      661 ttaatgaaaa cccaaaaact gcagcatctg gctgttgtct tgcttggaaa tgagcactgt
      721 gaaaatgact ggataatgca gttcctcaaa agaaatggag gctttgtgga tctgcttttc
      781 ataacatatg acagcccctg gattaatggt gcagacattc tccagtggcc tttaggtgta
      841 gcaacatata ggcagtttcc tgtagttgaa gccagctgga caatgctgca tgatgagagg
      901 ccctacatat gtaatttctt aggaactgcc tatgaaaatt catcaagaca agcactaatg
      961 aacattttga aacaagatgg aaatgataaa ctttgttggg tttctgcaag agaacagtgg
     1021 cagcctcagg agacaaatga aagccttaag aattaccaag atgctttgct tcacagtgat
     1081 ctcacattgt gccctgtagg agtgaacacg gaatgttaca ggatctatga ggcctgctcc
     1141 tttggctcca ttcctgtggt agaagatgtg atgacagctg gtcactgtgg aaacacaacc
     1201 agtcagcaca gtgctcctct gcagttactc aaggccatgg gggccccctt catcttcatc
     1261 aagaactgga aggagcttcc tgctatttta gaaaaggaga agactataag cttacaagaa
     1321 aagattcaaa gaagaaaagt gttacttcat tggtaccaac acttcaaaac agaactaaaa
     1381 tggaaattta ctaaaatttt agaaagttca ttttttatta ataataaagt ttaattatgt
     1441 ctagtaccat gtattcataa gtgtaaatag ttatagtgct gtctaagctg actccatcag
     1501 ctccatcatg taacagacca aatactctcc tttggctact actatgcaca agattaaaga
     1561 gatggcaata tttttctaag cttgaactgg caggatggtt gagtggttaa aggtgcttgc
     1621 tcccaagcct gatgacctaa gttcaatccc ccgaagccac ataatagaag gagagaaatg
     1681 agtctcacga ctgtcttgtg acttccccac cagcatgcac acagaaacac gcagcagata
     1741 agtaaataaa taaataactt actcaga
//
