LOCUS       NM_011306               2621 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus retinoid X receptor beta (Rxrb), transcript variant 2,
            mRNA.
ACCESSION   NM_011306
VERSION     NM_011306.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Shibata,M., Pattabiraman,K., Lorente-Galdos,B., Andrijevic,D.,
            Kim,S.K., Kaur,N., Muchnik,S.K., Xing,X., Santpere,G., Sousa,A.M.M.
            and Sestan,N.
  TITLE     Regulation of prefrontal patterning and connectivity by retinoic
            acid
  JOURNAL   Nature 598 (7881), 483-488 (2021)
   PUBMED   34599305
REFERENCE   4  (bases 1 to 2621)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2621)
  AUTHORS   Zeng,Y., Yan Wang,C., Xu,J. and Le Xu,X.
  TITLE     Overexpression of retinoid X receptor beta provides protection
            against oxidized low-density lipoprotein-induced inflammation via
            regulating PGC1alpha-dependent mitochondrial homeostasis in
            endothelial cells
  JOURNAL   Biochem Pharmacol 188, 114559 (2021)
   PUBMED   33872571
  REMARK    GeneRIF: Overexpression of retinoid X receptor beta provides
            protection against oxidized low-density lipoprotein-induced
            inflammation via regulating PGC1alpha-dependent mitochondrial
            homeostasis in endothelial cells.
REFERENCE   6  (bases 1 to 2621)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 2621)
  AUTHORS   Marks,M.S., Hallenbeck,P.L., Nagata,T., Segars,J.H., Appella,E.,
            Nikodem,V.M. and Ozato,K.
  TITLE     H-2RIIBP (RXR beta) heterodimerization provides a mechanism for
            combinatorial diversity in the regulation of retinoic acid and
            thyroid hormone responsive genes
  JOURNAL   EMBO J 11 (4), 1419-1435 (1992)
   PUBMED   1314168
REFERENCE   8  (bases 1 to 2621)
  AUTHORS   Mangelsdorf,D.J., Borgmeyer,U., Heyman,R.A., Zhou,J.Y., Ong,E.S.,
            Oro,A.E., Kakizuka,A. and Evans,R.M.
  TITLE     Characterization of three RXR genes that mediate the action of
            9-cis retinoic acid
  JOURNAL   Genes Dev 6 (3), 329-344 (1992)
   PUBMED   1312497
REFERENCE   9  (bases 1 to 2621)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1330328]
REFERENCE   10 (bases 1 to 2621)
  AUTHORS   Hamada,K., Gleason,S.L., Levi,B.Z., Hirschfeld,S., Appella,E. and
            Ozato,K.
  TITLE     H-2RIIBP, a member of the nuclear hormone receptor superfamily that
            binds to both the regulatory element of major histocompatibility
            class I genes and the estrogen response element
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8289-8293 (1989)
   PUBMED   2554307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5.
            
            On Mar 31, 2011 this sequence version replaced NM_011306.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049773.1, KJ663717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               CR974462.5         124984-125395
            413-630             CR974462.5         125999-126216
            631-787             CR974462.5         126727-126883
            788-967             CR974462.5         127194-127373
            968-1140            CR974462.5         128826-128998
            1141-1270           CR974462.5         129497-129626
            1271-1403           CR974462.5         129797-129929
            1404-1495           CR974462.5         130045-130136
            1496-1601           CR974462.5         130339-130444
            1602-2621           CR974462.5         130556-131575
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2621
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /note="retinoid X receptor beta"
                     /db_xref="GeneID:20182"
                     /db_xref="MGI:MGI:98215"
     exon            1..412
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1749
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /note="isoform 2 is encoded by transcript variant 2;
                     retinoic acid receptor RXR-beta; nuclear receptor
                     subfamily 2 group B member 2; MHC class I regulatory
                     element-binding protein H-2RIIBP; putative retinoid X
                     receptor beta"
                     /codon_start=1
                     /product="retinoic acid receptor RXR-beta isoform 2"
                     /protein_id="NP_035436.1"
                     /db_xref="CCDS:CCDS89073.1"
                     /db_xref="GeneID:20182"
                     /db_xref="MGI:MGI:98215"
                     /translation="MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLD
                     PAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPL
                     TPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGS
                     GPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKR
                     TIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDG
                     DGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQL
                     FTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHR
                     NSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEIL
                     REKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTF
                     LMEMLEAPHQLA"
     exon            413..630
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            631..787
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            788..967
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1140
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1270
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1403
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1495
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1601
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..2621
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /note="hexamer: CATAAA"
     polyA_site      2617
                     /gene="Rxrb"
                     /gene_synonym="H-2RIIBP; Nr2b2; RCoR-1; Rub"
                     /note="major polyA site"
ORIGIN      
        1 gtacaaagat ggcggccgcg ccggtgctgt catctcagtg ccgagccgag cgcggctctt
       61 gagtcgcgct gccacaggcc gcggcctgct cgcctccgcg gcttcgtcgc ggcccccgag
      121 tcccccgctg tcccccctgc gcgtccctgg cgcctctccg gcttccccgc cctcggcccg
      181 ggcgtcatgt cttgggccac tcgtccgccc ttcctcccgc cgcggcatgc cgcggggcag
      241 tgtgggccgg tgggggtgag aaaagagatg cattgtgggg tcgcgtcccg gtggcggcgg
      301 cggcggccct ggctggatcc cgcggcggcg gcggcggcgg ccggagagca gcaagccctg
      361 gagccggagc cgggggaggc tggccgggac gggatgggcg acagcgggcg ggattcccga
      421 agcccagaca gctcctcccc aaatcccctt tctcagggga tccgtccgtc ttctcctcct
      481 ggcccacctc ttaccccttc agcacctcca cctccaatgc cacccccgcc actgggctcc
      541 cccttcccag tcatcagttc ttccatgggg tcccctggtc tgccccctcc ggctccccca
      601 ggattctccg ggcctgtcag cagccctcag atcaactcca cagtgtcgct ccctgggggt
      661 gggtctggcc cccctgaaga tgtgaagcca ccggtcttag gggtccgggg cctgcactgt
      721 ccaccccctc caggtggtcc tggggctggc aaacggctct gtgcaatctg cggggaccga
      781 agctcaggca agcactatgg ggtttacagc tgcgagggct gcaagggttt cttcaagcgc
      841 accattcgga aggacctgac ctactcgtgt cgtgataaca aagactgtac agtggacaag
      901 cgccagcgga atcgctgtca gtactgtcgc tatcagaagt gcctggccac tggcatgaaa
      961 agggaggcgg ttcaggagga gcgtcaacgg gggaaggaca aagacgggga tggagatggg
     1021 gctgggggag cccctgagga gatgcctgtg gacaggatcc tggaggcaga gcttgctgtg
     1081 gagcagaaga gtgaccaagg cgttgagggt cctggggcca ccgggggtgg tggcagcagc
     1141 ccaaatgacc cagtgactaa catctgccag gcagctgaca aacagctgtt cacactcgtt
     1201 gagtgggcaa agaggatccc gcacttctcc tccctacctc tggacgatca ggtcatactg
     1261 ctgcgggcag gctggaacga gctcctcatt gcgtccttct cccatcggtc cattgatgtc
     1321 cgagatggca tcctcctggc cacgggtctt catgtgcaca gaaactcagc ccattccgca
     1381 ggcgtgggag ccatctttga tcgggtgctg acagagctag tgtccaaaat gcgtgacatg
     1441 aggatggaca agacagagct tggctgcctg cgggcaatca tactgtttaa tccagacgcc
     1501 aagggcctct ccaaccctgg agaggtggag atccttcggg agaaggtgta cgcctcactg
     1561 gagacctatt gcaagcagaa gtaccctgag cagcagggcc ggtttgccaa gctgctgtta
     1621 cgtcttcctg ccctccgctc catcggcctc aagtgtctgg agcacctgtt cttcttcaag
     1681 ctcattggcg acacccccat tgacaccttc ctcatggaga tgcttgaggc tccccaccag
     1741 ctagcctgag cccagatgca caccgagtgt cactgaggag gacttgagcc tgggcagggg
     1801 gcagagccat gggacaggtg cagagcagga ggggacttgc ccagcctgcc agggatctgg
     1861 caacacttag cagggttcgt ttggtctcca agtcagaggg gaccccagat ccctgtgagg
     1921 actatatgtc taccttcagt ggccttgagt ctctgaattt gtcggggtct cccatggtgc
     1981 aggtgattct tcatcctggc tccccagcac aaagcactgc cctgcttcct tctcatttgg
     2041 cctcactccc ttctgaagag tggaacagag ctcccccaga aaggggtgtt gtggggcagg
     2101 ccccccaagc tgatgatcat gggagcaggg ctctgacagc ctttatcctc tcagacttga
     2161 cagatggggc agaggaggga cctgcctctg actcctgtca gccccatttc cacagtccct
     2221 cctgcagtca gactgaagaa taaaggggta gtgaaggggc tgctggaggt ggaggaaccc
     2281 attgctcttt taatttcctg tgaggagaga ctgggagtta gactcaaaga agtactgtac
     2341 atccccaggt tgacttaaat gtcagggctg gagatggcat gtgggcaagg aggcccctca
     2401 ggtgggctgt cccaaagctc cctgggctct gcctcgggtg gccctacagc tcttccctag
     2461 tcctcagcac agctaggctg ggagcaagtg gggacattga tgggggtggc cagcctgcag
     2521 agttgggtgc tgggctgcat ggtttttgcc ctggacctct tttgggggtt ccctcccatc
     2581 tttcacttgc acataaagtt gctttccagt taaaatagcc a
//
